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All Journal Jurnal Keperawatan Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Biology, Medicine, & Natural Product Chemistry The Indonesian Biomedical Journal Journal of Islamic Medicine Abdimasku : Jurnal Pengabdian Masyarakat Heart Science Journal JSMARTech : Journal of Smart Bioprospecting and Technology Malang Respiratory Journal Cermin Dunia Kedokteran
Djanggan Sargowo
Pascasarjana Fakultas Kedokteran, Universitas Brawijaya, Malang
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Comparison of Clinical Outcomes of Patients With Chronic Vein Insufficiency Underwent Endovenous Laser Ablation With Puncture Above The Knee And Below The Knee Techniques Based on Venous Clinical Severity Score And Venous Disability Score Assessment Suprayoga, Imam Mi'raj; Kurnianingsih, Novi; Sargowo, Djanggan
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.9

Abstract

Background: In chronic venous insufficiency (CVI), a puncture below the knee is done to access the great saphenous vein for endovenous laser ablation (EVLA). Getting a puncture below the knee is difficult in some conditions. Puncture above the knee to access the incompetent saphenous vein is another option. Objective: This study compared CVI patients' clinical results after EVLA with above- and below-the-knee punctures.Methods/Design: This retrospective, single-centre cohort study compared clinical outcomes after two EVLA technical punctures. Puncturing the GSV below the knee was one way. An above-knee GSV puncture was chosen as an alternative. At all follow-up visits, clinical outcomes, closure rate, and complications such as thrombosis, bruising, burn damage, and paresthesia were assessed.  Results: This study has recruited 248 patients, with 132 patients in the below-knee group and 116 patients in the above-knee group. Similar clinical outcomes after the procedure with the Venous Clinical Severity Score (VCSS) were seen in both groups (p = 0.875) and with the Venous Disability Score (VDS) were seen in both groups (p = 0.777) without significant difference. The closure rate in both groups was 100%. Complications, including thrombosis, did not show statistical significance between groups (p = 1.000). Bruising, burn injuries, and paresthesia were absent in both groups.Conclusion: The EVLA for incompetence GSV using an above-knee puncture was safe and effective and should be considered as an alternative method if the below-knee puncture fails.
Effect of β-1,3-1,6-D-glukan (polysaccharide peptide) from miselia ganoderma lucidum extract as antioxidant and antiinflammation towards left ventricular systolic function in cardiometabolic patients Aryanugraha, Teguh; Sargowo, Djanggan; Rahimah, Anna Fuji
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.9

Abstract

Background: Cardiometabolic disease (CMD) describes a metabolic condition often associated with cardiovascular disease. It has been revealed that the Ganoderma lucidum polysaccharide peptide (GLPP) possesses anti-inflammatory and antioxidant qualities. Objective: This study aimed to find out how GLPP affected oxidative stress, inflammation, and left ventricular function in individuals with cardiometabolic syndrome.Methods: A multicenter double-blinded randomized controlled trial was carried out. Subjects with cardiometabolic syndrome received either GLPP or a placebo for ninety days. Before taking the initial treatment and one day following the last treatment intake, blood samples were taken from every participant. The enzyme-linked immunosorbent assay was used to evaluate the levels of serum tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), malondialdehyde (MDA), and high-sensitivity-C-Reactive Protein (hs-CRP) while the colorimetric test was used to measure the levels of superoxide dismutase (SOD). Global longitudinal strain (GLS)  and Left ventricle ejection fraction (LVEF) were measured by single echocardiographer expert validation.Results: The MDA level was decreased in the GLPP treatment group (mean 56.0 ± 71.4 ng/mL to 27.7 ± 12.0 ng/mL, p= 0.023) compared to the control group (mean 39.3 ± 29.2 ng/mL to 38.3 ± 17.7 ng/mL, p= 0.719). However, the SOD level remained constant in the GLPP treatment (mean 122.2 ± 176.1 U/mL to 93.0 ± 40.9 U/mL, p=0.925) instead of significantly declining in the control group (mean 102.0 ± 67.3 U/mL to 64.0 ± 52.0 U/mL, p=0.016). The marker of TNF-α and hsCRP were significantly decreased in all groups (both p<0.05), but IL-6 was only significantly decreased in the control group (mean 1149.3 ± 581.7 pg/mL to 744.8 ± 336.5 pg/mL, p=0.010). The GLS was significantly decreased in the GLPP treatment group (-16.1 ± 4.1 to -17.5 ± 4.8, p=0.048) but there was no difference in LVEF in both groups (p>0.05).Conclusion: Patients with cardiometabolic syndrome may benefit from GLPP treatment for 90 days in terms of reduced inflammation, oxidative stress, and improved systolic left ventricular performance.
Cardiac imaging in cardiovascular complications due to COVID-19 Galuh, Lukitasari Ayu; Sargowo, Djanggan; Satrijo, Budi; Handari, Saskia Dyah; Rahimah, Anna Fuji
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.6

Abstract

Cardiovascular complications are a common manifestation of acute phase and chronic phase of coronavirus disease 2019 (COVID-19) infection. Complications include cardiomyopathy, myocardial infarction, arrhythmias, heart failure, and deep venous thrombosis. Imaging is widely used in patients with suspected myocardial injury or myocarditis. Because of its availability and portability, transthoracic echocardiography (TTE) is used as the initial imaging modality in patients with suspected COVID-19 myocarditis. Echocardiographic studies performed on patients with suspected or confirmed COVID-19 should be as focused as necessary to obtain diagnostic views but should also be comprehensive enough to avoid the need to return for additional images. Following COVID-19 infection, a variety of persistent respiratory, neurological, cardiovascular, and other symptoms can persist for weeks, months, or even years. A cardiac examination and any resulting abnormalities in the structure and function of the heart may occasionally last for several months following a COVID-19 diagnosis. This is referred to as long  COVID syndrome. Cardiac magnetic resonance (CMR) imaging has often been used clinically to complement echocardiography, particularly tissue characterization imaging which demonstrated subclinical myocardial edema with or without fibrosis in patients recovered from illness.
Correlation Between Smoking and Il-1 Level and Arterial Stiffness as Measured By Cavi in the Young Adult Population Without other Cardiovascular Risk Factors. Galih Prakosa, Ardani; Tjahjono, Cholid Tri; Kurnianingsih, Novi; Sargowo, Djanggan; Anjarwani, Setyasih
Heart Science Journal Vol. 4 No. 3 (2023): The Essensial Role of the Metabolic Syndrome in the Development of Cardiovascul
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.03.5

Abstract

Background: Recent studies have shown that arterial stiffness is a strong predictor of cardiovascular events and all-cause mortality, with CAVI (Cardio-Ankle Vascular Index) as a non-invasive arterial stiffness testing method indaily practice.Objective: This study was conducted to examine the relationship between smoking -as a risk factor for arterial stiffness- and CAVI values, as well as levels of IL-1β (Interleukin 1β) as a cytokine that plays a role in the pathophysiology of arterial stiffness.Methods: Eighty-four participants, including smokers and non-smokers without other cardiovascular risk factors, were included in the study. Demographic data, medical history, and smoking behavior were taken using a questionnaire, then IL-1β and CAVI levels were examinedResults: The mean level of IL-1β in smoking subjects was significantly higher (15.09 ± 0.48) than in non-smoking subjects (5.53 ± 0.79; p=0.001). CAVI values in smoking subjects were also significantly higher (8.0 ± 0.06) than in non-smoking subjects (6.9 ± 0.02; p=0.001). Further analysis showed a strong positive correlation between smoking and IL-1β levels (r=+0.776; p=0.001) and CAVI values (r=+0.759; p=0.001).Conclusion: This study shows that smoking significantly correlates with IL-1β levels and CAVI values. The greater number of cigarettes used per day and the longer duration of smoking, there was a positive correlation between IL-1β levels and arterial stiffness as measured by CAVI.
Relationship of Circulating Endothelial Cells, Endothelial Progenitor Cells, and Endothelial Dysfunction after High-Intensity Exercise: Role of Nitric Oxide Kinanti, Rias Gesang; Sargowo, Djanggan; Widjajanto, Edi; Rifa’i, Muhaimin
The Journal of Experimental Life Science Vol. 13 No. 2 (2023)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2023.013.02.01

Abstract

Endothelial dysfunction after high-intensity exercise occurs through various mechanisms characterized by decreased nitric oxide (NO) bioavailability. This study aims to determine the relationship between circulating endothelial cells (CEC), endothelial progenitor cells (EPC), and endothelial dysfunction after high-intensity exercise through an experiment using male Wistar strain rats. This study uses the randomized control group posttest-only design. A total of 32 male Wistar rats aged 20-22 weeks with a body weight of 140±20 g were taken randomly and divided into two groups. Group 1 (n=16), the control group, was given low-intensity exercise. Meanwhile, group 2 (n=16), named the treatment group, was given high-intensity exercise. The groups were run on a special treadmill where light-intensity exercise is done at a speed of 5-8 meters.minute-1 for 30 minutes and high intensity at 25-30 meters.minute-1 for 30 minutes. The treatment was performed at 5 to 10 pm, 3 times weekly for 12 weeks. Blood and aortic tissue samples were taken after the mice were rested for 12 hours after the last exercise. ELISA and Flow cytometry measured NO, CEC, and EPC levels. This research showed that CEC and EPC expression and high-intensity exercise have a positive relationship, yet not significant to the occurrence of endothelial dysfunction (NO), with a value of Sig. (0.111); p > 0.05, and the relationship value is r = 0.414 (R²= 17.15%). In conclusion, endothelial dysfunction after high-intensity exercise is not associated with CEC and EPC expression, which indicates endothelial damage.  Keywords: exercise, circulating endothelial cells, endothelial dysfunction, endothelial progenitor cells, nitric oxide
Pemberdayaan Komunita Lansia: Pendidikan Gizi pada Sekolah Lansia SMART Kota Malang Viantry, Paramita; Sargowo, Djanggan; Puspitarini, Marinda Dwi
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 8, No 2 (2025): MEI 2025
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62411/ja.v8i2.2945

Abstract

The nutritional issues faced by the elderly significantly affected the occurrence of non- communicable diseases (degenerative diseases), especially among elderly individuals with obesity. Education and nutrition training played an important role in preventing and managing these conditions through the promotion of balanced nutrition for the elderly. Nutritional education significantly reduced the risk of chronic diseases and increased individual awareness, particularly among the elderly, about the importance of implementing balanced nutrition. The main objective of this community service program was to enhance knowledge about balanced nutrition for the elderly to prevent and manage these conditions at the SMART Elderly School under the Abiyoso Gerontology Foundation in Malang City. The implementation of this community service activity included nutritional education using PowerPoint presentation materials, facilitating Focus Group Discussions (FGDs), conducting anthropometric measurements, and practicing the preparation of balanced nutritional menus for the elderly. Before and after the nutritional education, knowledge assessments regarding balanced nutrition for the elderly were conducted, with paired t-test analysis. The results showed significant data that improved the elderly's understanding of the causes, prevention, and management of non- communicable diseases. Therefore, the importance of regular activities in raising awareness among the elderly about the habit of applying balanced nutrition was highlighted.
Correlation Between Smoking and Il-1 Level and Arterial Stiffness as Measured By Cavi in the Young Adult Population Without other Cardiovascular Risk Factors. Galih Prakosa, Ardani; Tjahjono, Cholid Tri; Kurnianingsih, Novi; Sargowo, Djanggan; Anjarwani, Setyasih
Heart Science Journal Vol. 4 No. 3 (2023): The Essensial Role of the Metabolic Syndrome in the Development of Cardiovascul
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.03.5

Abstract

Background: Recent studies have shown that arterial stiffness is a strong predictor of cardiovascular events and all-cause mortality, with CAVI (Cardio-Ankle Vascular Index) as a non-invasive arterial stiffness testing method indaily practice.Objective: This study was conducted to examine the relationship between smoking -as a risk factor for arterial stiffness- and CAVI values, as well as levels of IL-1β (Interleukin 1β) as a cytokine that plays a role in the pathophysiology of arterial stiffness.Methods: Eighty-four participants, including smokers and non-smokers without other cardiovascular risk factors, were included in the study. Demographic data, medical history, and smoking behavior were taken using a questionnaire, then IL-1β and CAVI levels were examinedResults: The mean level of IL-1β in smoking subjects was significantly higher (15.09 ± 0.48) than in non-smoking subjects (5.53 ± 0.79; p=0.001). CAVI values in smoking subjects were also significantly higher (8.0 ± 0.06) than in non-smoking subjects (6.9 ± 0.02; p=0.001). Further analysis showed a strong positive correlation between smoking and IL-1β levels (r=+0.776; p=0.001) and CAVI values (r=+0.759; p=0.001).Conclusion: This study shows that smoking significantly correlates with IL-1β levels and CAVI values. The greater number of cigarettes used per day and the longer duration of smoking, there was a positive correlation between IL-1β levels and arterial stiffness as measured by CAVI.
Correlation Study of Cotinine and Monocyte Chemoattractant Protein-1 (MCP-1) with Carotid Intima-Media Thickness (cIMT) in Male Active Tobacco Smoke Satwikajati, Sawitri; Kurnianingsih, Novi; Tjahjono, Cholid Tri; Wihastuti, Titin Andri; Sargowo, Djanggan; Rizal, Ardian
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.6

Abstract

Background : Tobacco smoke exposure induces intima-media thickness by reducing nitric oxide and increasing adhesive molecule activity, with circulating cotinine serving as a marker; we hypothesize a correlation between monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (cIMT) in active male smokers. Method : We conducted an observational cross-sectional analytic study involving 125 male participants, with 62 being active tobacco smokers and 63 non-smokers. Data were presented as mean ± SD, and the correlation between variables was analyzed using Pearson correlation. Result : Cotinine and MCP-1 levels were significantly higher in the smoker population (p 0.000) compared to non-smokers. The incidence of positive cIMT findings was higher in the smoker group (5%) than in the non-smoker group (2%). In the active smoker population, cotinine (r 0.21; p 0.11) showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 showed a negative correlation (r -0.19, p 0.14) with positive cIMT findings. Smoking duration (r 0.162; p 0.223) and the amount of tobacco smoke (r 0.003; p 0.982) demonstrated a positive correlation with cotinine. MCP-1 exhibited a non-significant positive correlation with smoking duration (r 0.122; p 0.345) and a non-significant negative correlation with the amount of tobacco smoke (r -0.002; p 0.989). Conclusion : Among active tobacco smokers, cotinine showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 exhibited a non-significant negative correlation with positive cIMT findings. 
The Role of Antioxidants and Anti-Inflammatory Agents in Cardiometabolic Disease Aryanugraha, Teguh; Sargowo, Djanggan; Rahimah, Anna Fuji; Tjahjono, Cholid Tri
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.3

Abstract

Cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Cardiovascular diseases associated with metabolic disorders are collectively referred to as Cardiometabolic Diseases (CMDs). Oxidative stress and inflammation are key contributors to the development and progression of CMDs. Antioxidants and anti-inflammatory agents have garnered significant attention as potential therapeutic strategies for preventing and managing cardiovascular disorders. To better understand the complex interactions between oxidative stress, inflammation, and cardiovascular health, this review paper will focus on the mechanisms of action and potential advantages of antioxidants and anti-inflammatory drugs in reducing the risk factors associated with CVDs and enhancing cardiovascular health in general.
Is Targeting Inflammation the Key to Unlocking HFpEF?: Focus on anti-inflammatory therapy Yurista, Salva Reverentia; Sargowo, Djanggan
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.1

Abstract

Chronic inflammation plays a crucial role in the formation of atherosclerosis and is also associated with the advancement of heart failure. Clinical and epidemiological evidence has increasingly supported the link between low-grade inflammation and heart failure with preserved ejection fraction (HFpEF). From a fundamental scientific standpoint, inflammation in HFpEF has notable detrimental impacts on the endothelium and the microvasculature of the heart. HFpEF clinical studies focusing on inflammation are a sign of hope because they show a shift toward treating the condition's cause instead of just its symptoms.
Co-Authors -, Vidyawati Abdillah Iskandar Achdiat Agoes Ahdi, Iwal Reza Andri Andri Anjarwani, Setyasih Arief Rachman Hakim Aryanugraha, Teguh Askandar Tjokroprawiro Cholid Tri Tjahjono Dwi Sarbini Edi Widjajanto Elvira Sari Dewi Endah Kusuma Rastini Erawati, Dini Rachma Ermin Rachmawati Galih Prakosa, Ardani Galuh, Lukitasari Ayu Handirosiyanto, Ikhwan I Ketut Gede Muliartha Ismail, Mahrus Ivan Setiawan Kurnianingsih, Novi Lalu Aries Fahrozi, Lalu Larasati Sekar Kinasih Machdaniar, Maulidya Maulana, Syafiq Mohammad Saifur Rohman Paramita Viantry Parsama Putra, Ngakan Putu Puspitarini, Marinda Dwi Puspitasari, Alvina Putri, Fayza Cinta Rahmadina Rahimah, Anna Fuji Retnani, Diah Prabawati Rias Gesang Kinanti Rifa'i, Muhaimin Rifa’i, Muhaimin riskiyah, Riskiyah - Rizal, Ardian Saputra, Indra Wahyu Saputri, Diana Nanda Saskia Dyah Handari Satrijo, Budi Satuman Satuman Satwikajati, Sawitri Sidarta, Erdo Puncak Sri Andarini Suprayoga, Imam Mi'raj Syarifuddin, Brillian Putra Tarsadi, Tarsadi Teuku Heriansyah, Teuku Titi A W Titin A Wihastuti, Titin A Titin Andri Wihastuti Tony Suharsono, Tony Totowiputro, Dicky Kurniawan Viera Wardhani Wardhani, Syanindita Puspa Widodo Widodo Yurista, Salva Reverentia