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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Mathematical and Fundamental Sciences Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Sains Natural: Journal of Biology and Chemistry Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Medfarm: Jurnal Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat Jurnal Kefarmasian Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Helium: Journal of Science and Applied Chemistry
Bina Lohita Sari
Universitas Pakuan
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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FORMULASI GRANUL INSTAN EKSTRAK HERBA PEGAGAN (Centella asiatica) DAN ANALISIS ASIATIKOSIDA - Prasetyorini; Bina Lohitasari; Ahmad Amirudin
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 12, No 1 (2012): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v12i1.252

Abstract

The research was conducted in the month from February until April 2011 in the laboratory of Pharmacy Faculty of Mathematics and Natural Sciences, University Pakuan. The research objective is to make a health drink formulation of herbs gotu kola extract and determine the form of instant granules asiatikosida content. Herb gotu kola is used in this study is the collection BALITRO. In this study of instant granules prepared by wet granulation method and made three formulas are: FI (formula without essence), F II (formula with caramel essence, and F III (formula with mango essence.) Asiatikosida analysis performed on dry ekstrakt by TLC method the scanner. the results showed all formulas have the instant granule flow rate and good Sagat compressibility, organoleptic tests (smell and color), which are the F III, asiotikosida content showed a decrease during processing. Gynecology asiatikosida ekstrakt dry is 1.75% (4.375 mg asiatikosida) , instant granules FI of 0.46% (0.052 mg asiatikosida), F II by 0.68% (0.072 mg asiatikosida), and F III amounting to 0.48% (0.056 mg asiatikosida). Rf value on testing asiatikosida in extracts obtained 0.81 with a standard 0.80. Rf value on testing for FI 0.28 instant granules; FII 0.28, and F III 0.29, the standard used for Rf value of 0.28 Kata kunci :   ekstrak herba pegagan, granul instan, asiatikosida
PENAMBATAN DAN SIMULASI DINAMIKA MOLEKULER SENYAWA BIOAKTIF TANAMAN BAWANG DAYAK (Eleutherine Sp.) SEBAGAI INHIBITOR KAPSID VIRUS HEPATITIS B Bina Lohita Sari; Usep Suhendar; Ridho Hamdani
Jurnal Farmamedika (Pharmamedika Journal) Vol 8 No 2 (2023): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v8i2.201

Abstract

Hepatitis B merupakan penyakit infeksi hati yang disebabkan oleh virus hepatitis B. Kapsid pada virus hepatitis B adalah lapisan yang berfungsi untuk melindungi RNA dan DNA virus dari kerusakan. Tanaman yang diketahui memiliki aktivitas sebagai antivirus adalah bawang dayak. Penelitian ini bertujuan untuk menghasilkan senyawa hit hasil penambatan dan simulasi dinamika molekuler. Target Makromolekul yang digunakan adalah PDB ID : 5GMZ dan 33 senyawa dari tanaman bawang dayak. Penambatan molekuler menggunakan AutoDock Vina dan validasinya dengan menentukan kurva ROC dan perhitungan nilai AUC, menentukan RMSD secara redocking. Seleksi dengan aturan Lipinski Rule of 5 untuk menghasilkan senyawa yang dapat digunakan secara oral. Simulasi dinamika molekuler menggunakan program Gromacs 5.1.5 dan g_mmpbsa. Hasil seleksi Lipinski Rule of 5 menghasilkan 28 senyawa. Hasil penambatan menunjukkan senyawa Eleuthosida A memiliki nilai afinitas lebih negatif (-7,5 kkal/mol) dibandingkan pembanding 6XU dan isothiafludine (-7,4 dan -6,1 kkal/mol). Simulasi dinamika selama 20ns menunjukkan nilai RMSD dan RMSF Eleuthosida A dalam keadaan stabil dengan okupansi ikatan hidrogen sebesar 18,81% pada asam amino Asp29. Energi bebas MM-PBSA pada senyawa Eleuthosida A merupakan senyawa dengan paling negatif yaitu -133,430 kkal/mol. Berdasarkan hasil tersebut, Eleuthosida A dapat dijadikan kandidat inhibitor kapsid virus hepatitis B.
The Antioxidant Activity of Avocado (Persea americana Mill) Seed Extract and Lotion Preparation Fatmi, Mindiya; Wulandari, Asri; Sari, Bina Lohita; Honifa, .; Widjaya, Andrea Palleva
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.9860

Abstract

Excessive exposure to free radicals can cause skin to look dry and thin. Avocado seeds are a part of the fruit that is very rarely used and is even considered waste by society. Avocado seeds are known to contain good antioxidant activity to ward off free radicals. Topical preparations that are widely used to protect the skin from exposure to free radicals, one of which is lotion preparations with natural ingredients that contain antioxidants. This research aims to determine the antioxidant activity of avocado seed extract with different concentrations, formulate avocado seed extract lotion, distribute avocado seed extract lotion preparations, and determine the antioxidant activity of avocado seed extract lotion. The method used in this research is the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Each avocado seed was extracted with ethanol 50 %; 70 %; and 96 %. The best antioxidant results are made into cream preparations in 3 formulas, namely F1 0.01 %; F2 0.05 %; and F3 0.1 %. The best antioxidant test results were obtained from avocado seed extract with ethanol 70 % and an IC50 of 20.68 ppm with very strong antioxidant intensity. The three lotion formulations met the evaluation requirements for topical preparations and provided an antioxidant value of F1 of 128 ppm, F2 of 72 ppm, and F3 of 55 ppm. The conclusion of this research is that the highest antioxidants in avocado seed extract are found in the 70 % ethanol extract and in the formula 3 lotion preparation.
Peningkatan Pengetahuan Masyarakat dalam Rangka Pencegahan dan Penatalaksanaan Stunting di Kelurahan Tegallega Kota Bogor Nhestricia, Nhadira; Setiani, Lusi Agus; Sari, Bina Lohita; Nurlita
KENDURI : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 2 (2024): August
Publisher : Yayasan Darussalam Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62159/kenduri.v4i2.1266

Abstract

Salah satu masalah gizi di Indonesia yang masih menjadi perhatian utama saat ini adalah balita pendek (stunting). Stunting merupakan gangguan pertumbuhan dan perkembangan yang dialami oleh anak-anak akibat gizi buruk infeksi berulang dan dampak psikososial yang tidak mendukung. Kekurangan gizi yang dialami oleh anak dapat menyebabkan stunting. Kejadian ini paling sering terjadi di Negara dengan penghasilan rendah. World Health Organization (WHO) bahkan mencatat bahwa ada sekitar 156,8 Juta terkena dampak stunting pada tahun 2015. Hasil Riset Kesehatan Dasar (RISKESDAS) Republik Indonesia tahun 2018 menunjukkan persentase kejadian stunting 30,8%, persentase kejadian wasting sebesar 10,2% dan persentase kejadian gizi buruk sebesar 17,7% (Kementerian Kesehatan RI, 2018). Di Provinsi Sumatera Barat pada tahun 2018 prevalensi balita stunting yakni 9,58%, balita wasting 2,87% dan gizi buruk 3,51% (Kementerian Kesehatan RI, 2019). Berbagai kegiatan edukasi sudah dilaksanakan di beberapa wilayah Puskesmas di Kota Bogor, namun sebatas kegiatan insidental belum terlaksana secara rutin dengan bekerjasama dengan Puskesmas dalam rangka membantu tenaga kesehatan atau tenaga gizi dalam mencegah dan mengatasi stunting. Pemerintah Kota Bogor memiliki program khusus untuk penanganan stunting bernama “Taleus” Bogor (Tanggap Laleungitkeun Stunting di Kota Bogor). Kolaborasi Universitas Pakuan melalui dukungan LPPM Universitas Pakuan dengan Posyandu Kenanga dan Posyandu Nusa Indah 1 di Kelurahan Tegallega, Kota Bogor melakukan kegiatan dengan memberikan edukasi kepada para ibu balita peserta posyandu dalam rangka pencegahan stunting dengan media edukasi poster. Kegiatan pengabdian ini menunjukkan peningkatan pengetahuan peserta posyandu tentang stunting dalam rangka mencegah dan mengatasi kejadian stunting melalui edukasi menggunakan media poster, dari 56% menjadi 99%.
Pengaruh Iradiasi Sinar Gamma terhadap Kandungan Flavonoid dan Tanin Total Teh Putih (Camellia sinensis L.) dan Benalu Teh (Scurulla atropurpurea BL. Dans) Sari, Bina Lohita; Rahayu, Dien Puji; Rohdiana, Dadan; Nurlita, Selvi; Sahara, Putri Siti
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3719

Abstract

Camellia sinensis L. leaves, commonly known as white tea, are cultivated from unfurled bud leaves and protected from the sun while were hand picked. Scurulla atropurpurea [BL] Dans is well-known as loranthus of tea. The active compounds of both samples are flavonoid (flavanol, flavonol) and tannin. High humidity conditions can damage the simplicia of medicinal plants in the long-term storage process.The irradiation process with gamma rays can extent the shelf life of simplicia.Gamma irradiation is one of the most effective methods to extend the shelf life of simplicia. Both simplicia were irradiated in room temperature at 60Co source at doses of 0; 2.5; 5; 7.5; 10 and 12.5 kGy. Irradiation simplicia was immediately extracted with microwave assisted extraction (MAE) using 60% ethanol solvent to produce white tea and loranthus of tea extract. Flavonoid and total tannin content were determined using aluminium chloride and folin-ciocalteau methods. Flavonoids and total tannin in the tea samples were 2.56; 2.50; 3.73; 3.14; 2.68; 2.34 mgQE/g and 109.67; 132.87; 149.40; 107.29; 141.82;134.95 mgGAE/g, respectively. Meanwhile in the loranthus of tea were 7.10; 5.68; 5.79; 8.84; 5.01; 5.44 mgQE/g and 60.34; 58.61; 58.59; 71.37; 54.16; 65.99 mgGAE/g, consecutively. Results of the research showed that radiation dose of 5 kGy was found to be effective dose for white tea whilest 7.5 kGy for loranthus of tea to reach highest flavonoid and total tannin content.
MIKROGRANUL MUKOADHESIF EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight.)) DENGAN PERBEDAAN POLIMER HPMC DAN KITOSAN Erni Rustiani; Bina Lohita Sari; Dea Safira Nur Izmah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.481

Abstract

Daun salam (Syzygium polyanthum (Wight.)) mengandung senyawa polifenol yang bermanfaat dalam pengobatan hiperkolesterolemia dengan menurunkan kadar low density lipoprotein (LDL). Bentuk sediaan mikrogranul mukoadhesif mampu memperpanjang waktu kontak zat aktif dengan mukosa sehingga efek terapi lebih baik. Penelitian ini bertujuan membuat mikrogranul mukoadhesif ekstrak daun salam dengan perbedaan polimer Hidroksi Propil Metil Selulosa (HPMC) dan kitosan. Sediaan dibuat sebanyak 4 formula yaitu formula I (HPMC 25%), formula II (HPMC 30%), formula III (Kitosan 25%) dan formula IV (Kitosan 30%). Mikrogranul dibuat dengan metode granulasi basah. Parameter pengujian mikrogranul meliputi kadar air, laju alir, sudut diam, ukuran partikel, kadar polifenol total, uji wash off dan uji morfologi. Hasil penelitian mikrogranul mukoadhesif ekstrak daun salam menunjukkan seluruh formula memiliki kadar air < 5%, laju alir dan sudut diam termasuk mudah mengalir. Ukuran mikrogranul berada pada range 48,7 – 637 µm dengan kadar polifenol total 4,15 – 4,27%. Hasil uji wash off menunjukkan kadar polifenol total mikrogranul di lambung 1,33 - 3,23 % (31,97 - 75,63%) dan di usus 1,26 – 3,76% (27,95 - 88,03%). Mikrogranul mukoadhesif ekstrak daun salam terbaik menggunakan polimer HPMC 30%.
Optimation of meniran (Phyllanthus niruri L.) leaf extract using natural deed eutectic solvent basis choline cloride–glycol on antioxidant Handayani, Marybet Tri Retno; Yulianita, Yulianita; Lohitasari, Bina; P, Rieke Fitria
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1561

Abstract

Phyllanthus niruri L. has many benefits because it is known that meniran leaves contain secondary metabolites in the form of alkaloids, flavonoids, tannins, saponins and phenolics. The content of phenol compounds which are constituent compounds for antioxidant activity. This research was conducted to determine the combination of Natural Deep Eutectic Solvents (NADES) which can produce extracts with strong antioxidant activity. The preliminary stage determines the best combination of NADES with choline chloride as the Hydrogen Bond Acceptor and the type of sugar as the Hydrogen Bond Donor. The NADES screening obtained the best combination of choline chloride: glycerol, then the optimization stage was carried out using the RSM method with a Central Composite Design. Three variables used were temperature (25°, 40°, 60°C), time (10, 30, 60 minutes) and the ratio of NADES usage (50%, 70% and 90%). Antioxidant activity was determined with the value of in Meniran extract with positive control of vitamin C. The best NADES combination was choline chloride–glycerol (1:1) with an value of 18.039 ppm. Optimization with variations in temperature time and ratio variables obtained optimal conditions at temperature of 60°C with an extraction time of 44 minutes and ratio of 90% NADES obtained values ​​of 8.040 ppm and positive control of vitamin C obtained values ​​of 4.307 ppm. The best results for antioxidant activity are at a temperature of 60°C gives an value of 8.050 ppm was obtained and the average is 8.075 ppm.
THE THE EFFECT OF ADDING TOMATO EXTRACT (Solanum lycopersicum L.) to APPLE-BASED SHEET JAM (Malus sylvestris L.) AS AN ANTIOXIDANT SARI, BINA LOHITA
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.572

Abstract

Antioxidants are substances that can prevent or reduce oxidative stress in physiological systems. The natural antioxidants found in our food are substances that can protect cells from the dangers of free radicals produced by the body's metabolism. Tomato (Solanum lycopersicum L.) and apple (Malus sylvestris L.) are natural compounds with strong antioxidant capacities which can be used in functional food. Both natural compounds will be made into jam sheets, a modified jam printed in sheet which is very easy to serve on bread and cakes. This research aimed to find the best formula of apple puree sheet jam added with differences of tomato juice concentration. There are 4 sheet jam formulas which are F1, F2, F3, and F4 use 100 g of apple puree and add tomato juice as 0 g, 60 g, 75 g, and 90 g respectively. The parameter test used for this research were hedonics test for panelists, water content test, pH value, total plate count, mold/yeast test, and antioxidant activity. The results showed that F4 was the best formula preferred by the panelists. The water content, pH value, total plate count, and mold/yeast test were 21.62%, 4.23, and 7.5 x102, respectively. The antioxidant activity value with an IC50 value of 87.14 ppm. The addition of 90 g of tomato juice on 100 g of apple puree produces sheet jam with strong antioxidant activity.
Quantitative Structure-Activity Relationship of O-methyl Quercetin Analogs, Structure Modification, and Molecular Docking as Lung Anticancer EGFR-TK Inhibitor Sari, Bina Lohita; Setiani, Lusi Agus; Aulia, Shafana Zahra
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.316-326

Abstract

Cancer arises from the uncontrolled proliferation of cells. Lung cancer stands as one example among the diverse array of cancer types. The main cause of the development of lung cancer is the activation of epidermal growth factor receptor (EGFR)-tyrosine kinases (TK). O-methyl quercetin analogs, as one of the quercetin derivatives, can be potential drug candidates for treating lung cancer. In this study, we disclose our findings that O-methyl quercetin analogs and their modified forms, O-methylamino analogs, predicted EGFR-TK inhibitors as lung anticancer. The O-methylated quercetin analogs can be predicted using a Quantitative Structure-Activity Relationship (QSAR) model. The structures were optimized using the parameterized method 3 (PM3) and analyzed through multiple linear regression (MLR). A lower PRESS QSAR values are used for structural modification of O-methylamino as new compounds. Structures of O-methyl quercetin and O-methylamino analogs were docked to the EGFR-TK receptor using molecular docking. The best QSAR model of IC₅₀ predicted result is expressed as log IC50 = 23.059 + (7.397 × log P) + (0.273 × dipole moment) – (0.005 × heat of formation) – (0.733 × ELUMO) – (0.501 × EHOMO) with statistical parameters: R = 0.966; R2 = 0.933; Fcount/Ftable = 3.829853; and Q2 = 0.752226. The O-methyl quercetin analog QC14 (quercetin 5,3’,4’-trimethyl ether) and the modified derivative QC6_8 (3,5-dihydroxy-2-(3-hydroxy-4-((methylamino)methoxy)phenyl)-7-methoxy-4H-chromen-4-one) exhibited the lowest docking scores. Both compounds interact with the key residue Met769 of the EGFR-TK receptor, suggesting their potential as drugs for lung cancer.
Qualitative Profiling of Antimalarial Compounds from Endophytic Fungi Associated with Rhizophora mucronata Suhendar, Usep; Fawziah, Rieskha; Lohita Sari, Bina; Yoshida Srie Rahayu, Sata; Sulastri, Lilik; Wulandari, Ratna; Anisa, Dede; Namira, Raisa
Sains Natural: Journal of Biology and Chemistry Vol. 15 No. 3 (2025): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v15i3.816

Abstract

Malaria remains one of the deadliest infectious diseases worldwide, underscoring the urgent need for novel antimalarial sources. Endophytic fungi associated with mangrove roots of Rhizophora mucronata represent promising candidates, as they are capable of synthesizing secondary metabolites such as alkaloids, flavonoids, and terpenoids with known antiplasmodial activity. This study aimed to qualitatively identify antimalarial bioactive compounds from endophytic fungal extracts previously exhibiting the highest heme polymerization–inhibition activity. Fungal isolates were fermented in liquid medium for 21 days and extracted with ethyl acetate. The extracts were profiled by Thin-Layer Chromatography (TLC) using two solvent systems: n-hexane : ethyl acetate (5:1) and dichloromethane : methanol (10:1). Band visualization was performed under UV light (254 nm and 366 nm) and with semi-specific reagents (Dragendorff and citro-boric), followed by Rf value comparison. TLC analysis revealed blue-green fluorescent bands corresponding to flavonoids and brown-orange bands indicative of alkaloids, with optimal Rf values of 0.46 (n-hexane : ethyl acetate) and 0.54 (dichloromethane : methanol). These findings confirm the presence of key antimalarial compound classes in the endophytic fungal extract, supporting its potential as a coastal bioresource for drug discovery and development.
Co-Authors - Prasetyorini Abdurrahman Hafidh Ahmad Amirudin Ahmad Amirudin, Ahmad Akhmad Endang Zainal Hasan Amalia, Desy Rizky Anisa, Dede Asri Wulandari Aulia, Shafana Zahra D Prasetyorini Dadan Rohdiana Dadan Rohdiana Daryono Hadi Tjahjono Dea Safira Nur Izmah Desy Rizky Amalia Dien Puji Rahayu Erni Rustiani Fawziah, Rieskha Fitria Dewi Sulistiyono Handayani, Marybet Tri Retno Harry Noviardi Honifa, . Indah Nur Sayyidah Indriani, Lusi Jupersio Jupersio Jupersio, Jupersio Kalista, Ananda Putri Kasman Marsuan Lilik Sulastri Lusi Agus Setiani Lusi Indriani Mindiya Fatmi Mira Miranti Muhamad Wildan Malik Muntaza, Windry Namira, Raisa Nhestricia, Nhadira Nina Herlina Nina Sakinah Nina Sakinah Novi Fajar Utami Nur Apriani Kartini Nurlita Nurlita, Selvi Nurtiyah Nurulia Susanti Nurulia Susanti, Nurulia Nyanyu Siti Aminah Lily Elfrieda Oom Komala P, Rieke Fitria Partomuan Simanjuntak Partomuan Simanjuntak Puput Sapitri Putri Siti Sahara Rahayu, Dien Puji Ratna Wulandari Ridho Hamdani Rurianti, Wandesta S Sabila Sahara, Putri Siti Salma Hanunah Ulfa SATA YOSHIDA SRIE RAHAYU Selvi Nurlita Septia Andini Slamet Ibrahim - Sofihidayati, Trirakhma Sri Wardatun Sutanto Sutanto Sutanto Sutanto Tri Saptari Haryani Triastinurmiatiningsih, Triastinurmiatiningsih Trirakhma Sofihidayati Triyani Sumiati usep suhendar Usep Suhendar Wandesta Rurianti Widjaya, Andrea Palleva Wildan Aristyo Yulianita, Yulianita Zaldy Rusli Zaldy Rusli