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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Mathematical and Fundamental Sciences Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Sains Natural: Journal of Biology and Chemistry Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Medfarm: Jurnal Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat Jurnal Kefarmasian Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Bina Lohita Sari
Universitas Pakuan
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Optimization Of Microwave-Assisted Extraction Of Flavonoids From Binahong (Anredera cordifolia) Leaves Using Respon Surface Methodology Zaldy Rusli; Bina Lohita Sari; Novi Fajar Utami; S Sabila
Jurnal Fitofarmaka Indonesia Vol 7, No 3 (2020): JURNAL FITOFARMAKA INDONESIA (English Edition)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i3.596

Abstract

Binahong (Anredera scandens (L.) Moq.) leaves are one of the plants that empirically can be used for wound healing and contain flavonoids which have antibacterial and antioxidant activities. Determination of the optimum conditions of the Binahong leaf extraction process needs to be done to ensure the extraction quality of the Binahong leaves associated with the given activity. Microwave Assisted Extraction (MAE) is an extraction that utilizes microwave radiation to heat the solvent quickly and efficiently. This study aims to determine the most effective binahong leaf extraction conditions that produce optimal levels of flavonoids and antioxidant activity. The extraction process was carried out using the Microwave assisted extraction (MAE) method. Determination of optimum conditions is done based on Response Surface Method (RSM) with variable ethanol concentration (70%, 80% and 90%), extraction time (4, 12 and 20 minutes) and power (450, 600, and 800 watts) using Box- Behnken Design (BBD) with Design Expert 7.0 software. The extract quality parameters measured were total flavonoid levels and antioxidant activity. The results showed the optimum conditions with the BBD method were obtained at an ethanol concentration of 81.49%, extraction time of 13.84 minutes, and power of 626.19 watts with flavonoid levels of 3.8561% and antioxidant activity (IC50) of 95.51834 ppm with active categories.
Pharmacophore Modeling, Docking, and Molecular Dynamics Simulation of Flavonoids as Inhibitors of Urokinase-type Plasminogen Activator Bina Lohita Sari; Slamet Ibrahim; Daryono Hadi Tjahjono
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 3 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.3.8

Abstract

The urokinase-type plasminogen activator (uPA) system plays a significant role in the invasion and metastasis of cancer cells. The present study was conducted to investigate natural product compounds as inhibitors and hit molecules of uPA using in-silico analysis. A pharmacophore model was built to screen the Indonesian Herbal Database (HerbalDB) to obtain inhibitors of different scaffolds. Based on the molecular docking score, four ligands were selected as potential uPA inhibitors. Subsequently, the stability of the ligand-uPA complex was analyzed using molecular dynamics (MD) simulation. An RMSD graph of the backbone protein and the RMSF values of the amino acid residues were also determined. In addition, the MM-PBSA method was applied to calculate the free binding energy. According to the results, Model_3, characterized by aromatic rings 23 (F1 and F2), cationic H-bond donor (F3), and metal ligator (F4) features, had an adequate goodness-of-hit score (GH). The four top-ranked ligands, isorhamnetin, rhamnetin, quercetin, and kaempferol, showed higher docking scores compared to the others. This study confirmed that isorhamnetin, rhamnetin, and kaempferol build stable complexes with uPA with lower binding energy than quercetin.
ANALISIS SILDENAFIL SITRAT DALAM JAMU KUAT DI KECAMATAN BOGOR BARAT DAN TANAH SAREAL DENGAN MENGGUNAKAN KROMATOGRAFI CAIR SPEKTROMETRI MASSA Triyani Sumiati; Bina Lohita Sari; Nurtiyah
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.256 KB) | DOI: 10.47219/ath.v2i2.37

Abstract

Herbal medicineisthe treatment of choicebecause ofmerit in maintainingthe health ofthe peopleof the human body. Strongherbal medicineisherbal medicinethat isefficacious asstaminaandvitality ofman, but in its developmentpuritypowerfulherbsare addedsildenafilcitratebyparties who are notresponsible. This study was adescriptiveanalysis ofexperimentaldesign. Analysis of sildenafilcitrate compounds using Thin Layer Chromatography (TLC) and Liquid Chromatography Mass Spectrometry (LC-MS) were sampled in two districts, namely sub-district, Bogor Barat and Tanah Sareal thus obtained 32 samples, of which 18 samples of Bogor Barat coded A and 14 samples from Tanah Sareal coded B. TLC results were eluted at Silica gel 60 F254 with eluent methanol:chloroform (4:1), there were 5 samples showed close Rf value standard sildenafil citrate is 0.83, the sample code A4 value of Rf 0.84, A13 Rf value of 0.84, A17 Rf value of 0.83, B11 Rf value of 0.83, and B14 Rf value of 0.84. Results LC-MS where separation using column Phenomenex Synergi Fusion RP-100A, the pumping system with a mobile phase gradient of 0.2 M ammonium acetate pH 7 in water and 0.2 M ammonium acetate pH 7 in acetonitrile, was obtained the samples for A4, A13, A17, B11 dan B14 amounted to 198.01; 1734.14; 226.00; 156.77; 443.87 μg/kg
OPTIMASI WAKTU MASERASI SILDENAFIL SITRAT DALAM JAMU KUAT YANG BEREDAR DI BOGOR BARAT Harry Noviardi; Bina Lohita Sari; Muhamad Wildan Malik
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.393 KB) | DOI: 10.47219/ath.v1i2.55

Abstract

Herbal medicine is types traditional medicine that is consumed by people. One type of herbal medicine on the market is Jamu Kuat. According Indonesian Food and Drug Administration, herbal medicine can not contain chemical of drugs. But, Jamu Kuat on the market still found contain chemical of drug, that is sildenafil citrate. In previous research, analysis of sildenafil citrate in the Jamu Kuat has not been accompained by the optimization of extraction time.The aim of research is optimizing the time of maceration sildenafil citrate in Jamu Kuat circulating on the West Bogor. Sampling of Jamu kuat was used purpusive sampling. The sample macerated with constant stirring was used a magnetic stirrer with 560 rpm and analyzis with Thin Layer Chromatography and Spectrophotometry UV-Vis method. Results of the research show that there was 5 from 8 samples Jamu Kuat contained sildenafil citrate. Optimum times of maceration was 60-90 minutes in four samples, 120-150 minutes in one sample and contains sildenafil citrate 8.00-11.00% in four samples and 20.00-21.00% in one sample. The results was concluded there different optimal times for samples
OPTIMASI WAKTU MASERASI PARASETAMOL DALAM JAMU PEGAL LINU YANG BEREDAR DI BOGOR BARAT Bina Lohita Sari; Harry Noviardi; Nur Apriani Kartini
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 1 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.638 KB) | DOI: 10.47219/ath.v2i1.56

Abstract

Jamu is a traditional medicine that is consumed by people.One type of herbal medicine on the market is Jamu Pegal Linu. Indonesian Govermment’s rule that this traditional medicine may not contain any synthetic chemical substance or drug functioned isolated compound. In reality there are still found some jamu pegal linu that contain medicine compound especially paracetamol. Analyzis chemical of drugs in herbal medicine has not been accompanied by the optimum times extraction. The aim of research to optimize of the time maceration and determine the contained of paracetamol in jamu pegal linu had circulated in Bogor Barat. Sample was taken by purposive sampling. Maceration from samples were using ethanol were within varying. Analysis of thin layer chromatography was using silica gel GF254 as the stationary phase, chloroform:ethanol (9:1) as the mobile phase with short waved UV as detection method. The results showed that 7 samples contained paracetamol from 10 samples of jamu pegal linu. The optimum of the time maceration between 0-30 minutes for herbal optimum simulation, sample D, F and S with a concentration of 2,49 to 22,33 %. The optimum of the time maceration between 60-90 minutes for the sample A, E and Q with levels of 4,47 to 7,12 %. Sample H had the optimum maceration time for 120 minutes with a concentration of 18.38%. Optimization of sample maceration time is dominated by the span of time between 30-90 minutes. Therefore, it is known that the samples of jamu pegal linu spread had maceration on the optimal time period between 30-90 minutes.
KADAR FENOLIK DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL RUMPUT LAUT COKLAT (Padina australis) Tri Saptari; Triastinurmiatiningsih Triastinurmiatiningsih; Bina Lohita Sari; Indah Nur Sayyidah
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 9, No 1 (2019): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (519.427 KB) | DOI: 10.33751/jf.v9i1.1254

Abstract

Rumput laut coklat Padina australis merupakan salah satu sumber daya alam laut yang keberadaannya sangat melimpah di perairan pantai Bayah, Banten Indonesia. Kandungan senyawa fenolik dan turunannya (flavonoid) berhubungan dengan aktivitasnya sebagai antibakteri dan antioksidan. Fenolik dianggap sebagai molekul dengan potensi tertinggi untuk menetralkan radikal bebas. Penelitian ini bertujuan untuk menentukan kadar fenolik dan aktivitas antioksidan ekstrak etanol P. australis menggunakan pereaksi Follin-ciocalteu dan 1,1-diphenyl-2-picryl hydrazyl (DPPH) ekstrak etanol P. australis. Hasil penelitian menunjukkan kadar fenolik sebesar 42,62 mg SAG/g serbuk dan pada konsentrasi 5000 ppm menghambat sebesar 66, 01 % radikal bebas DPPH.
EFEKTIVITAS EKSTRAK Padina australis SEBAGAI ANTIBAKTERI Escherichia coli PENYEBAB DIARE Tri Saptari Haryani; Bina Lohita Sari; Triastinurmiatiningsih Triastinurmiatiningsih
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 4, No 2 (2014): FITOFARMAKA
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.405 KB) | DOI: 10.33751/jf.v4i2.186

Abstract

Organisme laut merupakan sumber senyawa obat yang berpotensi besar, tetapi sampaisaat ini masih belum dimanfaatkan secara maksimal. Penelitian efektivitas ekstrak Padina
PENETAPAN KADAR FLAVONOID DAN AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL KULIT BAWANG MERAH (Allium cepa L.) TERHADAP Staphylococcus aureus Trirakhma Sofihidayati; Fitria Dewi Sulistiyono; Bina Lohita Sari
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 8, No 2 (2018): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (443.49 KB) | DOI: 10.33751/jf.v8i2.1573

Abstract

Bawang merah (Allium cepa L.) merupakan salah satu komoditas sayuran penting di Indonesia dan banyak digunakan sebagai bahan pengobatan tradisional.   Kulit bawang dianggap sebagai limbah, tetapi ternyata pada kulit bawang merah  terkandung berbagai bahan alami dengan nilai fungsional tinggi. Bawang merah dan kulitnya  kaya akan senyawa seperti senyawa flavonoid dan organosulfur (allicin) yang bertindak sebagai antibakteri. Penelitian ini bertujuan untuk menentukan kadar flavonoid ekstrak etanol 70% kulit bawang merah dari hasil ekstraksi metode   Microwave Assisted Extraction (MAE) dan menentukan aktivitasnya terhadap bakteri Staphylococcus aureus. Uji aktivitas ditentukan pada konsentrasi ekstrak 20, 40, 60, 80 dan100 % dengan mengukur lebar daerah hambat (LDH) menggunakan metode difusi agar. Hasil penelitian ini menunjukkan ekstrak etanol kulit bawang merah mengandung flavonoid sebesar 14,57 % dan uji aktivitas antibakteri menghasilkan lebar daerah hambat berturut-turut sebesar 18,00; 19,50; 19,50; 22,00 dan 21,50 mm.
SKRINING TOKSISITAS AKUT BEBERAPA FRAKSI BUAH KARONDA (Carissa carandas L.) PADA EMBRIO ZEBRAFISH (Danio rerio) Zaldy Rusli; Bina Lohita Sari; Sri Wardatun; Wildan Aristyo
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 10, No 1 (2020): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (672.016 KB) | DOI: 10.33751/jf.v10i1.1923

Abstract

Dalam pengembangan obat baru, perlu dilakukan penelitian untuk menentukan keamanan dan efek dari suatu tanaman obat. Buah karonda (Carissa carandas L.) adalah tanaman yang memiliki potensi sebagai obat anti-inflamasi. Penelitian ini bertujuan untuk menentukan toksisitas akut fraksi n-heksana, etil asetat, dan air buah karonda menggunakan model hewan uji embrio ikan zebra (Danio rerio). Pengujian toksisitas akut mengacu pada protokol OECD No. 236 tahun 2012 dan dilakukan pengamatan perubahan morfologi embrio ikan zebra yaitu tulang ekor, yolk sac dan pericardium.  Hasil toksisitas fraksi n-heksana, etil asetat, dan air masing-masing menunjukkan nilai LC50 adalah 608,26 μg/mL; 571,78 μg/mL; dan 546,69 μg/mL. Hasil pengamatan perubahan morfologi pada usia 96 hours post fertilization (hpf) pada ketiga fraksi menunjukkan kelainan perubahan pada tulang ekor, edema yolk sac dan pericardium. Kategori ketoksikan bahan uji termasuk kategori tidak toksik.
TOKSISITAS, AKTIVITAS ANTIOKSIDAN DAN ANTIBAKTERI EKSTRAK AIR KULIT KAYU MASSOI (Cryptocarpa massoy (Lauraceae)) Bina Lohita Sari; Wandesta Rurianti; Partomuan Simanjuntak
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 4, No 1 (2014): FITOFARMAKA
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.548 KB) | DOI: 10.33751/jf.v4i1.183

Abstract

Massoi (Cryptocarya massoy) merupakan tanaman yang digunakan masyarakat Papuasebagai obat tradisional. Kulit batang tanaman ini memperlihatkan beberapa aktivitasbiologis. Penelitian ini bertujuan untuk menentukan toksisitas, aktivitas antioksidan danantibakteri ekstrak air kulit batang Massoi (EAKM). Uji toksisitas menggunakan metodeBrine Shrimp Lethality Test (BSLT), aktivitas antioksidan diuji dengan metode PeredamanRadikal Bebas menggunakan DPPH (1,1-diphenyl-2-picrylhydrazyl), dan uji antibakterimenggunakan metode cakram difus terhadap Staphylococcus aureus dan Escherichia coli.Penapisan fitokimia menunjukkan adanya steroid, flavonoid, saponin, tannin, kumarin danminyak atsiri. Hasil LC50sebesar 493,00 g/mL menunjukkan bahwa EAKM adalah toksik.Nilai IC50sebesar 14,06 g/mL (vitamin C sebagai control positif 7,78 g/mL) menunjukkanpotensi EAKM sebagai antioksidan. Sementara EAKM tidak menunjukkan aktivitasantibakteri terhadap S. aureusdan E. coli. Kromatografi kolom menggunakan silika geldengan fasa gerak kloroform:metanol (1:1) dan kloroform:metanol:air (5:5:1) pada EAKMmenghasilkan empat fraksi. Semua fraksi diidentifikasi dengan KCKT menggunakan fasagerak metanol : air (1:1). Profil KCKT keempat fraksi menunjukkan profil kromatogram yanghampir sama, yaitu pada waktu menit ke 10,0.Kata kunci :Toksisitas, antioksidan, antibakteri, Cryptocarya massoy
Co-Authors - Prasetyorini Abdurrahman Hafidh Ahmad Amirudin Ahmad Amirudin, Ahmad Akhmad Endang Zainal Hasan Amalia, Desy Rizky Anisa, Dede Asri Wulandari Aulia, Shafana Zahra D Prasetyorini Dadan Rohdiana Dadan Rohdiana Daryono Hadi Tjahjono Dea Safira Nur Izmah Desy Rizky Amalia Dien Puji Rahayu Erni Rustiani Fawziah, Rieskha Fitria Dewi Sulistiyono Handayani, Marybet Tri Retno Harry Noviardi Honifa, . Indah Nur Sayyidah Indriani, Lusi Jupersio Jupersio Jupersio, Jupersio Kasman Marsuan Lilik Sulastri Lusi Agus Setiani Lusi Indriani Mindiya Fatmi Mira Miranti Muhamad Wildan Malik Muntaza, Windry Namira, Raisa Nhestricia, Nhadira Nina Herlina Nina Sakinah Nina Sakinah Novi Fajar Utami Nur Apriani Kartini Nurlita Nurlita, Selvi Nurtiyah Nurulia Susanti Nurulia Susanti, Nurulia Nyanyu Siti Aminah Lily Elfrieda Oom Komala P, Rieke Fitria Partomuan Simanjuntak Partomuan Simanjuntak Puput Sapitri Putri Siti Sahara Rahayu, Dien Puji Ratna Wulandari Ridho Hamdani Rurianti, Wandesta S Sabila Sahara, Putri Siti Salma Hanunah Ulfa SATA YOSHIDA SRIE RAHAYU Selvi Nurlita Septia Andini Slamet Ibrahim Sofihidayati, Trirakhma Sri Wardatun Sutanto Sutanto Sutanto Sutanto Tri Saptari Haryani Triastinurmiatiningsih, Triastinurmiatiningsih Trirakhma Sofihidayati Triyani Sumiati usep suhendar Usep Suhendar Wandesta Rurianti Widjaya, Andrea Palleva Wildan Aristyo Yulianita, Yulianita Zaldy Rusli