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Maya Savira
Mikrobiologi Fakultas Kedokteran Universitas Riau Pekanbaru
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

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Genetic diversity in the E6 and E7 gene of human papillomavirus type 16 among cervical cancer patients in Riau Province, Indonesia Savira, Maya; Rachmadina, Rachmadina; Mahargyarani, Azza Enggar; Admiral, Muhammad Zhafran; S, Donel; Sofian, Amru; Razali, Renady Reza; Ilmiah, Zidny; Farniga, Analdi
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.6652

Abstract

Cervical cancer mostly occurs due to persistent high-risk human papillomavirus (HPV), with type 16 being the most frequent. In Indonesia, cervical cancer ranks second in mortality, with a fatality rate of 57%. The E6 and E7 genes of HPV-16 play crucial roles in the virus’s oncogenic transformation, leading to cervical cancer. This study was conducted to determine the prevalence and genetic diversity of the E6 and E7 genes of HPV-16 in Riau Province, Indonesia. There were 37 HPV-positive samples analyzed using the MY09/11 primers. This was followed by the amplification of the E6 and E7 genes. Nineteen samples were detected as HPV-16, thirteen of which were coinfected with HPV-18. Seven E6 and E7 sequences were aligned compared with the reference sequence NC_001526.4. The most common nucleotide changes in the E6 gene, 7318A>G, was detected in 30.7% of samples, leading to an amino acid change from 65N>S. Three nucleotide changes were identified in the E7 gene of sample 89: two synonymous (7831T>C, 7837T>G) and one non-synonymous (7989A>G), resulting in an amino acid change of 29N>S. The most frequent E7 nucleotide change, 7708G>A, was found in 80% of samples. Phylogenetic analysis revealed that HPV-16 isolates from Riau have close kinship with the European lineage, with 57.1% (E6) and 85.7% (E7). In conclusion, the incidence of cervical cancer in Riau Province caused by HPV-16 is 52.8% and 7318A>G and 7708G>A are the most common genetic diversity. Furthermore, the majority of HPV-16 isolates in Riau Province show close kinship with the European lineage.
Co-Authors Admiral, Muhammad Z. Admiral, Muhammad Zhafran Afief, Arief R. Ahmad Fahruddin Amalia, Aisyah Sabrina Amelia, Putri Amru Sofian Ardha, Nabilah Shofiyyah Boby Franswinsly Ritonga Citra Ayu Anggreli Darmawi Darmawi Daulay, Milahayati Dedi Ardinata Dewi Anggraini Dhini Aiyulie Novri Dhita Natasha Dwiriyanti H Dino Irawan Donel S Donel S Eka Roina Megawati Enikarmila Asni Erfina Mallinda, Erfina Farah Mardhiyah Farniga, Analdi Farniga, Arnaldi Fauzia Andrini Fitri, Aida Gusti Yulindra, Utari Hidayat, Nopian Ika A. Rini, Ika A. Ilmiah, Zidny Inayah Inayah Inglin, Mark Irham, Lalu M. Kemal, Rahmat A. Lintang, Letta Sari Lubis, Nenni Dwi Aprianti M. Yulis Hamidy Machyuddin T.M Pangaribuan Mahargyarani, Azza E. Mahargyarani, Azza Enggar Maryanti, Yossi Muhammad Ihsan Nuraiza Meutia Nurfi Pratiwi, Nurfi Putra, Andani E. Rachmadina, Rachmadina Rahmat Azhari Kemal Rangkuti, Ina F. Ratu Astuti Dwi Putri Razali, Renady Reza Razali, Renardy R. Resty Yuwandari Rindi Rosalina Fadly rusdiana Rusdiana Rusdiana Ruza Prima Rustam Ruza Prima Rustam, Ruza Prima S, Donel Sabella Gustika Vernanda Selly Azmeila ShintaPuja Tilusari Sholihin, Uswathun Hasanah Siahaan, Sulyaprilawati Battri Sofie R. Krisnadi Suyanto " Tobing, Tina CL. Tri Widyawati, Tri Ulfah, Aida J. Usman Pato Vani Ardiani Viandy , Vincent Wardana, Rexi Dwi Widjaja, Sry Suryani Wirawan Adikusuma Wongso, Venessa Yetty Machrina Yosephine, Astrid G. Yossi Maryanti Yuana Nurulita Yuwandari, Resty Zarfiardy Af, Zarfiardy Zulmaeta