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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Syiah Kuala Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Jurnal Kesehatan Andalas Biomedika Chimica et Natura Acta Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Obstetrics & Gynecology Science Acta Biochimica Indonesiana Bioscientia Medicina : Journal of Biomedicine and Translational Research Indian Journal of Forensic Medicine & Toxicology Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research
Maya Savira
Mikrobiologi Fakultas Kedokteran Universitas Riau Pekanbaru
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Studi Awal Analisis Molekuler Human Papillomavirus dari Apusan Glans dan Batang Penis Maya Savira; Resty Yuwandari; Yossi Maryanti; Rahmat Azhari Kemal; Donel S
Jurnal Kesehatan Andalas Vol 9, No 4 (2020): Online December 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1493

Abstract

Pria juga dapat mengalami keganasan akibat infeksi Human Papillomavirus (HPV) serta bertindak sebagai reservoir virus. Metode skrining HPV pada wanita telah terstandardisasi, namun belum ada standar metode skrining pada pria di Indonesia. Beberapa studi pada populasi pria di luar negeri menunjukkan potensi sampling pada daerah genitalia eksterna untuk skrining HPV. Tujuan: mengoptimasi metode skrining HPV secara molekuler pada pria. Metode: Responden adalah partner seksual wanita pansien kanker serviks di RSUD Arifin Achmad Provinsi Riau. Apusan dari glans dan batang penis diambil menggunakan nylon-flocked swab yang kemudian dimasukkan ke dalam 350µl viral transport medium terpisah. DNA diisolasi dari sampel yang kemudian dianalisis untuk mendeteksi gen human β-globin dan HPV. Hasil: Optimasi awal menunjukkan gen β-globin dapat terdeteksi dari hasil ekstraksi dengan kit Zeesan Viral RNA Extraction. Pita HPV hasil PCR dengan primer MY09 dan MY11 dapat muncul namun masih tipis. Simpulan: Studi awal ini menunjukkan bahwa apusan glans dan batang penis dapat digunakan untuk deteksi HPV secara molekuler pada pria, namun proses pengambilan sampel, ekstraksi DNA, dan PCR masih perlu dioptimasi.Kata kunci: apusan, glans, HPV, penis
GAMBARAN SKRINING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) PADA PASIEN ORTOPEDI DI RS X RIAU Dewi Anggraini; Muhammad Ihsan; Maya Savira; Fauzia Andrini Djojosugito; Farah Mardhiyah
Biomedika Vol 13, No 2 (2021): Biomedika Agustus 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i2.11875

Abstract

ABSTRAKMethicillin-resistant Staphylococcus aureus (MRSA) adalah strain Staphylococcus aureus yang resisten terhadap antibiotik golongan beta laktam. Pasien karier MRSA dinilai meningkatkan kejadian komplikasi paska operasi pada pasien ortopedi. Penelitian ini bertujuan untuk mengetahui gambaran dan prevalensi skrining MRSA pada pasien ortopedi di Bangsal Bedah RS X Riau.  Metode penelitian ini adalah deskriptif dengan rancangan cross-sectional menggunakan data primer dan sekunder responden.  Penelitian ini dilakukan pada 34 responden di Bangsal Bedah RS X Riau sejak Januari 2019 – Maret 2020.  Persentase responden yang memiliki faktor risiko sebagai karier MRSA yaitu: 5,9% dengan riwayat operasi 3 bulan terakhir; 2,9% dengan riwayat penggunaan antibiotik dalam 6 bulan terakhir, 29,4% dengan luka terbuka akut, 11,8% dengan riwayat rawat inap, 0% dengan riwayat kultur MRSA, dan 17,6% merupakan rujukan rumah sakit lain. Pada responden berisiko tersebut ditemukan kolonisasi Staphylococcus aureus pada 9 orang responden (26%) di bagian nasal anterior dan tidak ditemukan adanya bakteri MRSA (0%). Kesimpulan yang didapat dari penelitian ini adalah tidak ditemukannya bakteri MRSA pada seluruh sampel yang diperiksa. Kata Kunci: MRSA, Ortopedi, Skrining, Staphylococcus aureus..  ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) is a strain of Staphylococcus aureus that is resistant to beta-lactam antibiotics. Patients with MRSA carrier are considered to increase the incidence of post-operative complications in orthopedic patients. This study aimed to determine the prevalence and illustration of MRSA screening in orthopedic patients in X Hospital Riau. This research method was descriptive with cross-sectional design using primary and secondary data of respondents. This study was conducted on 34 respondents in surgical ward at X Hospital Riau from January 2019 to March 2020. The percentage of respondents who had risk factors as MRSA carriers were: 5.9% with a history of surgery in the last 3 months; 2.9% with a history of antibiotic use in the last 6 months, 29.4% with an acute open wound, 11.8% with a history of hospitalization, 0% with a history of MRSA culture, and 17.6% a referral to another hospital. Colonization of Staphylococcus aureus was found in 9 respondents (26%) in the anterior part of the nose and no MRSA bacteria were found (0%). The conclusion from this study is that MRSA bacteria were not found in all samples because only a few respondents had risk factors for becoming MRSA carrier. Keywords: MRSA, Orthopedic, Screening, Staphylococcus aureus.
GEJALA PENYERTA PADA BALITA DIARE DENGAN INFEKSI ENTEROPATHOGENIC Escherichia coli (EPEC) DI PUSKESMAS RAWAT INAP KOTA PEKANBARU Citra Ayu Anggreli; Dewi Anggraini; Maya Savira
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTEnteropathogenic Escherichia coli (EPEC) is a major cause of diarrhea in children below 5 years of age in the developing countries. The present study to detect the symptoms EPEC from childhood diarrhea has been done on April 2014 until October 2014. A total of 47 fecal specimens were collected from five hospitality primary health care in Pekanbaru and examination has been done in Microbiology Laboratory of Medical Faculty Riau University. The clinical manifestations are obtained is fever (57.45%), vomiting (46.80%), mucoid stools (36.17%), no symptoms (17.20%) and mild-moderate dehydration (74.46%). Results found that from all of the fecal specimen, 2 (4.35%) samples were positive EPEC. The infants with diarrhea who had positive EPEC experiencing fever and moderate dehydration.Keywords : Diarrhea, infants, hospitality primary health care, Enteropathogenic Escherichia coli
KARAKTERISTIK PADA BALITA DIARE DENGAN INFEKSI ENTEROPATHOGENIC Escherichia coli (EPEC) DI PUSKESMAS RAWAT INAP KOTA PEKANBARU Sabella Gustika Vernanda; Maya Savira; Dewi Anggraini
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTDiarrheal diseases remain one of the leading cause of childhood morbidity and mortality in most developing countries, with Enteropathogenic Escherichia coli (EPEC) being one of the most important aetiologic agents of children under-five years diarrhea in many of these countries. In Indonesia especially Pekanbaru, the epidemiology of these EPEC have not been well studied. During the period from April 2014 to September 2014, 47 stool sample were collected from children under-five years with acute diarrhea in the hospitality primary health care in Pekanbaru and the examination has been done in Microbiology Laboratory of Medical Faculty Riau University. The Escherichia coli were isolated and diagnosed by standard microbiological methods. The isolates confirmed to be Esherichia coli were subjected to a slide agglutination test with Escherichia coli polyvalent antisera. This study was a descriptive study using a consecutive sampling method to describe the characterization of Enteropathogenic Escherichia coli (EPEC) infection on children under-five years at the hospitality primary health care in Pekanbaru. Based on gender and age from all specimens that were collected, the diarrhea mostly found in male (59.5%), and in 12-59 months patients (93.6%). Out of the 47 stool samples, 1 isolate (2.2%) were positive for EPEC. The isolate was recovered from the 19 months female.Key words: diarrhea, enteropathogenic Escherichia coli, EPEC, children under-five years, hospitality primary health care
Optimization of multiplex PCR composition to screen for SARS-CoV-2 variants of concern Maya Savira; Enikarmila Asni; Rahmat Azhari Kemal
Acta Biochimica Indonesiana Vol. 4 No. 2 (2021): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.58

Abstract

Background: The ongoing COVID-19 pandemic has led to the emergence of several variants of concern. To rapidly identify those variants, screening samples for whole-genome sequencing (WGS) prioritization could be performed. Objective: We optimized the polymerase chain reaction (PCR) screening method to identify the mutation in spike and ORF1a regions. Methods: We adopted primers targeting mutation in spike and ORF1a region from another study. We optimized the PCR screening method using kits readily available in Indonesia. Firstly, we compared N1 and N2 primers as internal positive control. We also compared GoTaq® 1-Step RT-qPCR System and Indonesia TFRIC-19 BioCOV-19 for the multiplex reaction. We used the optimized composition to screen SARS-CoV-2 positive samples from April – June 2021. Samples with spike and/or ORF1a target failure were subjected to whole genome sequencing (WGS). Results: The results demonstrated the N2 BioCOV-19 reaction as the optimized multiplex PCR composition for spike and ORF1a mutations screening. Whole-genome sequencing has shown that a sample with spike and ORF1a targets failure to be Alpha variant, while other samples with single target failure as non-variants of concern. Therefore, a multiplex RT-PCR composition has been optimized to detect mutation in spike and ORF1a regions. Conclusion: We have optimized a multiplex RT-PCR composition to detect mutation in spike and ORF1a regions.
Three-Month Iron Supplementation as Treatment for Microcytic Hypochromic Anemia in Pregnancy Donel Donel; Dhini Aiyulie Novri; Ruza Prima Rustam; Maya Savira
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2245

Abstract

In pregnant women there is a twofold increase in iron requirements due to increased blood volume without the expansion of plasma volume. Pregnant women are very prone to suffering from iron deficiency anemia. Iron deficiency anemia generally has an erythrocyte index which represents  hypochromic microcytic. This study aimed to determine the effect of three-month iron tablet supplementation as a therapy against microcytic hypochromic anemia in pregnancy. This was a quantitative quasi-experimental study using pre-test and post-test design. The study was conducted in May-September 2020 at the Arifin Achmad Regional General Hospital, Riau Province, Indonesia. Subjects were 30 pregnant women with microcytic hypochromic anemia. Primary data were analyzed using statistical paired sample t-tests. Results showed that there was an increase in hemoglobin levels after the supplementation of iron tablet from an average of 9.1 ± 1.2 gr/dl to 11.8 ± 1.0 g/dl. This change was significant based on the results of the T-test (p-0.003) Thus, iron supplementation for three month significantly increases hemoglobin levels in pregnant women.
Effectiveness of Vitamin D Suplementation in Pregnant Women with Vitamin D Deficiency to Improved Fetal Biometry Donel S.; Ruza Prima Rustam; Inayah Inayah; M. Yulis Hamidy; Ratu Astuti Dwi Putri; Machyuddin T.M Pangaribuan; Ahmad Fahruddin; Maya Savira
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 1 Maret 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6n1.461

Abstract

Objective: The aim of this study was to determine the effect and effectiveness of vitamin D on fetal biometry.Method: This study was a Quantitative Study of two quasi-experimental groups. The research was conducted in Rupat District, Bengkalis Regency, Riau Province from June 2022 to August 2022. The research sample was pregnant women with vitamin D deficiency who were divided into an intervention group of 20 subjects and a control group of 20 subjects.Results: Examination of vitamin D levels in pregnant women and examination of fetal biometry was carried out. Then given a 1000 IU vitamin D supplement to pregnant women with vitamin D deficiency levels, re-evaluated after 3 months vitamin D levels in pregnant women and re-measured fetal biometry. There were significant differences in Fetal Biometrics between the pre-Intervention and post-Intervention studies in the intervention group with p=0.001. The intervention group also showed that there was an increase in the proportion of Normal Biometrics from 8 subjects before the intervention compared to 13 subjects after 3 months of vitamin D supplementation interventionConclusion: Vitamin D supplementation for 3 months in pregnant women with Vitamin D deficiency is proven to improve fetal health through Fetal Biometry examination.Efektivitas Suplemen Vitamin D dalam Meningkatkan Biometri Janin pada Wanita Hamil dengan Defisiensi Vitamin DAbstrakTujuan: Studi ini bertujuan mengetahui dampak dan efektivitas vitamin D terhadap biometri janin.Metode: Studi kuantitatif ini mengunakan dua grup dengan pendekatan kuasi-eksperimental. Penelitian ini dilaksanakan di Rupat, Kabupaten Bengkalis, Provinsi Riau dari Juni 2022 hingga Agustus 2022. Sampel penelitian ini adalah Wanita hamil dengan defisiensi vitamin D yang dibagi menjadi grup intervensi sebanyak 20 orang dan grup kontrol sebanyak 20 orang.Hasil: Dilakukan pengukuran kadar vitamin D pada Wanita hamil dan biometri janin. Pada grup intervensi diberikan suplementasi vitamin D 1000IU dan dievaluasi kembali kadar vitamin D setelah tiga bulan dan dilakukan kembali biometri janin. Terdapat perbedaan signifikan pada biometri janin sebelum dan sesudah intervensi dengan p=0.001. Grup intervensi juga menunjukkan peningkatan proprorsi biometri normal dari 8 orang menjadi 13 orang setelah tiga bulan suplementasi vitamin DKesimpulan: Suplementasi vitamin D selama tiga bulan pada Wanita hamil dengan defisiensi vitamin D terbukti membantu kesehatan janin melalui pemeriksaan biometri janin.Key words: Biometri, Defisiensi Vitamin D, Kehamilan
Vaksin Terapeutik yang Menargetkan Onkoprotein E6 dan E7 pada Kanker Serviks Maya Savira
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.11-16

Abstract

Cervical cancer is caused by persistent high-risk type of human papillomavirus (HPV) infection. especially types 16 and 18. The choice of cervical cancer therapy is associated with many side effects, tumor drug resistance, and high costs. A more efficient, safe and effective cervical cancer therapy is needed, such as therapeutic vaccine which targets host factors related to E6 and E7 of HPV oncoprotein. The oncoprotein E6 targets and inhibits p53, whereas E7 inhibits pRb. Therapeutic vaccines can be used to treat cervical cancer in all stage. Currently, this therapeutic vaccine is under investigation in phase I/II/III clinical trials.
ISOLASI BAKTERIOFAG DARI LIMBAH CAIR DENGAN AKTIVITAS LITIK TERHADAP Escherichia coli Boby Franswinsly Ritonga; Maya Savira
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.23684

Abstract

Bakteriofag adalah virus yang menginfeksi bakteri tertentu secara spesifik. Pemanfaatan bakteriofag sudah mulai diterapkan dalam bidang kedokteran sejak meningkatnya kasus resistensi antibiotik. Salah satu pemanfaatannya adalah terapi bakteriofag yang bertujuan untuk mengatasi atau mencegah infeksi bakteri. MDR Escherichia coli merupakan salah satu bakteri yang memiliki strain MDR yang telah menjadi masalah kesehatan di beberapa negara. E.coli merupakan bakteri basil gram negatif yang merupakan organisme penyebab banyak penyakit seperti diare, disentri, sistitis tanpa komplikasi, pneumonia, bakteremia, dan peritonitis. Dalam penelitian ini, bakteriofag litik yang dapat menginfeksi E.coli diisolasi dari limbah cair instalasi pengolahan limbah rumah sakit. Penelitian ini bertujuan untuk mengidentifikasi bakteriofag litik E.coli, serta melihat potensinya sebagai agen antibakteri terhadap E.coli ATCC 35218 . Penelitian ini merupakan penelitian deskriptif laboratorik yang diuji pada metode spot test dan plaque assay. Sediaan bakteriofag phage#1a yang merupakan produk akhir pada penelitian ini menunjukkan hasil spot test positif dan memiliki konsentrasi ±7.7x106 PFU/mL. Hasil penelitian ini menandakan bahwa bakteriofag dapat diisolasi dari limbah cair rumah sakit dan telah diuji dapat digunakan sabagai bahan antibakteri. Bakteriofag yang berhasil diisolasi ini diharapkan dapat digunakan untuk mengatasi permasalahan resistensi antibiotik yang selalu meningkat setiap tahunnya.
Association between type of congenital heart disease with child growth and development status: A cross-sectional study in Medan, Indonesia Amelia, Putri; Yosephine, Astrid G.; Tobing, Tina CL.; Savira, Maya; Viandy , Vincent; Inglin, Mark
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.414

Abstract

Congenital heart disease (CHD) is a congenital disorder primarily affecting newborns and children. Children with CHD have a greater risk of experiencing growth delays or disorders compared to healthy children. CHD also affects various aspects of a child’s development. The aim of this study was to determine the association of CHD types (cyanotic and acyanotic) with the growth and development status of children. A cross-sectional study was conducted among CHD patients at a national reference hospital in Sumatra, H. Adam Malik General Hospital in Medan, Indonesia. The children's growth status was assessed using the WHO growth chart, and the developmental condition was evaluated through the Denver Developmental Screening Test-II. Chi-squared test and Fisher’s exact test were used to assess the association between the type of CHD with growth and development status in children. Using a consecutive sampling method, a total of 53 individuals were included in this study. Almost half of CHD patients (48.1%) were within the age group of 0–2 years and more than half (61.1%) were girls. Acyanotic CHD (74.1%) was more prevalent than cyanotic CHD (25.9%), with ventricular septum defect (VSD) as the most common diagnosis. A total of 37% of children with CHD suffered from malnutrition, whereas the remaining 62.9% had good nutrition. The Denver Developmental Screening Test-II indicated that 81.4% of the children were normal, whereas 18.5% had developmental disorders. Our data suggested a significant association between cyanotic CHD and poor growth status in children based on weight-for-age, weight-for-length, and body mass index (BMI)-for-age. However, there was no association between the type of CHD and developmental status in children. This study highlights that the type of CHD is significantly associated with the growth status of children, but not with their developmental status.
Co-Authors Admiral, Muhammad Z. Afief, Arief R. Ahmad Fahruddin Amalia, Aisyah Sabrina Amelia, Putri Amru Sofian Boby Franswinsly Ritonga Citra Ayu Anggreli Darmawi Darmawi Dewi Anggraini Dhini Aiyulie Novri Dhita Natasha Dwiriyanti H Dino Irawan Donel S Donel S Enikarmila Asni Erfina Mallinda, Erfina Farah Mardhiyah Farniga, Arnaldi Fauzia Andrini Gusti Yulindra, Utari Hidayat, Nopian Ika A. Rini, Ika A. Ilmiah, Zidny Inayah Inayah Inglin, Mark Irham, Lalu M. Kemal, Rahmat A. Lubis, Nenni Dwi Aprianti M. Yulis Hamidy Machyuddin T.M Pangaribuan Mahargyarani, Azza E. Maryanti, Yossi Muhammad Ihsan Nurfi Pratiwi, Nurfi Putra, Andani E. Rachmadina, Rachmadina Rahmat Azhari Kemal Rangkuti, Ina F. Ratu Astuti Dwi Putri Razali, Renardy R. Resty Yuwandari rusdiana Ruza Prima Rustam Ruza Prima Rustam, Ruza Prima S, Donel Sabella Gustika Vernanda ShintaPuja Tilusari Sholihin, Uswathun Hasanah Sofie R. Krisnadi Suyanto " Tobing, Tina CL. Ulfah, Aida J. Vani Ardiani Viandy , Vincent Wardana, Rexi Dwi Widjaja, Sry Suryani Wirawan Adikusuma Yosephine, Astrid G. Yossi Maryanti Yuana Nurulita Yuwandari, Resty Zarfiardy Af, Zarfiardy Zulmaeta