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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Syiah Kuala Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Biomedika Chimica et Natura Acta Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Obstetrics & Gynecology Science Acta Biochimica Indonesiana INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Indian Journal of Forensic Medicine & Toxicology Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research

Maya Savira

Mikrobiologi Fakultas Kedokteran Universitas Riau Pekanbaru

Author-ID : 374733

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Deteksi Mekanisme Efflux Pump Pada Resistensi Bakteri Staphylococcus haemolyticus, Sampel Pus Klinis Rumah Sakit Pekanbaru Wardana, Rexi Dwi; Savira, Maya; Anggraini, Dewi; Amalia, Aisyah Sabrina; Nurulita, Yuana
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.52038

Infeksi adalah masalah kesehatan yang disebabkan oleh mikroorganisme patogen seperti bakteri. Salah satu jenis infeksi yaitu infeksi kulit dan jaringan lunak yang umumnya disebabkan oleh Staphylococcus aureus dan menyebabkan pembentukan pus. Saat ini, telah dilaporkan bahwa kasus spesies CoNS (Coagulase Negative Staphylococcus) seperti Staphylococcus haemolyticus sebagai penyebab infeksi, mengalami peningkatan. Selain itu, spesies ini juga diketahui telah mengalami resistensi terhadap beberapa golongan antibiotik. Dalam penelitian ini dilakukan karakterisasi isolat bakteri klinis dari sampel pus agar yang dilakukan dengan identifikasi mikrobiologi (kultur isolat, pewarnaan Gram dan uji biokimia) pada bakteri patogen (Isolat 3887), dan dilanjutkan dengan identifikasi molekuler, antara lain ekstraksi DNA kromoson dan plasmid, amplifikasi gen 16S rRNA, sekuensing dan analisis bioinformatik menggunakan BioEdit, BLAST dan filogenetika. Uji suseptibilitas terhadap 25 jenis antibiotik dan deteksi gen resisten clindamycin (ermA, ermB, ermC dan msrA) dan cefazolin (blaTEM-1, blaSHV dan blaOXA-1) dilakukan untuk mengidentifikasi kemungkinan mekanisme resistensi bakteri patogen. Berdasarkan hasil identifikasi mikrobiologi dan molekuler, isolat 3887 merupakan CoNS dengan strain Staphylococcus haemolyticus. Isolat 3887 resisten terhadap 12 dari 25 antibiotik yang diuji dan memiliki fenotipe resisten tertinggi terhadap clindamycin dan cefazolin. Hasil uji deteksi gen resisten clindamycin dan cefazolin menunjukkan hanya gen msrA yang terdeteksi baik pada kromosom dan plasmid isolat 3887 yang menunjukkan bahwa mekanisme resistensi melalui efflux pump.

Promising candidate drug target genes for repurposing in cervical cancer: A bioinformatics-based approach Pratiwi, Nurfi; Ulfah, Aida J.; Rachmadina, Rachmadina; Irham, Lalu M.; Afief, Arief R.; Adikusuma, Wirawan; Darmawi, Darmawi; Kemal, Rahmat A.; Rangkuti, Ina F.; Savira, Maya
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.938

Cervical cancer is the fourth most common cancer among women globally, and studies have shown that genetic variants play a significant role in its development. A variety of germline and somatic mutations are associated with cervical cancer. However, genomic data derived from these mutations have not been extensively utilized for the development of repurposed drugs for cervical cancer. The objective of this study was to identify novel potential drugs that could be repurposed for cervical cancer treatment through a bioinformatics approach. A comprehensive genomic and bioinformatics database integration strategy was employed to identify potential drug target genes for cervical cancer. Using the GWAS and PheWAS databases, a total of 232 genes associated with cervical cancer were identified. These pharmacological target genes were further refined by applying a biological threshold of six functional annotations. The drug target genes were then cross-referenced with cancer treatment candidates using the DrugBank database. Among the identified genes, LTA, TNFRSF1A, PRKCZ, PDE4B, and PARP were highlighted as promising targets for repurposed drugs. Notably, these five target genes overlapped with 12 drugs that could potentially be repurposed for cervical cancer treatment. Among these, talazoparib, a potent PARP inhibitor, emerged as a particularly promising candidate. Talazoparib is currently being investigated for safety and tolerability in other cancers but has not yet been studied in the context of cervical cancer. Further clinical trials are necessary to validate this finding and explore its potential as a repurposed drug for cervical cancer.

Studi Awal Analisis Molekuler Human Papillomavirus dari Apusan Glans dan Batang Penis Savira, Maya; Yuwandari, Resty; Maryanti, Yossi; Kemal, Rahmat Azhari; S, Donel
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1493

Pria juga dapat mengalami keganasan akibat infeksi Human Papillomavirus (HPV) serta bertindak sebagai reservoir virus. Metode skrining HPV pada wanita telah terstandardisasi, namun belum ada standar metode skrining pada pria di Indonesia. Beberapa studi pada populasi pria di luar negeri menunjukkan potensi sampling pada daerah genitalia eksterna untuk skrining HPV. Tujuan: mengoptimasi metode skrining HPV secara molekuler pada pria. Metode: Responden adalah partner seksual wanita pansien kanker serviks di RSUD Arifin Achmad Provinsi Riau. Apusan dari glans dan batang penis diambil menggunakan nylon-flocked swab yang kemudian dimasukkan ke dalam 350Âµl viral transport medium terpisah. DNA diisolasi dari sampel yang kemudian dianalisis untuk mendeteksi gen human Î²-globin dan HPV. Hasil: Optimasi awal menunjukkan gen Î²-globin dapat terdeteksi dari hasil ekstraksi dengan kit Zeesan Viral RNA Extraction. Pita HPV hasil PCR dengan primer MY09 dan MY11 dapat muncul namun masih tipis. Simpulan: Studi awal ini menunjukkan bahwa apusan glans dan batang penis dapat digunakan untuk deteksi HPV secara molekuler pada pria, namun proses pengambilan sampel, ekstraksi DNA, dan PCR masih perlu dioptimasi.Kata kunci: apusan, glans, HPV, penis

Genetic variations of the L2 gene in human papillomavirus (HPV) type 16 from cervical cancer patients in Sumatra region, Indonesia Savira, Maya; Farniga, Arnaldi; Ilmiah, Zidny; Rachmadina, Rachmadina; Rini, Ika A.; Kemal, Rahmat A.; Mahargyarani, Azza E.; Admiral, Muhammad Z.; Sofian, Amru; Razali, Renardy R.; Suhaimi, Donel; Putra, Andani E.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1653

The L2 protein, a minor capsid component of human papillomavirus (HPV), plays a critical role in the HPV life cycle by packaging the viral genome with the L1 protein and facilitating DNA transport to the nucleus. Identifying genetic variations in the L2 gene is essential for improving vaccine development, diagnostic accuracy, and understanding viral evolution, potentially contributing to more effective HPV vaccines. The aim of this study was to investigate the genetic variation of the L2 gene in cervical cancer specimens collected from patients in Riau Province, Indonesia. A single-center, cross-sectional study was conducted at Arifin Achmad General Hospital, Riau Province, involving cervical cancer patients with confirmed HPV16 infection between January 2018 and August 2020. Demographic, clinical, and risk factor data were collected through structured interviews and direct assessments. Cervical biopsy specimens were collected, and viral DNA was extracted for L2 gene amplification using polymerase chain reaction (PCR). Sequencing was conducted on PCR products, followed by single-nucleotide polymorphism (SNP) identification through alignment with the HPV16 reference genome. The amplification and sequencing of the HPV16 L2 gene from 22 cervical cancer specimens revealed 36 SNPs, including 31 nonsynonymous and five synonymous mutations. High-frequency mutations were observed at nucleotide positions 4,074 and 4,177, each detected in 95.45% of the samples. Notable insertions were found at positions 3,668–3,669 and 4,275–4,276, indicating substantial sequence variation. Phylogenetic analysis grouped the sequences into three clusters, with most belonging to sub-lineage A2 (European), while others aligned with A4 (Asian) and East Asian lineages. The observed genetic diversity in the HPV16 L2 gene may reflect regional viral evolution and has potential implications for future vaccine development.

Health Nutrition and Sanitation Counseling Education in Improving Health Understanding in Sigapiton Village, Ajibata District, North Sumatra. Rusdiana; Lubis, Nenni Dwi Aprianti; Savira, Maya; Widjaja, Sry Suryani
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2021): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Healthy environmental sanitation and good nutrition are factors that determine human resources and quality of life. With healthy environmental sanitation, the community is protected from various infectious diseases and similarly with a good understanding of nutrition will produce individuals with good quality. For this reason, it is important to achieve resources and good quality of life. This understanding is enhanced by providing health education. and good nutrition so that people are protected from various diseases. Health matters are matters of the environment, attitudes and behavior of the community. One of the causes of this nutritional deficiency is stunting, namely short stature in which a child who is stunted produces a low level of intelligence. For this reason, it is necessary to educate the public to understand the importance of good nutrition for children's growth. There is a wrong perception in the general public that stature is a hereditary factor, not a factor in malnutrition so that they do not pay attention to the nutritional status of children. Wrong choice of food for consumption, as well as nutritional balance between intake and output of substances (nutritional imbalance), namely intake that exceeds output or vice versa is the result of nutritional problems that occur in toddlers. This causes several impacts, including chronic disease, overweight and underweight, pica, dental caries, and allergies. For this reason, in this case the community service team wants to provide education about counseling to the community where the targets to be carried out are pregnant women, school children and young women. During the Covid 19 pandemic, the targets we educate are through cadres and village officials, this is to avoid infection with the covid 19 virus. By providing counseling to cadres and village officials, we hope that it will reach the people of Sigapiton village. Where in this counseling we provide pocket books to the cadres and village officials that we educate. We hope that this service can increase public knowledge about nutrition understanding and the creation of healthy environmental sanitation. We will publish the output of this service in an international journal indexed by Scopus

Comparison Ghrehlin at Obesity Without Metabolic Sydrome With Obesity with Metabolic Syndrome Rusdiana; Savira, Maya; Widjaja, Sry Suryani
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2021): ABDIMAS TALENTA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Obesity is principal causative factor in the development of metabolic syndrome and Ghrelin as human natural hormones is involved in fundamental regulatory processof eating and energy balance.Obesity, which has become a global public health problem, is one of the major risk factors for development metabolic syndrome and type 2 diabetes mellitus.This study aimed to analyze the comparison of ghrelin hormone levels in obese with metabolic syndrome and obese non metabolic syndrome . The sample population is obese adults, then we examined the weight, height, waist size, blood pressure, laboratory tests such as blood sugar levels and lipid profile of sample population to separate obese with metabolic syndrome and obese non metabolic syndrome. After we determined each group we measured stress oxidative levels in blood in obese with metabolic syndrome and obese non metabolic syndrome by ELISA method.With statistical analysis using T test found that there was significant difference of ghrelin hormone levels between obese with metabolic syndrome and obese without metabolic syndrome (p<0.005).

Adjunctive Vaginal Probiotic Therapy for Preterm Premature Rupture of Membranes: A Systematic Review and Meta-Analysis of Latency Period, Maternal Infection, and Neonatal Morbidity Vani Ardiani; Donel S; Maya Savira; Zulmaeta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1484

Background: Preterm premature rupture of membranes (PPROM) significantly drives preterm birth rates and consequent neonatal morbidity and mortality. While standard antibiotic therapy aims to prolong pregnancy latency, it concurrently disrupts the protective vaginal microbiota. Adjunctive vaginal probiotics have been investigated as a means to restore beneficial flora, potentially mitigating ascending infection and improving perinatal outcomes. This study systematically synthesized the current randomized trial evidence regarding this adjunctive therapeutic strategy. Methods: We performed a systematic review and meta-analysis following PRISMA guidelines. PubMed, EMBASE, and CENTRAL databases were searched (2014–October 2025) for randomized controlled trials (RCTs) comparing adjunctive vaginal probiotics plus antibiotics versus antibiotics (alone or with placebo) in singleton pregnancies complicated by PPROM between 24+0 and 34+0 weeks’ gestation. Primary outcomes included the latency period (days) and maternal chorioamnionitis or infectious morbidity. Key secondary outcomes were neonatal intensive care unit (NICU) admission, neonatal sepsis, and neonatal mortality. Data were pooled using a random-effects model, calculating Mean Differences (MD) or Risk Ratios (RR) with 95% Confidence Intervals (CI). Risk of bias was assessed using the Cochrane RoB 2 tool. Results: Three RCTs, encompassing 330 participants, met the inclusion criteria. Significant methodological limitations, including high risk of bias and critical baseline confounding by gestational age in the largest trial, were identified across the included studies. A sensitivity analysis addressing high heterogeneity (I²=98%) for latency (excluding one retrospective study; n=290) indicated a modest but statistically significant prolongation associated with probiotics (MD 2.98 days; 95% CI 1.80–4.16; p<0.0001; I²=0%). Probiotic use was linked to a significantly lower risk of maternal infection (RR 0.43; 95% CI 0.24–0.77; p=0.005; I²=0%; n=270). Statistically significant reductions were also observed for NICU admission (RR 0.59; 95% CI 0.46–0.75; p<0.0001; I²=55%; n=330) and neonatal mortality (RR 0.38; 95% CI 0.18–0.81; p=0.01; I²=0%; n=270), although these estimates are likely inflated due to baseline confounding. Conclusion: This meta-analysis suggests adjunctive vaginal probiotics may offer benefits in PPROM management by modestly prolonging latency and significantly reducing maternal infectious morbidity. While substantial reductions in NICU admission and neonatal mortality were observed, these findings must be interpreted with extreme caution due to the limited quantity and low quality of the primary evidence, particularly the high risk of bias and confounding. Definitive conclusions cannot be drawn, and routine clinical adoption is not supported by current evidence. High-quality, large-scale RCTs are imperative.

Combination Effect of Slow Interval Training and Lemongrass Ethanol Extract (Cymbopogon citratus) on Body Weight and Fat Mass in Male Wistar Rats (Rattus norvegicus Sp) Obesity Model Siahaan, Sulyaprilawati Battri; Machrina, Yetty; Widyawati, Tri; Rusdiana, Rusdiana; Savira, Maya
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28284

Background: Obesity, a global health crisis affecting over 890 million adults, requiring effective and safe management strategies. Lifestyle-based interventions, such as physical exercise and herbal supplementation, provide promising non-invasive alternatives. Slow Interval Training (SIT) improves fat metabolism with low injury risk, while lemongrass (Cymbopogon citratus) contains bioactive compounds with anti-obesity potential.Objective: This study investigates the combined effects of SIT and lemongrass ethanol extract on body weight and fat mass in a high-fat diet (HFD)-induced obese male Wistar rat model.Methods: Thirty-five male Wistar rats were divided into five groups: healthy control, obese control, SIT only, lemongrass extract only, and SIT + lemongrass. Obesity was induced through a high-fat diet before intervention. Body weight was measured weekly, and fat mass was analyzed after eight weeks of treatment.Results: Obese controls showed significant weight gain (p<0.001). The lemongrass-only group showed a 12.7% weight reduction, while the combination group achieved the lowest final weight (200 g) and the lowest fat mass (2.39 g, p=0.048). Significant intergroup differences appeared from week 1 and persisted until week 13 (p<0.05). The combination group maintained stable weight after intervention, outperforming SIT or lemongrass alone.Conclusion: The combination of SIT and lemongrass ethanol extract significantly reduces body weight and fat mass in obese rats, demonstrating synergistic efficacy. Lemongrass inhibits fat absorption and enhances metabolic regulation, while SIT promotes fat oxidation. This dual approach offers a viable, non-invasive strategy for obesity management, warranting further clinical exploration.

Genetic diversity in the E6 and E7 gene of human papillomavirus type 16 among cervical cancer patients in Riau Province, Indonesia Maya Savira; Rachmadina Rachmadina; Azza Enggar Mahargyarani; Muhammad Zhafran Admiral; Donel S; Amru Sofian; Renady Reza Razali; Zidny Ilmiah; Analdi Farniga
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.6652

Cervical cancer mostly occurs due to persistent high-risk human papillomavirus (HPV), with type 16 being the most frequent. In Indonesia, cervical cancer ranks second in mortality, with a fatality rate of 57%. The E6 and E7 genes of HPV-16 play crucial roles in the virus’s oncogenic transformation, leading to cervical cancer. This study was conducted to determine the prevalence and genetic diversity of the E6 and E7 genes of HPV-16 in Riau Province, Indonesia. There were 37 HPV-positive samples analyzed using the MY09/11 primers. This was followed by the amplification of the E6 and E7 genes. Nineteen samples were detected as HPV-16, thirteen of which were coinfected with HPV-18. Seven E6 and E7 sequences were aligned compared with the reference sequence NC_001526.4. The most common nucleotide changes in the E6 gene, 7318A>G, was detected in 30.7% of samples, leading to an amino acid change from 65N>S. Three nucleotide changes were identified in the E7 gene of sample 89: two synonymous (7831T>C, 7837T>G) and one non-synonymous (7989A>G), resulting in an amino acid change of 29N>S. The most frequent E7 nucleotide change, 7708G>A, was found in 80% of samples. Phylogenetic analysis revealed that HPV-16 isolates from Riau have close kinship with the European lineage, with 57.1% (E6) and 85.7% (E7). In conclusion, the incidence of cervical cancer in Riau Province caused by HPV-16 is 52.8% and 7318A>G and 7708G>A are the most common genetic diversity. Furthermore, the majority of HPV-16 isolates in Riau Province show close kinship with the European lineage.

Co-Authors Admiral, Muhammad Z. Afief, Arief R. Ahmad Fahruddin Amalia, Aisyah Sabrina Amelia, Putri Amru Sofian Amru Sofian Analdi Farniga Azza Enggar Mahargyarani Boby Franswinsly Ritonga Citra Ayu Anggreli Darmawi Darmawi Dewi Anggraini Dhini Aiyulie Novri Dhita Natasha Dwiriyanti H Dino Irawan Donel S Donel S Donel S Enikarmila Asni Erfina Mallinda, Erfina Farah Mardhiyah Farniga, Arnaldi Fauzia Andrini Gusti Yulindra, Utari Hidayat, Nopian Ika A. Rini, Ika A. Ilmiah, Zidny Inayah Inayah Inglin, Mark Irham, Lalu M. Kemal, Rahmat A. Lubis, Nenni Dwi Aprianti M. Yulis Hamidy Machyuddin T.M Pangaribuan Mahargyarani, Azza E. Maryanti, Yossi Muhammad Ihsan Muhammad Zhafran Admiral Nurfi Pratiwi, Nurfi Putra, Andani E. Rachmadina Rachmadina Rachmadina, Rachmadina Rahmat Azhari Kemal Rangkuti, Ina F. Ratu Astuti Dwi Putri Razali, Renardy R. Renady Reza Razali Resty Yuwandari rusdiana Rusdiana Rusdiana Ruza Prima Rustam Ruza Prima Rustam, Ruza Prima S, Donel Sabella Gustika Vernanda ShintaPuja Tilusari Sholihin, Uswathun Hasanah Siahaan, Sulyaprilawati Battri Sofie R. Krisnadi Suyanto " Tobing, Tina CL. Tri Widyawati, Tri Ulfah, Aida J. Vani Ardiani Viandy , Vincent Wardana, Rexi Dwi Widjaja, Sry Suryani Wirawan Adikusuma Yetty Machrina Yosephine, Astrid G. Yossi Maryanti Yuana Nurulita Yuwandari, Resty Zarfiardy Af, Zarfiardy Zidny Ilmiah Zulmaeta

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