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All Journal Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JFL : Jurnal Farmasi Lampung AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Jurnal Abdimas Mahakam Jurnal Riset Kefarmasian Indonesia Bivalen: Chemical Studies Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Media Farmasi Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Risa Supriningrum
Sekolah Tinggi Ilmu Kesehatan Samarinda
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Penetapan Kadar Flavonoid Total Ekstrak Etanol Kulit Buah Labu Kuning (Cucurbita moschata) Berdasarkan Perbedaan Konsentrasi Pelarut Secara Spektrofotometri UV-Vis ilham, ilham; Supriningrum, Risa; Warnida, Husnul
Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia Vol 25, No 1 (2024): CHEMICA
Publisher : Jurusan Kimia FMIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/chemica.v25i1.59074

Abstract

ABSTRAKKulit labu kuning ( Cucurbita moschata ) yang selama ini dianggap sebagai limbah ternyata memiliki manfaat antara lain sebagai antibakteri, antioksidan, karena senyawa metabolit sekunder yang dikandungnya. Salah satu senyawa metabolit sekundernya adalah flavonoid. Penyarian senyawa aktif dalam bahan alam dapat dipengaruhi oleh konsentrasi pelarut. Tujuan penelitian ini adalah mengetahui kadar flavonoid total ekstrak etanol kulit buah labu kuning berdasarkan perbedaan konsentrasi pelarut etanol. Tahapan penelitian meliputi penentuan tanaman, pengumpulan bahan baku, pembuatan simplisia, penetapan kadar flavonoid total secara spektrofotometri UV-Vis. Variabel bebas pada penelitian ini adalah variasi konsentrasi etanol 70% dan 95%, variabel ikatan berupa kadar flavonoid total, variabel kontrol berupa metode ekstraksi, tempat pengambilan sampel. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menyatakan persen rendemen ekstrak etanol 70% dan 95%, masing-masing adalah 13,68% dan 15,54%. Kadar flavonoid total dari ekstrak etanol 70% dan 95%, masing-masing sebesar 1,1931% ± 0,0810; dan 1,2045% ± 0,0854. Sehingga dapat disimpulkan bahwa konsentrasi pelarut etanol berpengaruh terhadap kadar rendemen dan ekstrak flavonoid kulit buah labu kuning.Kata kunci : Cucurbita moschata , flavonoid, konsentrasi pelarut, spektrofotometri UV-Vis. ABSTRACTThe skin of pumpkin (Cucurbita moschata) which has been considered as waste so far has benefits such as antibacterial, and antioxidant, because of the secondary metabolites it contains. One of the secondary metabolites is flavonoids. The Extraction of active compounds in natural products can be affected by solvent concentration. The purpose of this study was to determine the total flavonoid content of the ethanol extract of pumpkin peel based on differences in ethanol solvent concentration. The stages of the research included plant determination, raw material collection, simplicia manufacture, extraction by maceration with variations in ethanol concentration, flavonoid phytochemical screening, and determination of total flavonoid content by UV-Vis spectrophotometry. The independent variable in this study was the variation of 70% and 95% ethanol concentration, the dependent variable was the total flavonoid content, and control variable was the extraction method, where the sample was taken. The data analysis used is descriptive analysis. The results of the study stated that the percent yield of 70% and 95% ethanol extract were 13.68% and 15.54%, respectively. The total flavonoid content of 70% and 95% ethanol extract, respectively, were 1.1931% ± 0.0810, 1.2045% ± 0.0854. So it can be concluded that the concentration of ethanol solvent affects the yield and flavonoid levels of pumpkin peel extract.Keywords : Cucurbita moschata, flavonoids, solvent concentration, UV-Vis spectrophotometry.
TOTAL FLAVONOID CONTENT OF KAPUL FRUIT PEEL EXTRACT (Baccaurea macrocarpa) BASED ON SOLVENT TYPE VARIATION USING UV-VIS SPECTROPHOTOMETRY Rahmadani, Rahmadani; Supriningrum, Risa; Sa'adah, Hayatus
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 10, No 3 (2024)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v10i3.16642

Abstract

The solvent type plays a crucial role in influencing the extraction of active compounds from natural materials. The peel of kapul fruit (Baccaurea macrocarpa) is known to contain flavonoid compounds with notable antibacterial properties. This study aimed to quantify the total flavonoid content in kapul fruit peel extract by evaluating the effects of different solvent types using the UV-Vis spectrophotometric method. The analysis revealed the presence of secondary metabolites, including alkaloids, saponins, and flavonoids. The total flavonoid content of the kapul fruit peel extract varied significantly across different solvents: 4.7238 ± 0.5807 mgQE/g for ethanol, 2.9699 ± 0.1539 mgQE/g for ethyl acetate, and 2.0417 ± 0.4236 mgQE/g for n-hexane. Statistical analysis demonstrated a significant difference in flavonoid content among the three solvent extracts. These results highlight the importance of solvent selection in maximizing the extraction efficiency of flavonoids from kapul fruit peel, which may have implications for its potential therapeutic applications.
UJI PENDAHULUAN DAUN TENEM Litsea cubeba (Lour.) Pers Risa Supriningrum; Medi Hendra; Hendri Misak
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i1.42

Abstract

Litsea cubeba (Lour Pers.) has been used by the Dayak community Lundayeh and Kenyah, the village of Long Berang, District Mentarang, North Borneo, as drug . Leaves and bark used as medicine for diarrhea. Preliminary data concerning the characteristics and content of secondary metabolites has not been reported. This study aims to determine the organoleptic, macroscopic,  microscopic characteristics and content of secondary metabolites tenem leaves. The results showed that the leaf tenem have organoleptic characteristics typical aromatic smell like citrus (lemon), taste slightly bitter, slightly spicy, chelates. Macroscopic characteristics in the form of a single leaf, lanceolate, elongated, tapered leaf tip, leaf base tapering, bone pinnate leaves, upper surface shiny, lower surface dull and slightly hairy, color light green to dark green. Microscopy test results showed fragments of sklereid, oil cell, stomata type of parasitic, non-glandular trichomes. Simplicia tenem leaf powder contains alkaloids, tannins and terpenoids. The ethanol extract of leaves tenem containing compounds, terpenoids, tannins, alkaloids
UJI TOKSISITAS AKUT EKSTRAK ETANOL AKAR KB (Coptosapelta tomentosa Valeton ex K.Heyne) DENGAN METODE Brine Shrimp Lethality Test (BSLT) Risa Supriningrum; Sapri Sapri; Vici Ali Pranamala
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.61

Abstract

The roots of KB plants (Captosapelta tomentisa) is used empiricallyby  Dayak Kenyah community as a drug leukorrhea. Leukorrhea is one of the early symptoms of cervical cancer. Early methods to determine the LC50 value or toxicity of anticancer KB roots have not been reported. The aim of research is to determine the value of the toxicity of KB root. Research was conducted by an experimental study. Research stages include sample processing, extraction and acute toxicity test by Brine Shrimp Lethality Test (BSLT). BSLT testing to determine LC50 values with a concentration of 250 ppm, 300 ppm, 400 ppm, 450 ppm and a negative control. Analysis of the data used are probit analysis method. The results showed  the presence of flavonoids, alkaloids and saponins in of the ethanol extract of KB root . The test results obtained acute toxicity LC50 value is 299.226 mg / ml, so that the ethanol extract of roots KB potentially toxic to the larvae of Artemia salina Leach.
PENETAPAN KADAR FLAVONOID EKSTRAK ETANOL DAUN PACAR KUKU (Lawsonia inermis L.) BERDASARKAN PERBEDAAN CARA PENGERINGAN Risa Supriningrum; Nurul Fatimah; Sri Nur Wahyuni
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.195

Abstract

Leaves of Lawsonia inermis L. are one of the medicinal plants that have antibacterial properties, medicine for wounds on the skin, drugs for inflammation of the knuckles and as a nail dye. One of the active substances contained in the henna leaf is flavonoids. The level of active ingredient extract can be influenced by the way of drying simplicia. The purpose of this study was to determine the levels of flavonoid ethanol extract of girlfriend nail Lawsonia inermis L. leaves based on simplicia drying method. Research conducted was non-experimental research. The stages of the study included collecting samples, determining plants, making simplicia by drying the wind and artificial drying with an oven at 550C, extracting by maceration and determining flavonoid levels by UV-Vis spectrophotometry. The data obtained were analyzed descriptively. Based on the results of the study, obtained flavonoid levels of ethanol extract of leaves on wind-dried drying of 6.15% ± 0.1373 and drying with an oven of 7.37% ± 0.2158.
TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF YELLOW PUMPKIN (Cucurbita moschata Duch) FRUIT EXTRACT Yudha Pratama; Risa Supriningrum; Supomo Supomo
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 10, No 1 (2024)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v10i1.14302

Abstract

Pumpkin (Cucurbita moschata Duch) is a food rich in vitamin A, vitamin C, minerals, carbohydrates, and flavonoid compounds. Flavonoids have several pharmacological activities, including as antioxidants to ward off free radicals. This study aims to determine the total flavonoid content and antioxidant activity of pumpkin fruit. The extraction of pumpkin fruit was done by the maceration method in a 70% ethanol solvent. The total flavonoid test used the colorimetric method with a 10% AlCl3 reagent and quercetin as a positive control. Antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results obtained for the total flavonoid content of the ethanol extract of pumpkin fruit amounted to 1.741 mgQE/g ± 0.2438 and an IC50 value of 379.44 ppm, including the category of weak antioxidant, compared with the positive control.
EFFECT OF DPPH CONCENTRATION VARIATION ON ANTIOXIDANT ACTIVITY OF EXTRACT OF RASAM FERN LEAF (Dicranopteris linearis) Henny Nurhasnawati; Risa Supriningrum; Ardani Ardani
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11, No 1 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i1.18488

Abstract

Dicranopteris linearis (rasam fern) is known to contain flavonoid compounds that exhibit significant antioxidant activity. In this study, the antioxidant potential of rasam fern leaf extract was assessed using the DPPH assay at three different concentrations: 30 ppm (P1), 40 ppm (P2), and 50 ppm (P3). Phytochemical screening confirmed the presence of flavonoids, tannins, and saponins in the extract. The IC50 values obtained for each treatment were as follows: P1 = 8.37 ppm, P2 = 12.31 ppm, and P3 = 13.57 ppm, all of which fall within the category of very strong antioxidant activity. Statistical analysis using one-way ANOVA revealed a significant difference in IC50 values among the three DPPH concentrations. These results indicate that variations in DPPH concentration significantly influence the IC50 values, thereby affecting the accuracy and interpretation of antioxidant activity measurements.
Kandungan total senyawa fenol, total senyawa flavonoid dan aktivitas antioksidan ektsrak etanol kulit batang sekilang (Embelia borneensis Scheff.) Sundu, Reksi; Supriningrum, Risa; Fatimah, Nurul
Bivalen: Chemical Studies Journal Vol. 5 No. 2 (2022)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v5i2.1388

Abstract

Kulit batang sekilang (Embelia borneensis Scheff.) secara empiris oleh suku Dayak Kenyah digunakan untuk penangkapan ikan di sungai dan mengusir lintah. Flavonoid merupakan kelompok terbesar dari senyawa fenolik yang memiliki sifat sebagai antioksidan. Tujuan penelitian ini adalah untuk mengetahui kandungan total senyawa fenol, total senyawa flavonoid dan aktivitas antioksidan dari ekstrak etanol kulit batang sekilang. Metode ekstraksi yang digunakan adalah metode maserasi, penetapan kadar fenol dengan metode Folin-Ciocalteu, penetapan kadar flavonoid dengan metode AlCl3 dan pengujian aktivitas antioksidan menggunakan metode 2,2 -diphenyl-1-picrylhydrazyl (DPPH). Berdasarkan hasil penelitian, ekstrak etanol kulit batang sekilang mengandung total senyawa fenol sebesar 42,605 mg GAE/g ekstrak dan total senyawa flavonoid sebesar 6,165 mg QE/g ekstrak. Ekstrak etanol kulit batang sekilang memiliki aktivitas antioksidan dengan nilai IC50 sebesar 141,27 ppm dengan kategori aktivitas sedang. Hasil penelitian ini menunjukkan bahwa bahwa kulit batang sekilang memiliki potensi sebagai agen antioksidan alami.
Pemanfaatan kulit buah dan kulit ubi sebagai indikator asam-basa alternatif alami dengan variasi suhu pengeringan Nathalia, Nyda; Sundu, Reksi; Supriningrum, Risa
Bivalen: Chemical Studies Journal Vol. 6 No. 1 (2023)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v6i1.2009

Abstract

Indikator asam basa alami dapat dibuat dengan mengesktrak bagian dari tanaman, seperti batang, daun, bunga, buah dan kulit buah atau kulit ubi. Antosianin merupakan pigmen warna yang terdapat pada berbagai jenis tumbuhan. Kadar antosianin akan menurun pada suhu 100oC karena terjadi degradasi pada antosianin. Penelitian ini bertujuan untuk mengetahui pengaruh variasi suhu pengeringan pada kulit buah dan kulit ubi terhadap pembuatan indikator asam-basa dan mengetahui potensi ekstrak kulit buah dan kulit ubi untuk dijadikan indikator asam-basa. Tahapan penelitian ini dimulai dengan persiapan sampel, mengeringkan sampel dengan variasi suhu 30, 40, 50, 60 dan 70°C selama 10 jam, pembuatan ekstrak dan pengujian indikator asam-basa. Hasil penelitian ini menunjukkan bahwa variasi suhu pengeringan berpengaruh terhadap hasil kertas indikator asam-basa alami. Kulit buah naga, kulit buah manggis dan kulit ubi ungu memiliki potensi untuk dijadikan indikator asam-basa alternatif dan ekstrak dari kulit ubi ungu yang dikeringkan dengan suhu 60 dan 70°C memiliki potensi yang paling besar untuk dijadikan kertas indikator asam-basa alternatif karena dapat memberikan hasil perbedaan warna ketika diujikan dengan larutan asam kuat, basa kuat, asam lemah dan basa lemah
Karakterisasi dan Analisis Vitamin C dalam Teh Kombucha Biji Alpukat (Persea americana Mill.) dengan Variasi Lama Fermentasi: Characterization and Analysis of Vitamin C in Avocado Seed Kombucha Tea (Persea americana Mill.) with Variation of Fermentation Duration Annaza, Alwan Darwissy; Jubaidah, Siti; Supriningrum, Risa
Jurnal Sains dan Kesehatan Vol. 7 No. 3 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i3.2472

Abstract

Avocado seeds contain several minerals and vitamin C, these seeds can be fermented into tea with kombucha culture, SCOBY (Symbiotic Cultures of Bacteria and Yeats). The length of fermentation will have an impact on the vitamin C content in the tea. The purpose of this study was to determine the characteristics and vitamin C content based on variations in the length of fermentation time of avocado seed kombucha tea. The research conducted was experimental research and used the RAL (Completely Randomized Design) method with variations in the length of fermentation. The research stages include plant determination, simplisia processing, making kombucha tea based on variations in fermentation time, characteristic tests, qualitative and quantitative analysis of vitamin C, and data analysis using SPSS IBM 25 with a 95% confidence level. The results obtained vitamin C content of avocado seed kombucha tea with 1 day fermentation time of 0.4628 ± 0.0099%, 3 days fermentation time of 0.4740 ± 0.0059%, 5 days fermentation time of 0.5081 ± 0.0118%, 7 days fermentation time of 0.6439 ± 0.0148%, 9 days fermentation time of 0.7048 ± 0.0255% and 11 days fermentation time of 0.6216 ± 0.0411%. Statistical data analysis of vitamin C levels using the One Way ANOVA test with p < 0.05 and obtained a significance value of 0.0000, namely there is a significant difference between the six fermentation lengths. Keywords:          Kombucha Tea, Characterization, Vitamin C, Long Fermentation   Abstrak Biji alpukat mengandung beberapa mineral dan vitamin C, biji ini dapat difermentasi menjadi teh dengan kultur kombucha yaitu SCOBY (Symbiotic Cultures of Bacteria and Yeats). Lama fermentasi akan berdampak pada kandungan vitamin C yang ada dalam teh. Tujuan penelitian ini untuk mengetahui karakteristik dan kandungan vitamin C berdasarkan variasi lama waktu fermentasi dari teh kombucha biji alpukat. Penelitian yang dilakukan adalah penelitian eksperimental dan menggunakan metode RAL (Rancangan Acak Lengkap) dengan variasi lama fermentasi. Tahapan penelitian meliputi determinasi tanaman, pengolahan simplisia, pembuatan teh kombucha berdasarkan variasi lama waktu fermentasi, uji karakteristik, analisis kualitatif dan kuantitatif vitamin C, dan analisis data menggunakan SPSS IBM 25 dengan taraf kepercayaan 95%. Hasil penelitian diperoleh kadar vitamin C teh kombucha biji alpukat dengan lama fermentasi 1 hari sebesar 0,4628 ± 0,0099%, lama fermentasi 3 hari sebesar 0,4740 ± 0,0059%, lama fermentasi 5 hari sebesar 0,5081 ± 0,0118%, lama fermentasi 7 hari sebesar 0,6439 ± 0,0148%, lama fermentasi 9 hari sebesar 0,7048 ± 0,0255% dan lama fermentasi 11 hari sebesar 0,6216 ± 0,0411%. Analisis data statistik kadar vitamin C menggunakan uji One Way ANOVA dengan p<0,05 dan didapatkan nilai signifikansi 0,0000 yaitu terdapat perbedaan yang signifikan antara keenam lama fermentasi. Kata Kunci:         Teh Kombucha, Karakterisasi, Vitamin C, Lama Fermentasi
Co-Authors Achmat Kadri Ansyori Andi Wijaya Annaza, Alwan Darwissy Anugerah, Olanda Ardani Ardani Ari Saptowo Asmi Risyah Ekawati Bebie Ayu Rismayuti Dewi Rahmasuari Dwi Ajeng Dwi Setyawati Eka Kumalasari Eka Siswanto Syamsul Fitri Handayani Ghina Adhilla Hayatus Sa'adah Hayatus Sa’adah Hendri Misak Henny Nurhasnawati Ilham Ilham Inayah Herman Goetie Kusumawati, Eko Liya Liya Liya, Liya Margareta, Sully Maria F.K. Hayon Medi Hendra, Medi Misak, Hendri Nathalia, Nyda Nurul Fatimah Nurul Fatimah Nurul Fatimah Pranamala, Vici Ali Qarriy ‘Aina Urfiyya Rahmadani Rahmadani Rakhmadhan Niah Reksi Sundu Risaldi Junaid Rozadi, Reza Rusdiati Helmidanora Sa'adah, Hayatus Sapri - Sapri Sapri sapri sapri Siti Faisah Siti Jubaidah Siti Jubaidah, Siti Siti Jubidah Sri Nur Wahyuni Supomo Supomo - Supomo Supomo Susilowati, Agustina Syamsiar, Syamsiar Triswanto Sentat Vici Ali Pranamala Wahyuni, Sri Nur Warnida, Husnul Yenni Eka Purwanti Yudha Pratama