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All Journal Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JFL : Jurnal Farmasi Lampung AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Jurnal Riset Kefarmasian Indonesia Bivalen: Chemical Studies Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Media Farmasi Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Abdimas Mahakam
Risa Supriningrum
Sekolah Tinggi Ilmu Kesehatan Samarinda
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF YELLOW PUMPKIN (Cucurbita moschata Duch) FRUIT EXTRACT Yudha Pratama; Risa Supriningrum; Supomo Supomo
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 10, No 1 (2024)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v10i1.14302

Abstract

Pumpkin (Cucurbita moschata Duch) is a food rich in vitamin A, vitamin C, minerals, carbohydrates, and flavonoid compounds. Flavonoids have several pharmacological activities, including as antioxidants to ward off free radicals. This study aims to determine the total flavonoid content and antioxidant activity of pumpkin fruit. The extraction of pumpkin fruit was done by the maceration method in a 70% ethanol solvent. The total flavonoid test used the colorimetric method with a 10% AlCl3 reagent and quercetin as a positive control. Antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results obtained for the total flavonoid content of the ethanol extract of pumpkin fruit amounted to 1.741 mgQE/g ± 0.2438 and an IC50 value of 379.44 ppm, including the category of weak antioxidant, compared with the positive control.
EFFECT OF DPPH CONCENTRATION VARIATION ON ANTIOXIDANT ACTIVITY OF EXTRACT OF RASAM FERN LEAF (Dicranopteris linearis) Henny Nurhasnawati; Risa Supriningrum; Ardani Ardani
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11, No 1 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i1.18488

Abstract

Dicranopteris linearis (rasam fern) is known to contain flavonoid compounds that exhibit significant antioxidant activity. In this study, the antioxidant potential of rasam fern leaf extract was assessed using the DPPH assay at three different concentrations: 30 ppm (P1), 40 ppm (P2), and 50 ppm (P3). Phytochemical screening confirmed the presence of flavonoids, tannins, and saponins in the extract. The IC50 values obtained for each treatment were as follows: P1 = 8.37 ppm, P2 = 12.31 ppm, and P3 = 13.57 ppm, all of which fall within the category of very strong antioxidant activity. Statistical analysis using one-way ANOVA revealed a significant difference in IC50 values among the three DPPH concentrations. These results indicate that variations in DPPH concentration significantly influence the IC50 values, thereby affecting the accuracy and interpretation of antioxidant activity measurements.
Kandungan total senyawa fenol, total senyawa flavonoid dan aktivitas antioksidan ektsrak etanol kulit batang sekilang (Embelia borneensis Scheff.) Sundu, Reksi; Supriningrum, Risa; Fatimah, Nurul
Bivalen: Chemical Studies Journal Vol. 5 No. 2 (2022)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v5i2.1388

Abstract

Kulit batang sekilang (Embelia borneensis Scheff.) secara empiris oleh suku Dayak Kenyah digunakan untuk penangkapan ikan di sungai dan mengusir lintah. Flavonoid merupakan kelompok terbesar dari senyawa fenolik yang memiliki sifat sebagai antioksidan. Tujuan penelitian ini adalah untuk mengetahui kandungan total senyawa fenol, total senyawa flavonoid dan aktivitas antioksidan dari ekstrak etanol kulit batang sekilang. Metode ekstraksi yang digunakan adalah metode maserasi, penetapan kadar fenol dengan metode Folin-Ciocalteu, penetapan kadar flavonoid dengan metode AlCl3 dan pengujian aktivitas antioksidan menggunakan metode 2,2 -diphenyl-1-picrylhydrazyl (DPPH). Berdasarkan hasil penelitian, ekstrak etanol kulit batang sekilang mengandung total senyawa fenol sebesar 42,605 mg GAE/g ekstrak dan total senyawa flavonoid sebesar 6,165 mg QE/g ekstrak. Ekstrak etanol kulit batang sekilang memiliki aktivitas antioksidan dengan nilai IC50 sebesar 141,27 ppm dengan kategori aktivitas sedang. Hasil penelitian ini menunjukkan bahwa bahwa kulit batang sekilang memiliki potensi sebagai agen antioksidan alami.
Pemanfaatan kulit buah dan kulit ubi sebagai indikator asam-basa alternatif alami dengan variasi suhu pengeringan Nathalia, Nyda; Sundu, Reksi; Supriningrum, Risa
Bivalen: Chemical Studies Journal Vol. 6 No. 1 (2023)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v6i1.2009

Abstract

Indikator asam basa alami dapat dibuat dengan mengesktrak bagian dari tanaman, seperti batang, daun, bunga, buah dan kulit buah atau kulit ubi. Antosianin merupakan pigmen warna yang terdapat pada berbagai jenis tumbuhan. Kadar antosianin akan menurun pada suhu 100oC karena terjadi degradasi pada antosianin. Penelitian ini bertujuan untuk mengetahui pengaruh variasi suhu pengeringan pada kulit buah dan kulit ubi terhadap pembuatan indikator asam-basa dan mengetahui potensi ekstrak kulit buah dan kulit ubi untuk dijadikan indikator asam-basa. Tahapan penelitian ini dimulai dengan persiapan sampel, mengeringkan sampel dengan variasi suhu 30, 40, 50, 60 dan 70°C selama 10 jam, pembuatan ekstrak dan pengujian indikator asam-basa. Hasil penelitian ini menunjukkan bahwa variasi suhu pengeringan berpengaruh terhadap hasil kertas indikator asam-basa alami. Kulit buah naga, kulit buah manggis dan kulit ubi ungu memiliki potensi untuk dijadikan indikator asam-basa alternatif dan ekstrak dari kulit ubi ungu yang dikeringkan dengan suhu 60 dan 70°C memiliki potensi yang paling besar untuk dijadikan kertas indikator asam-basa alternatif karena dapat memberikan hasil perbedaan warna ketika diujikan dengan larutan asam kuat, basa kuat, asam lemah dan basa lemah
Karakterisasi dan Analisis Vitamin C dalam Teh Kombucha Biji Alpukat (Persea americana Mill.) dengan Variasi Lama Fermentasi: Characterization and Analysis of Vitamin C in Avocado Seed Kombucha Tea (Persea americana Mill.) with Variation of Fermentation Duration Annaza, Alwan Darwissy; Jubaidah, Siti; Supriningrum, Risa
Jurnal Sains dan Kesehatan Vol. 7 No. 3 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i3.2472

Abstract

Avocado seeds contain several minerals and vitamin C, these seeds can be fermented into tea with kombucha culture, SCOBY (Symbiotic Cultures of Bacteria and Yeats). The length of fermentation will have an impact on the vitamin C content in the tea. The purpose of this study was to determine the characteristics and vitamin C content based on variations in the length of fermentation time of avocado seed kombucha tea. The research conducted was experimental research and used the RAL (Completely Randomized Design) method with variations in the length of fermentation. The research stages include plant determination, simplisia processing, making kombucha tea based on variations in fermentation time, characteristic tests, qualitative and quantitative analysis of vitamin C, and data analysis using SPSS IBM 25 with a 95% confidence level. The results obtained vitamin C content of avocado seed kombucha tea with 1 day fermentation time of 0.4628 ± 0.0099%, 3 days fermentation time of 0.4740 ± 0.0059%, 5 days fermentation time of 0.5081 ± 0.0118%, 7 days fermentation time of 0.6439 ± 0.0148%, 9 days fermentation time of 0.7048 ± 0.0255% and 11 days fermentation time of 0.6216 ± 0.0411%. Statistical data analysis of vitamin C levels using the One Way ANOVA test with p < 0.05 and obtained a significance value of 0.0000, namely there is a significant difference between the six fermentation lengths. Keywords:          Kombucha Tea, Characterization, Vitamin C, Long Fermentation   Abstrak Biji alpukat mengandung beberapa mineral dan vitamin C, biji ini dapat difermentasi menjadi teh dengan kultur kombucha yaitu SCOBY (Symbiotic Cultures of Bacteria and Yeats). Lama fermentasi akan berdampak pada kandungan vitamin C yang ada dalam teh. Tujuan penelitian ini untuk mengetahui karakteristik dan kandungan vitamin C berdasarkan variasi lama waktu fermentasi dari teh kombucha biji alpukat. Penelitian yang dilakukan adalah penelitian eksperimental dan menggunakan metode RAL (Rancangan Acak Lengkap) dengan variasi lama fermentasi. Tahapan penelitian meliputi determinasi tanaman, pengolahan simplisia, pembuatan teh kombucha berdasarkan variasi lama waktu fermentasi, uji karakteristik, analisis kualitatif dan kuantitatif vitamin C, dan analisis data menggunakan SPSS IBM 25 dengan taraf kepercayaan 95%. Hasil penelitian diperoleh kadar vitamin C teh kombucha biji alpukat dengan lama fermentasi 1 hari sebesar 0,4628 ± 0,0099%, lama fermentasi 3 hari sebesar 0,4740 ± 0,0059%, lama fermentasi 5 hari sebesar 0,5081 ± 0,0118%, lama fermentasi 7 hari sebesar 0,6439 ± 0,0148%, lama fermentasi 9 hari sebesar 0,7048 ± 0,0255% dan lama fermentasi 11 hari sebesar 0,6216 ± 0,0411%. Analisis data statistik kadar vitamin C menggunakan uji One Way ANOVA dengan p<0,05 dan didapatkan nilai signifikansi 0,0000 yaitu terdapat perbedaan yang signifikan antara keenam lama fermentasi. Kata Kunci:         Teh Kombucha, Karakterisasi, Vitamin C, Lama Fermentasi
KARAKTERISASI DAN SKRINING FITOKIMIA EKSTRAK BUNGA TELANG (Clitoria ternatea L.) Bebie Ayu Rismayuti; Risa Supriningrum; Supomo
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.796

Abstract

Characterization is a step to determine the quality of an extract of natural materials, which includes specific, non-specific parameters, and phytochemical screening. This study aims to determine the specific, non-specific characteristics and secondary metabolite compounds of telang flower extract. Telang flowers are made into powdered simplisia, and the drying shrinkage is determined. Furthermore, extraction was carried out using the maceration method with 70% ethanol solvent. The drying shrinkage of the simplisia was 10% and the extract yield was 43.8%. Specific characterization results include organoleptic observations in the form of thick blue-black extract with a distinctive odor and bitter taste. The average content of soluble compounds in water is 58% and the average content of soluble compounds in ethanol is 17.67%. Non-specific characterization results include an average moisture content of 21.93%. Average ash content of 5% and acid insoluble ash content of 2%. The average specific gravity was 1.015 g/ml and the results of mold/chamir numbers were 1 × 102 colonies/g and total plate numbers were 1.3 × 103 colonies/g. Secondary metabolite compounds contained in telang flower extract include alkaloids, flavonoids, saponins, steroids and terpenoids.
KADAR FLAVONOID EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) BERDASARKAN VARIASI KONSENTRASI PELARUT ETANOL Henny Nurhasnawati; Risa Supriningrum; Rusdiati Helmidanora; Margareta, Sully
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.921

Abstract

Butterfly pea (Clitoria ternatea L.) is a plant used for medicinal purposes, including therapeutic, cosmetic, nutritional, and beauty applications. Flavonoids, as secondary metabolites with diverse chemical structures in plants, perform various important functions. These functions include growth regulation, coloration, protection from UV rays, and roles in defense mechanisms and signaling systems with microorganisms. These compounds also have pharmacological effects as antidiabetics, antioxidants, and antibacterials. Solvent concentration plays an important role, as it can affect the amount of active compounds extracted from natural materials. The purpose of this study was to determine the flavonoid content in butterfly pea flower extracts using ethanol solvents at concentrations of 50%, 70%, and 95%. The results of phytochemical screening tests showed that all extracts contained secondary metabolites in the form of flavonoids. Other parameters analyzed included yield, moisture content, and flavonoid content from the three ethanol concentration variations. The yields obtained were 57.14%, 54.08%, and 40.72%, respectively, while the moisture content was 9.44 ± 2.17%, 8.99 ± 2.12%, and 7.75 ± 1.97%, respectively.The highest flavonoid content was obtained in the extract with 95% ethanol solvent at 1.2939 ± 0.0880%, followed by 70% ethanol at 0.6958 ± 0.0573%, and 50% ethanol at 0.5811 ± 0.0142%. Statistical analysis using ANOVA showed that there were differences in flavonoid content between the ethanol concentration variation groups
IDENTIFIKASI JENIS SAPONIN DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL KULIT BATANG SEKILANG (Embelia borneensis Scheff.) TERHADAP BAKTERI Pseudomonas aeruginosa ATCC 9027 DAN Streptococcus mutans ATCC 25175 Hayon, Maria F.K.; Supriningrum, Risa; Fatimah, Nurul
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.368

Abstract

Sekilang stem bark (Embelia borneensis Scheff.) contains secondary metabolites, such as alkaloids, flavonoids, tannins, and saponins. Saponin compounds are divided into two types, namely steroids and triterpenoids which have the ability as antibacterial, antifungal, antidiabetic and expectorant. The purpose of this study was to determine the type of saponin and to determine the antibacterial activity of the methanolic extract of sekilang bark against Streptococcus mutans and Pseudomonas aeruginosa bacteria. The research stages included plant determination, sample collection, simplicia making, extract preparation by maceration method using methanol, phytochemical screening, identification of saponins and antibacterial activity test of methanol extract of sekilang stem bark by disc diffusion method against Streptococcus mutans and Pseudomonas aeruginosa bacteria with a concentration of 15% , 20%, 25%, 30%, and 35%. The results showed that the methanol extract of sekilang stem bark contained triterpenoid saponins and had antibacterial activity against Streptococcus mutans bacteria at concentrations of 15%, 20%, 25%, 30%, and 35% with an inhibition zone formed of 7.65 mm, 7.89 mm, 7.67 mm, 7.98 mm, and 7.13 mm the criteria for antibacterial strength were categorized as moderate. The methanolic extract of the bark of sekilang did not show antibacterial activity against Pseudomonas aeruginosa bacteria, because there was no inhibition zone formed around the paper disc. The positive control used was amoxicillin 0.1% and the negative control used 1% DMSO.
KARAKTERISASI DAN SKRINING FITOKIMIA BUAH LABU KUNING (Cucurbita moschata Duch.) Budiman, Hariyadi; Supriningrum, Risa; Sundu, Reksi
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.420

Abstract

Pumpkin (Cucurbita moschata Duch.) is one of the plants that contain carotenoids, water-soluble vitamins, phenolics, flavonoids polysaccharides, mineral salts. Pumpkin is a vegetable that has many health benefits. Empirically, the pulp is used to treat diabetes, hypertension, tumors, immunomodulators and antibacterials. The benefits of a natural material with medicinal properties need to be proven scientifically through research. As a first step, characterization of simplisia and ethanol extract of pumpkin fruit and secondary metabolite content were carried out.  This study aims to determine the characteristics of simplisia and pumpkin fruit flesh extract and its secondary metabolite content. Characterization includes specific and non-specific parameters. Pumpkin fruit was extracted by maceration with 70% ethanol and obtained an extract yield of 29.68%. Specific characterization results include organoleptic observations in the form of thick blackish brown extract, bitter taste, and distinctive smell. Organoleptic simplicia simplicial piece, odorless, yellow, and bitter taste. The average level of soluble compounds in water extract is 47.33% and simplisia is 22%, while the average soluble compound in ethanol extract is 51.77% and simplisia is 31.33%. Non-specific characterization results include the average total ash content of extracts of 6.52% and simplisia of 8.33%, acid insoluble ash content test averaged 0.31% extracts and 0.22% simplisia. The average water content was 17.55%. The average specific gravity of the extract was 1.02 g/mL and the results of the total microbial contamination in the extract were 4.2 × 103 colonies/g and simplisia were 4.6 x 103 and the yeast mold number in the extract was 1.3 × 102 colonies/g and simplisia was 1.7 × 102 colonies/g. Pumpkin fruit extract and simplisia contain secondary metabolites including alkaloids, flavonoids, saponins, and terpenoids.
Antioxidant activity of pumpkin leaf extract(Cucurbita moschata duch.) Using the dpph method Supriningrum, Risa; Khusnah, Miftahul Nabila; Supomo, Supomo
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.948

Abstract

Pumpkin leaves (Cucurbita moschata Duch.) have benefits as an antidiabetic agent, stomach protector, and can increase blood hemoglobin levels, thereby treating anemia. Pumpkin leaves contain vitamin A, vitamin B, carbohydrates, phosphorus, calcium, iron, vitamin C, and secondary metabolites that have antioxidant potential. The purpose of this study was to determine the antioxidant activity of yellow pumpkin leaf extract using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The research stages included plant identification, simplisia preparation, extraction by maceration with 95% ethanol solvent, phytochemical screening, and testing of antioxidant activity with DPPH free radicals and vitamin C as a comparison. The results of the antioxidant activity test of the ethanol extract of pumpkin leaves showed very strong antioxidant activity with an IC50 value of 24.29 ppm, and a vitamin C IC50 value as a comparison of 9.809 ppm.
Co-Authors Achmat Kadri Ansyori Andi Wijaya Annaza, Alwan Darwissy Anugerah, Olanda Ardani Ardani Ari Saptowo Asmi Risyah Ekawati Bebie Ayu Rismayuti Budiman, Hariyadi Dewi Rahmasuari Dwi Ajeng Dwi Setyawati Eka Kumalasari Eka Siswanto Syamsul Fitri Handayani Ghina Adhilla Goetie, Inayah Herman Hayatus Sa`adah Hayatus Sa’adah Hayon, Maria F.K. Hendri Misak Henny Nurhasnawati Ilham Ilham Inayah Herman Goetie Khusnah, Miftahul Nabila Kusumawati, Eko Liya Liya Liya, Liya Margareta, Sully Maria F.K. Hayon Medi Hendra, Medi Misak, Hendri Nathalia, Nyda Nurul Fatimah Nurul Fatimah Nurul Fatimah Pranamala, Vici Ali Qarriy ‘Aina Urfiyya Rahmadani Rahmadani Rakhmadhan Niah Reksi Sundu Risaldi Junaid Rozadi, Reza Rusdiati Helmidanora Sapri - sapri sapri Sapri Sapri Siti Faisah Siti Jubaidah Siti Jubaidah, Siti Siti Jubidah Sri Nur Wahyuni Supomo Supomo - Supomo Supomo Supomo Supomo Susilowati, Agustina Syamsiar, Syamsiar Triswanto Sentat Vici Ali Pranamala Wahyuni, Sri Nur Warnida, Husnul Yenni Eka Purwanti Yudha Pratama