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All Journal Signifikan : Jurnal Ilmu Ekonomi JURNAL BISNIS STRATEGI MANDALA of Health Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention MEDISAINS JIET (Jurnal Ilmu Ekonomi Terapan) Journal Of Vocational Health Studies Iqtishoduna: Jurnal Ekonomi Islam Sulawesi Tenggara Educational Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) el-Jizya: Jurnal Ekonomi Islam Al-Muzdahir: Jurnal Ekonomi Syariah Journal of Business Management and Islamic Banking Jurnal Ekonomi, Manajemen, Akuntansi Ulil Albab
Joko Setyono
FK UNSOED
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : MANDALA of Health

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HUBUNGAN ANTARA MEROKOK DENGAN PENYAKIT PARKINSON DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO Setyono, Joko; Noviani, Erni; Gunarto, Untung
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Cigarettes contain 2,3,6-trimethyl-4-napthoquinone which can inhibit the breakdown of dopamine;therefore, smoking can reduce the risk of Parkinson’s disease. On the other hand, smoking is the secondcause of death in the world. This study was aimed to investigate the relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease. This study was ananalytical observational research using case control approach that involved 34 patients of Parkinson’sdisease as a case group and 34 respondents that were non Parkinson as a control group. The former and thelater were age- and sex-matched control subjects selected by using purposive sampling technique. InParkinson group it was obtained that as much as 64.7% of the respondents were non smokers, 14.7% wereformer smokers, 8.8% were current less than daily smokers, and 8.8% were current daily smokers. In nonParkinson group, 41.2% of the respondents were non smokers, 23.5% were former smokers, 8.8% werecurrent less than daily smokers, and 26.5% were current daily smokers. The data were analyzed usingWilcoxon test and it was found that there was a significantly negative relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease (p<0,05). There was asignificantly negative relationship between smoking status, smoking duration, smoking quantity, types ofcigarettes and Parkinson’s disease.
POLIMORFISME GENA RESEPTOR MCP-1 (CCR2) SEBAGAI FAKTOR RISIKO NEFROPATI DIABETIKA PADA PENDERITA DIABETES MELLITUS TIPE 2 DI RSUD PROF DR MARGONO SOEKARJO DAN RSUP SARDJITO Setyono, Joko; Sadewa, A Hamim; Madiyan, Maliyah
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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The infiltration of the glomeruli and interstitium by immunocompetent cells are common finding ofkidney with diabetic nephropathy. On the other hand, there is an increasing synthesis of chemokines andother inflammatory mediators by glomerular and tubular cells in hyperglycemic conditions. Single nucleotidepolymorphisms (SNPs) G46295A of MCP-1 (CCR2 are thought playing a key role in the development ofdiabetic nephropathy in type 2 diabetes. Therefore, the aim of this research is to determine whether the riskof diabetic nephropathy is influenced by polymorphisms of CCR2. In addition, this research is also aimed todetermine whether the gender in the diabetic nephropathy patient is influenced by polymorphisms of CCR2 intype 2 diabetes in Indonesian population especially ethnic of Java. A case-control study was performed,including 60 type 2 diabetes patients, 31 subjects with diabetic nephropathy and 29 subjects with nondiabetic nephropathy in Margono Soekarjo Hospital and Sardjito hospital. Polymorphisms of CCR2 wereanalyzed by PCR-RFLP method. The results were analyzed by chi-square. Amount of male in the casesubjects (67,7%) more than amount of male in control subjects (44,8%). G46295A of MCP-1 (CCR2)receptor gene had higher risk of developing diabetic nephropathy in type 2 diabetes (X2 = 12.308, p =0.002). Male individual carry the GA genotype of CCR2 had significant risk of developing diabeticnephropathy (p = 0.004, OR 9.6). This study showed that G46295A MCP-1 (CCR2) receptor gene had higherrisk of developing diabetic nephropathy in type 2 diabetes in Indonesian population especially ethnics ofJava. Male with G46295A MCP-1 (CCR2) receptor gene were more than female and had higher risk ofdeveloping diabetic nephropathy in type 2 diabetes in Indonesian population, especially Java ethnic.
Co-Authors . HERNAYANTI A Fahira Nur A Hamim Sadewa, A Hamim Agus Prastowo Ahmad Choiri Ahyar Ahyar Albab Al Umar, Ahmad Ulil Aminuddin Ardhi, Ardhi Ariga, Adi Dwi Utami Anjarwati Erni Noviani, Erni Fadlan, Arif Fareza, Muhamad Salman Febrian, Dicky Rizky Fitranto Arjadi Heru Ismaya K, Neneng Rika J. Kurniawan, Anang Kusuma, Muhammad Nanang Himawan Lantip Rujito Lintang, Ferlanda Mahfuzh, Muhammad Ady Maliyah Madiyan, Maliyah Mega Rahmawati, Mega Melisa Putri Mujiburrahman, Husnan Mukarromah, Lukluil Nendyah Roestijawati Nur Amalia Choironi Nur Latifah , Ramadhani Nur Rohman Qodri Santosa, Qodri Ramadan, Hendra Rispriandari, Aulia Ayu Riza, Alex Fahrur Rizak Tiara Yusan Samodro, Pugud Sarmoko Sarmoko Saryono, Shoolihah, Muhayyijah Fil Qurbah Siti Rahmawati Soegianto, Jap Yulius Billy Sujiran Untung Gunarto, Untung Wahyu Wibowo Wahyudin Wahyudin Wisesa, Sindhu Yahya, Padli Pawaid Zainuddin Zainuddin