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All Journal Jurnal Biologi Tropis Jurnal Ners JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Journal of Health and Behavioral Science Timorese Journal of Public Health Lontar : Journal of Community Health Media Kesehatan Masyarakat Jurnal Pangan, Gizi dan Kesehatan Jurnal Pengabdian pada Masyarakat Kepulauan Lahan Kering Pancasakti Journal Of Public Health Science And Research Sehat Rakyat: Jurnal Kesehatan Masyarakat Kelimutu Nursing Journal
Regaletha, Tadeus A. L.
Universitas Nusa Cendana
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Antibacterial Activity Test of 70% Ethanol Extract of Kersen Leaves (Muntingia calabura L.) against Cutibacterium acnes Willybrordus Dewanto Un Lala; Tadeus A. L. Regaletha; Cahyani Purnasari; Insani Fitrahulil Jannah
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12838

Abstract

Acne ranks among the most prevalent skin issues and is linked to infection by Cutibacterium acnes. The rising rates of antibiotic resistance seen in Cutibacterium acnes necessitate the exploration of alternative plant-based treatments with antibacterial properties. One such plant that has demonstrated these antibacterial effects is the kersen leaf (Muntingia calabura L.). This research aimed to evaluate the antibacterial effects of a 70% ethanol extract of kersen leaves (Muntingia calabura L.) on the proliferation of Cutibacterium acnes. The research employed a true experimental design featuring a posttest only control group. The treatment categories included a positive control using Clindamycin, a negative control with sterile aquadest, and varying concentrations of kersen leaf extract at 1%, 2%, 4%, 8%, and 12%, with each group replicated four times. Data were assessed using the One-Way ANOVA method. The findings of the antibacterial test indicated that the 70% ethanol extract of kersen leaves effectively inhibited the growth of Cutibacterium acnes. The One-Way ANOVA analysis produced a p-value of less than 0.0001, which is lower than α = 0.05, signifying a notable discrepancy in the average inhibition zone diameters across the treatment groups. Ethanol extract from kersen leaves (Muntingia calabura L.) exhibits antibacterial properties against Cutibacterium acnes growth.
Analysis of the GC-MS Volatile Compound Profile and Antibacterial Activity of 95% Ethanolic Extract of Siam Weed (Chromolaena odorata L.) Leaves from Kupang Regency Against Staphylococcus aureus Mathias Endrico Saingo; Tadeus A. L. Regaletha; Cahyani Purnasari; Matias Nataniel Kolobani
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12895

Abstract

The need for new antibacterial medicines derived from natural sources is highlighted by the dangerous bacterium Staphylococcus aureus, which causes a variety of diseases and is increasingly linked to antibiotic resistance. The leaves of Chromolaena odorata (L.) contain a variety of bioactive compounds that may have antibacterial qualities. This study aimed to characterize the metabolite profile of the 95% ethanol extract of C. odorata leaves using gas chromatography–mass spectrometry (GC-MS) and evaluate its antibacterial activity against S. aureus. This true experimental post-test-only control group study was conducted from January to May 2026 using leaves collected from Mata Air Village, Kupang Tengah District, Kupang Regency, East Nusa Tenggara, Indonesia. Antibacterial assays were performed in four replicates using the disk diffusion method at extract concentrations of 5–25%. GC-MS identified 118 compounds, with ethyl palmitate, α-linolenic acid, phytol, stigmasterol, squalene, caryophyllene oxide, and α-muurolol as dominant metabolites that may contribute to the observed antibacterial activity based on previous studies. S. aureus was inhibited by the extract in a concentration-dependent manner; inhibition zones increased from 8.03 ± 0.04 mm (5%) to 11.41 ± 0.13 mm (25%), and there were significant differences between treatments (one-way ANOVA, p < 0.001). This study shows how GC-MS metabolite profiling and antibacterial assessment of the 95% ethanol extract of C. odorata can be combined in a unique way. These results suggest that the extract has antibacterial action against S. aureus and could be a source of natural antibacterial chemicals.
Co-Authors Abigail Mega Amelya Betsalonia Sir Anivista, Sisilia Cahyani Purnasari Chintya G. Kale Daniela Boeky David R. L. Sirait Dodo, Dominirsep Ovidius Dominika Priska Tsu Enjelita M. Ndoen Friska Rosiana Atolo Helmi M. Bolla Honey I. Ndoen Insani Fitrahulil Jannah Juliana Marlin Y Benu Keron, Maria Sahra Kolifa Ayu Wulansari Limbu, Ribka Manek, Leopoltus D. Manu, Neneng N. K . Manurung, Imelda Februati Ester Maria Hildaburga Wua Masrida Sinaga Mathias Endrico Saingo Mathilda Primordiani Rinmalae Matias Nataniel Kolobani Muntasir, Muntasir Nurina, Rr. Listyawati Nyai Harifah Akbar Oktaviana A. Bano Abin Rahmawati Alil Rina Waty Sirait Riwu, Yuliana Radja Rizqia Amanda Nafisah Nurawi Sani, Hafaf Lutfiani Serlie K.A. Littik Sinaga, Masrida Takaeb, Afrona E. L. Tokan, Rany Upa, Erny E Pua Vinelda Mathilda Wetangterah Viviyanti Viviyanti Wihelmus Kopong Doren Willybrordus Dewanto Un Lala Yoseph Kenjam