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Herny E.I. Simbala
Faculty Of Mathematics And Basic Science, University Of Sam Ratulangi Manado
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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TOXICITY TEST OF THE COMBINATION Eleutherine americana Merr. AND Areca vestiaria EXTRACTS AGAINST THE INTESTINAL ORGANS OF Rattus norvegicus Sarai Raehilda Febriansi Korban; Herny Simbala; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.41911

Abstract

Dayak onions (Eleutherine americana Merr.) and Pinang Yaki (Areca vestiaria) have been used by the community as traditional medicine. The purpose of this study was to determine the safety level of extracts of Dayak onion and Pinang Yaki against the macroscopic appearance of the intestinal organs of Wistar male white rats. This study used an experimental method with 18 male white rats of the Wistar strain who were given ethanol extract of Dayak onion and Pinang Yaki orally at a dose of 10,8mg, 14,4mg, and 21,6mg for 14 days. The results showed that there was a decrease in body weight, in each treatment group but the largest weight loss occurred in the dose group V from 199gram to 182gram while the smallest weight loss occurred in the dose group I from 199gram to 198gram and for the macroscopic picture of the intestinal organs there was no significant difference between the test group with the control group. In conclusion, the administration of extracts of Dayak onion and Pinang Yaki does not affect the macroscopic picture of the intestinal organs.
Uji Toksisitas Akut Kombinasi Ekstrak Bawang Dayak (Eleutherine americana Merr.) dan Pinang Yaki (Areca vestiaria Giseke) Terhadap Organ Jantung Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Sitti Tasya Putri Ibrahim; Herny Simbala; Julianri Lebang
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.41934

Abstract

Umbi bawang dayak (Eleutherine americana Merr.) termasuk familia Iridaceae, secara turun temurun telah dipergunakan oleh masyarakat dayak sebagai tumbuhan obat untuk berbagai jenis penyakit seperti kanker payudara dan kolon, hipertensi, diabetes mellitus dan strok, sedangkan buah Pinang Yaki (Areca vestiaria) termasuk familia Arecaceae yang telah digunakan oleh masyarakat Sulawesi Utara sebagai obat kanker, diabetes dan kontrasepsi pria. Penelitian ini bertujuan untuk melihat pengaruh konsumsi ekstrak umbi dayak dan buah pinang yaki terhadap gambaran makroskopis organ jantung pada tikus putih. Penelitian ini dilakukan menggunakan hewan percobaan tikus putih jantan yang berjumlah 18 ekor yang dibagi menjadi 6 kelompok. Pengujian dilakukan selama 15 hari, berat organ dan pengamatan makroskopik dilakukan pada hari terakhir. Hasil penelitian menunjukkan bahwa pemberian ekstrak umbi bawang dayak dan buah pinang yaki tidak berpengaruh terhadap gambaran makroskopis organ jantung.Umbi bawang dayak (Eleutherine americana  Merr.) termasuk familia Iridaceae, secara turun temurun telah dipergunakan oleh masyarakat dayak sebagai tumbuhan obat untuk berbagai jenis penyakit seperti kanker payudara dan kolon, hipertensi, diabetes mellitus dan strok, sedangkan buah Pinang Yaki (Areca vestiaria) termasuk familia Arecaceae yang telah digunakan oleh masyarakat Sulawesi Utara sebagai obat kanker, diabetes dan kontrasepsi pria. Penelitian ini bertujuan untuk melihat pengaruh konsumsi ekstrak umbi dayak dan buah pinang yaki terhadap gambaran makroskopis organ jantung pada tikus putih. Penelitian ini dilakukan menggunakan hewan percobaan tikus putih jantan yang berjumlah 18 ekor yang dibagi menjadi 6 kelompok. Pengujian dilakukan selama 15 hari, berat organ dan pengamatan makroskopik dilakukan pada hari terakhir. Hasil penelitian menunjukkan bahwa pemberian ekstrak umbi bawang dayak dan buah pinang yaki tidak berpengaruh terhadap gambaran makroskopis organ jantung. 
Non-Specific Standardization Test for Areca Yaki Fruit Extract (Areca Vestiaria) Nadine Natari; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42039

Abstract

The chemical substances contained in the extracts of natural ingredients must be maintained in quality, so standardization is required. This study aims to prove that ethanol extract of Areca yaki Fruit (Areca Vestiaria) meets the non- specific parameters on the standardization of natural ingredients extract. Ethanol extract of Areca Yaki Fruit  is extracted using maceration method. The extracts obtained were tested for several non-specific parameters including desiccant shrinkage, moisture content, total ash content and acid insoluble ash content. The test results are compared with the standard parameters. Areca Yaki Fruit ethanol extract has a drying shrinkage of 0.027%, moisture content of 0.5242%, total ash content of 0.712% and 0.883%, and insoluble acid ash content of 0.048% and 0.056%. Areca Yaki Fruit ethanol extract meets the standard parameters, desiccant shrinkage, moisture content, total ash content, and insoluble acid ash content.
Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria Wiranatika Jhonatan Sangkoy; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42307

Abstract

WIRANATIKA SANGKOY. Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria. Under the guidance of HERNY EI SIMBALA as a leader and ERLADYS RUMONDOR as a member.One of the native plants of Indonesia that is widespread in several areas in Indonesia that has the potential to be developed in research testing antibacterial activity is the areca yaki leaf plant. This study aimed to determine the antibacterial activity of areca yaki (Areca vestiaria) leaves against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa at concentrations of 20%, 40%, and 60%. This research was conducted using the Kirby-Bauer method. From the results of this study, the data obtained that concentrations of 20%, 40%, and 60% of Staphylococcus aureus and Escherichia coli bacteria are concentrations that are included in the moderate group, while Pseudomonas aeruginosa at a concentration of 20% is included in the strong group and 40% and 60% are only included in the moderate group.
POTENTIAL OF RED FRUIT (PANDANUS CONOIDEUS CAROTEN LAMK) PAPUA BASED ON LITERATURE REVIEW Hermelina Yosephina Burdam; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42896

Abstract

                              ABSTRACRed fruit plant (Pandanus conoideus Lamk) Papua. is an endemic plant that can grows in almost all areas of Papua, from the lowlands to the highlands. Red Fruit (Pandanus conoideus Lamk,) belongs to the Pandanus family. This plant is widely available Find in Papua, Papua New Guinea, And This Research Aims To know the potential of red fruit (Pandanus conoideus Lamk) Papua based on literature review, research It Uses Qualitative Descriptive Method Aims to Draw, Describe, Explain, Explain, and answer in detail the research results. Based on literature review, red fruit has potential As Socio-Economic Value, As Traditional Medicine, Cure Cancer And tumors, HIV/Aids,High Blood Pressure, Gout, Stroke, Eye Disorders, Osteoporosis, Diabetes Mellitus, Increases Sperm Production in Men, Increases Intelligence, As a Food Source, As Antioxidant, Antidiabetic, Anti-Inflammatory Antibacterial Cardiovascular, Hypertension 
In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction Dolongtelide, Jeclin Inebel; Fatimawali, Fatimawali; Tallei, Trina Ekawati; Suoth, Elly Juliana; Simbala, Herny Emma Inonta; Antasionasti, Irma; Kalalo, Marko Jeremia
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.26

Abstract

Chrysanthemum indicum L., commonly known as Chrysanthemum flower, is an herbaceous plant that has a long-established history of medicinal usage. There has been extensive research about C. indicium L, especially about its antioxidant activities, but not much has been done on its fraction. This study aimed to explore the efficacy of the ethanol extract and its fraction derived from Chrysanthemum flowers in scavenging free radicals. The antioxidant potential of the ethanol extract, as well as its aqueous and n-hexane fractions, was evaluated using the 2,2-diphenyl-1-picrilhidrazine (DPPH) method in vitro. The degree of antioxidant activity was quantified by determining the IC50 value, which corresponds to the concentration of the extract or fractions required to inhibit 50% of DPPH free radicals. The results obtained from this investigation provide strong evidence that the ethanolic extract, as well as its aqueous and n-hexane fractions, exhibited significant antioxidant activity. The measured IC50 values for the ethanolic extract, aqueous fraction, and n-hexane fraction were 1.350 µg/mL, 1.109 µg/mL, and 7.588 µg/mL, respectively.
A Comprehensive Network Pharmacology Study on the Diabetes-Fighting Capabilities of Yacon Leaf Extract Wawo, Arsianita Ester; Simbala, Herny Emma Inonta; Fatimawali, Fatimawali; Tallei, Trina Ekawati
Malacca Pharmaceutics Vol. 2 No. 2 (2024): September 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i2.161

Abstract

Indonesia ranks fourth in the world for the number of diabetes mellitus (DM) sufferers. DM is a group of metabolic disorders characterized by hyperglycemia due to insulin abnormalities. This research employs Network Pharmacology analysis to examine the target proteins and pharmacological network profiles predicted to be influenced by compounds in the leaves of Smallanthus sonchifolius (yacon) for their anti-diabetic effects. Gas chromatography-mass spectrometry (GC-MS) identified 41 secondary metabolite compounds in yacon leaves, seven of which have a Pa value > 0.5. Compound C28 has the highest Pa value as an insulin promoter, at 0.662. A total of 129 target proteins were found for the secondary metabolite compounds in yacon leaves, and 5,112 target proteins were identified for Type 2 Diabetes Mellitus (T2DM). The intersection analysis between yacon leaves and T2DM revealed 32 common proteins. Network analysis highlighted 10 top proteins: ESR1, PPAR-α, HMGCR, CYP19A1, PPARD, PTP1N, GRIN2B, FYN, AR, and SHBG. Among these, PPAR-α shows great potential and promising prospects as a target for further exploration. Considering several parameters, it can be concluded that PPAR-α is a promising protein and a potential target for new drug candidates for T2DM.
Antibacterial Efficay Test of Ethanol Extract of Yaki Areca Nut (Areca vestiaria) Against the Growth of Propionibacterium acnes, the Cause of Acne. Pabundu, Daniel; Simbala, Herny; Hariyanto, Yuanita Amalia
PHARMACON Vol. 13 No. 3 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55524

Abstract

A bacterial skin infection that is often experienced by everyone, especially in adolescence, is acne(Acne vulgaris). Acne is caused by the accumulation of excess oil in the skin, thus becoming a medium for bacterial growth, which causes acne. The use of natural antibiotics can be a therapeutic option in the treatment of acne. One of the plants that potentially has antbacterial activity is Pinang Yaki (Areca vestiaria). The purpose of this study was to determine the antibacterial activity of ethanol extract of areca nut fruit against the growth of Propionibacterium acnes that causes acne. The test of antibacterial activity of areca nut extract with the pitting method found that at a concentration of 10% the antibacterial activity was included in the weak group, 20% was included in the medium group, while those included in the strong group in inhibiting the growth of Propionibacterium acnes were extracts with concentrations of 40%, 60% and 80%..
Uji Aktivitas Antibakteri Ekstrak Daun Insulin (Smallanthus sonchifolius) terhadap Pertumbuhan Bakteri Staphylococcus  aureus dan Escherichia coli Waas, Riviani Angela; Wewengkang, Defny Silvia; Simbala, Herny Emma Inonta
Jurnal Lentera Farma Vol. 3 No. 2 (2024): Jurnal Lentera Farma
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/d4nvme43

Abstract

Insulin (Smallanthus sonchifolius) termasuk salah satu tumbuhan dari famili asteraceae yang dapat dimanfaatkan untuk pengobatan. Kandungan senyawa metabolit sekunder yang terdapat pada insulin dapat digunakan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antibakteri ekstrak daun insulin (Smallanthus sonchifolius) terhadap pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Sampel daun insulin diekstraksi dengan metode maserasi dengan pelarut etanol 96%. Aktivitas antibakteri diuji menggunakan metode difusi cakram (disc diffusion Kirby and Bauer). Hasil yang diperoleh dari uji aktivitas antibakteri pada bakteri Staphylococcus aureus, mendapatkan hasil rata–rata diameter zona hambat 11,6 mm. Sedangkan untuk bakteri Escherichia coli, mendapat hasil rata-rata diameter zona hambat 11,3 mm. Oleh karena itu, ekstrak daun insulin (Smallanthus sonchifolius) memiliki aktivitas antibakteri pada bakteri Staphylococcus aureus dan Escherichia coli dengan daya hambat kategori kuat.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Pangi (Pangium edule Reinw ex. Blume) terhadap Bakteri Staphylococcus aureus, Escherichia coli, dan Salmonella typhi Mokalu, Ribka G.; Simbala, Herny E. I.; Bakti, Andi Ikhtiar
Jurnal Lentera Farma Vol. 2 No. 2 (2023): Jurnal Lentera Farma
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/69vqz257

Abstract

Tumbuhan Pangi merupakan salah satu tumbuhan asli Indonesia yang termasuk dalam family Flacourticeae dimana semua bagian tumbuhan dapat dimanfaatkan. Daun pangi memiliki kandungan senyawa fitokimia sebagai antibakteri dan antiseptik. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun Pangi (Pangium edule Reinw ex. Blume) terhadap Staphylococcus aureus, Escherichia coli, dan Salmonella typhi dengan menggunakan metode difusi cakram ditinjau dari diameter zona hambat. Hasil pengujian aktivitas antibakteri ekstrak etanol daun pangi diperoleh hasil rata-rata diameter zona hambat pada bakteri S.aureus dengan konsentrasi 20% sebesar 7,9 mm, konsentrasi 40% sebesar 9,7 mm, konsentrasi 60% sebesar 10,64 mm. Pada bakteri E.coli didapatkan konsentrasi 20% sebesar 6,6 mm, konsentrasi 40% sebesar 6,7 mm, konsentrasi 60% sebesar 9,3 mm. Pada bakteri S.typhi konsentrasi 20% 6,2 mm, konsentrasi 40% sebesar 6,8 mm, konsentrasi 60% sebesar 7,54 mm. Hal tersebut membuktikan bahwa ekstrak etanol daun pangi memiliki aktivitas antibakteri dengan kategori daya hambat sedang.
Co-Authors Agustinus Mokoginta Ahmad Sugandi Altini O. Kosegeran Altini O. Kosegeran, Altini O. Anggraini Toar Antasionasti, Irma Bakti, Andi Ikhtiar Defny S. Wewengkang, Defny S. Dolongtelide, Jeclin Inebel Edi, Hosea Jaya Edwin de Queljoe Eka Julianti Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Erladys Rumondor Fatimawali . Feky R Mantiri Feky R. Mantiri Gayatri Citraningtyas Gerald Rundengan Grafland Langkay Hariyanto, Yuanita Amalia Henki Rotinsulu, Henki Hermelina Yosephina Burdam Hosea Jaya Edy Irma Antasionasti Jayanto, Imam Johanis Pelealu Juliana Mabe -, Juliana Mabe Julianri Lebang Kalalo, Marko Jeremia Karlah L. R. Mansauda Karundeng, Glorya Khairunnisa Mutiara Thaib Kotel, Marcelinda Kotel, Marcelinda N. Kristiani Walesasi Kumakauw, Vanesa Vebiola Lawani, Vaneza C. Lawani, Vaneza Christine Ludong, Raynaldo M. Marampung, Wahyuni Marhaenus Rumondor Marhaenus Rumondor Marhaenus Rumondor Mayor, Troce Meilani Jayanti Mende, Rivaldo Mokalu, Ribka G. Mokodongan, Triswa Mokodongan, Triswa A. Mokoginta, Rizkah V. Mongi, Rifo Nadine Natari Ngantung, Yunike Ngantung, Yunike E. Oeiyano, Walen Oeiyano, Walen E. Olvie Syenni Datu Pabundu, Daniel Pristian Sibua Purwoko, Agus Putri, Rafi’a Adinda Rambi, Christani Rante, Trian Rizki Kala’ Ratu, Kartini Redwik, Danni U. W. Redwik, Danni Umbu Wira Ribka G. Mokalu Rondonuwu, Greifen Triky Roni Koneri Roring, Tirza Rumondor, Erladys Rundengan, Gerald Sagay, Steleynes Sakul, Glorya Sarai Raehilda Febriansi Korban Sartje J. Rondonuwu Sendy Rondonuwu Sendy Rondonuwu, Sendy Sharon Colin Tangkere Sitti Tasya Putri Ibrahim Toding, Serly D. S. TRINA EKAWATI TALLEI Tunggali, Sitti Tunggali, Sitti N Valensia J. Takapaha Waas, Riviani Angela Walesasi, Kristiani Wawo, Arsianita Ester Wewengkang, Defny Wewengkang, Defny Silvia Wiranatika Jhonatan Sangkoy Yulien C. Sambode