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Yahwardiah Siregar
Department Of Biochemistry, Faculty Of Medicine, Universitas Sumatera Utara, Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
STUDI PRELIMINARI TENTANG PENGARUH D-GALAKTOSA DALAM MENGINDUKSI STRES OKSIDATIF PADA MENCIT JANTAN GALUR OUTBRED FK USU Bintang, Siti Sarah Bintang Sarah; Siregar, Yahwardiah; Ichwan, Muhammad
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.922 KB) | DOI: 10.35451/jfm.v2i1.191

Abstract

Abstract Oxidative stress occurs due to imbalance of free radicals over antioxidant level in the body. This condition causes lipid peroxidation and DNA damage. D-Galaktosa is The mechanism of oxidative stress induced by d-galactose occurs in the subcellular, especially in the brain's mitochondria. Increasing the concentration of d-galaktosa is oxidized by galaktosa oxidase to form hydrogen peroxide (H202) which causes a decrease in superoxide dismutase (SOD). H202 reacts with reduced iron and forms hydroxide ions (OH-). Objective: The aim of this study was to determine the effect of d-galaktosa induction on oxidative stress levels (MDA) in male mice. Methods: Methods of samples of mice given d-galaktosa and blood collection from the heart were carried out at the Pharmacology Laboratory of the Faculty of Medicine, University of North Sumatra. Results: The results showed that administration of d-galaktosa, through intraperitonial injection every day for 6 weeks, had an effect on the levels of oxidative stress in male mice. Conclusion: The results of this study indicate that administration of d-galaktosa, through intraperitonial injection every day for 6 weeks, has an effect on levels of oxidative stress in male mice.
Co-Authors Ameta Primasari Ariyati Yosi Bahagia Loebis, Bahagia Bintang Y.M. Sinaga Bintang Y.M. Sinaga, Bintang Y.M. Bintang, Siti Sarah Bintang Sarah Blondina Marpaung Chandra, Vincent Alexander Cut Aria Arina Debby Mirani Lubis Donny Nauphar Elmeida Effendy Essie Octiara Febriani, Husnarika Hadyanto Lim Henny Erina Saurmauli Ompusunggu Heriandi Sutadi Herla Rusmarilin Herla Rusmarilin Herla Rusmarilin Husnarika Febriani Indah Permata Sari Indah Permata Sari1 Isra Thristy Jaminsen Sinaga Juwita -, Juwita Lucia Aktalina Melvariani Syari Batubara Miftahul Zannah Muhammad Amin Muhammad Ichwan Muhammad Ichwan Noni Novisari Soeroso Nurmiati Amir Oentari, Widyaningsih Ompusunggu, Henny E.S. Ozar Sanuddin Pardede, Sumondang M. Pratiwi, Astrid Siska Pratiwi, Astrid Siska Putri Chairani Eyanoer, Putri Chairani Rahmiwita, Rahmiwita Roesyanto-Mahadi, Irma D Sarah, Dewi Maya Seri Rayani Bangun Siregar, Kamal B. Sori M Sarumpaet, Sori M Soviani, Sri Sri Soviani Sri Soviani Syarifah, Siti Tarigan, Amira Permatasari Umar Zein Wilson Arthur Zein