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All Journal Nurse Media Journal of Nursing MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Manuju : Malahayati Nursing Journal Jurnal Respirologi Indonesia Heart Science Journal MAHESA : Malahayati Health Student Journal Narra J Cermin Dunia Kedokteran Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Bambang Budi Siswanto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, University Of Indonesia, And National Cardiovascular Center Harapan Kita, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Periodontitis and venous thromboembolism risk: Investigating the connection through a systematic review and meta-analysis Pratama, Erlan Anugrah; Sadikaningtya, Lirasati; Indarto, Malik Jantra; Adi, Andi Wahjono; Siswanto, Bambang Budi
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.8

Abstract

BACKGROUND: The relationship between periodontitis and venous thromboembolism (VTE) remains controversial. Some studies show an association, while others do not show an association between periodontitis and VTE. OBJECTIVES: This study aims to determine the relationship between periodontitis and the risk of VTE using a meta-analysis approach. METHODS: A meta-analysis study, registered in PROSPERO, was conducted from August to September 2024. The sources for article searches in this study were Scopus, Embase, and PubMed. Data on the proportion of VTE occurrences in the periodontitis and non-periodontitis groups were collected from each article, and pooled point estimates were calculated using the Mantel-Haenszel test. RESULTS: We identified 40,397 VTE cases and 2,215,063 controls from six articles. Among these six articles, three showed an association between periodontitis and an increased risk of VTE. Additionally, we identified one article reporting that periodontitis was associated with a decreased risk of VTE. Furthermore, two articles revealed that periodontitis had no association with VTE occurrence. Our calculations using the Mantel-Haenszel test showed that, overall, an increased risk of VTE was found in individuals with periodontitis compared to those without (RR: 1.61; 95% CI: 1.09 – 2.39; Egger's p: 0.7917; Heterogeneity p: <0.0001; p: 0.0200). CONCLUSION: We have identified that periodontitis is an important factor in the occurrence of VTE.
KEYAKINAN DAN DUKUNGAN PELAKU RAWAT KELUARGA DALAM PERAWATAN MANDIRI PASIEN GAGAL JANTUNG DI RUMAH Suharsono, Tony; Ulya, Ikhda; Fatoni, Mukhamad; Herliana , Rini; Huda , Khoirul; Yona, Sri; Budi Siswanto, Bambang
Majalah Kesehatan Vol. 12 No. 1 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.01.3

Abstract

Gagal jantung merupakan masalah global yang melibatkan 64 juta orang di seluruh dunia. Pasien gagal jantung mempunyai kapasitas fungsi yang jelek, kondisi yang komplek dan gejala yang fluktuatif menyebabkan pasien berada dalam kondisi tidak berdaya ketika menjalankan perawatan mandiri di rumah. Keluarga sebagai pelaku rawat pasien selama di rumah memegang peranan penting untuk ikut menjaga kestabilan kondisi pasien gagal jantung. Penelitian ini bertujuan untuk mengetahui hubungan antara keyakinan dengan dukungan yang diberikan oleh pelaku rawat keluarga terhadap pasien gagal jantung melakukan perawatan mandiri di rumah. Penelitian ini merupakan penelitian observasional analitik yang menggunakan pendekatan potong lintang. Pengambilan data dilakukan di Poliklinik Jantung RSUD Dr. Saiful Anwar Malang pada bulan Juni-Desember 2023 yang melibatkan 66 pelaku rawat keluarga, yang diambil dengan teknik purposive sampling. Dukungan pelaku rawat keluarga dalam melakukan perawatan diri dalam kategori cukup, sedangkan keyakinan diri pelaku rawat keluarga juga berada dalam kategori yakin. Terdapat korelasi yang signifikan antara dukungan dan keyakinan diri pelaku rawat keluarga untuk melakukan perawatan mandiri pada pasien gagal jantung di rumah. Aspek yang perlu ditingkatkan dalam dukungan dan keyakinan pelaku rawat keluarga adalah pada pemantauan dan pengambilan keputusan. Perawat perlu meningkatkan kesiapan dan keterlibatan pelaku rawat keluarga dalam pelaksanaan perawatan mandiri pasien gagal jantung selama dirumah melalui dokumen perencanaan pulang.
Periodontitis and venous thromboembolism risk: Investigating the connection through a systematic review and meta-analysis Pratama, Erlan Anugrah; Sadikaningtya, Lirasati; Indarto, Malik Jantra; Adi, Andi Wahjono; Siswanto, Bambang Budi
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.8

Abstract

BACKGROUND: The relationship between periodontitis and venous thromboembolism (VTE) remains controversial. Some studies show an association, while others do not show an association between periodontitis and VTE. OBJECTIVES: This study aims to determine the relationship between periodontitis and the risk of VTE using a meta-analysis approach. METHODS: A meta-analysis study, registered in PROSPERO, was conducted from August to September 2024. The sources for article searches in this study were Scopus, Embase, and PubMed. Data on the proportion of VTE occurrences in the periodontitis and non-periodontitis groups were collected from each article, and pooled point estimates were calculated using the Mantel-Haenszel test. RESULTS: We identified 40,397 VTE cases and 2,215,063 controls from six articles. Among these six articles, three showed an association between periodontitis and an increased risk of VTE. Additionally, we identified one article reporting that periodontitis was associated with a decreased risk of VTE. Furthermore, two articles revealed that periodontitis had no association with VTE occurrence. Our calculations using the Mantel-Haenszel test showed that, overall, an increased risk of VTE was found in individuals with periodontitis compared to those without (RR: 1.61; 95% CI: 1.09 – 2.39; Egger's p: 0.7917; Heterogeneity p: <0.0001; p: 0.0200). CONCLUSION: We have identified that periodontitis is an important factor in the occurrence of VTE.
Adiponectin and Endothelin-1 are Correlated with the Development of Normal-tension Glaucoma in Metabolic Syndrome Patients Prayitnaningsih, Seskoati; Oktarina, Virna Dwi; Nusanti, Syntia; Diarsvitri, Wienta; Rif'ati, Lutfah; Siswanto, Bambang Budi; Santoso, Anwar
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3196

Abstract

BACKGROUND: Glaucoma can lead to irreversible blindness, but normotension glaucoma (NTG) often shows no early symptoms. However, to date, there is limited knowledge regarding the potential parameters for early detection. Therefore, in this study, various metabolic parameters and biomarkers which may contribute to NTG in metabolic syndrome (MetS) patients were evaluated.METHODS: A retrospective cross-sectional study was conducted in the National Cardiac Center Harapan Kita Hospital. Mets were confirmed following the IDF criteria. NTG was determined based on normal intraocular pressure (IOP) with a mean defect (MD) of the visual field, thinning of the retinal nerve fiber layer (RNFL), and enlargement of cup disc ratio (CDR) by ocular coherence tomography (OCT). Metabolic parameters results of waist circumference (WC), body weight, body height, body mass index (BMI), blood pressures, HbA1c, fasting blood glucose (FBG), lipid profiles; and biomarkers including thiobarbituric acid reactive substance (TBARS) and ferric reducing antioxidant power (FRAP), leptin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and endothelin-1 (ET-1) were analyzed. Statistical analysis was performed using comparative and correlative tests.RESULTS: From 29 subjects, 19 subjects (65.5%) were included in the NTG group and 10 subjects (34.5%) were included in the non-NTG group. In the NTG group, we found significant correlation between MD with systolic blood pressure (p=0.035); CDR with ET-1 (p=0.049); and CDR with adiponectin (p=0.010). The non-NTG group had a significant correlation between MD with BMI (p=0.043); CDR with LDL (p=0.042); and CDR with TG (p=0.031).CONCLUSION: There are correlation between adiponectin and ET-1 with NTG in MetS patients. Therefore, they might be considered as potential early detectors for NTG in MetS patients.KEYWORDS: normal tension glaucoma, metabolic syndrome, biomarker, endothelin-1, adiponectin
Pengalaman Pasien Sindroma Koroner Akut yang Mengalami Serangan Jantung Berulang Jaya, Irvantri Aji; Waluyo, Agung; Sekarsari, Rita; Siswanto, Bambang Budi
MAHESA : Malahayati Health Student Journal Vol 5, No 11 (2025): Volume 5 Nomor 11 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i11.23049

Abstract

ABSTRACT Acute Coronary Syndrome (ACS), as the acute manifestation of Coronary Heart Disease (CHD), remains a major contributor to global morbidity and mortality, accounting for 85% of deaths from heart attacks and strokes (Universitas Muhammadiyah Magelang, 2025). In Indonesia, while the specific CHD prevalence was reported at 0.85% in 2023 (SKI, 2023), the incidence of ACS cases is high, exemplified by 840 cases reported in the ED of NCCHK Jakarta (January–May 2025). Recurrent ACS is a serious threat, primarily driven by poor patient adherence to secondary prevention regimens (Universitas Muhammadiyah Magelang, 2025) and atherosclerosis progression(Universitas Hasanuddin, 2025). This is compounded by profound physical (chronic fatigue, pain) and psychological impacts (anxiety, PTSD) (Jackson, 2021; Lee & Chen, 2023). Given the complexity of medication management challenges (Smith, 2021) and the need for holistic healthcare support (Brown, 2020), this study aims to explore the subjective experiences and preventive behaviors of patients facing recurrent ACS. Method: This qualitative study utilized an exploratory phenomenological approach to describe preventive behaviors and analyze risk factors for recurrent heart attacks in ACS patients. Results: Five key themes were identified: 1) Physical Impact, including chest pain, weakness, and reduced functional capacity. 2) Psychosocial Impact, encompassing anxiety, fear, restlessness, and thoughts of death. 3) Post-Attack Medication Management, highlighting adherence barriers and treatment ineffectiveness due to irregular medication consumption. 4) Behavioral Changes, involving the adoption of positive healthy behaviors. 5) Healthcare Support, indicating a strong need for more optimal, comprehensive, and continuous health education from healthcare providers. Conclusion: The study identifies five core themes detailing the complex post-recurrent ACS experience, dominated by significant physical and psychological burdens. Non-adherence to treatment exacerbates this experience, underscoring the necessity for more holistic, patient-centered healthcare support.  Keywords: Patient, Experience, Recurrent ACS     ABSTRAK Sindrom Koroner Akut (SKA), sebagai manifestasi akut Penyakit Jantung Koroner (PJK), merupakan kontributor signifikan terhadap morbiditas dan mortalitas global, menyumbang 85% kematian akibat serangan jantung dan stroke (Universitas Muhammadiyah Magelang, 2025). Di Indonesia, meskipun prevalensi PJK spesifik berada pada 0,85% pada tahun 2023 (Survei Kesehatan Indonesia, 2023).Angka kejadian SKA di indonesiacukup tinggi dimana  berdasarkan Data Laporan Unit Gawat Darurat  di National Cardiovascular Center Harapan Kita (NCCHK) Jakarta terdapat 840 kasus SKA periode bulan Januari 2025 sampai Mei 2025.Serangan SKA berulang menjadi ancaman serius, terutama akibat ketidakpatuhan pasien terhadap regimen pengobatan sekunder (Universitas Muhammadiyah Magelang, 2025) dan progresivitas aterosklerosis (Universitas Hasanuddin, 2025), yang diperparah oleh dampak fisik (kelelahan kronis) dan psikologis mendalam, termasuk kecemasan, depresi, dan PTSD (Jackson, 2021; Lee & Chen, 2023). Mengingat kompleksitas tantangan manajemen pengobatan (Smith, 2021) dan kebutuhan akan dukungan layanan kesehatan holistik (Brown, 2020).  Penelitian kualitatif fenomenologi dengan eksploratif gambaran prilaku pencegahan  terhadap risiko serangan jantung berulang dan menganalisa faktor risiko serangan jantung berulang pada pasien SKA. Tema pertama yang teridentifikasi adalah dampak fisik, berupa gejala fisik dan penurunan kapasitas fungsional, gejala nyeri dada, lemas, kaku leher, sesak nafas. Tema kedua yang teridentifikasi adalah dampak psikososial serangan jantung berulang, yaitu perasaan cemas, takut, gelisah, hingga munculnya pikiran akan kematian Temaketiga Managemen pengobatan paska serangan meliputi kepatuhan pengobatan dan inefektif pengobatan, ketidakteraturan dalam konsumsi obat merupakan hambatan utama dalam efektivitas pengobatan pada pasien Sindrom Koroner Akut (SKA). Tema keempat perubahan perilaku, yaitu melakukan perubahan perilaku positif. Temakelima dukungan layanan kesehatan paska serangan berulang, yaitu menunjukkan kebutuhan yang kuat terhadap dukungan layanan kesehatan yang lebih optimal dalam bentuk edukasi yang komprehensif dan berkelanjutan. Penelitian ini mengidentifikasi lima tema kunci yang menggambarkan pengalaman kompleks paska serangan jantung berulang, dimulai dari dampak fisik yang signifikan dan psikososial. Ketidakpatuhan terhadap pengobatan merupakan keseluruhan pengalaman ini diperburuk oleh tantangan dalam manajemen pengobatan dan kebutuhan akan dukungan layanan kesehatan yang lebih holistik yang  berpusat pada pasien. Kata Kunci:  Pasien, Pengalaman , SKA berulang
Co-Authors Achir Yani S. Hamid Adi, Andi Wahjono Agung Waluyo Ambari, Ade Meidian Amiliana M Soesanto Amiliana M. Soesanto Andi Mahavira Andy Kristyagita Anna Ulfah Rahajoe Anwar Santoso Aria Kekalih Asrory, Virna Dwi Oktariana Astari Pranindya Sari Basuni Radi BRM Ario S. Kuncoro Budhi Antariksa Budhi S. Purwowiyoto Dedi Afandi Desandri, Dwita Rian Dewi H Suprobo Dewi H Suprobo DEWI IRAWATI Dewi Irawati Dewi Irawati Diana Septiyanti Doni Firman Dwiputra, Bambang Emir Yonas Endang Ratnaningsih Erwin Mulia Fatoni, Mukhamad Ganesja M Harimurti Ganesja M Harimurti Gipta Galih Widodo Hadrian Deka Hananto Andriantoro Harahap, Alida R. Harahap, Alida Rosita Hari Utomo Hariadi Hariawan Harmani Kalim Herliana , Rini Huda , Khoirul I Made Putra Swi Antara Idrus Alwi Ikhda Ulya, Ikhda Indarto, Malik Jantra Indriwanto Sakidjan Januar W Martha Jaya, Irvantri Aji Junaiti Sahar Jusup Endang Juzni Alkatiri Katsukawa, Hajime Kusuma, Nico Listyaningsih, Erlin Lukman H. Makmun Muhammad Munawar Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nico Kusuma Nico Kusuma Nitia A. Asbarinsyah Nur Haryono Nurhay Abdurachman Nusanti, Synthia Oktarina, Virna Dwi Pius Almindu Leki Berek Poppy S Roebiono Pranata, Raymond Pratama, Erlan Anugrah Prima Almazini Purwowiyoto, Budhi S. Rachel Vania Rachel Vania Radityo Prakoso Raja Adil C Siregar Rarsari S. Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Raymond Pranata Retna Dewayani Rif'ati, Lutfah Rizki Rizki Rony Mario Candrasatria, S Taofan Sadikaningtya, Lirasati Sekarsari, Rita Seskoati Prayitnaningsih Siska Sulistiowati Sri Yona Syntia Nusanti Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Teuku Heriansyah, Teuku Tony Suharsono, Tony Triangto, Kevin Vania, Rachel Vidya Gilang Rejeki Wahju Aniwidyaningsih Wendy M. Saragih Wienta Diarsvitri William Sanjaya Wisnu Jatmiko Yoga Yuniadi Yonas, Emir