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Tri Agus Siswoyo
Program Studi Magister Bioteknologi, Universitas Jember, Jl. Kalimantan, Kampus Tegal Boto, Jember 68121, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Physics Veterinary

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Journal : CHEMPUBLISH JOURNAL

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Artikel Uji toksisitas akut oral xilooligosakarida dari hidrolisis xilan jerami menggunakan enzim rekombinan Endo-β-1,4-D-Xylanase : Studi Toksisitas Xilooligosakarida Vergian, Putra; stri Ratnadewi, Anak Agung I; Riandy, Cahyaningtyas Tetta; Rukmana, Riesma; Ulfa, Evi Umayah; Siswoyo, Tri Agus; Syafriadi, Mei
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49759

Abstract

Xylooligosaccharides (XOS) are recognized as prebiotics that stimulate the proliferation of probiotic bacteria and enhance short-chain fatty acid (SCFA) production. Compared to other prebiotics, XOS offer notable advantages, including thermal stability and tolerance to a broad pH range. Building on these attributes, this study aimed to evaluate the potential toxicity of XOS derived from rice straw xylan hydrolyzed using recombinant endo-β-1,4-D-xylanase expressed in Saccharomyces cerevisiae. Acute oral toxicity was assessed in male Wistar rats at a single dose of 2000 mg/kg body weight, with observations conducted over a 14-day period. Parameters evaluated included body weight, clinical signs, hematological and biochemical indices, as well as macroscopic and histopathological alterations. Signs of toxicity were observed as changes in stool consistency within the first 4 to 24 hours, while mortality occurred in three male rats. Although body weight showed a tendency to increase, particularly in males, the estimated LD₅₀ value ranged between >500 and 2000 mg/kg body weight, classifying XOS as moderately toxic. Moreover, histopathological examination revealed pathological alterations in the kidneys and liver, while serum biochemical analysis indicated metabolic changes that remained within normal limits. Overall, these findings suggest that XOS possess promising prebiotic potential; however, further studies are required to confirm their long-term safety for application in food products.
Co-Authors A.A. Istri Ratnadewi AA Sudharmawan, AA Adrian Syawaluddin Siregar Adrian Syawaluddin Siregar Agustin, Vira Audita Ahnaf, Yusuf Dary Ali Santosa Anandini Aulia Safiera Aprila Iga Mufidah Arbi Bahtiar Boedi Iman Halanobis Azmi Saleh Bambang Kusmanadhi Bambang Sugiharto Bambang Sugiharto Bambang Sukowardojo Bambang Sukowardojo Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Djenal . Djenal Djenal Dwi Setyawan Endah Puspitasari Erfan Efendi Erma Sulistyaningsih Evi Umayah Ulfa Fariza Oktaviani Fitra Dea Wafa Frida Oktaningtias Widiarthi Harianti Novita Ika Oktavianawati Irma Novita Sari Jainur Rochman Kacung Hariyono Kartika Tari Azhar Khozin, Mohammad Nur Kumalasari, Ardine Kumalasari, Ardine Laily Ilman Widuri, Laily Ilman Lenny Widjayanthi Lina Asri Wulandari listya purnamasari Martiyas Pujirahayu Mei Syafriadi Mohammad Ubaidillah Muhammad Hazmi Nabila Nur Aisyah Al Ayyubi Niagra, Risnanda Deva Martha Norry Eka Palupi Nur Fauziah Matra Nurul Pratiwi Parawita Dewanti Rahmawati Rahmawati Restanto, Didik Restanto, Didik Pudji Reza Septyan Pratama Riandy, Cahyaningtyas Tetta Rukmana, Riesma Sari, Leny Yulia Widia Sholeh Avivi Sigit Soeparjono Siswandono, Siswandono Sitompul, Novrida Yanti Slameto Slameto Sri Hartatik stri Ratnadewi, Anak Agung I Tri Ardiyati TRI HANDOYO Ubaidillah, Mohammad Untung Murdiyanto Untung Murdiyanto Untung Murdiyanto Vergian, Putra Widya Kristiyanti Putri Wulanjari, Distiana Wuryanti Handayani Yagus Wijayanto Yeni Tri Puspitaningrum Yudi Wicaksono