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Evaluation of potential drug-drug interactions in stage 5 chronic kidney disease patients on routine hemodialysis at Dr. Cipto Mangunkusumo General Hospital, Jakarta Ulfa, Nusmirna; Soetikno, Vivian; Hustrini, Ni Made
Indonesian Journal of Pharmacology and Therapy Vol 6 No 2 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.19437

Patients with chronic kidney disease (CKD) face heightened susceptibility to adverse drug reactions (ADRs) owing to alterations in the pharmacokinetics and pharmacodynamics of medications. Patients with Stage 5 CKD receiving hemodialysis (HD) have numerous medications that are eliminated during the HD process. This study aims to assess the prescribing patterns in stage 5 CKD patients undergoing routine HD and their association with drug-drug interactions (DDIs) and the potential for adverse drug reactions (ADRs) resulting from DDIs. This cross-sectional study encompassed stage 5 CKD patients undergoing routine HD at Dr. Cipto Mangunkusumo General Hospital from 2020 to 2021. Data were obtained from the medical records of the HD Unit. An evaluation was performed utilizing the Lexicomp software to discover DDIs. The study had 147 individuals, with 101 different medications taken, the most prevalent being epoetin alfa (70.4%). Eighty nine percent of patients who underwent treatment associated with a potential DDIs, with the bulk of these interactions classified as moderate (88%). Fifty percent of patients were suspected of experiencing ADRs due to DDIs. Diabetes mellitus exhibited a statistically significant association with suspected ADRs attributable to DDIs (p = 0.04). Hypertension was the most predicted ADR resulting from DDIs, and diabetes mellitus significantly contributed to the incidence of ADRs owing to DDIs in patients with stage 5 CKD on routine HD. In conclusion, DDI in patients undergoing routine HD is sometimes unavoidable considering the many comorbidities. The DDI that occurred was moderate in severity and could be managed well at the Dr. Cipto Mangukusumo General Hospital.

Antiviral Properties and Potential of Ginger (Zingiber Officinale) and Its Derivatives: A Systematic Review Ahmad, Nouman; Ahmad, Hamdan; Dewi Syarifah; Vivian Soetikno
Science Education and Application Journal Vol 7 No 2 (2025): Science Education and Application Journal
Publisher : Program Studi Pendidikan IPA, Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/seaj.v7i2.1205

Antiviral Properties and Potential of Ginger (Zingiber Officinale) and Its Derivatives: A Systematic Review. Ginger has long been valued in traditional medicine for its therapeutic benefits. Recently, its antiviral capabilities have attracted significant interest, highlighting its potential as a natural antiviral agent. This systematic review seeks to thoroughly evaluate the antiviral effects of ginger and its active compounds, providing valuable insights to support future research and clinical applications in natural antiviral therapies. A comprehensive electronic search was undertaken across PubMed, Embase, and Scopus databases, employing MeSH terms, Emtree, and relevant synonyms to capture studies on ginger and its antiviral effects. The initial search yielded 531 records, which were de-duplicated and subsequently screened by title and abstract using Rayyan software. Fourteen studies specifically addressing antiviral effects against human pathogens met the inclusion criteria. This systematic review was conducted in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure rigorous reporting of findings. The majority of included studies were in vitro, revealing anti-viral effects of ginger against various viruses, including Influenza A, Chikungunya, Dengue, hRSV, HSV-2, and SARS-CoV-2 in different cell lines across various concentrations. In addition, Ginger extracts also demonstrated efficacy against Influenza A in both in vivo and in ovo studies, and a randomized controlled trial showcased encouraging antiviral effects targeting SARS-CoV-2. Ginger shows promising antiviral effects in most of the in vitro studies. Translating these findings to in vivo models is imperative for clinical relevance. Further in vivo research is essential before progressing to human studies to ascertain ginger's potential as an effective antiviral agent

Iron-Overload Conditions: Manifestations to the Kidney Organs – A Review Heriatmo, Nadia Larasinta; Estuningtyas, Ari; Soetikno, Vivian
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4411

Excess iron is a risk factor for organ dysfunction and damage resulting in various organ diseases such as liver, heart, and kidney, diabetes mellitus, and neurodegenerative diseases. Iron overload in some individuals is caused by various factors, including genetic predisposition such as genetic hemochromatosis, repeated transfusion of red blood cells, and parenteral iron administration in conditions of transfusion-dependent anemia. A disturbance in the globin gene in diseases such as β-thalassemia major causes an imbalance of the globin chain, resulting in chronic anemia in the sufferer. It has been reported that the human body does not have a mechanism for eliminating excess iron levels. Routine transfusion has become a solution to overcome chronic anemia so that patients can maintain hemoglobin levels, and the result of this transfusion repetition is the accumulation of iron in various organs, such as the heart, liver, endocrine glands, pancreas, lungs, and kidneys. Excess iron can be toxic to the body due to the formation of harmful free radicals that can damage cells and tissues. An increase in excessive ROS can result in the saturation of the antioxidant system. The presence of free radicals can lead to damage and the occurrence of filtration dysfunction in the glomerulus.

Cardioprotective Effect of Quercetin in 5/6-Nephrectomized Rats: Focus on Myocardial fibrosis and Oxidative Stress Yuliani, Tri; Louisa, Melva; Arozal, Wawaimuli; Soetikno, Vivian; Nafrialdi, Nafrialdi; Dewijanti, Indah D
Jurnal Jamu Indonesia Vol. 2 No. 3 (2017): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v2i3.37

Uremic cardiomyopathy is the leading cause of death in patients with chronic kidney disease. Fluid overload and oxidative stress play important roles in its pathogenesis. This study aims to determine the effect of quercetin on uremic cardiomyopathy in 5/6-nephrectomized rats. To our knowledge, its cardioprotective effect on uremic cardiomyopathy induced in rats by 5/6 nephrectomy has not been investigated yet. Uremia was induced surgically in male Sprague-Dawley rats via 5/6 nephrectomy. Quercetin was administered per orally at a dose of 100 mg/kg/day for 8 weeks prior to sacrifice. Meanwhile, captopril was administered at a dose of 10 mg/kg/day. Lipid peroxidation was assessed using TBARS reaction, while GPX activity was determined to explore the endogen antioxidant mechanism. Myocardial fibrosis was analyzed using Massons’ Trichrome staining and the level of NT-proBNP in plasma was measured as a marker of cardiac dysfunction. Nephrectomy 5/6 had no effects on plasma NT– proBNP levels, cardiac and plasma MDA levels, but induced mild myocardial fibrosis and significant increase in cardiac GPX activity in comparison with normal rat (p<0.05). However, administration of quercetin or captopril did not ameleriote those mild myocardial fibrosis and increased GPX activity. Uremic cardiomyopathy induced by 5/6 nephrectomy demonstrated mild myocardial fibrosis but preservation of cardiac function demonstrated by NT-proBNP levels. Increased of GPX activity in the nephrectomized-rats compared to the control rats (p<0.05) suggests induction of antioxidant defense mechanisms that might not be exhausted yet. This condition highlighted a compensatory phase which was unchanged following chronic administration of either quercetin or captopril.

Antiviral Properties and Potential of Ginger (Zingiber Officinale) and Its Derivatives: A Systematic Review Nouman Ahmad; Hamdan Ahmad; Dewi Syarifah; Vivian Soetikno
Science Education and Application Journal Vol. 7 No. 2 (2025): Science Education and Application Journal
Publisher : Program Studi Pendidikan IPA, Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/seaj.v7i2.1205

Antiviral Properties and Potential of Ginger (Zingiber Officinale) and Its Derivatives: A Systematic Review. Ginger has long been valued in traditional medicine for its therapeutic benefits. Recently, its antiviral capabilities have attracted significant interest, highlighting its potential as a natural antiviral agent. This systematic review seeks to thoroughly evaluate the antiviral effects of ginger and its active compounds, providing valuable insights to support future research and clinical applications in natural antiviral therapies. A comprehensive electronic search was undertaken across PubMed, Embase, and Scopus databases, employing MeSH terms, Emtree, and relevant synonyms to capture studies on ginger and its antiviral effects. The initial search yielded 531 records, which were de-duplicated and subsequently screened by title and abstract using Rayyan software. Fourteen studies specifically addressing antiviral effects against human pathogens met the inclusion criteria. This systematic review was conducted in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure rigorous reporting of findings. The majority of included studies were in vitro, revealing anti-viral effects of ginger against various viruses, including Influenza A, Chikungunya, Dengue, hRSV, HSV-2, and SARS-CoV-2 in different cell lines across various concentrations. In addition, Ginger extracts also demonstrated efficacy against Influenza A in both in vivo and in ovo studies, and a randomized controlled trial showcased encouraging antiviral effects targeting SARS-CoV-2. Ginger shows promising antiviral effects in most of the in vitro studies. Translating these findings to in vivo models is imperative for clinical relevance. Further in vivo research is essential before progressing to human studies to ascertain ginger's potential as an effective antiviral agent

6-Gingerol Reduces Tumor Necrosis Factor-Alpha Levels in the Brain of Metabolic Syndrome Rats Kenneth Ren; Tommy Alfie Fibisono; Adilla Zakia Herjawan; Vivian Soetikno
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1439.%p

Metabolic syndrome (MetS), with its associated abnormalities, is linked with oxidative stress and inflammation in the brain, leading to cognitive decline. As a natural compound with promising antioxidant properties derived from ginger, 6-gingerol (6G) could be a potential therapeutic candidate. This study aimed to investigate the effects of 6G on alleviating inflammation, oxidative stress, and insulin signaling in the brain tissue of MetS rats. Male Sprague-Dawley Rats were randomized into five groups: normal control, negative control, and three groups receiving increasing doses of 6G for 8 weeks. A high-fat diet and a low-dose streptozotocin injection induced MetS. Brain tissues were analyzed for tumor necrosis factor (TNF-ɑ), interleukin-1 (IL-1β), malondialdehyde (MDA), glutathione peroxidase (GPx), glucagon-like peptide (GLP-1), and GLP-1 receptor (GLP-1R) levels. The study was conducted at the Pharmacokinetics Laboratory Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, in January-February, 2023. TNF- levels were significantly higher in the MetS group compared to the normal-control group (95% CI: -4.4 – -74.9; p = 0.024), whereas there were no significant differences in IL-1, MDA, GPx, GLP-1, and GLP-1R levels between the MetS and normal-control groups. Administration of 6G at 50 mg/kg/day significantly reduced TNF levels compared with the MetS group (95% CI: -12 to -82; p = 0.006), whereas 6G at 100 and 200 mg/kg/day did not improve all parameters. The present findings suggest that 6G, particularly at a dose of 50 mg/kg, may exert anti-inflammatory effects in MetS-induced brain inflammation. However, the importance of dose optimization for the potential translational application of 6G remains to be further researched.

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