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All Journal Jurnal Gizi dan Pangan JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Journal of Nutrition College Psikohumaniora: Jurnal Penelitian Psikologi Holistic Nursing and Health Science Medica Hospitalia Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Jurnal Penyakit Dalam Indonesia International Journal of Cell and Biomedical Science

Muchlis Achsan Udji Sofro

2Staf Pengajar Bagian Ilmu Penyakit Dalam FK UNDIP/RSUP Dr. Kariadi Semarang

Author-ID : 384564

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 18 Documents Claim Missing Document

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Kadar seng dan kadar malondialdehyde pada penderita multi drug resistant tuberculosis dan tuberkulosis sensitif Suparno, Suparno; Suhartono, Suhartono; Sofro, Muchlis Achsan Udji; Sulchan, Mohammad; Tjahjono, Kusmiyati
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 7, No 1 (2018)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Zinc is the main constituent element of Superoxide Dismutase (SOD) which acts to protect cells from inflammation and the toxic effects of Reactive Oxygen Species (ROS). High ROS production induces fat peroxidation, and forms malondialdehyde (MDA) which causes oxidative stress.Objectives: This study aimed to analyze the difference of zinc and malondialdehyde levels among Multi Drug Resistant Tuberculosis and sensitive Tuberculosis.Methods: Crossectional study with 55 subjects consisted of 32 MDR-TB subjects and 23 subjects TB sensitive. Selection of subjects using consecutive sampling. Zinc and MDA serum was obtained from venous blood. Zinc and MDA concentration were assessed by quantitative colometric and Thiobarbituric Acid Reactive Substances (TBARS) respectively. Data were analized statistic by independent t-test and Mann Whitney test.Results: Zinc level of MDR-TB and TB sensitive were 74.85 (64 - 97) Î¼g/dl and 73.03 (63 - 97) Î¼g/dl respectively, while MDA of MDR-TB and sensitive TB were 2.262Â±1.055 nmol/mL and 2.66Â±0.992 nmol/mL. There was no significantly different in zinc level between MDR-TB and sensitive TB (p=1.000). Furthermore, there was not significantly different of MDA level between MDR-TB and sensitive Tuberculosis (p=0,147).Conclusion: There are no differences in zinc and MDA levels in patient between MDR-TB and sensitive TB.

Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar Ariani, Ariani; Anjani, Gemala; Sofro, Muchlis Achsan Udji; Djamiatun, Kis
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 6, No 2 (2018)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulationÂ NO level at miceÂ who received standard antimalarial therapyÂ Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test.Results : The meanÂ NO level in K(-), K(+), X1, X2, and X3 were 1.008 Î¼mol/mL, K(+) 1.338 Î¼mol/mL; while at treatment X1 1.143 Î¼mol/mL, X2 1.410 Î¼mol/mL, dan X3 0.886 Î¼mol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 wasÂ proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.

Effect of zinc on milkfish nastar-cookies to albumin and hemoglobin levels in HIV/AIDS patients Hindaryani, Nurul; Sofro, Muchlis Achsan Udji; Agustini, Tri Winarni
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 2 (2020)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Human Immunodeficiency Virus (HIV) destroys the antibody system, which causes faster protein breakdown resulting in lower albumin concentration. Zinc supplementation when added to protein in milkfish flour may increase albumin and zinc levels that associated with activity of the aminolevulinic acid dehydrase (ALAD) that synthesizes heme. Objectives: This study aimed to prove the effect of zinc and milkfish flour addition on albumin and hemoglobin levels in HIV/AIDS patients.Methods: An experimental study with randomized pre and post-test with the control group design using control subjects (n=17) and treatment (n=21). The administration of milkfish nastar with zinc to treatment group was 100 g/day for 60 days, while the control group was given milkfish nastar without zinc 100 g/day for 60 days. The measurement of albumin level used auto photometric with enzymatic color test methods and reticulated method for hemoglobin level measurement conducted before and after treatments. Data were analyzed using Shapiro-Wilk, paired t-test, and independent t-test with a significance value at p<0.05. Results: The means of albumin level in the treatment group increased by 7.03%, while the control group increased by 4.33% (p>0.05). Means of hemoglobin level in the treatment group increased by 12.0%, while the control group increased by 7.9% (p<0.05). Conclusion: Albumin and hemoglobin levels increased after milkfish nastar administration with zinc addition in HIV/AIDS patients.

Co-Authors Alifiati Fitrikasari Anak Agung Gede Sugianthara Anindita, Yohana Prima Ceria Anisah, Retno Lusmiati Anjani, Gemala Ardani, Yanuar Ari Suwondo Ariani Ariani Arifah, Meika Rahmawati Chairunnisa, Andita Darmono Dessy Triana Ema Hidayanti Franzeska Anna Dewi Mursita Widinartasari, Franzeska Anna Dewi Mursita Gede Arya Bagus Arisudhana Gunasari, Lala Foresta Valentine Haidati, Titis Hari Peni Julianti Hindaryani, Nurul Ilham Uddin Innawati Jusup Joyeti Darni K. Heri Nugroho HS, K. Heri Kis Djamiatun Kusmiyati Tjahjono Linda Kartika Sari Martini Martini Megah Andriany Minuljo, Tania Tedjo Mochamad Arif Nugroho Mohammad Sulchan Muflihatunnaimah, Muflihatunnaimah Muhammad Ali Sodiq, Muhammad Ali Peni, Hari Piriyasart, Jitlada Pratama, Yanuar Surya Raharja, Tommy Ratmawati, Ratmawati S.S, Darmono Salahudin, Muhammad Ismail Sammy, Alwi Siti Fatimah-Muis, Siti Suparno Suparno Tjokorda Gde Dalem Pemayun Tri Nur Kristina Tri Winarni Agustini Udin Bahrudin, Udin Untung Sujianto Wicaksono, Yamaji Adi Widiastuti, Yuliati

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