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All Journal Teknotan: Jurnal Industri Teknologi Pertanian Akuntansi Krida Wacana Journal of Mechanical Engineering Education (Jurnal Pendidikan Teknik Mesin) Community Empowerment AL-MASHALIH (Journal of Islamic Law) NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Sains dan Praktis TechLINK: Jurnal Ilmiah Lingkungan (Indonesian of Interdisciplinary Journal) Jurnal Penelitian Pendidikan Indonesia (JPPI) Jurnal Akuntansi Medimuh : Jurnal Kesehatan Muhammadiyah Baktimu : Jurnal Pengabdian Kepada Masyarakat E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Multidisiplin Holistik Jurnal Kesehatan
Yadi Supriyadi
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Farmasi Sains dan Praktis

 1 
ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli Karlina, Nina; Septiyati, Tri Putri; Ahidin, Didin; Zam Zam, Muhammad Yani; Setyaningsih, Indah; Indriaty, Sulistiorini; Kunaedi, Aan; Supriyadi, Yadi
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.10781

Abstract

The African leaf (Vernonia amygdalina Delile) is an Indonesian plant used by the community as a traditional medicine. V.amygdalina contains active compounds such as flavonoids, tannins, saponins, and steroids which have antibacterial properties. This study aims to determine the antibacterial activity and the most effective concentration of purified extracts of V.amygdalina against the Escherichia coli bacteria. V.amygdalina simplicia was extracted using the maceration method. Ethanolic extract V.amygdalina was tested for the quality of the extract parameters and purified. Then, the purified extract V.amygdalina was tested for phytochemical screening and antibacterial activity against Escherichia coli bacteria by well-diffusion with concentrations of 30%, 40%, and 50%. The result of the quality parameter test for ethanolic extract V.amygdalina meets the requirements of specific and non-specific parameters. Purified extract V.amygdalina positively contains flavonoids, tannins, saponins, and steroids. Antibacterial activity of 0.05% chloramphenicol and purified extract V.amygdalina concentrations of 30%, 40%, and 50% against Escherichia coli bacteria had inhibition of 23.42 mm, 8.40± 0.315 mm, 9.44± 0.543 mm, and 11.59 ± 1,640 mm. The produced most effective inhibition was at a concentration of 50%. The results showed that the purified extract of V.amygdalina has antibacterial activity in the moderate to strong category, and the most effective concentration against Escherichia coli bacteria is the concentration of 50%.
ANALYSIS OF POTENTIAL DRUG INTERACTIONS IN PNEUMONIA PATIENTS AT GUNUNG JATI REGIONAL HOSPITAL INSTALLATIONS, CIREBON Su'udiyah, Kamilina; Hidayati, Nur Rahmi; Setyaningsih, Indah; Rohadi, Didi; Supriyadi, Yadi
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.10893

Abstract

Pneumonia patients with complex diseases require a variety of drugs so the possibility of drug interactions also increases. This study aims to determine patient characteristics, potential drug interactions, severity, description of the type of drug and number of interacting drugs, as well as the relationship between patient characteristics and drug interactions. This type of research is a retrospective analytical descriptive study. The research sample was the medical records of patients diagnosed with pneumonia who met the inclusion criteria. Determination of drug interactions using the Medscape application. The analysis uses a correlation test to determine the relationship between the number of drugs and comorbidities with potential drug interactions. The characteristics of patients based on age are 46-65 years (36%), the majority of gender is male (52%), the number of drugs most frequently used is ≥ 5 types of drugs (94%), the predominant comorbidity is asthma (19.3%). The number of potential drug interactions occurred in 60 patients (67%) out of a total of 90 pneumonia patients. The highest level of severity of potential drug interactions was 55.2%. The type and number of drugs that interacted most were dexamethasone with omeperazole (13.2%). The results of the Chi Square correlation test obtained a significance value of 0.00 where the significance result was <0.05, so it was concluded that the number of drugs used and comorbidities with drug interactions was correlated with an R value of 0.477, which means the correlation between the number of drugs used and comorbidities has a moderate level of correlation.
Co-Authors Aan Kunaedi Aan Nuraeni Adiibah, Siti Agustine, Hendra Karunia Ajmi, Daep Ulil Amelia Nurfauziyah Ananda, Rega Ayu Prihatini, Nok Endang Ayu, intan Azzahra, Siti Bachtiar, Arsyad Cahyani, Mufida Cecep Eli Kosasih Didi Rohadi Didin Ahidin Didit Haryadi Dimas, Gilang Dzohirul Jabar Edy Subroto Hafiudin, Didin Hapsari, Dinda Alifia Ichsan Fauzi Rahman Ifa Nabila Ikeu Liana Dewi Ina Herlina Indah Setyaningsih Inu Hardi Kusumah, Inu Hardi Iqbal Bagus Prayogo Ira Dwi Apriliyanti Mugianto Putri Jasmine, Aurellia Lela Sulastri, Lela Lestari, Trisna Luqman Alhakim Budiarto Maftukha Maryam, Diana Dwi Maulidiyani, Roqmah Melyandini Milhah, Mila Zainatul Mima Elistya Utami Muayyad, Deden Misbahudin mutmainah, iin Nina Karlina nirdukita ratnawati, nirdukita Nonok Bunga Enjeli Nur Rahmi Hidayati, Nur Rahmi Nuraisah, Alvia Nurhayati Nurhidayah, Sri Oom Komariah Pransiska, Siska R.A. Annita Meilina Ahmadi Rahmadina, Putri Renny Amelia Renny Amelia Rifka Kamalia Wardani Rima Yulia Senja, Rima Yulia Rossi Indiarto Sabur, Moch. Saputro, Wahyu Angko Septiyati, Tri Putri Setyaningsih, Indah Shadrina, Ghesani Nur Sidik Lingga Kusuma Siska Adeliyani Soeharjoto, Soeharjoto Su'udiyah, Kamilina Suharyani, Ine Sulistiorini Indriaty Susilo, Rinto Suyatna, Riki Gana Syamsul Huda Tatang Permana, Tatang Tomi Tribudhi, Debbie Aryani Wawan Gunawan Widia Ningsih, Widia Yasmin Yasmin Yayan Rizikiyan Yayan Sudrajat Zam Zam, Muhammad Yani Zamzam, Muh. Yani