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All Journal Jurnal Radioisotop dan Radiofarmaka Majalah Kedokteran Bandung JURNAL PENDIDIKAN TAMBUSAI JKPK (Jurnal Kimia dan Pendidikan Kimia) PROFICIO: Jurnal Pengabdian Masyarakat Damhil Education Journal Journal International Journal of Teaching and Learning (INJOTEL) Aspirasi : Publikasi Hasil Pengabdian dan Kegiatan Masyarakat Darma Diksani: Jurnal Pengabdian Ilmu Pendidikan, Sosial, dan Humaniora Mosaic: Jurnal Pengabdian Kepada Masyarakat
Sutari Sutari
Center for Radioisotopes and Radiopharmaceuticals, National Nuclear Energy Agency Puspiptek Area, Serpong, 15314, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Comparison Study Between Local TSH IRMA Kit (CRRT) and Imported TSH IRMA Kit (Riakey, Korea) Mondrida, Gina; Triningsih, Triningsih; Purwanti, Kristina Dwi; Sutari, Sutari; Setyowati, Sri; Yulianti S, V.; Lestari, Wening; Ariyanto, Agus; Widayati, Puji
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 4, No 2 (2019): JKPK ( Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (826.081 KB) | DOI: 10.20961/jkpk.v4i2.29756

Abstract

Thyroid Stimulating Hormone (TSH) is one of hormones that our body need for growth of brains, bones and other tissues and regulate the metabolism in the body. Normal range of TSH for adult is from 0.3 to 5.5 µIU/ml, whereas for baby ranged from 3 to 18 µIU/ml. An Immunoradiometricassay (IRMA) is one of immunoassay technique using radionuclide as the tracer to detect low quantity of analyte. This technique is suitable for determine TSH levels in human blood serum which has complex matrix and various concentration. The Center for Radioisotope and Radiopharmaceutical Technology (CRRT)-BATAN has developed a reagent of TSH IRMA kit. The aim of this research is to compare between local TSH IRMA kit (CRRT-BATAN) and imported TSH IRMA kit (Riakey, Korea) toward 110 adult samples obtained from PTKMR - BATAN. The results showed 97 samples as true negative, 5 samples as true positive, 1 sample as false negative and 7 samples false positive. The comparison study gave diagnostic sensitivity as much as 83.33 %, diagnostic spesificity as much as 93.27 % and accuracy as much as 92.72 %.
Rituximab Iodination Procedure for Radioiodinated Rituximab (131I-Rituximab) Preparation Ramli, Martalena; Hidayat, Basuki; Sutari, Sutari; Setyowati, Sri; Susilo, Veronica Yulianti
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1864.956 KB) | DOI: 10.15395/mkb.v51n2.1595

Abstract

Rituximab is a chimeric monoclonal antibody which has specific for CD20 antigen expressed by pre-B and mature B-cells. Radiolabelled Rituximab, 131I-Rituximab, has been sucessfully used for treatment of B-Cell NHL. Due to its short shelf-life, 131I-Rituximab is commonly freshly prepared in hospitals prior to its used.  This study aimed to validate rituximab iodination procedure for 131I-Rituximab preparation in order to find the most suitable procedure to be applied in hospitals which intend to produce 131I-Rituximab in-house.  Three different methods of radiolabelling using three types of oxidizing agents, namely Iodobeads, Iodogen, and Chloramine-T were performed. Prior to the validation, radiochemical purity test and purification procedures were also validated as these procedures are critical for producing an acceptable quality of  I-Rituximab. In addition, the shelf-life of 131I-Rituximab was also studied. This study was conducted at the Centre for Radioisotope and Radiopharmaceutical Technology, Serpong during the period of July 2015 to February 2018.  The results showed that the radiochemical purity test of 131I-Rituximab could be easily performed by using instance thin layer chromatography–silica gel (ITLC-SG) in the stationary phase and 85% methanol or saline in the mobile phase. Purification of 131I-Rituximab was conducted using a Sephadex G-25 M filled column with 0.1 M PBS, pH 7.2, as the eluent that was found to be quite reliable to give 131I-Rituximab with radiochemical purity of >95% and recovery of approximately 90%. Radiolabelling efficiency performed using Iodobeads was the lowest (60%) compared to that of Iodogen and Chloramine-T (80–90%). In addition, approximately 30% of  I was retained by Iodobeads and this procedure was time consuming(~ 1 hours). It is concluded that Chloramine-T and Iodogen are better than Iodobeads as the oxidizing agent for radiolabelling of Rituximab with 131I. The radiochemical purity of 131I-Rituximab is well maintained when stored at room temperature and in 4 °C temperature up to 6 hours.Validasi Prosedur Iodinasi Rituximab untuk Preparasi131 I-RituximabValidasi proseduri odinasi rituximab untuk preparasi131I-Rituximab telah berhasil dilakukan.  Validasi ini dilakukan untuk mendapatkan prosedur yang paling sesuai yang dapat diaplikasikan untuk produksi131 I-Rituximabdi rumah sakit yang ingin memproduksi131 I-Rituximab di laboratorium mereka.  Tiga metode radiolabelling menggunakan 3 jenis oksidator Iodobeads, Iodogen, dan Chloramine-T telah divalidasi. Sebelum validasi ini, prosedur uji kemurnian radiokimia dan pemurnian divalidasi terlebih dahulu karena prosedur-prosedur ini sangat berpengaruh dalam penyediaan131 I-Rituximab dengan kualitas yang baik. Disampingitu, lama simpan131I-Rituximab juga dipelajari. Penelitan ini dilaksanakan di Pusat Teknologi Radioisotop dan Radiofarmaka, Serpong, Juli 2015–Februari 2018. Hasil penelitian memperlihatkan bahwa uji kemurnian radiokimia 131I-Rituximab dapat dilakukan dengan mudah menggunakan instance thin layer chromatography – silica gel (ITLC-SG) sebagai fasa diam dan metanol 85% atau larutan salin sebagai fasa gerak. Pemurnian131I-Rituximab menggunakan kolom Sephadex G-25 M dan0.1 M PBS pH 7,2 sebagai eluen dapat diandalkan dan memberikan131I-Rituximab dengan kemurnian radiokimia >95% dan sekitar 90% perolehan kembali. Efisiensi penandaaan menggunakan Iodobeads didapatkan paling (60%) dibanding dengan Iodogen dan Chloramine-T (80 – 90%). Di samping itu, sekitar 30% 131I hilang karena terikat pada Iodobeads dan prosedur ini memakan waktu yang panjang (~1 jam). Penandaan Rituximab 131I menggunakan Chloramine-T and Iodogen dapat disimpulkan lebih baik dibanding dengan menggunakan Iodobeads. Kemurnian radiokimia131I-Rituximab terjaga dengan baik pada penyimpanan selama 6 jam pada suhu kamar dan 4 °C.
OPTIMASI RANCANGAN ASSAY KIT IRMA CA-125 Widayati, Puji; Ariyanto, Agus; Abidin, Zaenal; Yunita, F.; Sutari, Sutari
Jurnal Radioisotop dan Radiofarmaka Vol 9 (2006): jurnal PRR 2006
Publisher : Jurnal Radioisotop dan Radiofarmaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (63.149 KB)

Abstract

OPTIMASI RANCANGAN ASSAY KIT IRMA CA-125. Carbohydrate Antigen-125 (CA-125) adalah antibodi yang bereaksi spesifik dengan monoklonal CA-125. Antigen CA-125 dapat digunakan sebagai tumor marker dan penentuan kadarnya dapat dilakukan dengan teknik Immunoradiometricassay (IRMA). Pusat Pengembangan Radiosotop dan Radiofarmaka (P2RR-BATAN) telah membuat kit IRMA CA-125 untuk memenuhi kebutuhan dalam negeri. Telah dillakukan optimasi rancangan assay kit IRMA CA-125 buatan PRR tersebut, meliputi penetapan jumlah cacahan perunut, volume perunut, volume standar, waktu inkubasi dan suhu inkubasi yang terbaik sehingga diperoleh nilai %B/T dan % NSB yang optimum dan dapat digunakan sebagai acuan setiap kali assay. Hasil penelitian menunjukkan bahwa jumlah cacahan perunut terbaik adalah ± 100000 cpm, volume perunut terbaik adalah 50µL, volume standar terbaik adalah 50µL, waktu inkubasi terbaik adalah 16 jam dan suhu inkubasi terbaik adalah 25°C (suhu kamar). Penelitian optimasi assay kit IRMA CA-125 menyimpulkan bahwa dengan menggunakan komposisi pereaksi dan kondisi reaksi optimum dihasilkan nilai %B/T = 19,05% dan NSB = 0,53%. Kata kunci: Radioimmunoassay, Immunoradiometricassay, tumor marker, CA-125 ASSAY DESIGN OPTIMIZATION OF CA-125 IRMA KIT. Monoclonal Antibody CA-125 is an antibody against the Carbohydrate Antigen (CA-125). The CA-125 antigen can be used as a tumour marker, and its concentration can be determined by the Immunoradiometricassay (IRMA) method. The center for Radioisotopes and Radiopharmaceuticals (BATAN) has prepared the CA-125 IRMA kit for domestic use. This reportdiscuse the assay design optimization of the a bove mentioned CA-125 IRMA kit, covering determenation of total count oftracer, tracer volume, standart volume, optimum incubation time and temperature, that will be used in daily assay. Investigation showed that the optimum total countof tracer was approx ±100.000 cpm, optimation tracer volume was 50 µL, optimum standard volume was 50 µL, and the optimum incubation time and temperature were 16 hours and 25 °C respectively. It can be concluded that the optimum reagents compositation and reaction conditions can produce %B/T value of 19.05% and NSB value of 0.53%. Key words:Radioimmunoassay, Immunoradiometricassay, tumor marker, CA-125
PRODUCTION OF IMMUNORADIOMETRICASSA Y (IRMA) CA 15.3 KIT COMPONENT FOR DETECTION OF BREAST CANCER Widayati, Puji; Ariyanto, Agus; Sutari, Sutari; Mondrida, Gina; Darwati, Siti
Jurnal Radioisotop dan Radiofarmaka Vol 11 (2008): Jurnal PRR 2008
Publisher : Jurnal Radioisotop dan Radiofarmaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4199.326 KB)

Abstract

PRODUCTION OF IMMUNORADIOMETRICASSA Y (IRMA) CA 15.3 KITCOMPONENT FOR DETECTION OF BREAST CANCER. YKI has ranked that breast cancer as a second deseas in causing death of Indonesian women (, 2007). This phenomenon has been caused by the low level of public awareness in early detection of cancers. As a consequences this kind of cancer has generally been diagnosed in advanced stadium which is difficult to be treated  In spite of this, the disease actually can be detected early by measuring level of CA 15.3, a tumor marker for breast cancer. One of such in vitro method is immunoradiometricassay (IRMA) for CA 15.3. The CA 15.3 itself is a glycoprotein of heterogen compound capable of reacting with monoclonal antibody CA 15.3. Production of the IRMA CA 15.3 kit has been performed in the Center for Radioisotope and Radiopharmac.eutical, National Nuclear Energy Agency of Indonesia. Optimization of the kit component has been carried out using several parameter including type ofmonoclonal antibody for tracer and buffer coating type. The results showed that monoclonal anti CA M37901M type is better than M37552M type for tracer production. The M3790lM gave yield about 79.51%, with specific activity 29.12 ~Ci/~g, radiochemical purity 94.21% and %B/T about11.94%. Several buffers have been evaluated and 0.05 M pH 9.6 carbonate bicarbonate buffer showed the highest specific binding when it was used as coating buffer. Preparation of IRMA CA 15.3 standard solution gave a linier relation between CA 15.3 concentration and the maximumbinding (%B/T) Y=0.227X+0.5177 and correlation coefficient R 0.9840Keywords: Radioimmunoassay, Immunoradiometricassay, tumor marker, CA-15.3
DAMPAK MEDIA SOSIAL TERHADAP KARAKTER SANGUINIS PADA ANAK USIA DINI Salingkat, Sahrul; Bidjai, Tomi; Rahma, Rahma; sutari, Sutari; Poku, Asraty
Damhil Education Journal Vol 4, No 1 (2024)
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/dej.v4i1.2299

Abstract

The impact of social media is that children prefer to play cell phones or games and social media rather than interact with their friends. This study aims to determine the extent of the impact of social media on the optimistic character of early childhood conducted at ABA Luwuk Kindergarten. The method used is descriptive qualitative research method, which is a method in the form of observation, interviews. the object of this research is students while the resource persons are ABA Luwuk Kindergarten teachers, the data obtained is reduced and then concluded. From the results of the study, it was found that the impact of social media on the saunginis character "very social, optimistic, and very confident" in early childhood is decreasing. Children's self-confidence also begins to decrease, children are unable to answer questions given by the teacher and cannot play an active role in the learning process. The role of parents and teachers is very influential in character building in early childhood so that it will form children with good character
MENINGKATKAN EFEKTIVITAS PEMBELAJARAN SAINS PADA ANAK USIA DINI Lamadang, Karmila P.; Sutari, Sutari; Sukmawati, Sukmawati; Supardi, Lustiawati
PROFICIO Vol. 5 No. 2 (2024): PROFICIO : Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v5i2.3436

Abstract

Pendidikan pada anak usia dini harus dengan cara yang asyik dan menyenagnkan sehingga anak bisa belajar dengan baik. Maka dari itu dengan adanya program meningkatkan efektivitasn dan kreativitas anak usia dini membuat para guru bisa mengevisienkan waktu pembelajaran dengan baik. sebagai seorang guru atau pendidik dalam mengajar atau membawakan materi sesuai dengan waktu yang telah di tentukan agar tingkat keberhasilan yang di capai dari suatu metode pembelajaran terpenuhi sesuai dengan pembelajaran yang di rencanakan sehingga apa yang kita ajarkan kepada anak-anak bisa tercapai dengan baik sehingga dapat menyesuaikan antara materi pembelajarna dan jam pemeblajaran yang kita ajarkan kapada anak-anak.sama dengan meningkatkan kretivitas anak dengan adanya kegiatan ini dapat membantu meningkatkan kretivitas yang ada dalam diri anak sehingga anak dapat mengenali apa yang menjadi kelebihan yang ada dalam diri anak.kreativitas juga bisa mendorong minat belajar anak melalu kretiitas anak banyak belajar hal-hal yang belum perna mereka lihat
THE IMPACT OF PARENTAL INVOLVEMENT IN TEACHING AND LEARNING ACTIVITIES ON EARLY CHILDHOOD SOCIAL-EMOTIONAL DEVELOPMENT Sutari, Sutari
International Journal of Teaching and Learning Vol. 2 No. 9 (2024): SEPTEMBER
Publisher : Adisam Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This literature research aims to evaluate the impact of parental involvement in teaching and learning activities on the social-emotional development of early childhood through systematic analysis of data available in academic literature. The methods used include a review of published empirical studies, journal articles, and educational theories with a focus on parental involvement and family dynamics, as well as their implications for children's social and emotional growth. The research results show that parental involvement substantially contributes to strengthening children's interpersonal skills, increasing emotional intelligence, and communicating a positive self-concept. Various factors such as the presence of parents during learning activities, consistency in emotional and educational support, and the parenting methods used, have been proven to be closely related to improving children's social skills and ability to regulate emotions. Furthermore, this research concludes that the supporting strategies implemented by educational institutions to increase parental involvement provide optimal benefits for children's development. Recommendations are aimed at educational practitioners to design collaborative frameworks that actively involve parents in the educational process, with the main aim of strengthening the social-emotional foundations of early childhood.
Meningkatkan Kemampuan Motorik Halus Anak Usia Dini Melalui Kegiatan Finger Painting Sutari, Sutari; Rais, Risky Diya Amalia; Setiadi, Kusno; Azizah, Amana Tun; Rahim, Wulandari A.; Maharani, Puan
Jurnal Pendidikan Tambusai Vol. 9 No. 1 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i1.26121

Abstract

Perkembangan motorik halus memiliki peran penting dalam tumbuh kembang anak usia dini, terutama dalam keterampilan menulis, menggambar, dan aktivitas lainnya. Salah satu cara efektif untuk mengasah kemampuan motorik halus adalah melalui kegiatan finger painting. Penelitian ini bertujuan untuk mengeksplorasi sejauh mana finger painting dapat membantu meningkatkan koordinasi tangan serta kelincahan jari anak usia dini. Penelitian ini menggunakan pendekatan kualitatif dengan teknik observasi dan wawancara terhadap guru serta pengamatan langsung terhadap anak-anak yang berpartisipasi dalam kegiatan tersebut. Hasil penelitian menunjukkan bahwa finger painting mampu meningkatkan motorik halus seperti kelenturan jari, koordinasi antara mata dan tangan, serta kreativitas anak. Dengan demikian, finger painting dapat dijadikan sebagai metode pembelajaran yang menyenangkan dan efektif dalam mendukung perkembangan motorik halus anak usia dini.
Pendampingan Guru dalam Meningkatkan Motorik Halus Anak Usia Dini Melalui Pembelajaran Kolase Menggunakan Bahan Alam Setiadi, Kusno; Sutari, Sutari; Alma M. Djon
ASPIRASI : Publikasi Hasil Pengabdian dan Kegiatan Masyarakat Vol. 3 No. 4 (2025): Juli : ASPIRASI : Publikasi Hasil Pengabdian dan Kegiatan Masyarakat
Publisher : Asosiasi Periset Bahasa Sastra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/aspirasi.v3i4.2204

Abstract

The purpose of this activity is to assist teachers in designing activities that can stimulate the fine motor skills of children in Early Childhood Education (PAUD) KB-Mawar, West Longkoga Village, Bualemo District, Banggai Regency. Method implementation is carried out in the form of direct face-to-face meetings between the activity implementers and the children of PAUD KB-Mawar. The implementation of this activity was carried out on January 25 to February 13, 2025. The desired end result of this activity is that teachers can enrich their skills in managing activities involving natural material media and deepen their understanding of children's fine motor skills.
Sosialisasi Strategi Pengembangan Literasi Digital dalam Pendidikan Sutari, Sutari; Rahma, Rahma; Djayadin, Chairunnisa; Jannah, Miftahul; Salingkat, Sahrul; Ladaka, Laraswati S; Setiadi, Kusno
DARMADIKSANI Vol 4 No 1 (2024): Edisi Juni
Publisher : Jurusan Pendidikan Bahasa dan Seni, FKIP, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/darmadiksani.v4i1.4587

Abstract

Literasi digital dalam pendidikan merupakan upaya adaptasi pembelajaran pada abad 21. Dengan konsep seminar Pendidikan Pengabdian kepada Masyarakat (PKM) bertujuan untuk meningkatkan pemahaman guru (KKG Kecamatan Toili Barat) tentang strategi pengembangan literasi digital serta pengimplementasiannya di dalam Pendidikan di sekolah. Pelaksana kegiatan adalah dosen dan mahasiswa Program studi Islam Anak Usia Dini bertempat di Kecamatan Toili Barat pada bulan April-Mei 2024. Kegiatan dilakukan dengan memberikan seminar pendidikan tentang literasi digital kepada KKG PAUD-SD Kecamatan Toili Barat PKM ini menghasilkan guru mendapatkan pengetahuan dan memahami strategi pengembangan literasi digital untuk diterapkan didalam pembelajaran sehingga literasi digital dapat memberi manfaat bagi guru dan siswa di sekolah. Keberlanjutannya PKM ini menginspirasi guru-guru lain untuk dapat menerapkan literasi digital agar pembelajaran semakin inovatif dan menyenangkan.
Co-Authors Agus Ariyanto Alma M. Djon Azizah, Amana Tun Basuki Hidayat BIDJAI, TOMI Desyandri Desyandri Djayadin, Chairunnisa F. Yunita Gina Mondrida Hamzah Hasyim Karmila P Lamadang Kusuma, Titin Ladaka, Laraswati S Maharani, Puan Martalena Ramli Miftahul Jannah Poku, Asraty Puji Widayati Purwanti, Kristina Dwi Rahim, Wulandari A. Rahma Rahma Rais, Risky Diya Amalia Sahrul Salingkat Salingkat, Sahrul Setiadi, Kusno Siti Darwati Sri Setyowati Sukmawati Sukmawati Supardi, Lustiawati Susilawati, Susilawati Susilo, Veronica Yulianti Syafni, Eliza Syafrianto, Syafrianto Syofyanengsih, Syofyanengsih Triningsih Triningsih Wening Lestari Yulianti S, V.