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All Journal Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Indonesian Journal of Pharmaceutical Science and Technology Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Narra J Jurnal Kedokteran Hewan
Dedy Syahrizal
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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Antioxidant Potential, Anti-Diabetes, and Toxicity of Aceh Cinnamon Extract (Cinnamomum burmannii) Husna, Fauzul; Suhaila, Suhaila; Syahrizal, Dedy; Zulkarnain, Zulkarnain; Washilah, Hasya; Sahriana, Ananda Putri
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.43182

Abstract

Indonesia as a mega biodiversity country must take a role in the development of herbal-based medicine. Cinnamon is often used empirically to overcome various health problems, especially diabetes.   This study aims to assess the effectiveness of Aceh cinnamon extract as an antioxidant and antidiabetic in vitro and to evaluate the toxicity of the extract. Cinnamons, obtained from coffee plantations in Simpang Teritit, Bener Meriah, Aceh, were macerated with 96% ethanol for extraction.  Furthermore, the extract phytochemical content was determined qualitatively, semiquantitatively (GC-MS), and quantitatively (levels of phenols, flavonoids, and total tannins).  The toxicity level was measured by an acute toxicity test based on the OECD and the BSLT assay.  The effectiveness as an antioxidant and anti-diabetes was determined in vitro by the DPPH inhibition method and α-glucosidase inhibition. The results of this study showed that cinnamon extract contains alkaloids, flavonoids, polyphenols, tannins, quinones, saponins, and triterpenoid compounds. The total amount of phenol, flavonoid, and tannin extract levels were 66.34 mg GAE/gr, 80.52 mg QE/gr, and 566.33 mg AT/gr. The IC50 extract value against DPPH was 16.07 ppm and against the enzyme, α-glucosidase was 123.52 ppm. In the acute toxicity test, the value of LD50 ≥15 grkg BWW was obtained and in the toxicity test with BSLT, LC50 extract was 350.57 ppm. Aceh cinnamon extract (Cinnamomum burmannii) has LD50 > 15 gr/kg BW and LC50 value >500 ppp which is categorized as a practically non-toxic ingredient and low toxicity agent with strong antioxidant activity and moderate antidiabetics.
Co-Authors . Ikhsan Azharuddin Azharuddin, Azharuddin Bakhtiar Bakhtiar Bani, Ika I. Basri A. Gani, Basri A. Cut Mustika Dytha Putri Harwani Emril, Dessy R. Ferdi Riansyah Gholib Gholib, Gholib Habibie, Yopie A. Hasan, Denny Irmawati Haslinur, Sari Husna, Fauzul Irwan Saputra Maryatun Hasan Miswari, Irna Mudatsir Mudatsir Mulkan Azhary Muslim Akmal Nora Maulina, Nora Novita Andayani Qarani, Waisul Rahmi Aprilianti Ramadhan, Akmal Rizanna Rosemary Rosaria Indah Saffutra, Hasrizal Safrizal Rahman Sahriana, Ananda Putri Said Usman Salsabila, Hilwa Saputra, Irwan Sary, Nirwana L. Suhaila, Suhaila Suryawati Suryawati Syahputra, Andika Ari Taufiq P. Nugraha, Taufiq P. Usman, Said Wardhani, Bantari WK. Washilah, Hasya Winda Yulia Yahya, Mustanir Zaman, Nasrul Zulkarnain Zulkarnain