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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Indonesian Journal of Biotechnology The Indonesian Biomedical Journal Science and Technology Indonesia Jurnal Akta Jurnal Fitofarmaka Indonesia Jurnal Pro Hukum : Jurnal Penelitian Bidang Hukum Universitas Gresik JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia JURNAL RECTUM: Tinjauan Yuridis Penanganan Tindak Pidana Devotion: Journal of Research and Community Service Narra J International Journal of Social Service and Research Jurnal Impresi Indonesia International Journal of Science and Society (IJSOC) Journal of Social Research Journal Of World Science MEDICINUS Journal of Law, Poliitic and Humanities The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy INJURITY: Journal of Interdisciplinary Studies Eduvest - Journal of Universal Studies Journal of Social Science Influence: International Journal of Science Review Al Makki Health Informatics Journal Journal of Food and Pharmaceutical Sciences Asian Journal of Social and Humanities Indonesian Journal of Jamu
Raymond R. Tjandrawinata
Fakultas Bioteknologi, Universitas Katolik Indonesia Atma Jaya
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Journal : JFIOnline

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A Model of Rat Thrombocytopenia Induced by Cyclophosphamide Kristiana, Hery; Nailufar, Florensia; Winoto, Imelda L; Tjandrawinata, Raymond R
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.566 KB)

Abstract

This study is aimed at optimizing the dose of cyclophosphamide in thrombocytopenia rat model. A suitable drug dosage that coulds induce thrombocytopenia rat model. A suitable drug dosage that could induce thrombocytopenia in rat was then investigated. Animal model of 25 rats were randomly divided into five groups: Normal (group A), Cyclophosphamide low dose (group B), medium dose (group C), high dose (group D), very high dose (group E) with each of 5 rats. The four dosage groups were given 25, 50, 100, 150 mg/kg BW cyclophosphamide, respectively. Cyclophosphamide was given by subcutaneous injection once a day for 3 consecutive days. All groups were under investigation for 8 days. The result suggested that a decrease in the platelet count, white blood cell, and mean corpuscular volume of all group cyclophosphamide induced at the 7th day were significantly different than that of Normal. The platelets count was reduced but fluctuated greatly, all of the rats dies in group E at 7th day and group D at 8th day. Though all 4 dosages successfully initiated thrombocytopenia as the platelets number dorpped at the 7th day, the low dose was considered to be a suitable one that was of high efficacy and low toxicity. Thus, using Wistar rats challenged by subcutaneous injection of cyclophosphamide 25 mg/kg per day for 3 consecutive days showed one simple, feasible and stable rat thrombocytopenia model that could be used for phamacodynamic test of the drugs which are supposed to have platelet increasing effect. Keywords : rat, thrombocytopenia, cyclophosphamide
A Model of Rat Thrombocytopenia Induced by Cyclophosphamide Kristiana, Hery; Nailufar, Florensia; Winoto, Imelda L; Tjandrawinata, Raymond R
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.566 KB) | DOI: 10.35617/jfi.v6i3.139

Abstract

This study is aimed at optimizing the dose of cyclophosphamide in thrombocytopenia rat model. A suitable drug dosage that coulds induce thrombocytopenia rat model. A suitable drug dosage that could induce thrombocytopenia in rat was then investigated. Animal model of 25 rats were randomly divided into five groups: Normal (group A), Cyclophosphamide low dose (group B), medium dose (group C), high dose (group D), very high dose (group E) with each of 5 rats. The four dosage groups were given 25, 50, 100, 150 mg/kg BW cyclophosphamide, respectively. Cyclophosphamide was given by subcutaneous injection once a day for 3 consecutive days. All groups were under investigation for 8 days. The result suggested that a decrease in the platelet count, white blood cell, and mean corpuscular volume of all group cyclophosphamide induced at the 7th day were significantly different than that of Normal. The platelets count was reduced but fluctuated greatly, all of the rats dies in group E at 7th day and group D at 8th day. Though all 4 dosages successfully initiated thrombocytopenia as the platelets number dorpped at the 7th day, the low dose was considered to be a suitable one that was of high efficacy and low toxicity. Thus, using Wistar rats challenged by subcutaneous injection of cyclophosphamide 25 mg/kg per day for 3 consecutive days showed one simple, feasible and stable rat thrombocytopenia model that could be used for phamacodynamic test of the drugs which are supposed to have platelet increasing effect. Keywords : rat, thrombocytopenia, cyclophosphamide
Co-Authors Achmad K. Harzif Agung Endro Nugroho Agung Endro Nugroho Andon Hestiantoro Andri Prasetiyo Anindini Winda Amalia Anindyajati Anindyajati Anita Artarini Armini Syamsidi ARTARINI, ANITA B. Atawolo, Andreas Babu, Murali Mohan Budi Wiweko Caroline G. Puspita CATUR RIANI Danang Agung Yunaidi Dayana, Hepy Debbie S. Retnoningrum Debbie S. Retroningrum DEBBIE SOEFIE RETNONINGRUM Dewi Riskha Nurmalasari Diana Nur Afifah Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Gayatri, Anggi Gita Pratama Hapsari, Riani Hartati Tuna, Hartati Heliany, Ina Henry Soelistyo Budi Henry Soelistyo Budi, Henry Soelistyo Herbert Situmorang Herbert Situmorang Huda Shalahudin Darusman Indriawati, Iin Irsan Hasan Ismaya, Wangsa T. Kaka Renaldi Kanadi Sumapradja Krisnayanti, Ni Putu Eka Kristiana, Hery Kristiana, Hery Laurentia Stephani Liana W. Susanto Lilik Sulastri Luh Putu Nurshanti, Ni Maggy T. Suhartono Maggy T. Suhartono Maggy Thenawidjaja Suhartono Marcellus Simadibrata Martha Wijaya, Harry Melva Louisa Murdani Abdullah Nafrialdi Nafrialdi Nailufar, Florensia Nailufar, Florensia Novia Tri Astuti Novia Tri Astuti Novitasari, Putri Rachma Permanasari, Silmi Citra Rachman, Andika Raden Muharam Natadisastra Retroningrum, Debbie S. Santi Tan Saut Horas Hatoguan Nababan Setiabudy, Rahajuningsih D Shirly Kumala SILMI MARIYA Simatupang, Stefeny Theresia Sinaga, Wenny S.L. Soelistyo Budi, Henry Susanto, Liana W Suwijiyo Pramono Suwijiyo Pramono Tan, Santi Viedya Novalinda Said Wangsa T. Ismaya Wangsa Tirta Ismaya Widjaja, Nadia Winoto, Imelda L Winoto, Imelda L Yanti Lim Zaelani, Bella Fatima Dora