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Journal : Influence: International Journal of Science Review

The Role of Enzymatic DNA Synthesis in Protein Circuitry Regulation Tjandrawinata, Raymond R.
INFLUENCE: INTERNATIONAL JOURNAL OF SCIENCE REVIEW Vol. 6 No. 3 (2024): INFLUENCE: International Journal of Science Review
Publisher : Global Writing Academica Researching and Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/influencejournal.v6i3.268

Abstract

Synthetic biology represents a groundbreaking frontier in biotechnological innovation, empowering researchers to design and construct genetic and protein networks with a level of precision previously unattainable. At the heart of this transformative field lies enzymatic DNA synthesis, a cutting-edge technology revolutionizing how genetic information is assembled and applied. By facilitating the rapid and accurate creation of DNA sequences, enzymatic DNA synthesis has significantly advanced our ability to engineer compact protein circuits, enabling precise regulation of protein expression and cellular communication. This review explores the multifaceted impact of enzymatic DNA synthesis, highlighting its pivotal role in addressing complex biological challenges. The technology's ability to support the construction of highly efficient and compact protein circuits has unlocked new possibilities in therapeutic applications, such as personalized medicine and gene therapy, as well as industrial innovations in biotechnology and synthetic manufacturing. Furthermore, the integration of enzymatic DNA synthesis with other synthetic biology tools has opened avenues for creating synthetic organisms and programmable cellular systems, paving the way for novel applications in agriculture, environmental sustainability, and biopharmaceuticals. Despite its transformative potential, enzymatic DNA synthesis is not without challenges. Issues related to scalability, cost-effectiveness, error rates in synthesis, and integration with existing biotechnological frameworks remain areas requiring further refinement. Emerging trends in automation, machine learning, and integration with high-throughput screening platforms, however, offer promising solutions to these hurdles. By synthesizing recent advancements, this review underscores the disruptive potential of enzymatic DNA synthesis in reshaping our understanding of cellular communication and protein regulation. As the technology continues to mature, its contributions are poised to redefine synthetic biology's role in solving pressing global challenges across medicine, industry, and beyond.
Co-Authors Achmad K. Harzif Agung Endro Nugroho Agung Endro Nugroho Andon Hestiantoro Andri Prasetiyo Anindini Winda Amalia Anindyajati Anindyajati Anita Artarini Armini Syamsidi ARTARINI, ANITA B. Atawolo, Andreas Babu, Murali Mohan Budi Wiweko Caroline G. Puspita CATUR RIANI Danang Agung Yunaidi Dayana, Hepy Debbie S. Retnoningrum Debbie S. Retroningrum DEBBIE SOEFIE RETNONINGRUM Dewi Riskha Nurmalasari Diana Nur Afifah Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Gayatri, Anggi Gita Pratama Hapsari, Riani Hartati Tuna, Hartati Heliany, Ina Henry Soelistyo Budi Henry Soelistyo Budi, Henry Soelistyo Herbert Situmorang Herbert Situmorang Huda Shalahudin Darusman Indriawati, Iin Irsan Hasan Ismaya, Wangsa T. Kaka Renaldi Kanadi Sumapradja Krisnayanti, Ni Putu Eka Kristiana, Hery Kristiana, Hery Laurentia Stephani Liana W. Susanto Lilik Sulastri Luh Putu Nurshanti, Ni Maggy T. Suhartono Maggy T. Suhartono Maggy Thenawidjaja Suhartono Marcellus Simadibrata Martha Wijaya, Harry Melva Louisa Murdani Abdullah Nafrialdi Nafrialdi Nailufar, Florensia Nailufar, Florensia Novia Tri Astuti Novia Tri Astuti Novitasari, Putri Rachma Permanasari, Silmi Citra Rachman, Andika Raden Muharam Natadisastra Retroningrum, Debbie S. Santi Tan Saut Horas Hatoguan Nababan Setiabudy, Rahajuningsih D Shirly Kumala SILMI MARIYA Simatupang, Stefeny Theresia Sinaga, Wenny S.L. Soelistyo Budi, Henry Susanto, Liana W Suwijiyo Pramono Suwijiyo Pramono Tan, Santi Viedya Novalinda Said Wangsa T. Ismaya Wangsa Tirta Ismaya Widjaja, Nadia Winoto, Imelda L Winoto, Imelda L Yanti Lim Zaelani, Bella Fatima Dora