Article Per Year (5 Year)
p-Index From 2021 - 2026
2.59
P-Index
This Author published in this journals
All Journal WMJ (Warmadewa Medical Journal) WICAKSANA: Jurnal Lingkungan dan Pembangunan ISM (Intisari Sains Medis) : Jurnal Kedokteran Narra J Aesculapius Medical Journal Community Services Journal (CSJ)
Agus Santosa
Universitas Warmadewa
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Correlation of miR-150, hsa-let-7e, and miR-146a and gene expression of IL-6, IL-8, IP-10, and MIP-1β during dengue virus infection Sri Masyeni; Kuntaman Kuntaman; Aryati Aryati; Muchlis AU Sofro; Usman Hadi; Gondo Mastutik; Windu Purnomo; Agus Santosa; Benediktus Yohan; Erni Juwita Nelwan; R. Tedjo Sasmono
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.31

Abstract

Growing evidence suggests that microRNAs (miRNAs) play a pivotal role in viral infection. The objective of this study was to assess the association between the expression of miR-150, hsa-let-7e, and miR-146a on cytokine expression during dengue infection. Dengue virus (DENV) strain SJN-006, a serotype 2 DENV strain of the Cosmopolitan genotype, isolated in Bali, Indonesia, was used to infect peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals. The relative gene expressions of miR-150, hsa-let-7e, and miR-146a as well as the gene expression of cytokines (IL-6, IL-8, IP-10, and MIP-1β) were determined using quantitative real time - polymerase chain reaction (qRT-PCR) at 6, 12 and 24 hours post infection (hpi). Correlations between the microRNAs and cytokines were analyzed by means of causality tests. Our data suggests that miR-150 and hsa-let-7e were significantly higher in infected-PBMCs after 12 hpi compared to the uninfected-PBMCs (p<0.05). The causality tests demonstrated that miR-150 and hsa-let-7e were negatively correlated with IL-8 expression, meanwhile miR-146a was the contrast. DENV infection was negatively and positively correlated with miR-150 and hsa-let-7e, respectively, after 24 hpi. In conclusion, our data demonstrates the vital role of miR-150, hsa-let-7e, and miR-146a in regulating IL-8 expression with possible different pathways.
Pengaruh tingkat pengetahuan, sikap dan perilaku dengan kejadian COVID-19 pada mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warwadewa Agus Santosa; Luh Gde Evayanti; Angga Priyana
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.1450

Abstract

Introduction: Efforts in preventing COVID-19 are carried out by increasing knowledge and improving attitudes and behavior. These three components affect the occurrence of COVID-19, especially among medical students. This study aimed to determine the relationship between knowledge, attitudes, and behavior and the incidence of COVID-19 in students of the Faculty of Medicine and Health Sciences (FKIK Unwar). Methods: Analytical design and a cross sectional study were used. The study was conducted from October – November 2021. Several 88 samples were selected by purposive sampling from 2018-2020 class students in the Unwar FKIK environment. Data were analyzed using Fisher Exact test (p<0.05). Results: Medical students have knowledge of 94.3% in the good category, 79.5% positive attitude and 55.7% positive behavior towards COVID-19, although there is no significant relationship (p>0.05). Conclusion: Education and implementation of strict health protocols at FKIK Unwar increase the knowledge, behavior, and attitudes of FKIK Unwar students. Those were related to the low incidence of COVID-19 at FKIK Unwar for the last 3 months.   Latar Belakang: Peningkatan pengetahuan, perbaikan sikap serta perilaku dilaksanakan dalam upaya pencegahan COVID-19. Ketiga komponen tersebut mempengaruhi kejadian COVID-19 terutama dikalangan mahasiswa kedokteran. Penelitian ini bertujuan mengetahui pengaruh tingkat pengetahuan, sikap dan perilaku dengan kejadian COVID-19 pada mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan (FKIK Unwar). Metode: Rancangan analitik ini menggunakan studi cross sectional dan dilaksanakan pada bulan Oktober – November 2021. Sebanyak 88 sampel dipilih dengan purposive sampling dari mahasiswa angkatan 2018-2020 di lingkungan FKIK Unwar. Data dianalisis sengan uji Fisher Exact (p<0,05). Hasil: Mahasiswa kedokteran memiliki pengetahuan persentase 94,3% dalam kategori baik, sikap positif 79,5% dan perilaku positif 55,7% terhadap COVID-19 meskipun tidak terdapat pengaruh bermakna (p>0,05). Simpulan: Edukasi dan penerapan protokol kesehatan yang ketat di FKIK Unwar meningkatkan pengetahuan, perilaku, dan sikap mahasiswa FKIK Unwar. Hal ini terkait rendahnya kejadian COVID-19 di FKIK Unwar selama 3 bulan terakhir.
Hubungan hipertensi dengan kejadian presbikusis di Poliklinik THT-KL RSUP Sanglah Denpasar Agus Santosa; Pande Ayu Naya Kasih Permatananda; I Putu Wirasatya Eka Putra
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.1451

Abstract

Introduction: Presbycusis or age-related hearing loss has several risk factors, with hypertension as one of them. Hypertension might cause presbycusis since it can interfere with nutrient and oxygen intake to the auditory nerve cells of the ear. This study aimed to determine the relationship between hypertension with the incidence of presbycusis at the Poliklinik THT-KL RSUP Sanglah Denpasar. Methods: This study used an analytic retrospective design and cross-sectional method. The study was conducted at the Poliklinik THT-KL RSUP Sanglah Denpasar with a sample of 60 people. Data were obtained using medical records and analyzed univariately and bivariate using SPSS for Windows with a p-value of 0.05. Results: Most subjects are 65-75 years old rather than >75, with male subjects of the same amount as female subjects. Chi-square test (x2) distribution table analysis demonstrated an association between hypertension and presbycusis incident in Poliklinik THT-KL RSUP Sanglah Denpasar with a p-value of 0,002. Conclusion: Most samples are in the 65-75 age range with the same proportionate amount of gender. There is an association between hypertension and presbycusis in Poliklinik THT-KL RSUP Sanglah Denpasar.   Latar Belakang: Presbikusis atau age related hearing loss memiliki beberapa faktor resiko dengan hipertensi sebagai salah satunya. Hipertensi dapat menyebabkan presbikusis karena dapat mengganggu asupan nutrisi dan oksigen sel-sel saraf auditori di telinga. Penelitian ini bertujuan mengidentifikasi hubungan hipertensi dan kejadian presbikusis di poliklinik Telinga, Hidung, Tenggorokan, Bedah Kepala dan Leher (THT-KL) RSUP Sanglah Denpasar. Metode: Desain yang digunakan yakni retrospektif analitik dan metode cross-sectional. Lokasi penenlitian yakni poliklinik THT-KL RSUP Sanglah Denpasar dan jumlah sampel 60 orang. Data diperoleh dengan menggunakan rekam medis dan dianalisis secara univariat dan bivariat melalui aplikasi SPSS dengan nilai p ≤ 0,05. Hasil: Didapatkan sampel lebih banyak berumur 65-75 tahun dibanding sampel berumur >75 tahun. Untuk jenis kelamin, ditemukan sampel dalam proporsi yang sama dan dari hasil uji chi square, didapat adanya korelasi antara hipertensi dengan kejadian presbikusis di Poliklinik THT-KL RSUP Sanglah Denpasar dengan nilai p = 0,002. Simpulan: Mayoritas sampel berumur 65-75 tahun dengan proporsi jenis kelamin yang sama. Diperoleh hubungan hipertensi dan kejadian presbikusis di poliklinik THT-KL RSUP Sanglah Denpasar.
The role of mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) on cytokine production during dengue virus infection Sri Masyeni; Kuntaman Kuntaman; Aryati Aryati; Muchlis AU. Sofro; Usman Hadi; Gondo Mastutik; Windu Purnomo; Agus Santosa; Muhammad Iqhrammullah; Benediktus Yohan; Erni J. Nelwan; R. Tedjo Sasmono
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.167

Abstract

Inability to understand the pathogenesis of severe dengue, in particular the control mechanism of immune responses, has led to high mortality rate for patients with dengue shock syndrome (DSS). The aim of this study was to determine the control mechanism of cytokine production by mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) during DENV infection. Peripheral blood mononuclear blood cells (PBMC), isolated from healthy individuals, were infected with dengue virus (DENV)-2 strain SJN-006 Cosmopolitan genotype (isolated from Bali, Indonesia). The relative gene expression of SOCS-3, TLR-3, NFκB, and the cytokine genes (interleukin (IL)-6, IL-8, interferon inducible protein 10 (IP-10), and macrophage inflammatory protein-1 beta (MIP-1β)) were measured using qRT-PCR at 6, 12 and 24 hours post infection (hpi). Student t-test and Mann-Whitney test were used to compare the gene expressions while causal correlations were analyzed using regression test and path analyses. DENV-2 infection increased the gene expression of SOCS-3, TLR-3, and NFκB after 12 and 24 hpi. The expression of IL-6, IL-8, IP-10, and MIP-1β genes was increased and peaked at different times post-infection. NFκB and SOCS-3 genes likely have role in the upregulation of IL-8 and IL-6 gene expression, respectively. MIP-1β gene expression was significantly induced by both NFκB and SOCS-3. In conclusion, our study suggested that SOCS-3, TLR-3, and NFκB are important in regulating the production of IL-6, IL-8, IP-10, MIP-1β during early phase of DENV-2 infection. This enriches our understanding on pathogenesis pathway of DENV-associated cytokine storm.
The Effect of Type II DM on the Incidence of Sensorineural Deafness at Bali Royal General Hospital Agus Santosa; I Wayan Sulistiawan
WMJ (Warmadewa Medical Journal) Vol 7 No 1 (2022): May 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.1.4147.1-12

Abstract

Type II diabetes mellitus (DMT II) is a major health threat, and DM is known to be associated with sensorineural deafness. Age, duration of DM, hypertension and hypertriglycerides are believed to influence this process. This study aims to determine the relationship between type II DM and the incidence of sensorineural hearing loss at Bali Royal General Hospital. The study used a case control design which was carried out on patients admitted between July-September 2021 at Bali Royal General Hospital. The sampling technique employed in the DMT II group with sensorineural deafness was total random sampling, while for comparison, simple random sampling was used. The analyses were carried out by descriptive analysis, chi square test for bivariate data, and logistic regression test for multivariate analysis. The p value is said to be meaningful if <0.05. The whole process of data analysis in this study used SPSS.sav 25. The number of samples was 8 patients with an average age of 49.62 ± 8.45. The mean of RBS (Random Blood Sugar) sugar was 152.25±60.92 mg/dL, and FBS (Fasting Blood Sugar) was 87.87±14.09 mg/dL. Patients with low FBS values ​​and diabetes duration of <5 years had more normal hearing conditions in the right ear (60%), while patients with high FBS and diabetes duration of ≥5 years had more SNHL (66.7%). However, the two conditions did not show a statistically significant relationship (p>0.05). The results of multivariate analysis found that there was no significant relationship between FBS levels and age with hearing conditions in the left ear (p> 0.05). In this study, there was no significant relationship between FBS, duration of DM, pattern of drug consumption, age, and hypertension status of DM patients with the incidence of SNHL in the right and left ears. Keywords: Type II diabetes mellitus, sensorineural deafness, hearing loss
PEMBERDAYAAN KELOMPOK IBU PKK DI DESA KERTA KECAMATAN PAYANGAN KABUPATEN GIANYAR BALI SEBAGAI PEMBANTU JUMANTIK UNTUK MENCEGAH INFEKSI DEMAM BERDARAH DENGUE Sri Masyeni; A.A.G Indraningrat; P.A Suryanditha; Agus Santosa
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 4 No. 1 (2020)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wicaksana.4.1.2020.1-5

Abstract

Demam berdarah dengue (DBD) yang terjadi akibat infeksi virus Dengue merupakan penyakit yang mewabah tiap tahunnya di Bali dan Indonesia pada umumnya. Upaya menekan laju DBD khususnya melalui eradikasi vektor pembawa virus yaitu nyamuk Aedes aegypti perlu terus dilakukan dengan melibatkan peran serta masyarakat secara langsung. Penyuluhan mengenai DBD terhadap kelompok ibu PKK di Desa Kerta, Kecamatan Payangan, Kabupaten Gianyar, Provinsi Bali telah dilaksanakan dengan hasil yang memuaskan. Metode yang digunakan adalah presentasi dan diskusi melalui tatap muka. Hasil penyuluhan menunjukkan peningkatan pemahaman ibu-ibu PKK terhadap DBD dan upaya pencegahannya. Sebagai tindak lanjut kegiatan pengabdian ini, tim pembantu Jumantik dari anggota PKK Desa Kerta, Kecamatan Payangan telah dibentuk. Tim ini diharapkan berperan aktif dalam memonitoring dan meminimalisir tempat berkembang biak jentik nyamuk Aedes aegypti, serta secara aktif mensosialisasikan pencegahan DBD di lingkungan tempat tinggal mereka.
PEMBERDAYAAN KELOMPOK IBU PKK DI DESA RENON DALAM PENGELOLAAN DIIT DAN PEMANTAU MINUM OBAT PASIEN DIABETES Agus Santosa; D A P Niti Widari; K Irwan Setiawan; Vemi Hendrayani; Sri Masyeni
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 6 No. 2 (2022)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wicaksana.6.2.2022.47-52

Abstract

Penyakit diabetes mellitus merupakan penyakit metabolik yang ditandai dengan peningkatan kadar gula darah yang diakibatkan oleh berbagai faktor seperti kerusakan sel beta pancreas atau penyakit autoimun yang menimbulkan kerusakan pancreas. Kadar gula darah yang berkepanjangan akan memicu kerusakan sel endotel yang dapat mengakibatkan komplikasi seperti penyakit ginjal kronis, penyakit jantung dan stroke yang akan memicu permasalahan yang lebih kompleks. Salah satu cara untuk memperlambat munculnya komplikasi diabetes adalah melalui pengontrolan gula darah melalui pengelolaan diit diabetes serta mengonsumsi obat secara rutin. Dukungan keluarga terdekat sangat dibutuhkan dalam membantu penderita diabetes dalam kontrol gula darah. Kegiatan pengabdian ini bertujuan untuk memberdayakan mitra, yaitu kelompok ibu di desa Renon supaya bisa berperan sebagai pengelola diit dan pemantau minum obat pasien diabetes. Kegiatan diawali dengan rapat koordinasi, focus group discussion untuk menemukan permasalahan prioritas mitra. Solusi untuk mitra adalah pemberdayaan kelompok ibu tersebut yang diawali dengan pre-tes untuk mengukur tingkat pengetahuan ibu mengenai diabetes, penyampaian materi, praktek mengatur diit diabetes serta mengawasi minum obat. Pemaparan materi dilakukan melalui peragaan pamphlet, poster serta video dan diakhiri dengan post-test. Out-put kegiatan diukur dari peningkatan pengetahuan mitra dari hasil pre dan post-test dimana ditemukan peningkatan pengetahuan mitra sebanyak 75%. Outcome akan diukur dari tercapainya kontrol gula darah pasien dan terhambatnya komplikasi diabetes.
Hubungan Body Mass Index dengan Risiko Terjadinya Obstructive Sleep Apnea pada Mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa I Kadek Reynata Wihendra Pasek; Agus Santosa; Ni Wayan Rusni
Aesculapius Medical Journal Vol 5 No 1 (2025): February
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.5.1.2025.83-93

Abstract

Obstructive Sleep Apnea (OSA) is a sleep disorder that causes a reduction or blockage of airflow despite efforts to breathe. Body Mass Index (BMI) is one of the indicators used to determine an individual's weight status, whether they are underweight, have an ideal weight, or are overweight (obese). This study aims to determine the relationship between BMI and the risk of OSA among students at the Faculty of Medicine and Health Sciences, Warmadewa University. This is an observational analytical study with a cross-sectional design. The sample was obtained using stratified random sampling with a total of 97 samples. Data collection was done through questionnaires filled out by the respondents to obtain primary data. The independent variable in this study is Body Mass Index (BMI), while the dependent variable is the risk of Obstructive Sleep Apnea (OSA). Data analysis was performed using univariate and bivariate analysis. The correlation between BMI and OSA risk was measured using the Spearman test and crosstab. The results showed that the majority of respondents were male and 19 years old (35.1%), with a normal BMI status (58.8%). A total of 35.1% were at risk of developing OSA based on the Berlin questionnaire, and 64.9% were at risk of OSA based on the ESS questionnaire. The Berlin questionnaire showed a significant and very strong positive correlation between BMI and students at risk of OSA (p = 0.001; r = 0.899). Meanwhile, the ESS questionnaire showed a significant and moderate positive correlation between BMI and OSA risk (p = 0.001; r = 0.442).  
Hubungan Usia dan Jenis Kelamin dengan Kejadian Otitis Media Supuratif Kronik di RSUD Wangaya Tahun 2018 - 2024 Pande Made Adhitya Yogantara; Ni Wayan Widhidewi; Agus Santosa
Aesculapius Medical Journal Vol 5 No 2 (2025): June
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.5.2.2025.113-121

Abstract

Otitis Media Supuratif Kronik (OMSK) merupakan infeksi kronis pada telinga tengah yang ditandai dengan adanya perforasi atau kerusakan pada membran timpani, yang berlangsung selama lebih dari dua bulan, baik secara terus-menerus maupun kambuhan. Terdapat dua jenis OMSK yaitu tipe tubotimpani atau yang tidak berbahaya dan tipe atikoantral atau jenis yang cukup berbahaya. Kejadian tersering terjadi pada anak-anak hingga dewasa muda dan jenis kelamin laki-laki lebih banyak terdampak karena dikaitkan dengan aktifitas fisik yang lebih banyak dan pola hidup kurang sehat dibandingkan perempuan.
Pemberdayaan Kelompok Ibu PKK di Desa Kerta Kecamatan Payangan Kabupaten Gianyar Bali Sebagai Pembantu Jumantik untuk Mencegah Infeksi Demam Berdarah Dengue DAP Sri Masyeni; AAG Indraningrat; PA Suryandhita; Agus Santosa
Community Service Journal (CSJ) Vol. 3 No. 2 (2021)
Publisher : Lembaga Pengabdian Kepada Masyarakat, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/csj.3.2.2021.66-69

Abstract

Demam berdarah dengue (DBD) yang terjadi akibat infeksi virus Dengue merupakan penyakit yang mewabah tiap tahunnya di Bali dan Indonesia pada umumnya. Upaya menekan laju DBD khususnya melalui eradikasi vektor pembawa virus yaitu nyamuk Aedes aegypti perlu terus dilakukan dengan melibatkan peran serta masyarakat secara langsung. Penyuluhan mengenai DBD terhadap kelompok ibu PKK di Desa Kerta, Kecamatan Payangan, Kabupaten Gianyar, Provinsi Bali telah dilaksanakan dengan hasil yang memuaskan. Metode yang digunakan adalah presentasi dan diskusi melalui tatap muka. Hasil penyuluhan menunjukkan peningkatan pemahaman ibu-ibu PKK terhadap DBD dan upaya pencegahannya. Sebagai tindak lanjut kegiatan pengabdian ini, tim pembantu Jumantik dari anggota PKK Desa Kerta, Kecamatan Payangan telah dibentuk. Tim ini diharapkan berperan aktif dalam memonitoring dan meminimalisir tempat berkembang biak jentik nyamuk Aedes aegypti, serta secara aktif mensosialisasikan pencegahan DBD di lingkungan tempat tinggal mereka.
Co-Authors Anak Agung Gede Indraningrat Anak Agung Sri Agung Aryastuti Angga Priyana Aryati Aryati Aryati Aryati Asri Lestarini Benediktus Yohan Benediktus Yohan Cahyawati, Putu Nita DAP Sri Masyeni Dewa Ayu Niti Widari Erni J. Nelwan Erni Juwita Nelwan, Erni Juwita Gondo Mastutik I Kadek Reynata Wihendra Pasek I Putu Wirasatya Eka Putra I Wayan Sulistiawan K Irwan Setiawan Kuntaman Kuntaman Kuntaman Kuntaman Luh Gde Evayanti Muchlis AU Sofro Muchlis AU. Sofro Muhammad Iqhrammullah Ni Luh Anik Puspa Ningsih Ni Wayan Rusni Ni Wayan Widhidewi P.A Suryanditha PA Suryandhita Pande Ayu Naya Kasih Permatananda Pande Made Adhitya Yogantara R. Tedjo Sasmono R. Tedjo Sasmono Sri Masyeni, Dewa Ayu Putri Usman Hadi Vemi Hendrayani Windu Purnomo