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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL KIMIA SAINS DAN APLIKASI Teknotan: Jurnal Industri Teknologi Pertanian Jurnal Ilmu Kimia Universitas Brawijaya Journal of Innovation and Applied Technology Jurnal Pembangunan dan Alam Lestari Natural B The Journal of Pure and Applied Chemistry Research Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry Indonesian Food Science and TechnologyJournal Media Akuakultur ALKIMIA : Jurnal Ilmu Kimia dan Terapan Makara Journal of Science Bulletin of Chemical Reaction Engineering & Catalysis
Siti Mariyah Ulfa
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Engineering Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences Other

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Shortcut Approach to 1,4-Diazepine from 3-Pyridylnitrene Intermedietes under Mild Condition Ulfa, Siti Mariyah; Okamoto, Hideki; Satake, Kyosuke
The Journal of Pure and Applied Chemistry Research Vol. 3 No. 3 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (493.978 KB) | DOI: 10.21776/ub.jpacr.%y.03.03.188

Abstract

The reaction of nitropyridine derivatives and tributylphosphine (Bu3P) with the existence of nucleophilic solvent gives ring expansion product as diazepines in medium yield. Reaction mechanism subjected the formation of phenylnitrene, followed by intramolecular electrophilic insertion reaction to pyridine ring and subsequent ring enlargement. The intermediate in the reaction confirmed by computational calculation using B3LYP/6-31G* level. The intramolecular insertion reaction of pyridylnitrene is considered suppressed by the low HOMO (-9.932 eV) energy level of pyridine ring compared to that of benzene (-9.653 eV), hence 1,4-diazepine is obtained when employed 3-nitro-2,6-lutidine as starting material. The formation of diazepines was confirmed by the analysis of 1H NMR data. Separation of the product mixture using column chromatography on SiO2 was carried out and found to give expected diazepine along with the reduction product.
RETRACTED ARTICLE: Study on Esterification Reaction of Starch Isolated from Cassava (Manihot Esculenta) with Acetic Acid and Isopropyl Myristate Using Ultrasonicator Amini, Helda Wika; Masruri, Masruri; Ulfa, Siti Mariyah
The Journal of Pure and Applied Chemistry Research Vol. 6 No. 2 (2017): Edition of May-August 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.%y.06.02.299

Abstract

This article has been retracted at the request of managing editor.REASON: One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not prepared and/or appeared in any other publication elsewhere. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.Similar article has appeared in http://iopscience.iop.org/article/10.1088/1757-899X/299/1/012079/pdf 
Hydrogenation of Alpha-pinene over Nickel Nanoparticles under Mild Condition Pressure Rizqi Alima Fabri, Ahmad; Warsito, Warsito; Ulfa, Siti Mariyah; Masruri
The Journal of Pure and Applied Chemistry Research Vol. 13 No. 3 (2024): Edition September-December 2024
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2024.013.03.7916

Abstract

Alpha-pinene is the main compound in turpentine oil and is widely used as a fragrance, fine chemistry, flavour, and antibacterial. Due to the presence of unsaturated double bonds in its structure, this compound’s chemical properties are relatively active. Hydrogenation is a common method for saturating compounds and nickel has shown good activity in this process as catalysts. However, it often shows reaction conditions such as high pressure. The research method added nickel chloride to a suspension mixture of NaBH4 in isopropyl alcohol until a black colloidal solution and a-pinene reagents were added. Hydrogen gas was added in different conditions, with a pressure of 2-4 atm at the temperature of 50-60 oC 24h. The result showed a nickel formed at a nanoparticle size of 34-81 nm. Furthermore, FT-IR results show a difference in intensity at wavelengths of 1600 and 3000 cm-1, indicating the formation of hydrogenation products. The GC-MS shows a new peak at a retentivity of 5.503, which characteristics show that it is identified as a pinane compound with the highest percentage of 63% at a reaction condition of 4 atm. 
Freeze-Drying Microencapsulation of Ruellia tuberosa L. Extracts: A Comparative Study Using Different Polymers as Encapsulants Gunawan, Firza Rajasa; Ulfa, Siti Mariyah; Safitri, Anna
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95246

Abstract

Ruellia tuberosa L. leaf and root extracts have been investigated for their biological activity and potential health advantages, including their antidiabetic, antioxidant, and antidiuretic qualities. This research evaluates the freeze-drying microencapsulation of R. tuberosa L. extracts using gum Arabic, maltodextrin, and their combination as coating materials. The resulting microcapsules were tested for encapsulation efficiency, biological activity, and controlled release. Characterization techniques included scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and particle size analysis (PSA). The choice of encapsulant significantly influenced encapsulation efficiency, morphology, and biological activity. Microcapsules using a combination of gum Arabic and maltodextrin exhibited more spherical shapes and smaller particle sizes than those using either material alone. Alpha-amylase inhibition tests showed that microcapsules effectively inhibit the enzyme, with the coating combination performing best, followed by gum Arabic and then maltodextrin. All microcapsules exhibit moderate antioxidant activity, again in the same order. The active compound release was greater at pH 7.4 compared to pH 2.2 from 0 to 120 min. Therefore, freeze-drying microencapsulation with biodegradable polymers is a viable method for delivering the health benefits of R. tuberosa L. extracts, yielding a convenient powder form suitable for drug delivery systems.
Daruju (Acanthus ilicifolius L.) May Exhibit Anti-Breast Cancer Activity Through Inhibition of Proliferation Regulators: A Computational Study: Daruju (Acanthus ilicifolius L.) as Anti-Breast Cancer Agent Rosyadah, Nuraini; Kamila, Fairuz Sarah; Hermanto, Feri Eko; Widyananda, Muhammad Hermawan; Grahadi, Rahmat; Dwijayanti, Dinia Rizqi; Widodo, Nashi; Ulfa, Siti Mariyah
Journal of Tropical Life Science Vol. 15 No. 1 (2025)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/

Abstract

Breast cancer's increasing prevalence globally underscores the urgent need for effective and gentle therapies, positioning the exploration of herbal remedies as a critical pursuit. Daruju (Acanthus ilicifolius L.) emerges as a compelling candidate due to its inherent bioactive components. This research pioneers the application of advanced computational techniques to unveil the latent anti-breast cancer potential within A. ilicifolius. Our in-silico investigation commenced by cataloging A. ilicifolius compounds using the KNApSAcK database and existing literature. These compounds underwent rigorous screening for drug-like characteristics via SWISS-ADME and potential biological activity using PASS ONLINE. Protein targets relevant to breast cancer were predicted through SWISS Target and the STRING database, integrated with Cytoscape for network visualization. Molecular docking, performed with PyRx 0.8, assessed the binding strength between the identified compounds and target proteins, with the most promising interactions selected for further scrutiny. The stability of these crucial interactions was then evaluated through molecular dynamics simulations using YASARA. This comprehensive computational strategy aims to pinpoint potential anti-breast cancer agents derived from A. ilicifolius. Initial analysis of 17 compounds from A. ilicifolius, based on chromatography, databases, and prior studies, narrowed down to five that adhered to Lipinski’s Rule of Five for drug-likeness: 4-O-beta-D-glucosyl-4-coumaric acid, (-)-lyoniresinol, α-amyrin, adenosine, and p-coumaric acid. These compounds were predicted to directly interact with key breast cancer-related proteins across pathways like estrogen signaling, JAK/STAT, and PI3K/AKT. Notably, molecular docking revealed strong binding affinities for α-amyrin with CDK4, ER, and EGFR (-7.5 kcal/mol, -9.5 kcal/mol, and -8.7 kcal/mol, respectively), comparable to known inhibitors. Molecular dynamics simulations further corroborated the stability of these complexes, analyzing RMSD and binding affinity parameters. Consequently, α-amyrin stands out as a promising anti-breast cancer agent within A. ilicifolius, exhibiting potential to inhibit proteins crucial for breast cancer cell proliferation and survival, including CDK4, ER, and EGFR.
Influence of Solvent Polarity on Color Intensity of Marigold Flower Extracts Retnowati, Rurini; Sulistyarti, Hermin; Suratmo; Ulfa, Siti Mariyah; Kamulyan, Budi; Destiara, Irena Amelia; Muzdhalifa, Sefira Putri; Ananda, Regina Ridha
ALKIMIA Vol 10 No 1 (2026): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/gfzt5f62

Abstract

In this paper, we report research on the extraction of natural dyes from yellow and orange marigold (Tagetes erecta L.) petals using different solvents. This research aims to determine the optimal dye removal process, investigate stability, and establish color intensity profiles. In order to extract natural dyes that produced various shades of the dried powder of yellow and orange marigold flower petals, two solvents with different polarities, n-hexane and ethyl acetate were used. The maceration procedure using different solvent types was carried out separately. The stability study revealed that all the dyes at room temperature showed better stability with minor changes observed by UV-Visible (UV-Vis) spectrum profiles, indicating that the extracts were stable until the 30th day. To ascertain the color intensity profiles, analytical tests such as UV-Vis spectroscopy and colorimetry utilizing a color reader device were carried out. The color intensity profile of the yellow and orange marigold flower extracts resulting from the UV-Vis spectrum analysis showed that the absorption of the ethyl acetate extract is higher. The pigment concentration, which is also expressed by absorbance, is connected to variations in color intensity. Additionally, the color intensity profile characterization using a color reader revealed that the n-hexane and ethyl acetate extracts had different Commission Internationale d'Eclairage (CIE) L*, a*, and b* values. The yield and color intensity of the extracts were affected by the solvent polarity. In conclusion, the study of the extract's color intensity profile using UV-Vis spectroscopy and a color reader shows that the intensity parameters are aligned.
Co-Authors A.A. Ketut Agung Cahyawan W Adam Mahfud Ade Cintyia Sally Al zamzami, Ilham Misbakudin Alma Miranda Amaniyah, Amaniyah Amin, Abd Aziz Amini, Helda Wika Ananda, Regina Ridha Andi Kurniawan Andi Kurniawan Anggayasti, Wresti L. Anjani, Ryzki Martha Arda Rista Lestari Budi Kamulyan Caterina Widya Astutik Chairulita Putri Kusumaningsih Destiara, Irena Amelia Dinia Rizqi Dwijayanti Dwi Susanti, Yogita Ayu Edi Priyo Utomo Edi Priyo Utomo Edi Priyo Utomo Efani, Anton Eka Novitasari Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah Esya, Firdausy Amalina Fadlilah, Lilik Nur Fath Dwisari Fatma, Aliya Galisong, Ridwan Danuarta Grahadi, Rahmat Gunawan, Firza Rajasa Hapsari, Febriyana Rizky Helda Wika Amini Hermanto, Feri Eko Hermin Sulistyarti Hidayatul Mustafidah Hideki Okamoto Hideki Okamoto Iftitah, Elvina Dhiaul Indah Nur Pramesti Inra Sari Kamila, Fairuz Sarah Karimah Karimah Kyosuke Satake Kyosuke Satake Lisa Aulia, Lisa Listianingsih, Lia Lukman Hakim Lutfi Ni’matus Salamah Luthfia Ayu Dhea Maharani Pertiwi Koentjoro Mahfuzh Huda Masruri Masruri Masruri Masruri Masruri Moehammad, Khibar Syiar Moh. Farid Rahman Mohammad Elham Firdaus Mohammad Farid Rahman Mohammad Farid Rahman Momodou Salieu Sowe Momodou Salieu Sowe Muzdhalifa, Sefira Putri Nashi Widodo Nisa', Khibrun Nur Ikhtiarini Nuraini Uswatun Chasana Pangesti, Laras Pramudia, Zulkisam Pratama, Safreno Panggih Pratiwi, Rahmania Tulus Setya Prihartini, Dita Puspitasari, Rizka Dwitya Rachmat Triandi Tjahjanto Rizka Fauzia Ohorella Rizqi Alima Fabri, Ahmad Rosyadah, Nuraini Rurini Retnowati Safitri, Anna Salamah, Lutfi Ni’matus Suratmo Suratmo, Suratmo SUTRISNO Sutrisno, Sutrisno Utomo, Edi Priyo Wardani, Eris Agustin Warsito Warsito Warsito Warsito Widia Edy Kuncoro Widodo Widodo Widyananda, Muhammad Hermawan Yanuar, Adi Tiya Yosua Yosua Yulistian, Dhoni Prielananta Yusnawan, Eriyanto Yusuf Hendrawan Zahara, Izaz Aqeiluz