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All Journal Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal SOLMA Dinamisia: Jurnal Pengabdian Kepada Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM Ensiklopedia of Journal Jurnal Keperawatan Florence Nightingale ASMAT: Jurnal Pengabmas Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS) JURNAL BIOLOGI PAPUA Barongko : Jurnal Ilmu Kesehatan International Journal of Health Sciences Gema Kesehatan Journal of Business, Accounting and Finance Miracle Get Journal Bulletin of Inspiring Developments and Achievements in Midwifery Science Get Journal Jurnal Keperawatan Tropis Papua Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Knowledge and Environmental Science for Living and Global Health
Yunita Kristina
Universitas Cenderawasih
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : science get journal

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A Comprehensive Review of Probiotic Mechanisms and Their Implementation in Gastrointestinal Health Management Yunita Kristina; Ipah Kurnia Putri
Science Journal Get Press Vol 2 No 2 (2025): April, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v2i2.131

Abstract

Probiotics, which are live microorganisms that benefit the host, have been shown to be effective in preventing and treating antibiotic-associated diarrhea (AAD). However, the specific molecular mechanisms of individual probiotic strains remain poorly understood. This study aims to explore strain-specific approaches for managing gastrointestinal disorders and to provide a scientific overview of the benefits and mechanisms of probiotics in maintaining and improving gut health through complex and interconnected pathways. A systematic literature search was conducted using keywords such as “probiotics,” “gut microbiota,” “strain-specific mechanisms,” “gastrointestinal health,” “host-microbe interaction,” and “synbiotics,” across reputable databases including PubMed, Scopus, ScienceDirect, and Google Scholar. The methodological quality and strength of evidence for each study were assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) framework. Numerous studies have confirmed that probiotics help prevent and treat AAD and may also reduce the risk of irritable bowel syndrome (IBS) and inflammatory bowel diseases. Clinical trials have also shown promising results regarding the ability of various probiotic strains to balance the mucosal immune system and gut microbiota. However, comprehensive research on the synergistic interactions between probiotic and prebiotic strains remains limited. Therefore, future studies should focus on cross-omic approaches, exploration of local strains from traditional diets, and personalized strategies to optimize the efficacy of probiotics in supporting gastrointestinal health.
Co-Authors Ainal Mardiah Andi Kamal M. Sallo Arie Anggraini Asikin, Siti Badria` Atun Qowiyyah B.B, Fransisca Cahyani, Vini Christy Wattimena Diyah Astuti Nurfa'izah Eka Afrika eka rahmawati Emma Jayanti Besan Endang Sulistyowati Ernawati Ernawati Eva Sinaga EVA SINAGA Evi Sinaga Fitri Khairani Fransisca B.B Hadija Hadijah Hadijah Happy Lumbantobing, Happy Hartaty, Hartaty Herlina Herlina Herman, Theresie Chindyana Hotnida Erlin Situmorang Ipah Kurnia Putri Ismiyanti H. Achmad Kaluku, Suratno Kismiyati Kismiyati Korinus Suweni Korinus Suweni Korinus Suweni Latumenase, Rony A. Lukita, Yenni M, Warda Mambrasar, Gloria A Mayland Hamong Mildaratu, Mildaratu Mutiara Hikmah Ningsih, Warti Nordianiwati, Nordianiwati Nukuhaly, Hasnawati Nurmiati Nurmiati Pannyiwi, Rahmat Pella, Yosin Herloheti Priskilla Irene Sahureka Purba, Ellen R.V. Puteri, Mahfuzhah Deswita R Siti Rukayah RACHMAT RAMLI Rahayu Tri Nuritasari Rahmat Pannyiwi Reffita, Lea Ingne Riswanti, Riswanti Rizky Auliah Juniarti Rohemah, Rohemah Sabriana, Riska Safridha Kemala Putri Salakory, Jacomina Anthonete Samsir Saputra, M. Khalid Fredy Sari, Rani Puspita Sasarari , Zusana A Sinaga, Jernita Sintia, Kiki Sitorus, Jenti Sri Ariyanti Srifitayani, Nur Rahma Sudarman, Dirman Sumarah Susanti Susanti, Ni Made Dewi Tianingsih, Yulis Wahidyanti Rahayu Hastutiningtyas Wahyuni, Emmy Putri Wattimena, Christy Wawan Gunawan Widya, Wastu Wuriani, Wuriani Yanti, Lilis Candra Yully Asmariana Zahra, Fadila Aulia Ziza Putri Aisyia Fauzi Zusana A Sasarari Zusana Anggreana Sasarari