Article Per Year (5 Year)
p-Index From 2021 - 2026
0.817
P-Index
This Author published in this journals
All Journal VALENSI Alchemy Jurnal Penelitian Kimia Indonesian Journal of Chemical Science ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia Bulletin of Chemical Reaction Engineering & Catalysis
Fajar Rakhman Wibowo
Departmen Of Chemistry, Faculty Of Mathematics And Natural Sciences, Sebelas Maret State University, Surakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Advances in Mesoporous Silica Nanoparticles: Synthesis, Characterization, and Biomedical Uses Saputra, Ozi Adi; Safitriono, Wahyu Nur; Istiqomah, Annisa; Kumalasari, Meiyanti Ratna; Irmawan, Muhammad; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art9

Abstract

Mesoporous silica nanoparticles (MSNs) have drawn significant attention due to their exceptional properties and diverse range of applications, particularly in nanomedicine. The distinctive properties of MSNs, such as their high surface area, tunable pore size, and versatile surface chemistry, make them ideal candidates for various biomedical applications. This review aims to present a detailed understanding of MSNs, from synthesis and characterization to their versatile applications in biomedicine, highlighting their significant potential in advancing healthcare technologies. The synthesis methods for MSNs were comprehensively discussed, emphasizing the influence of parameters like solvent, base, alkoxysilane concentrations, and template surfactants on the size and shape of the nanostructures. Different types of MSNs, including MCM-41, SBA-15, KIT-6, and hollow MSNs, are discussed, along with their synthesis protocols and unique characteristics. The review also covers various spectroscopic techniques, such as XRD, XPS, FTIR, NMR, and fluorescence spectroscopy, which are crucial for characterizing MSNs. Furthermore, the biomedical applications of MSNs are highlighted, demonstrating their potential in drug delivery systems, imaging, and diagnostics. The review concludes with a discussion of the future perspectives and challenges in the field, providing insights into potential developments and the prospects for clinical translation.
Search for SARS-CoV-2 Inhibitors. Is it still needed?Molecular Docking Study of Teicoplanin Derivatives and Vancomycin against SARS-CoV-2 Mpro Mulyani, Sri; Lestari, Nova Dwi; Samodra, Imam; Wibowo, Fajar Rakhman; VH, Elfi Susanti; Ardyanto, Tonang Dwi
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 1, May 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.44709

Abstract

Coronaviruses have been known since 2002 in the case of SARS (Severe Acute Respiratory Syndrome). SARS-CoV-2, the cause of the COVID-19 pandemic, is believed to be an evolution of the SARS-causing coronavirus (SARS-CoV). This evolution shows the complex interaction dynamics between the virus and the host, which have characterized the emergence of new SARS-CoV-2 strain variations until now. Therefore, the search for these antiviral drugs is still critical. MPro is one of the important proteins for the life cycle of pathogenic coronaviruses, so it is an attractive target for developing drugs that inhibit this virus. This study examined the interaction of teicoplanin derivatives and vancomycin as SARS-CoV-2 MPro (6LU7) inhibitors through molecular docking with Autodock Vina. The smallest RMSD value was selected and stored to calculate the energy value. The image of atoms in the ligand and receptor was processed with Autodock Tools, LigPlus, and PyMOL. The study showed that teicoplanin derivatives such as teicoplanin aglycone, teicoplanin-A3-1, and vancomycin had the potential as SARS-CoV-2 Mpro inhibitors. Based on the interaction at the active site and the obtained ΔG values, even the teicoplanin aglycon had a more significant inhibitory potential than other potent inhibitors such as N3.
Nanostructured Lipid Carriers Termodifikasi Kitosan dari Cangkang Keong Mas (Pomacea canaliculata) sebagai Penghantar Obat Kurkumin yang Terkontrol dan Tertargret Sel Kanker Payudara Husna Habib Musthofa; Puput Veronikasari; Rossalia Soraya; Muhammad Nursyam Maulana; Hilmi Amirul Haq; Fajar Rakhman Wibowo
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 2 (2025): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.2.92355.264-276

Abstract

Pengobatan kanker payudara saat ini masih sangat bergantung pada kemoterapi yang memiliki efek samping fisik dan psikologis. Kurkumin mudah terdegradasi dan memiliki biavaibilitas yang rendah. Kurkumin adalah senyawa lipofilik yang stabilitasnya dapat ditingkatkan dengan menggunakan sistem penghantaran obat berbasis Nanostructured Lipid Carriers (NLCs) yang dimodifikasi dengan kitosan untuk melindungi bahan tersebut dari degradasi dalam sistem oral. Asam folat juga digunakan untuk menargetkan sel kanker payudara T47D. Kitosan disintesis dari cangkang keong mas menghasilkan bubuk putih (32,28%) dengan derajat deasetilasi 76,55%. Kitosan dikonjugasikan dengan asam folat (Chi-FA). Material NLCs termuat kurkumin disintesis melalui reaksi emulsi-evaporasi-solidifikasi. Material NLCs termuat kurkumin (Cur@NLCs) menunjukkan dua model matriks berdasarkan uji transmitansinya dengan distribusi ukuran partikel sebesar 174,4 nm dan zeta potensial -56,9 mV. Modifikasi permukaan Cur@NLCs dengan Chi-FA menghasilkan ukuran partikel 105,5 nm dan potensial zeta -45,9 mV. Studi pelepasan menunjukkan bahwa keberadaan kitosan dapat menekan pelepasan kurkumin dalam phosphate buffered saline (PBS) pada pH 1,2 dan pH 7,4 serta meningkatkan laju pelepasan pada pH 6,8. Uji toksisitas material menunjukkan peningkatan toksisitas pada sel T-47D. Penelitian ini menunjukkan bahwa modifikasi tersebut dapat mengontrol dan menargetkan sel kanker.Nanostructured Lipid Carriers Modified with Chitosan from Golden Apple Snail Shells (Pomacea canaliculata) as Controlled and Targeted Curcumin Drug Delivery for Breast Cancer Cells. Current breast cancer treatment still relies heavily on chemotherapy, which has physical and psychological side effects. Curcumin is easily degraded and has low bioavailability. Curcumin is a lipophilic compound whose stability can be improved by using Nanostructured Lipid Carriers (NLCs)-based drug delivery systems modified with chitosan to protect the material from degradation in the oral system. Folic acid is also used to target T47D breast cancer cells. Chitosan was synthesized from golden apple snail shells to produce a white powder (32.28%) with a deacetylation degree of 76.55%. The chitosan was conjugated with folic acid (Chi-FA). Curcumin-loaded NLCs were synthesized through an emulsion-evaporation-solidification reaction. Curcumin-loaded NLCs (Cur@NLCs) showed two matrix models based on the transmittance test with a particle size distribution of 174.4 nm and a zeta potential of -56.9 mV. Surface modification of Cur@NLCs with Chi-FA resulted in a particle size of 105.5 nm and a zeta potential of -45.9 mV. Release studies showed that the presence of chitosan could suppress the release of curcumin in PBS at pH 1.2 and pH 7.4, and increase the release rate at pH 6.8. The material toxicity test showed an increase in toxicity to T-47D cells. This study shows that the modification can control and target cancer cells.
Co-Authors Ali Triambodo, Ali Angeline Prita C, Angeline Prita Annisa Istiqomah, Annisa Bambang Heru Susanto, Bambang Heru Desi Suci Handayani Elfi Susanti V. H. Elfrida Ratnawati Gesti Munasah Hilmi Amirul Haq Husna Habib Musthofa Irmawan, Muhammad Lestari, Nova Dwi Maulidan Firdaus Muhamad Widyo Wartono Muhammad Nursyam Maulana Nestri H, Nestri Nestri Handayani, Nestri Ozi Adi Saputra, Ozi Adi Puput Veronikasari Purwanti . Riandy Putra Rita Rakhmawati, Rita Rossalia Soraya Safitriono, Wahyu Nur Samodra, Imam Sari, Meiyanti Ratna Kumala Soerya Dewi M, Soerya Dewi Soerya Dewi Marliana, Soerya Dewi Soerya Dewi Marliyana Soerya Dewi Marliyana Sri Mulyani Tahara, Alfia Uke Teddy Prayoga, Teddy Tonang Dwi Ardyanto Triana Kusumaningsih Venty Suryanti Witri Wahyu Lestari