Article Per Year (5 Year)
p-Index From 2021 - 2026
1.642
P-Index
This Author published in this journals
All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Chemical Science ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia PRIMA: Journal of Community Empowering and Services Molekul: Jurnal Ilmiah Kimia Bulletin of Chemical Reaction Engineering & Catalysis
Fajar Rakhman Wibowo
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Environmental Science Materials Science & Nanotechnology

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 15 Documents
Search

 1   2 
The Initial Screening of Heavy Metal Adsorption on Highly Porous Metal-Organic Frameworks based on MIL-101(Cr), Ethylenediamine-modified MIL-101(Cr), and MIL-101(Cr)-NH2 Dendy, Dendy; Lestari, Witri Wahyu; Anshori, Isa; Rahardjo, Sentot Budi; Pramono, Edi; Saraswati, Teguh Endah; Wibowo, Fajar Rakhman
Molekul Vol 21 No 1 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.1.17186

Abstract

ABSTRACT. Heavy metal pollution is a significant environmental issue with detrimental effects on ecosystem and human health. Therefore, comprehensive handling need to be carried out. Herein we studied initial screening adsorption of heavy metals including Ni, Cu, Zn, Cd, and Pb using Metal-Organic Frameworks class of Materials Institute Lavoisier (MIL) based on Cr(III). MIL-101(Cr), and its modification with ethylenediamine (EA), and MIL-101(Cr)-NH2 were prepared under hydrothermal condition. X-ray diffraction and FT-IR analysis confirmed the formation of the targeted materials. A new absorption band at 1050 cm-1 corresponds to vibration of C-N which indicates the successful EA modification into MIL-101(Cr). Nitrogen sorption isotherm measurement revealed MIL-101(Cr) and EA@MIL-101(Cr) have a specific surface area of 2548.6 and 2079 m²/g with micropore-sized, while MIL-101(Cr)-NH2 has a specific surface area of 1583.4 m²/g with micro and mesopore-sized. Adsorption performance was assessed through batch experiments monitored by atomic absorption spectroscopy. The results show that MIL-101(Cr) and its modification with EA exhibit higher adsorption capacities on cadmium and nickel metal ions, compared to MIL-101(Cr)-NH2. Meanwhile, MIL-101(Cr)-NH2 and MIL-101(Cr) show more dominant adsorption capabilities on zinc and copper ions compared to the EA-modified MIL-101(Cr). This result suggests that the material's porosity still plays a dominant role in the adsorption processes compared to amine functionalize group on MIL itself. Keywords: adsorption, chromium(III), heavy metals, MOF, MIL
From Mesoporous Silica to MOF–Silica Composites: Advancements in Nanostructured Drug Delivery Systems Safitriono, Wahyu Nur; Saputra, Ozi Adi; Lestari, Witri Wahyu; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 9 No. 1 (2026): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol9.iss1.art4

Abstract

Recent advances in nanotechnology have enabled the development of versatile drug delivery systems (DDS) using nanoscale carriers, offering significant improvements over conventional therapies. Mesoporous silica nanoparticles (MSNs) and metal–organic frameworks (MOFs) are highly porous nanomaterials with tunable structures and large surface areas, making them promising platforms for drug delivery. MSNs provide controllable particle size, pore size, and surface functionality, allowing efficient loading and controlled release of both hydrophilic and hydrophobic drugs. MOFs, with their high surface area, adjustable pore structures, and chemical versatility, enable high drug loading capacity and stimuli-responsive release. Integrating MOFs with silica to form MOF–silica composites further enhance structural stability, biocompatibility, and drug delivery efficiency. Stimuli-responsive composites can minimize premature drug release and enable targeted delivery in response to environmental triggers, such as pH or near-infrared irradiation. This review highlights the structural and functional differences among MSNs, MOFs, and MOF–silica composites, and discusses their applications in delivering model therapeutic agents, including curcumin, quercetin, and doxorubicin. The advantages, limitations, and future perspectives of these nanocarriers for precision medicine are also addressed, emphasizing their potential to improve therapeutic efficacy while reducing off-target effects.
Pelapisan Phospolypid Lecithin pada Carbon Quantum Dots (CQDs) dari Tulang Ayam Terkonjugasi Silika Nanopartikel sebagai Penghantar Obat Vicky Ahava Ferdinansyah; Khoirun Nisa Ashar; Husna Habib Musthofa; Farikha Amalina Nurbaiti; Salma Aqilah Rachmadani; Fajar Rakhman Wibowo
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 1 (2025): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.1.80594.33-42

Abstract

Pengobatan kanker otak saat ini masih mengandalkan kemoterapi. Pada jaringan otak terdapat blood-brain barrier (BBB) yang menghambat pengiriman obat. Penelitian ini bertujuan untuk mengembangkan sistem penghantaran obat menggunakan Carbon Quantum Dots (CQDs) berbahan dasar tulang ayam terkonjugasi nanopartikel silika terkonjugasi (MSN) dan fosfolipid lesitin sebagai bahan yang potensial dalam mengobati kanker otak. Hasil CQDs yang disintesis secara hidrotermal menunjukkan pendaran cahaya biru di bawah sinar UV 365 nm dan puncak emisi pada 469 nm. MSN disintesis dan dikonjugasikan CQDs dengan metode solgel dan pemuatan doxorubicin (DOX) dengan adsorpsi obat. Pelapisan lipid pada DOX@MSN-CQDs dilakukan dengan teknik hidrasi lipid film dan ultrasonifikasi. Pelapisan lipid dan ukuran material pada MSN-CQDs dikonfirmasi menggunakan TEM dengan ukuran 93,77 ± 4,28 nm, FTIR, dan zeta potensial. Sintesis DOX@MSN-CQDs--L berhasil dilakukan diindikasikan dengan adanya perbedaan secara fisis dengan sifat lebih keruh dan warna yang lebih muda daripada MSN-CQDs. Hasil penelitian ini adalah pemuatan dan pelepasan doxorubicin berhasil dilakukan kapasitas pemuatan lebih dari 50% dan kumulatif pelepasan berkisar 73%. Material yang berhasil disintesis dalam penelitian ini berpotensi untuk diaplikasikan sebagai bahan teranostik dalam pengobatan kanker otak.The Coating of Phospolypid Lecithin on Carbon Quantum Dots (CQDs) Derived from Chicken Bone Conjugated with Silica Nanoparticle as Drug Delivery. Current brain cancer treatment still relies heavily on chemotherapy. However, the presence of the blood-brain barrier (BBB) in brain tissue hinders effective drug delivery. This study aims to develop a drug delivery system using carbon quantum dots (CQDs) prepared from chicken bone conjugated silica nanoparticles (MSN) and lecithin phospholipids as potential material for treating brain cancer. The CQDs synthesized via the hydrothermal method exhibited blue fluorescence under 365 nm UV light and an emission peak at 469 nm. MSN was synthesized and conjugated with CQDs using the sol-gel method, followed by doxorubicin (DOX) loading through drug adsorption. Lipid coating on DOX@MSN-CQDs was performed using the lipid film hydration technique and ultrasonication. The lipid coating and material size of MSN-CQDs were confirmed using TEM, with a size of 93.77 ± 4.28 nm, FTIR, and zeta potential measurements. The successful synthesis of DOX@MSN-CQDs-L was indicated by physical differences, such as a cloudier appearance and lighter color compared to MSN-CQDs. The results demonstrated successful DOX loading and release, with a loading capacity exceeding 50% and a cumulative release of approximately 73%. The materials successfully synthesized in this study have the potential to be applied as theranostic agents in brain cancer treatment.
Nanostructured Lipid Carriers Termodifikasi Kitosan dari Cangkang Keong Mas (Pomacea canaliculata) sebagai Penghantar Obat Kurkumin yang Terkontrol dan Tertargret Sel Kanker Payudara Husna Habib Musthofa; Puput Veronikasari; Rossalia Soraya; Muhammad Nursyam Maulana; Hilmi Amirul Haq; Fajar Rakhman Wibowo
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 2 (2025): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.2.92355.264-276

Abstract

Pengobatan kanker payudara saat ini masih sangat bergantung pada kemoterapi yang memiliki efek samping fisik dan psikologis. Kurkumin mudah terdegradasi dan memiliki biavaibilitas yang rendah. Kurkumin adalah senyawa lipofilik yang stabilitasnya dapat ditingkatkan dengan menggunakan sistem penghantaran obat berbasis Nanostructured Lipid Carriers (NLCs) yang dimodifikasi dengan kitosan untuk melindungi bahan tersebut dari degradasi dalam sistem oral. Asam folat juga digunakan untuk menargetkan sel kanker payudara T47D. Kitosan disintesis dari cangkang keong mas menghasilkan bubuk putih (32,28%) dengan derajat deasetilasi 76,55%. Kitosan dikonjugasikan dengan asam folat (Chi-FA). Material NLCs termuat kurkumin disintesis melalui reaksi emulsi-evaporasi-solidifikasi. Material NLCs termuat kurkumin (Cur@NLCs) menunjukkan dua model matriks berdasarkan uji transmitansinya dengan distribusi ukuran partikel sebesar 174,4 nm dan zeta potensial -56,9 mV. Modifikasi permukaan Cur@NLCs dengan Chi-FA menghasilkan ukuran partikel 105,5 nm dan potensial zeta -45,9 mV. Studi pelepasan menunjukkan bahwa keberadaan kitosan dapat menekan pelepasan kurkumin dalam phosphate buffered saline (PBS) pada pH 1,2 dan pH 7,4 serta meningkatkan laju pelepasan pada pH 6,8. Uji toksisitas material menunjukkan peningkatan toksisitas pada sel T-47D. Penelitian ini menunjukkan bahwa modifikasi tersebut dapat mengontrol dan menargetkan sel kanker.Nanostructured Lipid Carriers Modified with Chitosan from Golden Apple Snail Shells (Pomacea canaliculata) as Controlled and Targeted Curcumin Drug Delivery for Breast Cancer Cells. Current breast cancer treatment still relies heavily on chemotherapy, which has physical and psychological side effects. Curcumin is easily degraded and has low bioavailability. Curcumin is a lipophilic compound whose stability can be improved by using Nanostructured Lipid Carriers (NLCs)-based drug delivery systems modified with chitosan to protect the material from degradation in the oral system. Folic acid is also used to target T47D breast cancer cells. Chitosan was synthesized from golden apple snail shells to produce a white powder (32.28%) with a deacetylation degree of 76.55%. The chitosan was conjugated with folic acid (Chi-FA). Curcumin-loaded NLCs were synthesized through an emulsion-evaporation-solidification reaction. Curcumin-loaded NLCs (Cur@NLCs) showed two matrix models based on the transmittance test with a particle size distribution of 174.4 nm and a zeta potential of -56.9 mV. Surface modification of Cur@NLCs with Chi-FA resulted in a particle size of 105.5 nm and a zeta potential of -45.9 mV. Release studies showed that the presence of chitosan could suppress the release of curcumin in PBS at pH 1.2 and pH 7.4, and increase the release rate at pH 6.8. The material toxicity test showed an increase in toxicity to T-47D cells. This study shows that the modification can control and target cancer cells.
Peningkatan Rendemen Minyak Atsiri Melalui Maserasi Awal dengan Metode Ultrasonikasi di Rumah Atsiri Indonesia Firdaus, Maulidan; Suryanti, Venty; Kusumaningsih, Triana; Handayani, Desi Suci; Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo; Karimah, Qosrul; Darmawan, Dhea Afrisa
PRIMA: Journal of Community Empowering and Services Vol 9, No 1 (2025): June
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/prima.v9i1.86385

Abstract

Enhancing Essential Oils Yield through Initial Maceration using Ultrasonication Method at Rumah Atsiri Indonesia. Metode ekstraksi minyak atsiri yang paling umum digunakan adalah destilasi uap. Pada umumnya, metode destilasi uap banyak digunakan oleh industri kecil termasuk di Rumah Atsiri Indonesia (RAI), karena memiliki beberapa keuntungan, diantaranya pengoperasian yang mudah serta peralatan yang sederhana. Akan tetapi, metode ini juga memiliki beberapa kelemahan, seperti membutuhkan waktu yang cukup lama dan hasil produksi yang kurang optimal. Untuk mengatasi kelemahan tersebut, solusi yang dapat dilakukan adalah melakukan proses destilasi minyak atsiri yang didahului maserasi dengan bantuan ultrasonik. Bekerja sama dengan RAI, Tim Riset Group Natural Products and Synthetic Organic Chemistry Prodi Kimia FMIPA UNS telah melaksanakan Program Pengabdian kepada Masyarakat (PkM). PkM bertujuan memberikan penyuluhan sekaligus praktik mengenai cara destilasi minyak atsiri dengan memulai proses maserasi dan menerapkan teknik ultrasonikasi di RAI. Pendekatan ini bertujuan untuk meningkatkan efisiensi dan hasil proses destilasi dengan menggunakan gelombang ultrasonik untuk membantu memecah bahan tanaman sebelum destilasi. Hal ini memudahkan untuk mengekstrak lebih banyak minyak dan meningkatkan kualitas minyak atsiri secara keseluruhan. Kegiatan dimulai dengan diskusi tentang teori dan aplikasi maserasi awal dengan metode ultrasonikasi. Sesi selanjutnya adalah praktik maserasi awal dengan metode ultrasonikasi sebelum dilakukan destilasi. Luaran dari pelatihan ini adalah adanya peningkatan performa metode destilasi minyak atsiri. Hasil perlakuan ekstraksi awal dengan teknik ultrasonikasi bisa meningkatkan rendemen minyak sereh wangi dari 0,86% menjadi 1,86% atau meningkat 2,2 kali lebih banyak dibandingkan tanpa maserasi awal.
Co-Authors Ali Triambodo, Ali Angeline Prita C, Angeline Prita Annisa Istiqomah, Annisa Bambang Heru Susanto, Bambang Heru Darmawan, Dhea Afrisa Dendy, Dendy Desi Suci Handayani Desi Suci Handayani Edi Pramono Elfi Susanti V. H. Elfrida Ratnawati Ema Nur Annisa Farikha Amalina Nurbaiti Gesti Munasah Harno Dwi Pranowo Hilmi Amirul Haq Husna Habib Musthofa Husna Habib Musthofa Irmawan, Muhammad Isa Anshori Karimah, Qosrul Khoirun Nisa Ashar Lestari, Nova Dwi Lestari, Witri Wahyu Maulidan Firdaus Muhamad Widyo Wartono Muhammad Nursyam Maulana Nestri H, Nestri Nestri Handayani, Nestri Ozi Adi Saputra, Ozi Adi Puput Veronikasari Purwanti . Retno Sunarminingsih Sudibyo Riandy Putra Rita Rakhmawati, Rita Rossalia Soraya Safitriono, Wahyu Nur Salma Aqilah Rachmadani Samodra, Imam Sari, Meiyanti Ratna Kumala Sekar Handayani Sentot Budi Rahardjo Soerya Dewi M, Soerya Dewi Soerya Dewi Marliana, Soerya Dewi Soerya Dewi Marliyana Soerya Dewi Marliyana Sri Mulyani Surya Dewi Marliyana Tahara, Alfia Uke Teddy Prayoga, Teddy Teguh Endah Saraswati Tonang Dwi Ardyanto Triana Kusumaningsih Triana Kusumaningsih Umar Anggara Jenie Venty Suryanti Venty Suryanti Venty Suryanti Vicky Ahava Ferdinansyah Winarto Haryadi Witri Wahyu Lestari