Article Per Year (5 Year)
p-Index From 2021 - 2026
3.981
P-Index
This Author published in this journals
All Journal Jurnal Gizi dan Pangan The Indonesian Journal of Public Health Universa Medicina Paediatrica Indonesiana Journal of Medicine and Health Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal The New Ropanasuri Journal of Surgery Indonesian Journal of Global Health research JK Unila (Jurnal Kedokteran Universitas Lampung) The Indonesian Journal of Community and Occupational Medicine eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Tirtayasa Medical Journal Occupational and Environmental Medicine Journal of Indonesia Tirtayasa Medical Journal Journal of Medicine and Health
Indah S. Widyahening
Department Of Community Medicine, Faculty Of Medicine Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Other

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Paediatrica Indonesiana

 1 
Levothyroxine use and thyroid gland volumes in children with autoimmune thyroiditis: a systematic review and meta-analysis Annang Giri Moelyo; Indah Suci Widyahening; Bambang Tridjaja
Paediatrica Indonesiana Vol 59 No 4 (2019): July 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (764.737 KB) | DOI: 10.14238/pi59.4.2019.202-10

Abstract

Background Autoimmune thyroiditis may manifest as overt hypothyroidism, subclinical hypothyroidism, euthyroidism, or hyperthyroidism in children. Although there is no consensus on treating euthyroidism and autoimmune thyroiditis in children, some studies have demonstrated the efficacy of levothyroxine in reducing thyroid volume, improving thyroid function, and stabilizing the immunological process. Objective To determine the effect of levothyroxine on thyroid gland volume changes, thyroid function, and thyroid antibodies in euthyroid children with autoimmune thyroiditis. Methods We performed a literature search of electronic databases (the Cochrane Library, MEDLINE, EBSCO, ProQuest, clinicaltrials.gov, and other sources, as well as a non-electronic search (searching journals and conference proceedings by hand) to identify studies of euthyroid children with autoimmune thyroiditis published by August 2018. Only English-language articles were included in the search (electronic and non-electronic). Randomized controlled trials that compared levothyroxine with a control (placebo or no treatment) in euthyroid children with autoimmune thyroiditis were selected. The outcome measures were thyroid volume changes, thyroid function, and thyroid antibody levels in euthyroid children with autoimmune thyroiditis. Two authors independently extracted the data, assessed the risk of bias, and analyzed the pooled data from the included studies using a random effects model. The same authors performed a sensitivity analysis. Results We identified 57 studies. Of these, three studies, involving 97 subjects (51 subjects in an intervention group and 46 subjects in the control group) were selected for inclusion in a systematic review/meta-analysis. The meta-analysis revealed a significant difference in mean thyroid volume changes between the two groups (-1.10 SDs; 95%CI -1.56 to -0.64; P<0.0001; I2=6%). The mean difference in the thyroid-stimulating hormone (TSH) change of the two groups was -1.82 mU/L (95%CI -3.52 to -0.11; I2=87%; P=0.04). The standardized mean difference in free thyroxine (fT4) change of the two groups was 0.82 pmol/L (95%CI -1.14 to 2.78; I2=89%; P=0.41). Conclusion In euthyroid children with autoimmune thyroiditis, levothyroxine treatment reduces the thyroid volume better. The TSH level change in the intervention group is better than those in the control group. Levothyroxine treatment did not significantly improve free T4.
Community prevalence and distribution of dengue virus serotype based on antibody neutralization assay in Jakarta, Indonesia Karyanti, Mulya Rahma; Alam, Anggraini; Widyahening, Indah Suci; Hadinegoro, Sri Rezeki; Munasir, Zakiudin; Satari, Hindra Irawan; Sasmono, R. Tedjo
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.10-6

Abstract

Background Dengue infection is still rising globally despite the implementation of preventive efforts in many endemic countries. Monitoring the circulation of dengue virus (DENV) serotypes is not performed routinely in the Indonesian national surveillance program, primarily due to high cost and effort. Objective To evaluate the distribution of DENV serotypes based on serological profile and neutralizing antibody level against all four DENV serotypes in Jakarta, Indonesia. Methods This cross-sectional study was performed as part of a dengue vaccine effectiveness study, 10 years after a dengue vaccination program was initiated. It was conducted in five community public health centers in Jakarta in subjects aged 12 years and above who had not received the dengue vaccine. We collected serum samples and DENV neutralizing antibody titers were measured using a plaque reduction neutralization test (PRNT). Results Eighty healthy subjects with a median age of 15 (range 12-27) years were enrolled. The highest median antibody titer was that to DENV-2 [898 (range 29-91558) 1/dil], followed by that to DENV-3 [297.5 (range 10-36091); 1/dil], DENV-1 [288 (range 0-68237) 1/dil], and DENV-4 [164 (range 0-35812) 1/dil]. Neutralizing antibodies against the four DENV serotypes were found in all the 5 districts studied in Jakarta. A multitypic neutralizing antibody profile was observed in the majority (74/80 subjects; 92.5%). Three subjects were naïve. Conclusion All four dengue serotypes are widely circulating in Jakarta based on neutralizing antibody detection in the community, with the highest neutralizing antibody titer being against DENV-2, followed by DENV-3, DENV-1 and DENV-4.
Comparative analysis of COVID-19 incidence and neutralizing antibody response after primary COVID-19 vaccination and heterologous booster doses in adolescents vs. adults: the Indonesian experience Karyanti, Mulya Rahma; Satari, Hindra Irawan; Munasir, Zakiudin; Hadinegoro, Sri Rezeki; Widyahening, Indah Suci; Sasmono, R Tedjo
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.316-24

Abstract

Background The Indonesian COVID-19 immunization program has provided primary doses of a COVID-19 vaccine to adolescents and adults, while booster doses were given to adults only. Evaluation of this program is crucial to determine if boosters should be recommended for adolescents. Objective To compare COVID-19 incidence and SARS-CoV-2 IgG neutralizing antibody levels after COVID-19 vaccination in adolescents given a primary dose vs. adults given a primary dose and a booster. Methods: In this cross-sectional study, participants were given questionnaires on their COVID-19 history and evaluated for SARS-CoV-2 IgG neutralizing antibody titers. We included healthy individuals aged 12 years or older who resided in Jakarta and consented to participate, had received primary COVID-19 vaccine doses, and for adults, booster doses. Participants were stratified into two age groups, adolescents (12-17 years) and adults (18 years and above). We compared the incidence of COVID-19 and SARS-CoV-2 antibody titers between the two age groups. Results Out of 419 participants who met the inclusion criteria, 159 had blood specimens drawn for measurement of SARS-CoV-2 antibody titers. Before the widespread administration of the vaccine, the incidence of COVID-19 in was 4.9% in adolescents vs. 10.2% in adults (P=0.036). After widespread vaccination, the incidence of COVID-19 remained lower in adolescents than in adults (2.2% vs. 8.8%, respectively; P=0.005). The median SARS-CoV-2 antibody titer post-COVID-19 vaccination was 97.85 (range 46.46-98.23) U/mL in adults vs. 96.78 (range 22.08-98.23) U/mL in adolescents (P<0.05). Conclusion While the incidence of COVID-19 was significantly lower in vaccinated adolescents than in vaccinated adults, titers of SARS-CoV-2 IgG neutralizing antibody in adolescents were significantly lower compared to that of adults.
Co-Authors Ade Mutiara Adi, Nuri Purwito Aji B Widodo Ambar W Roestam Andon Hestiantoro Andrijono Andrijono Anggraini Alam, Anggraini Anis Karuniawati Anna nasriawati Annang Giri Moelyo Aria Kekalih Arnold Fernando Ascobat, Purwantyastuti Asmarinah Bambang Tridjaja AAP, Bambang Tridjaja Bernath Siagian Brodjonegoro, Sakti R Budi Wiweko Chandra, Dian Novita Danarto, Raden Deandra, Fadhila I. Denta Aditya Episana Dewi Friska Dewi S. Soemarko Dewi Sumaryani Soemarko Dewi Wulandari Dewi Yunia Fitriani Dicky Mahardhika Dina Tri Amalia Faraji, Mahsa Fauzia, Khalida Fedri Rinawan, Fedri Fuk, Liem Jen Gayatri, Anggi Gita Pratama Guntur Darmawan Handaya, Adeodatus Y. Hariwibowo, Rinto Hartanto Bayuaji Hendri, Ahmad Z Herman Mulijadi Hindra Irawan Satari Indrawarman Soeroharjo Indriastuti Soetomo Isbaniah, Fathiyah Iswanto, J. Judhiastuty Februhartanty KASMARA, E. Kokok, Andwi Setiawan Kresna, Andreas Lalisang, Toar JM. Leopando, Zorayda E. Luh Ade Ari Wiradnyani Luh Ade Wiradnyani, Luh Ade Marcellus Simadibrata Marcellus Simadibrata Mardiastuti H Wahid Muchammad Arief Gunawan Muhammad A Aufa Muhammad F Alhas Muhammad Ilyas Muhammad Ilyas Mulya Rahma Karyanti, Mulya Rahma Murdana, Nyoman Nasution, Safruddin Neni Nurainy Nina Mariana, Nina Nur Rasyid Nuri Purwito Adi Parmitasari, Parmitasari Ponco Birowo Prahara Yuri Raden I. Ismail Rakhmi Savitri Hoesein Retno Wibawanti Revata Utama Rimonta F Gunanegara Rimonta F Gunanegara, Rimonta F Rini Mulia Sari Rosdiana, Ano SANTOSO, S. S.I. Sasmono, R. Tedjo Saunar, Rofy S. Setiawati, Elsa P. Sinabutar, Klara Siti Darifah Sofyan, Marwan Sri Rezeki Hadinegoro, Sri Rezeki Sudadi Hirawan SUMAPRAJA, K. Tanoto, Rodri Tirza Z Tamin Tony Loho Trinovita Andraini Usman, Nurhayat Vivi Setiawaty Wangsa, Andrean Wibowo, Suryo Widianto, Eri Yefta Moenadjat Zakiudin Munasir