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Immunoexpression of cytokeratin 19 in oral cavity mucous smear of filter cigarette smokers Meira, Isra; Widyaputra, Sunardhi; Dardjan, Murnisari
Padjadjaran Journal of Dentistry Vol 20, No 2 (2008): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Smoking has become general habits in social life. One popular kind is filtered cigarette. As the base component is tobacco without clove and separated by the filter on it. Long irritation from heat and a toxic component of cigarette changed in oral mucosa epithelial. This condition can stimulate the increase of progenitor cells, which is marked by immunohistochemistry staining method of cytokeratin 19. This descriptive study is to find the expression of cytokeratin 19 in oral mucosa cytoplasm epithelial of filter cigarette smokers. There were 30 smokers which were selected with certain criteria. Samples were taken from a cytological smear of mucosa epithelial then stained with immunohistochemistry method. Analysis has taken by calculating the number of cells in the cytological smear. Then the immunoexpression of cytokeratin 19 was known from the percentage of cytoplasm cells which have brown colour compared with a total number of cells. In conclusion, the smoking filter cigarette would increase the number of progenitor cells from chronic inflammation, which is marked by cytokeratin 19 expression in oral mucosa cytoplasm epithelial of smokers.

Limfangiogenesis sebagai jalur alternatif metastasis kankerLymphangiogenesis as an alternative pathway for cancer metastasis Handayani, Pudji; Jasrin, Tadeus Arufan; Widyaputra, Sunardhi
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 28, No 2 (2016): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Metastasis merupakan salah satu sifat kanker yang dapat terjadi melalui berbagai cara yaitu melalui rongga tubuh, melalui pembuluh limfatik, dan melalui pembuluh darah (1,2). Pembuluh limfatik merupakan jalur penting dalam metastasis kanker karena sel kanker yang lepas dari kanker primernya dapat berjalan melalui pembuluh limfatik dan menuju nodus limfatikus untuk memasuki pembuluh vena serta menyebabkan metastasis ke organ sekitar. Studi pustaka ini bertujuan untuk menelaah limfangiongenesis sebagai alternative metastasis kanker. Metode: Artikel ini dikumpulkan dengan memanfaatkan pencarian di database jurnal kesehatan bereputasi internasional menggunakan kata kunci metastasis, lymphangiogenesis, lymphatic vessel, VEGFR-3 dari pencarian tersebut ditemukan 27 artikel yang dapat digunakan dalam penulisan sistematik review. Simpulan: Limfangiogenesis dapat terjadi pada kanker melalui interaksi antara VEGF-C dan VEGF-D yang dihasilkan oleh kanker ataupun oleh makrofag dengan reseptornya VEGFR-3 yang terdapat pada endotel pembuluh limfatik yang ada. Limfangiogenesis pada kanker akan menambah jalur metastasis sel kanker menuju pembuluh limfatik.Â ABSTRACTIntroduction: Metastasis is one of the characteristics of cancer that can occur through various ways, namely through the body cavity, through lymphatic vessels, and through blood vessels (1,2). Lymphatic vessels are an important pathway in cancer metastasis because cancer cells that are released from the primary cancer can travel through the lymphatic vessels and into the lymph nodes to enter the veins and cause metastasis to the surrounding organs. This literature study aims to examine limfangiongenesis as an alternative metastatic cancer. Methods: This article was collected using a search in a database of international reputable health journals using the keyword metastasis, lymphangiogenesis, lymphatic vessel, VEGFR-3 from the search, found 27 articles that could be used in systematic review reviews. Conclusion: Lymphangiogenesis can occur in cancer through the interaction between VEGF-C and VEGF-D produced by cancer or by macrophages with its receptor VEGFR-3 found in the existing lymphatic vessel endothelium. Lymphangiogenesis in cancer will increase the metastatic pathway of cancer cells to lymphatic vessels.Keywords: Metastasis, lymphangiogenesis, lymphatic vessel, VEGFR-3.

A Study of Cytomegalovirus Serology among HIV-Infected Patients in the Highly Active Antiretroviral Therapy Era Sufiawati, Irna; Widyaputra, Sunardhi; Djajakusumah, Tony S.
Majalah Kedokteran Bandung Vol 45, No 2 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.573 KB)

Cytomegalovirus (CMV) is one of the most common opportunistic viruses in human immunodeficiency virus (HIV)-infected patients. The aim of this study was to determine the CMV seroprevalence among HIV-infected patients and investigate the correlation between the CMV immunoglobulin G (IgG) antibody titers and cluster of differentiation 4 (CD4) T-cell counts, as well as highly active antiretroviral therapy (HAART) use. Serum samples from 69 HIV-infected patients and 65 HIV-seronegative persons attending Dr. Hasan Sadikin General Hospital Bandung in Marchâ€“June 2012 were examined to detect CMV IgG antibody using electrochemiluminescence immunoassay (ECLIA). Data were analyzed using chi-square test, t-tests and analysis of variance (ANOVA). The results show that there were no statistically significant differences in the seroprevalence of CMV between HIV-infected (97%) and HIV-seronegative persons (94%). The mean of CMV IgG antibodies titers in HIV-infected patients (335.39+174.87 U/mL) were significantly higher than that of HIV-seronegative persons (240.59+192.76 U/mL). There was no significant correlation between CMV IgG antibody titers and CD4 T-cell counts (the mean was 393.58+209.22 cells/mm3). The titers of CMV IgG antibodies were significantly inversely associated with HAART use. The mean of CMV IgG antibody titers in HIV-infected patients on HAART (335.41+172.98 U/mL) were significantly higher than patients without HAART (204.8+213.91 U/mL). In conclusions, this study confirms a high seroprevalence of CMV among HIV-infected patients. High titers of CMV are inversely associated with HAART use while no correlation with CD4 T-cell counts was found. [MKB. 2013;45(2):112â€“7]Key words: CD4, Cytomegalovirus (CMV), HAART, HIV, IgGStudi Serologi Cytomegalovirus pada Pasien yang Terinfeksi HIV di Era Highly Active Antiretroviral TherapyCytomegalovirus (CMV) adalah salah satu virus oportunistik yang paling umum pada pasien yang terinfeksi humanÂ immunodeficiency virus (HIV). Tujuan penelitian ini untuk mengetahui seroprevalensi CMV pada pasien HIV danÂ meneliti korelasi antara titer antibodi imunoglobulin G (IgG) CMV dan jumlah sel-T cluster diferensiasi 4 (CD4)Â serta penggunaan highly active antiretroviral therapy (HAART). Sampel serum dari 69 pasien HIV dan 65 HIVseronegatif yang berkunjung ke Rumah Sakit Dr. Hasan Sadikin Bandung pada bulan Maretâ€“Juni 2012 diperiksaÂ untuk mendeteksi antibodi IgG CMV dengan immunoassay electro chemiluminescence (ECLIA). Data dianalisisÂ dengan menggunakan uji chi-kuadrat, t, dan analysis of variance (ANOVA). Hasil penelitian menunjukkan tidakÂ ada perbedaan yang signifikan antara seroprevalensi CMV pada pasien HIV (97%) dan HIV-seronegatif (94%). TiterÂ antibodi rata-rata IgG CMV pasien HIV (335,39+174,87 U/mL) signifikan lebih tinggi daripada HIV-seronegatifÂ (240,59+192,76 U/mL). Tidak ada hubungan yang signifikan antara titer antibodi IgG CMV dan jumlah sel-TÂ CD4 (rata-rata 393,58+209,22 sel/mm3). Titer antibodi IgG CMV secara signifikan berhubungan terbalik denganÂ penggunaan HAART. Titer antibodi IgG CMV rata-rata pasien HIV dengan HAART (335,41+172,98 U/mL)Â signifikan lebih tinggi dibandingkan dengan pasien tanpa HAART (204,8+213,91 U/mL). Simpulan, penelitian ini menegaskan seroprevalensi CMV pasien HIV dan titer antibodi IgG CMV yang tinggi berhubungan terbalikÂ dengan penggunaan HAART tetapi tidak berkorelasi dengan sel-T CD4. [MKB. 2013;45(2):112â€“7]Kata kunci: CD4, Cytomegalovirus (CMV), HAART, HIV, IgGÂ DOI:Â http://dx.doi.org/10.15395/mkb.v45n2.114

Differences of Micro-CT evaluation of the obturation sealing capability between thermoplastic carrier-based condensing techniques and lateral heat condensation techniques Amida, Aya; Aripin, Dudi; Hayati, Ayu Trisna; Latief, Fourier Dzar Eljabbar; Djustiana, Nina; Cahyanto, Arief; Usri, Kosterman; Tjahajawati, Sri; Mariam, Marry Siti; Widyaputra, Sunardhi
Padjadjaran Journal of Dentistry Vol 34, No 2 (2022): July
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no2.41384

ABSTRACT Introduction: Root canal filling is an important part of root canal treatment that aimed to seal the root canal system, to prevent bacterial penetration and their toxins into periradicular tissues and to provide favourable environment for periapical healing. Thermoplasticized technique were developed to produce filling with homogenous mass, to achieve optimal sealing ability and to increase the quality of root canal filling. The aim of this study is to analyzed differences of Micro-Computed Tomography (Micro-CT) evaluation of the obturation sealing capability between thermoplastic carrier-based condensing techniques and lateral heat condensation techniques. Methods: This study was conducted under an in-vitro quasi experimental methode to 36 specimens of maxillaris centralis incisivus which were divided to 3 groups, (A) thermoplasticized carrier-based technique (GuttaCore System), (B) warm lateral condensation technique (heat carrier SystemB), (C) cold lateral condensation as control group. Sealing ability is evaluated based on the measurement results of volume percentages of filling material and sealer, volume of void, and surface density, that which was calculated from the 3D volumetric image of Micro-CT device. Data were statistically analysed using Analisis of Variance (ANOVA) and t-test. Result: The result showed significant difference of percentage filling material and sealer volume in apical third (p<0.05), whereas there were no significant differences of void volume in apical third, middle third, coronal third or along the canal (p>0.05). Conclusion: Thermoplastized carrier-based technique is not better than warm lateral technique.Keywords: sealing ability; root canal filling; thermoplasticized carrier-based technique; warm lateral technique.

Indonesian dentists knowledge, attitudes and practices in COVID-19 pandemic Suwargiani, Anne Agustina; Arief, Erry Mochamad; Setiawan, Asty Samiaty; Putri, Fidya Meditia; Hamdani, Ardena Maulidia; Sanjaya, Azlina Nuur; Yubiliani, Gilang; Susilawati, Sri; Aripin, Dudi; Djuastina, Nina; Widyaputra, Sunardhi
Padjadjaran Journal of Dentistry Vol 34, No 2 (2022): July
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no2.40838

ABSTRACTIntroduction: Dentists play a significant role in preventing the transmission of 2019-nCoV. Recommended infection control measures during dental practice can block the route of person-to-person transmission. Dentists and their personnel are used to assess the risk of cross-infection. This study aimed to obtain dentists' knowledge, attitudes, and practices regarding the Covid-19 pandemic in Indonesia. Methods: A cross-sectional study was conducted on a sample of licensed dentists using the convenience sampling technique. The minimum sample size was counted using the formula for a descriptive analysis of one group with the expected proportion of 50% and the confidence level of 95%, and obtained 407 respondents from 31 provinces. Data was collected using a questionnaire distributed via a shortened link. 99.75% of respondents knew personal protective equipment, but only 84.28% knew the proper removal procedure. 99.75% of respondents knew about dental devices that cause aerosols, and all respondents knew about social and physical distancing. Result: Dentists’ attitudes regarding personal protective equipment were that they needed and maintained it during the pandemic. All respondents stated that social and physical distancing was critical and must be maintained while providing health services. Regarding their practices, all respondents did social and physical distancing in their daily lives and during dental procedures. Conclusion: Dentists' knowledge is already good in several ways, but with several matters that still need to be improved, their attitudes and practices are good criteria. Keywords: smart Odontogram; medical record; application; usability testing; user’s experience

Correlation of pregnant oral health scoring models with inflammatory protein markers sCD14 and prostaglandins Suwargiani, Anne Agustina; Aripin, Dudi; Arief, Erry Mochamad; Widyaputra, Sunardhi; Susilawati, Sri; Kadir, Rahimah Abdul
Odonto : Dental Journal Vol 11, No 2 (2024): December 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.2.266-281

Background: To analyse correlation of pregnant oral health scoring model with inflammatory protein markers sCD14 and prostaglandins.Method: A cross-sectional consisted of 80 pregnant women who met inclusion criteria used consecutive sampling.Result: The POSC-p model which was based on oral health scoring, components of salivary condition was significantly correlated with sCD14 and the POSC-p model and combined of oral health scoring was significantly correlated with prostaglandins.Conclusion: The POSC-p score model and the sCD14 of clinical examination have correlation consist of tooth decay, occlusion and salivary condition consist of salivary pH level, salivary volume and salivary buffer. However, there was no substantial correlation between the pregnant oral health scoring model of felt need and the pregnant oral health scoring for salivary conditions or the combined POSC-p score and sCD14 levels and POSC-p Scores (combined) significant correlation with sCD14

Correlation of pregnant oral health scoring models with inflammatory protein markers sCD14 and prostaglandins Suwargiani, Anne Agustina; Aripin, Dudi; Arief, Erry Mochamad; Widyaputra, Sunardhi; Susilawati, Sri; Kadir, Rahimah Abdul
Odonto : Dental Journal Vol 11, No 2 (2024): December 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.2.266-281

Background: To analyse correlation of pregnant oral health scoring model with inflammatory protein markers sCD14 and prostaglandins.Method: A cross-sectional consisted of 80 pregnant women who met inclusion criteria used consecutive sampling.Result: The POSC-p model which was based on oral health scoring, components of salivary condition was significantly correlated with sCD14 and the POSC-p model and combined of oral health scoring was significantly correlated with prostaglandins.Conclusion: The POSC-p score model and the sCD14 of clinical examination have correlation consist of tooth decay, occlusion and salivary condition consist of salivary pH level, salivary volume and salivary buffer. However, there was no substantial correlation between the pregnant oral health scoring model of felt need and the pregnant oral health scoring for salivary conditions or the combined POSC-p score and sCD14 levels and POSC-p Scores (combined) significant correlation with sCD14

Relationship between filter cigarettes smoking habits with the appearance of smoker’s melanosis (Observation of smoking duration and the amount of cigarettes consumption) Akbar, Rizal Rizky; Widyaputra, Sunardhi; Kintawati, Silvi
Padjadjaran Journal of Dentistry Vol 26, No 2 (2014): July 2014
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol26no2.26698

Introduction: Smoking is one of bad habits that are difficult to abandon. Cigarettes contain more than 59 known carcinogenic substances. Cigarettes also contain some metal components and free radicals. Cigarettes consist of several types, one of which is cigarettes filter, which is the most frequently consumed cigarettes. One of the adverse effects of cigarette smoker’s melanosis is a pigmentation disorder that appears in oral cavity. The study aims to look at the relationship between smoking habits of filter’s smoker with appearance of smoker’s melanosis. Methods: This was a descriptive analytic with chi-square test to analyze the relationship between smoking in filter smokers with appearance of smoker’s melanosis. The samples were 90 students of the Faculty of Geology University of Padjadjaran. The smokers who have the criteria of the sample are examined to see the oral condition whether there is a melanosis lesion or not. Results: The result showed an association between smoking habit in filter smokers with the onset of smokers melanosis that observe through the duration of smoking and the amount of cigarettes consumption. Conclusion: There is a relationship between smoking habits in filter smokers and the onset of smoker’s melanosis in terms of smoking duration and the number of cigarettes consumed.

Oral health care practice of women with pregnancy experience Suwargiani, Anne Agustina; Arief, Erry Mochamad; Aripin, Dudi; Widyaputra, Sunardhi; Susilawati, Sri
Padjadjaran Journal of Dentistry Vol 32, No 3 (2020): November 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no3.30312

Introduction: Oral health of pregnant women is essential due to the physiological, psychological, and immune response changes. Oral health-related prenatal services, however, are still insufficient. There are some deficiencies in health care and health promotion activities provided for pregnant women. The purpose of this study was to determine the oral health care practice of women with pregnancy experience. Methods: A cross-sectional descriptive study was conducted towards Indonesian women with pregnancy experience—sample size calculation was conducted using the survey population to estimate the population proportion formula. Inclusion criteria were women with pregnancy experience, owns mobile phones, able to access the Google® Form questionnaire, and willing to take part in the study. Exclusion criteria were women with pregnancy experience who did not complete the Google® Form questionnaire and women who were having a miscarriage or stillborn. Sampling technique was performed using the non-probability sampling with consecutive sampling technique in August until September 2019. Data collection using questionnaire in form of Google® Form questionnaire and distributed online to women who has pregnancy experience throughout Indonesia. Results: The respondents were grouped in three age categories: 22-34 years, 35-44 years, and 45-65 years. Respondents came from 45 cities throughout Indonesia. 62.70% of pregnant women had never visited the dentist. Pregnant women who have visited the dentist were only 37.30%. Pregnant women visited the dentist because they experience a toothache, while the reason for most pregnant women did not visit the dentist because they dd not have any oral health complaints. Conclusion: 62.70% of pregnant women had never visited the dentist. Pregnant women who have visited the dentist were only 37.30%. Women with pregnancy experience mostly have oral health care to treat their oral health complaints. However, the majority of them never visits the dentist because they did not have any oral health complaints.

Association between Handgrip Strength and Oral Hygiene Skills Among The Older People in Rural Area: A Pilot Study Sari, Kartika Indah; Rizki, Friska Nur; Komara, Ira; Ong, Paulus Anam; Purba, Ambrosius; Widyaputra, Sunardhi
Journal of Indonesian Dental Association Vol 4 No 2 (2021): October
Publisher : Indonesian Dental Association

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Introduction: The aging process is characterized by a decrease in muscle mass and muscle strength. It causes the deterioration of handgrip muscles. Diminishing handgrip strength can impact the activities of daily life, including the maintenance of oral hygiene. A toothbrush handle must be gripped firmly enough to remove plaque. Objectives: The aim of this study was to examine handgrip muscle strength and oral hygiene skills in the elderly. Methods: This study was a correlational analysis using a cross-sectional study design with a consecutive sampling technique of the elderly. The study was conducted in the rural village of Sinartanjung, Banjar, West Java, Indonesia. Handgrip strength was measured twice using an Electronic Hand Dynamometer Camry EH 101. Oral hygiene skills were assessed using the O'Leary plaque index to measure plaque control. Data were presented in tables and as percentages. A non-parametric statistical Spearman rank test was used to measure the correlation between handgrip strength and oral hygiene skill. Results: Forty-two the elderly people participated in this study, 31 females (73.80%) and 11 males (26.19%). The average handgrip strength was in the normal category (19.80 ± 7.2) kg and the average plaque index was in the moderate category (0.34 ± 0.16). The Spearman rank correlation test showed a significant correlation between handgrip strength and oral hygiene skills, r=0.521, p=0.000 (p <0.05). Conclusion: Maintained handgrip strength in the elderly ensures an adequate toothbrush grip, thereby improving oral hygiene skills and increasing the amount of plaque that can be removed.

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