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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

ANTIOXIDANT CAPACITY OF FRANGIPANI (Plumeria alba) POWDER EXTRACT Wrasiati, Luh Putu; Wirawan, I Gede Putu; Agus Bagiada, Nyoman; Mantik Astawa, I Nyoman
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Abstract

This research aimed to identify the antioxidant capacity, vitamin C (ascorbic acid), and total phenolic compounds of frangipani flower powder. The powder was extracted using ethanol, methanol, acetic acid, and water (aquadest). Antioxidant capacity of each extract were determined using 2,2-diphenyl-1-picrylhydrazyl radical scavenging method, vitamin C were determined using 2,4 Dinitrophenylhydrazine, and total phenolic compounds were determined using Folin Ciocalteu reagent. All of parameters were measured by spectrofotometer. The result shows that the highest value of antioxidant capacity was ethanolic extract (18.19%) and the lowest value was acetic acid extract (12.74%). The highest value of vitamin C was aqueous extract (3.49 mg/100g) and the lowest value was acetic acid extract (3.02 mg/100g). The highest value of total phenolic content was aqueous extract (25.49 mg GAE/g) and the lowest value was acetic acid extract (22.74 mg GAE/g). In conclusion, the higher antioxidant capacity was not always followed by the higher of vitamin C and total phenolic compounds.
SEAWEED EXTRACTS IMPROVE LIPID PROFILE OF WISTAR RAT Marhaeni Julyasih, K. Sri; Suata, K.; Wirawan, I.G.P; Mantik Astawa, I. N.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.524 KB)

Abstract

Hypercholesterolemia or hyperlipidemia has been established as an important risk factor of cardiovascular disease. Patients with hypercholesterolemia usually require a prolonged treatment; and the newer and more potent generation of antilipid agents are costly.In Bali there are several types of seaweed that are generally consumed by the local people and known by the local names of Bulung Boni (Caulerpa spp.) and Bulung Sangu (Gracilaria spp.). Preliminary studies on the effect of Bulung Boni and Bulung Sangu extracts appeared to improve lipid profile, but the available data are still very limited both in extent and depth, and further investigations were considered relevant and needed.This experimental study used completely blind randomized design, using a total of 24 Wistar rats divided into six sample groups of equal size, all fed with a diet high in cholesterol content. The six sample groups were respectively designated as negative control group, positive control group, and four treated sample groups, respectively fed orally with a dose of 20 mg and 60 mg extracts of Bulung Boni per 100g of body weight per day, and 20 mg and 60 mg extracts of Bulung Sangu per 100g body weight per day. Each treatment was repeated four times.Our study showed that rats fed with high-cholesterol diet and treated with oral Bulung Boni or Bulung Sangu extract at a dose of 20 mg and 60 mg/100 g bw/ day were associated with statistically significantly increased plasma HDL levels (p < 0.05), and statistically significant decreased plasma LDL and total cholesterol levels (p < 0.05) as compared with those of rats fed with high cholesterol diet without treatment with Bulung Boni or Bulung Sangu extracts.From our data it could be implied that Bulung Boni and Bulung Sangu extracts improve lipid profile in the Wiatar rat by significantly increasing plasma HDL level, and lowering LDL and total cholesterol levels.
Co-Authors - Afrizal ANDRIANI ANDRIANI Antony Lay Aulanni ‘am Aulanni ‘am Bambang Sugiharto BAYU ARYA BAGASKARA Ciawi - DARWIN SILALAHI DEWA AYU RATIH Dewi, Ni Kadek Emi Sintha Dharmawibawa I.D. DINA RAHMAWATI Evy Prima FADEL ALKAHFI Gayatri, Anak Agung Sagung Intan Gresia Eldina Haryadi, Celvin Hengky Surya Bhuana I Gede Ketut Susrama I Gusti Ayu Diah Yuniti I Ketut Siadi I Ketut Suada I Ketut Suada I M. Sudarma I Made Parama Nanda Mahatya I N. WIJAYA I NYOMAN MANTIK ASTAWA I NYOMAN TRYADI CAHYA NUGRAHA I NYOMAN WIJAYA I NYOMAN WIJAYA I Putu Agus Hendra Wibawa I Putu Anom I Putu Sudiarta I Putu Wahyu Sanjaya I WAYAN PRASTITA DIASTAMA I WAYAN SUAMBA I.N. Wijaya Ida Ayu Putri Darmawati K. Sri Marhaeni Julyasih K. Suata Kalimutu, Putu Krisnawan Kayo Gouya Ketut Sri Marhaeni Julyasih Ketut Srie Marhaeni Julyasih Liliek Sulistyowati Linawati Linawati Luh Putu Wrasiati M. Puspawati Made Adnyana Made Heny Urmila Dewi MADE SRITAMIN Merlyna Rosalia Motoyuki Suzuki Munthe, Lambok Jenny Sagita MUSLIM MUSLIM NADIAH SILITONGA Nevy Widya Pangestika Ni Gusti Ayu Dewi Paramita Arisandi NI KADEK DWI PASARI Ni Kadek Emi Sintha Dewi Ni Kadek Sintya Dewi NI KADEK SINTYA DEWI NI MADE ADHYA NIDIDHYA SANI Ni Made Ayuratih Utami Ni Made Regina Prasetya Putri Ni Made Suaniti NI NENGAH DARMIATI NI WAYAN ARMINI Ningsih, Gusti Ketut Asti Dea Nobuyuki Kohno Novayolla, Alsha Nurftatmelia Nyoman Agus Bagiada Parwata, I Made Oka Pranata, Kadek Dwipayana Pranatayana, Ida Bagus Gede PUTU BAMBANG IKA WINJALISTA PUTU SENA WIDIATMA Riezchy Riando Mamanua Rindang Dwiyani Rizki, Muhamad Farrel ROMAULI THERESIA NAINGGOLAN Romulia Trielva Apriliani Rusmita, Gst Ayu Putu Ika Yulia Safitri R. Sahanggamu Y. P. Sang Ayu Made Putri Suryani Sang Ayu Made Putri Suryani, Sang Ayu Made Putri Sasadara, Maria Malida Vernandes Setianingsih, Ni Luh Putu Putri Shara Yulita Harianja Shchegolkova, Nataliya Shin-ichi Sekiyama Simarmata, Jonatan Alexius Suniti N.W. TRISNA AGUNG PHABIOLA VANI SILVANA VEDERIS LEUNARDUS VICKY TANDYA WAYAN ADIARTAYASA WHISNU IDA BAGUS YOLANDA HASSIAN MANALU Yundari, Yundari