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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Amerta Nutrition World Nutrition Journal Narra J eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Fiastuti Witjaksono
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial Putranto, Rudi; Setiati, Siti; Nasrun, Martina W.; Witjaksono, Fiastuti; Immanuel, Suzanna; Subekti, Imam; Harimurti, Kuntjoro; Siswanto, Agus; Shatri, Hamzah; Suwarto, Suhendro; Megantara, Marcelino A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1342

Abstract

The coexistence of depression and type 2 diabetes mellitus (T2DM) can significantly worsen disease prognosis and lower quality of life. Emerging evidence suggests that vitamin D deficiency contributes to the progression of T2DM and is closely associated with the development of depression. The aim of this study was to investigate the effects of cholecalciferol on depression in patients with T2DM, exploring its mechanisms by analyzing its impact on C-peptide, serotonin, and neurotrophin-3 levels. A double-blind, randomized, placebo-controlled clinical trial was conducted at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from April 2021 to September 2022. Patients with T2DM and depressive symptoms were randomly assigned to two groups: received 4000 IU of cholecalciferol daily and received a placebo for 12 weeks. Depression was assessed using the Beck Depression Inventory-II (BDI-II) before and 12 weeks after the intervention. The levels of C-peptide, serotonin, and neurotrophin-3 were measured at the end of the fourth week of intervention using the enzyme-linked immunosorbent assay (ELISA) method. Between-group comparisons were made using independent Student t-tests and Mann-Whitney U tests. Paired Student t-tests or Wilcoxon tests were applied for within-group comparisons between pre- and post-intervention. A total of 70 T2DM patients with depression were included in this study, comprising 38 patients in the cholecalciferol group and 32 in the placebo group. C-peptide levels increased significantly in the cholecalciferol group compared to the placebo group (p=0.006). No significant differences were observed in serotonin and NT-3 levels between the cholecalciferol group compared to the placebo group. The cholecalciferol group had a significantly greater reduction in BDI-II scores compared to the placebo group (p<0.001). This trial highlights that taking cholecalciferol might help ease mild to moderate depression symptoms in patients with T2DM by enhancing c-peptide levels, though its effects on serotonin and neurotrophin-3 are still unclear.
Correlation of calorie intake with 24-hour urinary urea nitrogen level changes in critically ill patients at RSUI Depok, Indonesia Githa Putri Puspita Sari; Witjaksono, Fiastuti; Sutanto, Krisadelfa; Singal, Anna Maurina
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0041

Abstract

Calorie together with protein intake has been proven to be important factors that play a role in critically ill patients. Hypermetabolism in the early acute phase increases energy expenditure and calorie requirement. Insufficient calorie intake will increase protein degradation for gluconeogenesis, which can be assessed by the level of 24-hour urinary urea nitrogen (UUN). Adequate daily calorie intake is expected to improve the UUN level in patients. This study aims to investigates the correlation of calorie intake with UUN level changes in critically ill patients.
The Effectiveness of a High-Protein Liquid Dietary Supplementation in Improving Nutritional Status of Malnourished Patients in Hospital Care: a Preliminary Study Simadibrata, Marcellus; Abdullah, Murdani; Witjaksono, Fiastuti; Muzellina, Virly Nanda; Utari, Amanda Pitarini; Wulandari, Yohannessa; Wijayanti, Ari; Mustikarani, Dewi; Haloho, Raja Mangatur; Rachman, Aditya; Simadibrata, Daniel Martin; Mutiara, Rizka; Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.108 KB) | DOI: 10.24871/231202243-51

Abstract

Background: Malnutrition is a very common problem in hospitalized patients. Based on studies conducted in various countries, the prevalence of hospital malnutrition ranges from 20-45%. Hospital malnutrition can occur as a result of insufficient nutrient intake, impaired absorption of nutrients in the gastrointestinal (GI) tract, loss of nutrients due to disease, or increased metabolic requirement during illness. Nutrition is the basis for the healing process as it requires good nutrients through various enzymatic reactions. Some studies have shown that hospital malnutrition increases morbidity, mortality, prolongs the duration of hospitalization, and delays recovery. To improve nutritional status, a high-protein diet can be given. Liquid diet is one of the alternative forms of nutrition because it is easier to swallow.Method: This study was a double-blind randomized controlled trial conducted to assess the effectiveness of high protein liquid dietary supplementation in malnourished hospitalized patients. The patients were assessed for their nutritional status based on ESPEN 2015 criteria. Patients who experienced malnutrition will be divided into 2 groups, namely the control group which was given normal protein liquid diet, while the intervention group was given high protein liquid diet supplementation as much as 2 bottles (200 mL) per day for 7-10 days. Furthermore, the nutritional status of the patient was assessed.Results: By administering high-protein liquid diet supplementation, there was a tendency to increase the strength of the right handgrip in 3 subjects (50%), the tendency to increase body mass index (BMI) in 3 subjects (50%), Subjective Global Assessment (SGA) score improved in 2 subjects with mild/moderate malnutrition (33.3%) and 1 subject with normal nutrition (16.7%), and the tendency to increase the fat-free mass in 3 subjects (50%).Conclusion: The administration of high protein liquid dietary supplementation tended to increase the strength of the right handgrip, BMI, SGA score, and body fat-free mass index.
The association between knowledge and attitude towards nutrition fact panels (NFP) with sugar intake of the Indonesian adolescents Yunita, Ulfi Rahma; Khusun, Helda; Witjaksono, Fiastuti
World Nutrition Journal Vol. 7 No. 2 (2024): WNJ. Volume 07 Issue 2, February 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V07.i2.0008

Abstract

The increasing sugar intake has become a global issue due to its impact on health. The survey conducted in Jakarta revealed that the median sugar intake for adolescents and adults is 18.8 g/capital/day and 24.5 g/capital/day, respectively. The government has taken several ways to reduce sugar intake, one of which is by using labels on packaged food. Therefore, this research aims to investigate the knowledge and attitude towards nutrition fact panels with sugar intake in Indonesian adolescent. This research was a cross-sectional study using an online questionnaire for adolescents in Indonesia with age range between 15-18 years old. Data on sociodemographic, mass media exposure, knowledge, and attitude were collected through online questionnaires, while sugar intake was assessed through online SQ-FFQ interviews. The study’s findings showed that the majority of respondents were women (90%), with parents having below 12 years of schooling on average. Additionally, the median monthly pocket money and pocket money for food and drinks below IDR 300,000 and IDR 200,000, and mass media exposure occurred more than 3 times per month. More than half of the respondents displayed good knowledge (51.7%) and a positive attitude towards NFP (60.8%), with the majority having high sugar intake (53.5%). There is a relationship between knowledge of NFP, mass media exposure, and mother education with sugar intake in adolescents. It recommended to enhance knowledge of NFP among adolescents and parents through social media platforms, posters and TV ads to enable them select and consume appropriate foods.
Co-Authors Aditya Rachman Aditya Rachman, Aditya Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Agus Siswanto Akmal Taher Amanda Pitarini Utari Andhika A. Perdana Andrijono Andrijono Andry Kelvianto Anni Rahmawati Anthony Eka Wijaya Ari Wijayanti Asmarinah Batara Bisuk Daniel Martin Simadibrata Dewi Krisna Yunda Diyah Eka Andayani Diyah Eka Andayani E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Erfi Prafiantini Fajriani, Rosalina Fariz, Nurwidya Fathiyyatul Khaira Ferry Safriadi Fitriyadi Kusuma Githa Putri Puspita Sari Haloho, Raja Mangatur Harahap, Alida Roswita Helda Khusun Imam Subekti Julianto Witjaksono Kaka Renaldi Krisadelfa Sutanto Kuntjoro Harimurti Lukman Halim Marcellus Simadibrata K Megantara, Marcelino A. Meirina Khoirunnisa Murdani Abdullah Mustikarani, Dewi Mutiara Riani Mutiara, Rizka Nasrun, Martina W. Nur Rasyid Ponco Birowo Rabbinu Rangga Pribadi Raja Mangatur Haloho Retno Asti Werdhani Rizka Mutiara Rudi Putranto Savira, Missy Shiela Stefani Simadibrata, Daniel Martin Singal, Anna Maurina Siti Setiati Sri Mutya Sekarutami Sri Wuryanti Suhendro Suwarto, Suhendro Susworo Susworo Suzanna Immanuel Umi Fahmida Virly Nanda Muzellina Widi Atmoko Wistara, Sevita Sathya Yoga Devaera Yohannessa Wulandari Yunita, Ulfi Rahma