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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Farmasi Udayana Jurnal Veteriner Jurnal Biologi Udayana Jurnal Sains Materi Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ISM (Intisari Sains Medis) : Jurnal Kedokteran Management Studies and Entrepreneurship Journal (MSEJ) Udayana Journal of Social Sciences and Humanities (UJoSSH) Journal of Health Sciences and Medicine Quantitative Economics and Management Studies JOURNAL SCIENTIFIC OF MANDALIKA (JSM) ProBisnis : Jurnal Manajemen Indonesian Journal of Multidisciplinary Science Journal Transformation of Mandalika Eduvest - Journal of Universal Studies J-CEKI Jurnal Farmasi Sains dan Teknologi
I Gusti Ngurah Agung Dewantara Putra
Program Studi Farmasi, Fakultas MIPA, Universitas Udayana 80361, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Multidisciplinary Science

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Expandable Ranitidine HCl tablets with Salak Bali seed matrix (Salacca zalacca) I Gusti Ngurah Agung Dewantara Putra; I Gusti Nyoman Darmaputra; Imron Hadi Tamim
Indonesian Journal of Multidisciplinary Science Vol. 4 No. 2 (2024): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v4i2.1061

Abstract

This research aims to develop ranitidine HCl tablets that can be expanded with a matrix from Balinese salak seeds (Salacca zalacca) as a natural matrix material. This formulation is expected to prolong the release time of the drug in the body, thereby increasing the effectiveness of ranitidine therapy in the treatment of gastric diseases. The research method included the extraction of the active components from Balinese salak seeds and the process of making tablets using the wet granulation method, followed by physical tests of the tablets which included the hardness, crushing time, and ability of the tablets to expand. The results showed that ranitidine HCl tablets with Balinese salak seed matrix had physical characteristics that met the requirements of pharmacopooeia, with a slower drug release time than tablets without a developer matrix. Analysis of development capabilities shows that Balinese salak seeds are effective as natural matrix agents to prolong the release time of ranitidine HCl. In conclusion, Balinese salak seed matrix can be used as an alternative in the development of expandable ranitidine HCl tablets, potentially increasing the therapeutic effect of the drug.
Co-Authors A. A. Yastawa Cakranegara, Pandu Adi Eka Indra Setyawan Eka Indra Setyawan Eka Kurnia Saputra Erlina, Ni Putu Natasha Ernianti Farida Akbarina Firstianty Wahyuhening Fibriany G.A. Aparigraha Hartatik Heri Sasono I G. N. Jemmy A I GA. Gede Minanjaya I Gusti Agus Tusan Wira Darma I Gusti Ayu Kusuma Dewi I Gusti Ngurah Jemmy Anton Prasetia I Gusti Nyoman Darmaputra I Made Arya Wiraguna I Made Wiracana I Nengah Sujaya IMD Dwi Putra Imron Hadi Tamim IRIANI SETYAWATI Julie Abdullah Kartini, Ni Komang Triayu Cita Ketut Widyani Astuti Komang Dede Saputra Kurniawan Arif Maspul Luh Ayu Putri Saraswati Luh Putu Febryana Larasanty Luh Putu Febryana Larasaty Made Krisna Adi Jaya Made Tresia Pramasta Diva Mekar Meilisa Amalia Muhammad Syafri N. P. A. D. Wijayanti Ni Gusti Ketut Roni Ni Made Ary Sarasmita Ni Putu Ayu Dewi Wijayanti Ni Putu Chintya Sandra Bhuana Ni Putu Linda Laksmiani Ni Putu Maya Ninditha Pangestu, Ade Winanda Pranatha, I Putu Adhi Prasetia Prasetia Raúl Eleazar Arias Sánchez Retno Murwanti Rhyce Dewata Sari Rohman, Abdul Sanita Dhakirah Sapitri, Putu Dian Savitri, Anava Salsa Nur Shabrina Herawati Shan Amadeus Sugianto, Efendi Sulaiman, T.N Saifullah Sutardjo, Agus Syahril Hasan - Politeknik Sains dan Teknologi Wiratama Maluku Utara, Syahril Hasan Teguh Setiawan Wibowo Uli Wildan Nuryanto Umar, Ahmad Ulil Albab Al Yanti, Ni Made Frida