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All Journal Health Science Journal of Indonesia Jurnal Neutrino : jurnal fisika dan aplikasinya Journal of Biomedicine and Translational Research Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Health Sains Indonesian Journal of Medical Chemistry and Bioinformatics Journal of Global Pharma Technology Indonesian Journal of Biomedicine and Clinical Sciences
Luluk Yunaini
Department Of Medical Biology, Faculty Of Medicine, University Of Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Journal of Global Pharma Technology

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DNA METHYLATION IN THYROID-STIMULATING HORMONE GENE: PREDICTOR OF GRAVE’S DISEASE RECURRENCE IN INDONESIA Luluk yunaini; Dwi Anita Suryandari; Trisia Lusiana Amir; Dwi Yanti; Fatimah Eliana
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Thyroid-stimulating hormone receptor (TSHR) has a critical role in Graves’ disease (GD). GD is an autoimmune disease which is multifactorial. Environmental factors can affect the epigenetic, a changes in gene expression without any changes in base sequence of the DNA. One of the epigenetic types is methylation. This study aims to determine the status of DNA methylation in TSHR gene in patients with GD to be one of the predictors of recurrence. This study used a case control design with 58 samples of GD patients divided into 29 groups of recurrence and 29 groups of non-recurrence. DNA methylation examination used methylation-specific PCR (MSP) method. Our result found that DNA methylation profile of GD in Indonesia were 5% with complete DNA methylation, 17% complete DNA unmethylation and 78 partial DNA methylation. Statistical analysis showed no significant different between recurrence and non-recurrence group (p>0.05). Nevertheless, our result showed no patient with complete status DNA methylation was found in recurrence group. This shows that in recurrence occur a reduction of DNA methylation resulting in increasing of TSHR production. Thus, DNA methylation in TSHR gene might be has a role in the risk of recurrence GD.
Expression relative of RANK, RANKL and OPG gene on Rat Femoral Fracture Healing Process in Delayed Union Model after Pulsed Electromagnetic Field exposure Luluk yunaini
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Pulsed electromagnetic field (PEMF) is application medical devices in healing bone fracture. Osteoblast and osteoclast cells have regulation in femoral fracture healing process. PEMF exposure has effect in cell nucleus activity. Genes that have critical role in bone remodelling are Receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG).This research aimed to analysis effect PEMF exposure in improve bone fracture healing process with delay union model, which its expression level in RANK, RANKL and OPG gene. Our research used experimental design. Sample for this research was callus from rat femoral fracture with delay union. qRT-PCR technique with Livak’s measurement were used to detection expression relative. Statistic analysis used two way ANOVA with a significant differences value p <0.05. The result showed that relative expression on RANK, RANKL and OPG have significance different in PEMF group and times (days) group. We found that the PEMF group can expedite the higher expression relative of RANK, RANKL and OPG than non PEMF group. The result has concluded using PEMF can improve the healing to normal union process on rat with delay union model.
Co-Authors Arleni Bustami Benedikta D. Saraswati Benedikta Diah Saraswati Budi Wiweko Christina Agusta Deviana Tanifan Debby Desmarini Dewi Sukmawati Dewi Sukmawati Dwi A. Suryandari Dwi A. Suryandari Dwi Anita Suryandari Dwi Ari Pujianto Dwi Yanti Fadilah Fadilah Fatimah Eliana Fatimah Eliana Hadi Sunaryo Irandi Putra Pratomo Khaerunissa Anbar Istiadi Kristanty, Diyah Kurniati, Mala Murdani Abdullah Panghiyangani, Roselina Prawiningrum, Aisyah Primariadewi Rustamadji Pudji Sari Puji Sari Puji Sari Puji Sari Puji Sari Ria Kodariah Ria Kodariah Sisca Sisca, Sisca Sofy Meilaini Surya Dwira Trisia Lusiana Amir Umiatin, Umiatin Widia Bela Oktaviani Yuda Nabella Prameswari Yurnadi Yurnadi