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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Program Kreativitas Mahasiswa - Penelitian Journal of Islamic Pharmacy Majalah Kesehatan FKUB Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Bioteknologi & Biosains Indonesia
VALENTINA YURINA
Program Studi Farmasi, Fakultas Kedokteran Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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OPTIMIZATION OF INTRANASAL COVID-19 VACCINE FORMULATION WITH Lactococcus lactis pNZ HCR BACTERIA AS VECTOR IN LIQUID AEROSOL PREPARATION Yurina, Valentina
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 1 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.1742

Abstract

Vaccination is an effective method to suppress COVID-19 transmission, but injection-based vaccination is less effective due to its inability to induce mucosal immunity. This study aimed to determine the effects of vaccine formulations on bacteria viability and antigen expression to find the optimal formulation. Three intranasal preparation formulations (F1, F2, and F3) were created with different ingredient compositions, along with a control. Physicochemical tests were conducted on day 0 and day 14 to assess bacterial viability, and antigen expression was evaluated using the western blot method. Formula 2, containing sodium alginate (0.615%), trehalose (4.125%), polyvinyl alcohol (0.1%), and calcium chloride (5%), exhibited the best viability test results, although no significant differences were observed among the groups. The study concluded that variations in composition concentrations could affect bacterial stability, with Formula 2 showing the best results in terms of bacteria viability and antigen expression up to 14 days after formulation.
Co-Authors Achmad Rudijanto Alvan Febrian Shalas Anggita Rosiana Putri Anggita Rosiana Putri Angi Nurkhairina, Angi Anita Puspa Widiyana Ardina Pramesti Putri, Ardina Pramesti Bachtiar Rifai Pratita Ihsan Bachtiar Rifai Pratita Ihsan Diah Royani Meisani Ema Pristi Yunita, Ema Pristi Eva Putri Arfiani Fredo Tamara, Fredo Ihsan, Bachtiar Rifai Pratita Kesuma, Suryanata Kusworini Handono Luthfi Ahmad Muchlashi Megasari, Suci Muchlashi, Luthfi Ahmad Nabila Ayu Safitri, Nabila Ayu Nashi Widodo Oktavia Eka Puspita Oktavia Eka Puspita, Oktavia Eka Oktavia Rahayu A, Oktavia Rahayu Oktavia Rahayu Adianingsih Poejiani, Soeyati Sri Winarsih Tamara Gusti Ebtavanny Thoha Muhajir Albaar, Thoha Muhajir Tri Yudani Mardining Raras