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All Journal Sari Pediatri Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia AcTion: Aceh Nutrition Journal Jurnal Ilmiah Mahasiswa Kedokteran Medisia AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Budapest International Research in Exact Sciences (BirEx Journal) Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Peradaban Journal of Religion and Society Narra X
Sulaiman Yusuf
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Household clean and healthy living behaviors and stunting severity among children under five in Indonesia: A cross-sectional study Maghfirah, Dhiyal; Safri, Mulya; Maharani, Cut R.; Yusuf, Sulaiman; Sofia, Sofia
Narra X Vol. 3 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i3.232

Abstract

The prevalence of stunting among children under five in Indonesia reached 21.5% in 2023, underscoring a persistent public health challenge. Behavioral factors, including Clean and Healthy Living Behavior (CHLB), are known to influence health outcomes and may contribute to child growth. The aim of this study was to examine the association between household CHLB and stunting severity among children under five years of age. A cross-sectional study was conducted from September to October 2024 in the Sukajaya Primary Health Center area. Using a total sampling technique, 62 mothers of stunted children aged 0–59 months were recruited. Data were collected through direct interviews using structured questionnaires and anthropometric measurements of children’s height and weight. Statistical analysis included chi-square tests and multivariable logistic regression using SPSS version 23.0. The results showed that children with severe stunting were significantly younger than those with moderate stunting (26.9±14.9 months, p<0.001). Overall, household CHLB implementation was suboptimal; however, no statistically significant association was identified between the overall CHLB and stunting severity (p=0.091). Multivariable analysis identified child age (OR=0.916, p=0.001) based on weight-for-age z-scores (OR=0.298; p=0.019) as an independent predictor of stunting severity, whereas household CHLB was not significantly associated (p=0.132). In conclusion, stunting severity among children under five was primarily associated with child age and nutritional status rather than household CHLB implementation. These findings highlight the importance of early-life nutritional interventions to prevent progression to severe stunting.
Evaluating reticulocyte hemoglobin as a marker of iron depletion in pediatric patients in Banda Aceh Oktariany, Ayu Rezky; Haris, Syafruddin; Noviat, Heru; Yusuf, Sulaiman; Edward, Eka Destianti; Andid, Rusdi
AcTion: Aceh Nutrition Journal Vol 11, No 1 (2026): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v11i1.2535

Abstract

Anemia in children remains a major public health problem worldwide and in Indonesia, where national data report a prevalence of 21.7% among children aged ≥1 year. Iron deficiency is the leading cause, with iron depletion representing the earliest subclinical stagewhich is often difficult to detect using conventional parameters. Reticulocyte hemoglobin (Ret-He) has been proposed as a marker of functional iron availability during erythropoiesis. This study aimed to evaluate the diagnostic performance of Ret-He in identifying iron depletion in pediatric patients. A cross-sectional analytical study was conducted at Dr. Zainoel Abidin General Hospital in Banda Aceh between July and September 2024. A total of 87 pediatric patients aged 1 month to 18 years were initially enrolled; after excluding subjects with anemia to focus on the iron depletion stage, 54 children were included in the final analysis. Iron depletion was identified in 12.6% of the subjects. Receiver operating characteristic (ROC) analysis showed an optimal Ret-He cut-off value of 29.5 pg, with an area under the curve (AUC) of 0.609, sensitivity of 70%, specificity of 63.6%, and a non-significant p-value (p = 0.398), indicating a limited diagnostic accuracy. Ret-He levels were significantly positively correlated with mean corpuscular volume (MCV) (r = 0.444; p = 0.001) and mean corpuscular hemoglobin (MCH) (r = 0.511; p < 0.001), but were not significantly associated with hemoglobin, ferritin, or transferrin saturation. In conclusion, Ret-He cannot be used as a standalone diagnostic marker of iron depletion in pediatric patients. However, its association with erythrocyte indices suggests that Ret-He may serve as a complementary parameter when interpreted alongside conventional iron status markers during the early evaluation of iron-related disorders.
Profile and outcome of atypical progressive acute kidney injury in children in a tertiary care hospital in Indonesia Fitria, Fitria; Sovira, Nora; Haris, Syafruddin; Yusuf, Sulaiman; Herdata, Heru Noviat; Ismy, Jufitriani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art8

Abstract

Background: Atypical progressive acute kidney injury (APAKI) in children is a severe form of acute kidney injury (AKI) marked by rapid progression to end-stage and high mortality. Since August 2022, Indonesia has reported a surge of pediatric AKI, predominantly in previously healthy children, linked to contamination of syrup medications with diethylene glycol (DEG) and ethylene glycol (EG).Objective: The objective of this research is to identify the characteristics and clinical outcomes of children with APAKI at Dr. Zainoel Abidin Hospital in Banda Aceh, a tertiary care hospital in Indonesia.Methods: This analytical observational study used secondary data from pediatric medical records of APAKI cases between June and December 2022. A total sampling technique identified 31 eligible patients aged 1–18 years old. Clinical characteristics, laboratory parameters, and outcomes were analyzed using descriptive statistics and Fisher’s Exact tests.Results: Thirty-one pediatric patients with APAKI are included; most are male (64.5%), aged 1–5 years (93.5%), domiciled outside Banda Aceh (58.1%), and had good nutritional status (80.6%). The mortality is high (74.2%). Genitourinary symptoms such as oliguria/anuria are the most frequent (87.1%), and dialysis is the main therapy (64.5%). Poor outcomes are significantly associated with respiratory symptoms (OR=16; 95%CI: 1.643-155.77), PELOD-2 score ≥10 (OR=10.89; 95%CI: 1.140-103.98), and mechanical ventilation (OR=16; 95%CI: 1.643-155.77). Laboratory predictors of mortality included leukocytosis (OR=11.11; 95%CI: 1.701-72.564), thrombocytopenia (OR=1.90; 95%CI: 1.207-2.957), elevated urea (OR=13.2; 95%CI: 1.124-154.920), elevated creatinine (OR=36.67; 95%CI: 3.124-430.333), reduced eGFR (OR=22; 95%CI: 1.924-251.539), and elevated SGOT (OR=22; 95%CI: 1.924-251.539) and SGPT (OR=36.67; 95%CI: 3.124-430.333). Toxicology testing is correlated with better survival (OR=0.07; 95% CI: 0.006-0.889).Conclusion: APAKI in children is associated with high mortality. Poor outcomes are strongly linked to respiratory involvement, high PELOD-2 scores, mechanical ventilation, and multiple laboratory abnormalities, highlighting the importance of early risk identification and timely management.
Faktor Risiko Determinan Gagal Napas pada Anak dengan Pneumonia Zuhaira, Zuhaira; Bakhtiar, Bakhtiar; Yusuf, Sulaiman; Safri, Mulya; Sovira, Nora; Edward, Eka Destianti
Sari Pediatri Vol 27, No 6 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.6.2026.401-7

Abstract

Latar belakang. Gagal napas merupakan fase lanjut dari gangguan pernapasan yang menyebabkan kegagalan paru untuk memenuhi kebutuhan oksigen dan mengeluarkan karbondioksida. Infeksi pernafasan, khususnya pneumonia merupakan penyebab paling umum gagal napas yang membutuhkan ventilasi mekanis pada anak. Tujuan. Mengetahui faktor risiko determinan gagal napas pada anak dengan pneumonia.Metode. Penelitian ini merupakan studi analitik observasional dengan pendekatan cross-sectional pada anak usia 1 bulan sampai < 18 tahun yang dirawat di ruang rawat anak dan Pediatric Intensive Care Unit (PICU) RSUD dr. Zainoel Abidin sejak 1 Januari 2022 sampai 31 Desember 2022 dengan data dari rekam medis yang memenuhi kriteria penelitian. Data dianalisis bivariat dengan uji chi square dan uji fisher dan selanjutnya dilakukan analisis multivariat dengan regresi logistik.Hasil. Total sampel dalam penelitian ini 182 pasien dengan pneumonia, 33 (18,1%) pasien mengalami gagal napas. Faktor risiko determinan gagal napas pada anak dengan pneumonia adalah sepsis (p=0,000) dengan OR 57,62 (IK95%:13,55-245,05), hipoksemia (p=0,002) dengan OR 7,19 (IK95%: 2,04-25,27), anemia (p=0,036) dengan OR 4,17 (IK95%: 1,097-15,87) dan penyakit jantung bawaan (p=0,047) dengan OR 3,86 (IK 95%: 1,02-14,599).Kesimpulan. Faktor risiko determinan gagal napas pada anak dengan pneumonia adalah sepsis, hipoksemia, anemia dan penyakit jantung bawaan.
Risk factors for increased transaminase enzymes in children with epilepsy using valproic acid Sari, Ina Julia; Anidar, Anidar; Akbar, Zaki; Yusuf, Sulaiman; Bakhtiar, Bakhtiar; Ismy, Jufitriani
Paediatrica Indonesiana Vol. 66 No. 2 (2026): March 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Valproic acid (VPA) is a commonly used first-line medication for generalized epilepsy. Hepatotoxicity, manifested by elevations in transaminase enzymes, is a serious, life-threatening adverse effect of VPA use. Objective To determine the prevalence and risk factors for elevated transaminase enzymes in children with epilepsy receiving VPA. Methods A cross-sectional study was conducted at Zainoel Abidin General Hospital, Banda Aceh, Indonesia on 50 children with epilepsy aged 1 month to 18 years who received VPA and experienced elevations in serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT). We compared clinical characteristics Results  Of 294 children with epilepsy, 50 children (17%) met the study criteria. Elevated AST was found in 31 (62%) subjects and elevated ALT in 35 (70%) subjects. Bivariate analysis revealed a significant negative association between elevated AST and duration of treatment (OR=0.925; P=0.044) and a positive association between elevated ALT and number of antiepileptic drugs (AEDs) received (OR=7.691; P=0.022). Nutritional status was significantly associated with elevated ALT (OR=0.412; P=0.041). Multivariate analysis showed that the number of AEDs was he only significant risk factor for elevated AST (OR=4.663; P=0.040), and VPA dose was the most significant only significant factor for elevated ALT (OR=1.183; P=0.029). Conclusion In children receiving VPA for the treatment of epilepsy, the number of AEDs received is a risk factor for elevated ALT, while VPA dose is a risk factor for elevated AST.
Co-Authors Adrian, Riki Akbar, Zaki Al-shather, Zain Amna, Eka Yunita Anidar Anidar Anidar Anidar, Anidar Arqam, Abil Arsa, Iwan Sabardi Badriul Hegar Badriul Hegar Bakhtiar Bakhtiar Carolina, Infra Yunita Cut Zahara Phoenna Darnifayanti Darnifayanti Darnifayanti, Darnifayanti Dora Darussalam Dora Darussalam, Dora Edward, Eka Destianti Fajri, Fauzan Feliatra Fitria Fitria Harrika, Fenny Hasan, Denny I. Herlina Dimiati, Herlina Heru Noviat Herdata Heru Noviat Herdata, Heru Noviat Intan Chaharunia Mulya Ismy, Jufitriani Isra Firmansyah, Isra Jufitriani Ismy Liza Salawati, Liza Maghfirah, Dhiyal Maharani, Cut R. Muliana, Cut Mulya Safri, Mulya Muntadhar, Muntadhar Muslim Akmal Muslim Muslim Muzakkir, Yumna Nadia, Nurul Nora Sovira, Nora Noviat, Heru Nuriyanto, Alivia R. Nurul Maghfirah Octavina Susanti Oktariany, Ayu Rezky Raihani, Rifa Ramadhan, Muhammad Haris Rusdi Andid Rusdi Andid, Rusdi Sari, Eva Devita Sari, Ina Julia Sentosa, Sukmawan F. Siti Hajar Sofia Sofia, Sofia Sri Rezeki Susanti, Nurhayani D. Syafruddin Haris Syafruddin Haris, Syafruddin Syahrun Nur T.M. Thaib Thaib, Teuku Muhammad Zuhaira, Zuhaira