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All Journal Jurnal Natur Indonesia Jurnal Ilmu Lingkungan Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Riset Kimia ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
Adel Zamri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Synthesis of 4-(5-(2,3-Dimenthoxyphenyl)-3-(4-Methoxyphenyl)-4,5-Dihydro-1H-Pyrazol-1-y1) Benzenesulfonamide as a Promosing Tyrosinase Inhibitor Candidate Rahayu, Rahayu; Herfindo, Noval; Oscifiani, Nelly; Frimayanti, Neni; zamri, Adel
Jurnal Riset Kimia Vol 13, No 1 (2022): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v13i1.486

Abstract

In this study, titled compound 5 has been successfully synthesized with 93% yield. The pyrazoline compound was obtained from the cyclocondensation reaction of 4-hydrazinylbenzenesulfonamide 3 with chalcone (E)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 4 under basic conditions. The molecular structure was confirmed through analysis of FTIR, NMR and HRMS spectroscopic data. Furthermore, its tyrosinase enzyme inhibitory activity was determined through in vitro assay against tyrosinase of Agaricus bisporus. However, the pyrazoline compound 5 showed lower inhibitory activity than the positive control, kojic acid, whereas the IC50 value of the compound 5 is higher than that of kojic acid. The compound 5 IC50 value was 262.15 µM, while kojic acid IC50 value was 88.52 µM.
PENYERAPAN TIMBAL (Pb) PADA SISTIM ORGAN IKAN MAS (Cyprinus carpio L) Yusni Ikhwan Siregar; Adel Zamri; Helmi Putra
Jurnal Ilmu Lingkungan Vol 6, No 1 (2012): Jurnal Ilmu Lingkungan
Publisher : Program Pascasarjana Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jil.6.1.p.43-51

Abstract

A study on the uptake of Pb in the organ system of carp was carried out in the laboratoryscale. The research aims to identify the uptake rate of Pb in the gill, intestine and muscle ofthe fish. A completely randomized design was done in the experiment laboratory with threetreatments and three replications. The total of 120 fish were exposed to three concentrationsof Pb (1, 3 and 5 ppm of PbNO3) in nine aquarium for 168 hours. Pb concentration in the organsystem of fish were analyzed at 24, 96 and 168 hours, respectively. The concentration of Pbin the intestine were 0.29, 0.44 and 0.47 ppm, for 24, 96 and 168 hour exposure, respectively.Meanwhile, Pb content in the gill were 0.21, 0.39 and 0.45 ppm, respectively. It revealed thatPb concentration in all organs of fish increased significantly (P<0.05) following increased ofexposure time.
S SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA 3ꞌ-BROMO-4-METOKSI KALKON TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli Rahma Dona; Haiyul Fadhli; Adel Zamri; Winda Tria Safitri; Abdi Wira Septama
Jurnal Penelitian Farmasi Indonesia Vol. 11 No. 2 (2022): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v11i2.1547

Abstract

Chalcone is a flavonoid derivative that has a variety of interesting biological activities. One of the compounds suspected of being an antibacterial agent is chalcone. The properties of chalcone compounds depend on the substituents that depend on the two aromatic rings, such as Cl, Br, OH groups and so on. The purpose of this study was to synthesize chalcone analogue compounds and determine the potential of these analog compounds as antibiotics. In this research, a chalcone analogue compound has been successfully synthesized, namely 3ꞌ-Bromo-4-methoxy-chalcone through the stirring method using KOH catalyst, ethanol solvent. The results of the synthesis carried out by recrystallization and the yield obtained were 64 %. Identification of compounds that have been carried out by TLC test, melting point, and HPLC analysis. The structure of the compound was characterized by UV-Vis spectroscopy, FTIR and 1H NMR, indicating that the analogue chalcone compound has a structure as expected. Testing the activity of chalcone analogue compounds was carried out on Staphylococcus aureus and Escherichia coli at a concentration of 1%, 5%, 10% and 20% test solutions. The test results showed that the antibacterial activity of the compound 3ꞌ-Bromo-4-methoxy-chalcone was categorized as weak.
SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES Eryanti, Yum; Nurulita, Yuana; Hendra, Rudi; Yuharmen, Yuharmen; Syahri, Jufrizal; Zamri, Adel
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.
Synthesis and Evaluation of Some Sulfonamide-Substituted of 1,3,5-Triphenyl Pyrazoline Derivatives as Tyrosinase Enzyme Inhibitors Herfindo, Nofal; Frimayanti, Neni; ikhtiarudin, Ihsan; eryanti, Yum; zamri, Adel
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.6936

Abstract

Pyrazoline is well-known as heterocycles compound that can exhibit many biological effects. In this work, we synthesized a series of sulfonamide-substituted 1,3,5-triphenyl pyrazoline compounds as a promising tyrosinase inhibitor agent. These compounds prepared by multicomponent reaction of corresponding aldehyde, ketone, and hydrazine using seal-vessel reactor. Pyrazolines compound were tested for their tyrosinase inhibitor activity through in vitro assay. The test result found that compound 4c, 4d, and 4e possessed better tyrosinase inhibitory activity compared to the reference drug, kojic acid. Compound 4c exhibited the strongest tyrosinase inhibitory effect with an IC50 value of 30.14 µM. The results suggested that hydroxyl and methoxy substituent at para position are preferable. Furthermore, molecular docking studies result match the pattern of in vitro assay where the compound will provide a stronger binding interaction and lower binding free energies.
Studi In Silico dan Pengaruh Gugus Metoksi pada Hasil Sintesis Analog Kalkon terhadap Inhibisi Enzim α-Glukosidase Dona, Rahma; Furi, Mustika; Frimayanti, Neni; Zamri, Adel; Nahdiah, Nahdiah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 1 (2022): J Sains Farm Klin 9(1), April 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.1.12-23.2022

Abstract

Kalkon (1,3-diaril-2-propen-1-on) merupakan golongan flavonoid yang memiliki banyak aktivitas salah satunya sebagai antidiabetes. Pada penelitian ini dilakukan sintesis tiga senyawa analog kalkon yaitu 2’-hidroksi-2-metoksi-kalkon (Kalkon1), 2’-hidroksi-3-metoksi-kalkon (Kalkon2) dan 2’-hidroksi-4-metoksi-kalkon (Kalkon3) dan serta dilakukan pengujian karakterisasi nya. Sintesis analog kalkon  dilakukan dengan metode irradiasi microwave menggunakan  katalis KOH, pelarut etanol dan PEG 400. Struktur setiap produk dikarakterisasi melalui spektroskopi UV-Vis, FTIR dan 1H NMR, menunjukkan bahwa ketiga senyawa analog kalkon hasil sintesis memiliki struktur sesuai dengan yang diharapkan, dengan hasil rendemen yaitu 91,53% (Kalkon1), 79,01% (Kalkon 2) dan 77,48% Kalkon 3. Berdasarkan studi in silico dari parameter nilai energi bebas ikatan didapatkan bahwa senyawa Kalkon 3 memiliki nilai energi bebas ikatan terkecil yaitu sebesar -8,8 kcal/mol dibandingkan senyawa Kalkon1 dan Kalkon2 yaitu sebesar -7,5 kcal/mol, -6,8 kcal/mol. Untuk  parameter  kecocokan asam amino dengan kontrol positif (akarbose), hanya senyawa Kalkon1 yang memiliki kecocokan dengan kontrol positif (akarbose) sedangkan untuk parameter ikatan hidrogen didapatkan bahwa semua senyawa uji tidak menunjukkan adanya interaksi berupa ikatan hidrogen antara ligand dan reseptor. Hasil ini menunjukkan senyawa Kalkon1, Kalkon 2 dan Kalkon 3 diperkirakan tidak aktif sebagai inhibitor enzim α-glukosidase.
Synthesis and Molecular Docking Study of 4-(3-(2-Chlorophenyl)-5-(2-Methoxyphenyl)-4,5-Dihydro-1H-Pyrazol-1-yl) Benzenesulfonamide as Antibreast Cancer Agent Putri, Eka Marisa; Herfindo, Noval; Guntur, Guntur; Frimayanti, Neni; Zamri, Adel
ALCHEMY Jurnal Penelitian Kimia Vol 18, No 1 (2022): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.18.1.48298.30-36

Abstract

Breast cancer is a disease in which cells in the breast tissue change and divide in an uncontrolled way. Pyrazoline is a promising agent reported against cancer. In this work, we have synthesized pyrazoline 4-(3-(2-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (EMP-1). The reaction was successfully carried out in one-pot three components from 2-chloroacetophenone, 2-methoxybenzaldehyde, and 4-hydrazinylbenzenesulfonamide as starting materials. The reaction was conducted by assisting the irradiation of Monowave 50 (Anton-Paar) with a high yield of 91%. Its potential anti-breast cancer was investigated by molecular docking and dynamic studies. The molecular docking study showed that EMP-1 had binding energy of -7.17 kcal/mol. The spatial arrangement of EMP-1 was similar to the positive control of doxorubicin. These results indicate that EMP-1 compound potentially developed as anti-breast cancer.
Co-Authors -, Lelani Abdi Wira Septama Darian Alfatos David Aprianto, David Destawira Hariani Elka Yuslinda Fitrah Hayati Furi, Mustika Gasella, Raja Mutya Guntur Guntur Haiyul Fadhli Helmi Putra Hendra, Rudi Herfindo, Nofal Herfindo, Noval Hilwan Yuda Teruna Ibnu Rush Ihsan Ikhtiarudin Jasril Jasril Jufrizal Syahri Kamal Rullah Karsana, Elsaria Kurniati, - Lusrianti, - Nahdiah Nahdiah, Nahdiah Neni Frimayanti Nur Balatif Nurwijayanti Oktavia, Denaria Oscifiani, Nelly Putri Bela Utama Putri, Eka Marisa Rahayu Rahayu Rahma Dona Rahmi Miftahul Jannah Riki Setiawan Rokim, Muhamad Siti Aisyah Syamsul Rizal Syilfia Hasti Veithzal Rivai Zainal Widya Rachmi Winda Tria Safitri Yuana Nurulita Yuharmen - Yuharmen, Yuharmen Yum Eryanti Yusni Ikhwan Siregar