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All Journal Proceeding of Mulawarman Pharmaceuticals Conferences

Fajar Prasetya

Laboratorium Penelitian dan Pengembangan Kefarmasian ?Farmaka Tropis? Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295755

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Uji Aktivitas Mukolitik Perasan Daun Miana (Plectranthus scutellarioides (L.) R.Br.) Secara In Vitro: Mucolytic Activity Test of a Squeeze of Miana leaves (Plectranthus scutellarioides (L.) R.Br.) by in Vitro Krismayani Krismayani; Fajar Prasetya; Febrina Mahmudah
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Mucolytics are drugs that can dilute airway secretions by preventing mucoprotein and mucopolysaccharide threads from being sputum. Empirically, the juice of miana leaves is used by the Toraja people to treat cough with pHlegm. There has been no testing of miana leaf juice as a mucolytic agent, therefore this study was conducted to see the mucolytic activity of miana leaf juice. The test was carried out in vitro using bovine intestinal mucus as a negative control and acetyl as a positive control. Mucolytic activity can be seen from the decrease in viscosity produced by each test sample. Samples were tested using a Rheosys viscometer with a temperature and pH that matched the pHysiological conditions of the body. The results showed that the concentration of 1% miana juice had a large mucolytic activity, compared to concentrations of 0.5%, 1.5, and 2%. The results of pHytochemical screening showed that miana leaf juice was positive for saponins and flavonoids which were thought to work in decreasing the viscosity of mucus.

Optimasi Basis Masker Gel Peel-Off dan Uji Stabilitas Fisik Sediaan Masker Gel Peel-Off dari Ekstrak Daun Sirih Hitam (Piper betle L. VAR. NIGRA): Optimization of Peel-Off Gel Mask Base and Physical Stability Test of Peel-Off Gel Mask from Black Betel Leaf Extract (Piper betle L. VAR. NIGRA) Nadira Yuli Istiana; Nurul Fitriani; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Gel peel-off masks have many advantages, namely that besides being easy to apply, this masks can also produce good release and penetration of active substances. Black betle (Piper betle L. var. Nigra) is a type of plant that has been studied to have good antibacterial activity against several types of bacteria, including Staphylococcus aureus. The aim of this study was to determine the best formulation for the gel mask and to determine the stability of the preparation of the gel peel-off mask after addition of black betel leaf extract (Piper betle L. var. Nigra). The optimization of the gel-base was carried out by formulating a gel peel- off mask preparation using carbopol in 4 different concentrations, namely F1 0.5%, F2 1%, F3 1.5% and F4 2%, then carried out a physical evaluation of the preparation including organoleptic tests, homogeneity, pH, dispersibility, adhesion, viscosity and drying time. After getting the best gel-base formula, black betle leaf extract was added, and the preparation was again performed for physical evaluation. The result of the optimization of the base gel peel-off mask obtained a base with the characteristics of a transparent white gel, homogeneous, characteristic aroma, thick, pH 5.37, adhesion 18 seconds ? 1 minute, spreading 4,5-7 cm cm, time drying time 14-19 minutes and viscosity of 3,987-26,164 Pa.s. The average results of the physical stability test of the preparation of the gel peel-off mask after the addition of black betle leaf extract were dark green, homogeneous, distinctive rose aroma, thick form, pH 5.6, adhesion 19 seconds, spread 6.4 cm, drying time 17 minutes, viscosity 3.251 Pa.s and absence of syneresis.

Formulasi Sediaan Patch Bukal Ekstrak Daun Sirih Hitam (Piper betle L. var Nigra ): Buccal Patch Preparation Formulation of Black Betel Leaf Extract (Piper betle L. var Nigra) Risma Indah Ardiyana; Novita Eka Kartab Putri; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black betel is one of the native plants from Indonesia which has many benefits for treating various diseases, one of which is for oral diseases such as thrush. This study aims to determine the formula of black betel buccal patch (Piper betle L. var Nigra) which is stable and has good patch activity and to know the formula for buccal patch preparation which is effective as a canker sore and fulfills the characteristics of a good pharmaceutical preparation. The black betel leaf extract was made using the maceration method with 70% ethanol as a solvent. Patches were made based on the extract concentration (0.5%, 1%, 2%) using chitosan as the polymer matrix. The results showed that the best buccal patch was owned at concentrations of 0.5% and 1%. The higher the extract content, the higher the weight, thickness, folding endurance, and swelling index.

Kajian In Silico Senyawa Turunan Pirazolina terhadap Bakteri Eschericia coli: In Silico Study of Pyrazoline Derivative Compounds against Eschericia coli Bacteria Tri Wulan Novi; Wisnu Cahyo Prabowo; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The development of antibiotics is needed to overcome drug resistance. Penicillin binding protein 5 (PBP5) Eschericia coli bacteria is one of the targets because it plays a role in maintaining cell shape. Pyrazolina is a compound that contains two nitrogen atoms where the two nitrogen atoms are close together and are responsible as an antibacterial agent that can disrupt the cell wall. The target molecule was downloaded from the Protein Data Bank (www.rcsb.org) (PDB ID: 6NTZ). The grid used is 20 ? x 26? x 32? with a center of 29,731?, -9,112 ? and 35,821 ?. Based on the results of the docking that has been carried out from 10 pyrazoline derivative test compounds, the resulting binding energy varies. There are 5 pyrazoline derivative compounds having binding energy lower than the natural ligands -6.27 kcal / mol. Compound P8 has the lowest value compared to other test compounds with a binding energy value of -7.69 kcal / mol. Based on the interaction, P2 and P3 compounds have interactions that are similar to the original ligands due to the presence of Pi-Donor hydrogen bonds with the amino acids SER 73 and SER 139. The results of molecular docking studies show that pyrazoline derivatives play a role in Eschericia coli bacteria.

Optimasi Basis Gel dan Evaluasi Sediaan Gel Anti Jerawat Ekstrak Daun Sirih Hitam (Piper betle L. Var Nigra): Gel Base Optimization and Evaluation of Anti-Acne Gel Black Betel Leaf Extract (Piper betle L. Var Nigra) Velita Rosari; Nurul Fitriani; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Gel is a semi-solid preparation that is clear, translucent and contains active ingredients. Acne is a skin disorder caused by the Propionibacterium acnes bacteria. Black betel (Piper betle L. var Nigra) contains alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and polyphenolates which function as antibacterial. So that it can be formulated as an active substance in anti-acne gel preparations. The purpose of this study was to obtain a gel base with good physical stability and to evaluate the gel preparations mixed with black betel leaf extract (Piper betle L. var Nigra). Base optimization is done with 4 formulas with variations of Carbopol and TEA, namely B1, B2, B3, and B4. After getting the best gel base, then 3 formulas were made with various concentrations of black betel leaf extract (Piper betle L. var Nigra), namely F1 5%, F2 10%, and F3 15%. Then performed the physical stability test of the anti-acne gel preparation including organoleptic, homogeneity, pH, dispersion, adhesion, syneresis and viscosity for 16 days. The results obtained in the base optimization are clear, smell typical of bases, thick, homogeneous, pH range 6.1-6.8, spreadability 5.8-6.9 cm, adhesion 8-21 seconds, and viscosity 2.75. -5.81 Pa.s. The results obtained on the anti-acne gel are dark green, unique extract odor, thick, homogeneous, no syneresis, pH range 5.6-6.1, spreadability 6.0-6.9 cm, adhesion 14-21. seconds, and a viscosity of 2.12-6.81 Pa.s. The results showed that the gel base formula B4 was in accordance with the standard physical stability parameters. The addition of black betel leaf extract (Piper betle L. var Nigra) to the gel base affected the physical stability of the anti-acne gel preparation, but it was still included in the standard parameters of a good gel.

Formulasi Sediaan Mouthwash Ekstrak Daun Sirih Hitam (Piper sp.) Terhadap Streptococcus mutans dan Candida albicans: Mouthwash Preparation Formulation of Black Betel Leaf Extract (Piper sp.) Against Streptococcus mutans and Candida albicans Deschania Noor Qhorina; Fajar Prasetya; Mirhansyah Ardana
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black betel (Piper sp.) contains compounds that function as antimicrobials, namely tannins, phenolic compounds, saponins, flavonoids, alkaloids, and steroids that can be used as active ingredients for making mouthwash. The purpose of this study was to determine the effective mouthwash formulation used as an antimicrobial. Antimicrobial testing method using well diffusion method with a reserve of 6 mm. Black betel leaf extract was dissolved with a variation of the concentration of glycerin 1:4; 1:8 and 1:12 and tested on Streptococcus mutans and Candida albicans bacteria, then tested for stability of the preparations, including organoleptic, pH and viscosity. The results obtained from various solvents were glycerin as the most stable solvent compared to 96% ethanol, tween 80 and aquades. The results obtained from the antimicrobial test with ANOVA analysis were for Streptococcus mutans bacteria p=0.004 (p<0.05) which means the p-value was significant between concentration variations and bacteria and for the fungus Candida albicans p=0.295 (p>0.05) which meant the p-value was not significant difference between concentration variations and fungi. The results of the evaluation test for the stability of the preparation, namely the organoleptic data, pH and viscosity at a temperature of 25ºC were relatively stable.

Optimasi Basis Formulasi Sediaan Handsanitizer Gel Ekstrak Daun Sirih Hitam (Piper betle var nigra) Sebagai Antibakteri: Optimization of the Hand Sanitizer Gel Preparation Base for Black Betel Leaf Extract (Piper betle var nigra) as an antibacterial Felina Alfiany; Novita Eka Kartab Putri; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black betel leaf (Piper betle var. nigra) is one of the plants that has the potential as an antibacterial. This research is a laboratory experiment and aims to determine the optimum concentration of hand sanitizer gel base which will then be used in the formulation of hand sanitizer gel preparations with the active ingredient of black betel leaf. Optimization was carried out for 7 days by looking at the physical properties of the gel preparation, namely organoleptic, homogeneity, pH test, viscosity, and spreadability test. Handsanitizer gel was made in three formulas with three different concentrations of Carbopol 940, namely A, B, and C. The results obtained in the evaluation of the organoleptic test were observed in clear color, semisolid dosage form and smelled of Carbopol 940. Homogeneity test was indicated by the absence of granules. rough on the preparation. The pH test is the pH of the gel preparation which is stable at pH 7. The dispersion test of 5-7 cm shows a semisolid consistency which is very comfortable to use. The viscosity test showed that the gel viscosity was in the range of 1,206 cps - 1,820 cps. The results of the evaluation of the optimum hand sanitizer gel base are obtained if it has good physical quality and meets the criteria for gel preparation. Based on the evaluation results on the optimization of the hand sanitizer gel base, it was obtained that the Carbopol 940 gel base with a concentration of A had met the criteria for making gel preparations.

Uji Antioksidan Ekstrak Metanol Kulit Batang Pule (Alstonia scholaris) khas Kalimantan dengan Metode DPPH: Antioxidant Test of Methanol Extract of Pule Bark (Alstonia scholaris) typical of Kalimantan with the DPPH Method Nur Halimah; Mahfuzun Bone; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Pule (Alstonia scholaris) is one of the plants that are empirically often used in medicine. Pule bark contains flavonoids which can generally be used as antioxidants. This study aims to determine the content of secondary metabolites and antioxidant activity of the methanol extract of pule bark by determining the IC50 value of the extract. The secondary metabolite test was carried out by reacting the extract with phenolic test reagents, steroids, terpenoids, saponins, flavonoids and alkaloids. The antioxidant activity test was carried out using the DPPH method (2,2-Diphenyl-1-Picrylhydrazil). Antioxidant activity was measured by the ability of the methanol extract of Pule bark to reduce DPPH which was measured using a UV-Vis Spectrophotometer so that absorbance data was obtained and then processed by linear regression method. The results showed that the extract contained phenolic and flavonoid compounds. While the DPPH test showed that the extract had weak antioxidant activity with an IC50 value of 472.473 ppm.

Kajian Literatur Tanaman Sirih Merah, Binahong, Dan Pegagan Sebagai Penyembuh Luka Insisi: Literature Study of Red Betel Plants, Binahong, and Gotu Kola as Incision Wound Healing Salinding Irene Septiani; Dewi Mayasari; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Injury is a condition where tissue function and structure of the body are damaged. Incision wounds can occur intentionally or unintentionally by sharp or blunt instrument. Red betel plants, binahong, and gotu kola are plants that can heal an incisioun wound. The results are obtained by the method of collecting data which related to the study that being studied and analyzed descriptively. The results obtained indicate the secondary metabolites that play a role in incision wound healing process are flavonoids, tannins, and triterpenoids.

Formulasi dan Optimasi Basis Serum Xanthan Gum dengan Variasi Konsentrasi: Formulation and Optimization of Xanthan Gum Serum Base with Variations of Concentration Chairunnisa Aprilia; Muhammad Faisal; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.613

Co-Authors Afif Ruchaemi Alia Nur Almeida, Maria Angga Cipta Narsa Arsyik Ibrahim Awalia Sariningsih Chairunnisa Aprilia Deschania Noor Qhorina Dewi Mayasari Dewi Rahmawati Elit Dita Paradila Elsa Akbar Wati Erwin Samsul Febrina Mahmudah Felina Alfiany Fika Aryati Hadi Kuncoro Hajrah Hajrah Imelia Rosalia Libba Jaka Fadraersada Jamal Habibullah Jeane Rose Christine Karmila Puspita Sari Krismayani Krismayani Laode Rijai Lia Angelika Lina Nur Amelia M Arifuddin Mahfuzun Bone Mega Ulfiyah Noor Mirhansyah Ardana Mitha Fransiska Muhammad Faisal Nadira Yuli Istiana Natalia Rara Samban Natanael Ramos Parapat Novita Eka Kartab Putri Novita Eka Kartab Putri Novita Eka Kartab Putri Noviyanty Indjar Gama Nur Halimah Nur Masyithah Z Nurhidayati Febriana Nurul Annisa Nurul Fitriani Oktaviany Triana Putri Anggreini Rahmadani, Agung Rany Silvi Mova Kalanarky Rika Nurlaili Putri Azizah Risma Indah Ardiyana Risna Agustina Rolan Rusli Salinding Irene Septiani Sega Ade Lilyawati Sekar Ningrum Sukartiningsih Sukartiningsih Suparningtyas, Juniza Firdha Supriatno Salam Tri Wulan Novi Velita Rosari Wisnu Cahyo Prabowo Yeni Fitri Handayani Zullies Ikawati

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