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All Journal Health Science Journal of Indonesia Global Medical and Health Communication The Indonesian Journal of Public Health The Indonesian Biomedical Journal Universa Medicina Oto Rhino Laryngologica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Binawan Student Journal The Indonesian Journal of Community and Occupational Medicine Jurnal Locus Penelitian dan Pengabdian eJournal Kedokteran Indonesia Lux Mensana: Journal of Scientific Health Cerdika: Jurnal Ilmiah Indonesia Jurnal Penyakit Dalam Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Occupational and Environmental Medicine Journal of Indonesia Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Dewi Sumaryani Soemarko
Departemen Ilmu Kedokteran Komunitas, Fakultas Kedokteran Universitas Indonesia
Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : The Indonesian Biomedical Journal

 1 
Biomonitoring of Acetylcholinesterase (AChE) Inhibitor and the Association with Hypertension among Farmers in Bandung, Indonesia Mulyana Mulyana; Iwan Sugiarta; Lim Jen Fuk; Vani Nur Pratami; Dewi Yunia Fitriani; Nuri Purwito Adi; Dewi Sumaryani Soemarko
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1220

Abstract

BACKGROUND: The use of acetylcholinesterase (AChE) insecticides is still widely used by farmers in flower and agricultural centers. However, biological monitoring of farmers is still very rare in Indonesia. AChE inhibitors are reported to have toxic effects on various organs.METHODS: This study involved 120 subjects in Cihideung, Cikole and Pangalengan areas. All subjects have been interviewed, physically examined and biological sample taken by medical team. Descriptive analysis was performed to assess general conditions of the subjects and AChE erythrocyte activity enzyme at pseudo-baseline and the next 3 months from pseudo-baseline. Statistical analysis have been performed of the pseudo-baseline AChE erythrocyte activity with hypertension and history of exposures.RESULTS: The median value of pseudo-baseline AChE erythrocyte activity was 8.10 (1.3-14.25) U/g hematocrit. In the comparison between pseudo-baseline and 3 month from pseudo-baseline AChE activity, 7 respondents from 19 respondents (36.84%) had lower enzyme activity than 70% and the others subjects have higher activity value. AChE erythrocyte activity is associate with frequency of insecticide exposures. AChE erythrocyte activity (p=0.04; Exp (B)=2.937 CI 95%=1.049-8.224) and age (p=0.025; Exp (B)=3.872 CI 95%=1.180-12.703) are independent risk factors for hypertension in farmworker.CONCLUSION: AChE erythrocyte activity associated with frequency of insecticide exposures and hypertension among farmworkers.KEYWORDS: AChE erythrocyte activity, frequency of insecticide expsoures, hypertension
Co-Authors -, Herqutanto Ade Mutiara Aditya Agung Prasetyo Agus Sugiharto Agustina, Amilya Ahmad Fuadi Ahmad Fuady Aldri Frinaldi Ambar Roestam Ambar W Roestam Amran Anggraeni, Caroline Anitasari Kusumawati Ari F Syam Aria Kekalih Arman, Fitri Arriz Akbar Sukadi Asep Barliana, Julie D. Bastaman Basuki Bernath Siagian Brastho Bramantyo Cahyono, Arie Dedy Pratama Denta Aditya Episana Desdiani, Desdiani Dewi Friska Dewi Yunia Fitria Dewi Yunia Fitriani Endang Parahyanti Ermita I. Ibrahim Evy Yunihastuti Faisal Yunus Ferdy Nurhadi Fifinela Raissa Finna Fitriana Firly Ratsmita Fita Rahmasari Fuk, Liem Jen Githa Rahmayunita Harahap, Sabasdin Harahap, Ummi Chairani Hardjono, Indra Herikurniawan, Herikurniawan Herlinah Herlinah Herqutanto - Herqutanto Herqutanto Herqutanto2 Hidayat, Marizca Saras Chitra Imron Khazim Indah S. Widyahening Indri, Olieve Irwan Suhadi Isbayuputra, Marsen Iwan Sugiarta Iwan Susilo Joko Izzatul Abadiyah Jonanda, Herik Okta Khoe, Levina Chandra Kresna, Andreas Kusuma, Mardiansyah Landauw, Martha Lim Jen Fuk Listya Tresnanti Mirtha, Listya Tresnanti Lusi Sandra Hutahaean Maha Putra, I Gede Mardianto, Umar Mariska, Tara Candida Marsen Isbayu Putra Marsen Isbayuputra Mohammad Firmansyah Monintja, Keyne Christa Muchtaruddin Mansyur Muhammad Ilyas Muhammad Ilyas Muhammad Ilyas Muhammad Ilyas Mulyana Mulyana Mulyantini, Astri Mutiara, Ade Novi Silvia Hardiany Nuri Purwito Adi Nuri Purwito Adi Nuri Purwito Adi Prasandhya Astagiri Yusuf Prihartanto, Joedo Priyono, Harim Pukovisa Prawiroharjo, Pukovisa Purnama, Ahmad Angga Putra, Marsen Isbayu Rakhmad Hidayat Ray Wagiu Basrowi Rayka, Ivan Restuti, Ratna Dwi Retno A. Werdhani Riani Dwianasari, Riani Rita Ingewaty Wijaya Rita Ingewaty Wijaya Rosady, Dony Septriana Salim, Stellon SEPTELIA INAWATI WANANDI Sjarifuddin, Citra Nurhayati Slamet Ichsan Sofyan, Marwan Sri L. Menaldi Sri Linuwih Susetyo Wardhani, Sri Linuwih Susetyo Sudadi Hirawan Sulistomo, Astrid Sumirat, Ratih Nurdiany Tenny Sutarto Tri Mawanti, Wening Tukimun, Suci Tria Meirisa Vani Nur Pratami Wibowo, Suryo Wiraguna, Andrian Wiratman, Winnugroho Yessi Kualasari Zarni Amri  Sugiarta,  Iwan