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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Nusantara Medical Science Journal Jurnal Keperawatan Padjadjaran Jurnal Kesehatan Prima Oceana Biomedicina Journal Jurnal Ilmu Kefarmasian Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Medical and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal journal of Basic Medical Veterinary Oceana Biomedicina Journal Cerdika: Jurnal Ilmiah Indonesia Jurnal Kedokteran Meditek
Yuani Setiawati
Departemen Farmakologi, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia
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Antibacterial Activity Test of Turmeric Extract (Curcuma longa) From Madura Island Against Staphylococcus aureus Baitul Fatimah; Dewangga Sakti Satria Kinasih; Wiwin Retnowati; Yuani Setiawati
Jurnal Kesehatan Prima Vol 16, No 1 (2022): FEBRUARY
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v16i1.825

Abstract

Staphylococcus aureus is a gram-positive bacteria, a normal flora of the body that can cause infection in various organs and has the potential to become resistant to antibiotics. Turmeric (Curcuma longa) is one of the herbs that has antibacterial effects and is often used by Madurese people as a traditional medicine. It is suspected that geographical differences and the natural conditions in which turmeric grows can affect its compounds and properties. This study aims to analyze the ethanolic extract of turmeric from Madura as an antibacterial against S. aureus. An in vitro laboratory research using agar well diffusion method was conducted with the concentration of turmeric extract used 20%, 40%, 80%, and 100%. The positive control used was penicillin. The negative control in this study was 100% DMSO. The results showed inhibition zone at concentrations of 20% (11.86 mm), 40% (12.04 mm), 80% (12.53 mm), and 100% (10.97 mm). The diameter obtained was lower than the positive control penicillin which was 27.59 mm. Turmeric extract (Curcuma longa) from Madura has antibacterial activity against Staphylococcus aureus.
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.61

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Aktivitas Antibakteri Ekstrak Etanol Daun Lamtoro (Leucaena Leucocephala) Terhadap Staphylococcus Aureus dengan Metode Dilusi Muhammad Khafidin Al Alim; Marijam Purwanta; Yuani Setiawati
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 2 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.947 KB) | DOI: 10.59141/cerdika.v2i2.345

Abstract

Latar Belakang: Lamtoro (Leucaena leucocephala) merupakan tumbuhan yang umum di indonesia. Tanaman ini selain bisa dimanfaatkan sebagai bahan pangan, daunnya juga sering dipakai masyarakat indonesia sebagai obat luka atau memar. Salah satu bakteri yang umumnya terdapat dalam luka adalah Staphylococcus aureus. Oleh karena itu, peneliti menduga bahwa ekstrak daun lamtoro memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Tujuan: Penelitian ini dilakukan untuk menguji aktivitas antibakteri daun lamtoro terhadap Staphylococcus aureus dengan metode dilusi. Metode: Ekstrak kental lamtoro dibuatkan seri pengenceran pada medium cair. Bakteri uji kemudian ditambahkan dengan proporsi yang sama pada setiap tabung. Tabung dengan konsentrasi ekstrak terendah yang masih terlihat jernih ditetapkan sebagai KHM. Selanjutnya dilakukan streaking pada media biakan. Setelah inkubasi, media dengan konsentrasi terendah yang tidak didapati pertumbuhan koloni ditetapkan sebagai KBM. Hasil: Kekeruhan yang disebabkan ekstrak tidak dapat dibedakan dengan kekeruhan yang disebabkan bakteri, sehingga KHM tidak dapat ditentukan. Dari hasil kultur, didapatkan pertumbuhan koloni pada seluruh media biakan, sehingga KBM juga tidak dapat ditentukan. Hasil hitung koloni menghasilkan bahwa ekstrak tidak membunuh bakteri namun masih dapat menghambat pertumbuhan bakteri tersebut paling optimal pada konsentrasi 125 mg/mL dan 62,5 mg/mL. Kesimpulan: KHM dan KBM ekstrak daun lamtoro terhadap Staphylococcus aureus pada penelitian ini tidak dapat ditentukan. Ekstrak lamtoro tidak membunuh Staphylococcus aureus, namun masih dapat menghambat pertumbuhan bakteri tersebut, paling optimal pada konsentrasi 125 mg/mL dan 62,5 mg/mL.
CARING FOR PUERPERIAL MOTHERS THROUGH THE UTILIZATION OF TRADITIONAL HERBS TO OPTIMIZE THEIR HEALTH Nurina Hasanatuludhhiyah; Danti Nur Indiastuti; Yuani Setiawati; Nurmawati Fatimah
Jurnal Layanan Masyarakat Vol. 7 No. 2 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i2.2023.161-172

Abstract

Puerperium is a critical period in which mothers often experience physical and psychological problems, however it is the beginning of the breastfeeding process and determines the success of exclusive breastfeeding. The use of traditional herbs for postpartum mothers is part of Indonesian culture that is starting to be abandoned in urban area. This community service activity aims to increase the knowledge, attitudes and behaviour of the community regarding the importance of postpartum maternal health care and the use of traditional herbs with proper processing methods as a promotive and preventive treatment. This activity was carried out in Gubeng Surabaya District with three stages including preparation, implementation of activities and evaluation. In the preparation stage, a situation analysis was performed. Activities were conducted by delivering lectures, discussions, video demonstrations and training. The evaluation was carried out by obtaining feedback from the social and community empowerment section as well as the pre-test and post-test questionnaires filled out by the participants. Based on the evaluation, the community service can increase participants' knowledge about postpartum health care and lactation management, thereby increasing awareness to play an active role by disseminating information to the community about the importance of family and the neighbourhood support for postpartum and breastfeeding mothers. The participants 'knowledge about the use of traditional medicinal plants for the maintenance of postpartum health and successful breastfeeding also increased, accompanied by an increase in the participants' willingness to prepare traditional jamu from fresh herbal ingredients themselves. This community service needs to be carried out in a sustainable manner with innovative delivery methods.
Efektivitas Mouthwash Berbahan Dasar Ekstrak Camellia sinensis dan Mentha piperita sebagai Antibakteri terhadap Streptococcus mutans Dennia Oktavia Zahidah Hulwah; Jihan Bobsaid; Muflikhah Ramadhani; Yuani Setiawati
Jurnal Kedokteran Meditek Vol 28 No 1 (2022): JANUARI-APRIL
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i1.2314

Abstract

Karies gigi merupakan masalah kesehatan yang disebabkan Streptococcus mutans. Salah satu upaya mencegah karies gigi adalah melalui penggunaan mouthwash. Oleh karena mouthwash di pasaran tinggi alkohol sehingga meningkatkan risiko kanker mulut, maka diperlukan formulasi mouthwash berbahan dasar tanaman herbal. Tanaman herbal yang memiliki aktivitas antibakteri diantaranya teh hijau (Camellia sinensis) dan peppermint (Mentha piperita). Penelitian ini bertujuan untuk mengetahui efektivitas mouthwash ekstrak teh hijau dan peppermint sebagai antibakteri terhadap Streptococcus mutans. Aktivitas antibakteri ditentukan melalui pengukuran zona hambat pada uji difusi. Mouthwash dibuat dalam 5 formula yaitu F1, F2, F3, F4, F5 dengan konsentrasi 20%, 40%, 60%, 80%, dan 100%. Dibuat pula FA (mouthwash ekstrak teh hijau 20%) dan FB (mouthwash ekstrak peppermint 20%) sebagai pembanding. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi ekstrak teh hijau dan peppermint maka semakin besar diameter zona hambat. Rata rata zona hambat F1 dan F2 8,34 dan 9,80 mm (daya hambat sedang). Rata rata zona hambat F3, F4 dan F5 masing masing 11,64 mm, 14,63 mm dan 15,91 mm (daya hambat kuat). Rata rata zona hambat FA dan FB 7,45 dan 6,20 mm (daya hambat sedang). Berdasarkan hasil tersebut disimpulkan bahwa mouthwash ekstrak Camellia sinensis dan Mentha piperita efektif sebagai antibakteri terhadap Streptococcus mutans.
Mental health and decision-making participation of adolescent orphans: A pilot study Annette d'Arqom; Farhan Nurdiansyah; Danti Nur Indiastuti; Mhd Zamal Nasution; Nurmawati Fatimah; Sri Purwaningsih; Yuani Setiawati; Kusuma Eko Purwantari
Jurnal Keperawatan Padjadjaran Vol. 11 No. 3 (2023): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v11i3.2358

Abstract

Background: Mental health has been brought to attention lately, with the increase of mental health problems during adolescence. In Indonesia, it is reported that one-third of adolescents develop mental health disorders. Childhood grief, separation from the family, child labor, or abuse affect the orphans’ mental health, including their decision-making participation. Purpose: As a pilot study, this study would like to investigate the mental health conditions and decision-making participation among orphans in one orphanage in Mojokerto district, East Java, Indonesia.Methods: This cross-sectional study utilizes the Depression Anxiety Scale Youth version (DASS-Y) and Child and Adolescent Participation in Decision Making Questionnaire (CAP-DMQ). Thirty-five adolescent orphans of one orphanage in Mojokerto were recruited using convenience sampling. The frequency of respondents’ mental health and decision-making participation were measured, and the mean differences between each group of sociodemographic factors were measured using the Mann-Whitney U test or the Kruskal Wallis test. Association between mental health and decision-making participation was calculated using Chi-square test.Results: The results show that 40% of respondents were categorized as having mild mental health problems, including depression, anxiety, and stress. Mental health problems are mostly found in males (22.90%) and elementary school (20%). The participation of the orphans in decision-making is considered good, with a median of 25.5. The bivariate analysis concludes the association between anxiety, age, grade, and decision-making participation (p= 0.024, p= 0.029, p=0.029, respectively).Conclusion: Taken together, attention to orphans, especially adolescents, and their problems are necessary to reduce the health discrepancies within these vulnerable groups. Broader respondents are needed to understand the complete picture of mental health conditions among Indonesian adolescent orphans, including late adolescents.
Antibacterial Activity of Ethanol Extract of Kemuning (Murraya Paniculata) Against Klebsiella pneumoniae ESBL by In Vitro Test Wiyogo, Illona Okvita; Endraswari, Pepy Dwi; Setiawati, Yuani
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 2 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i2.9328

Abstract

Klebsiella pneumoniae Extended-spectrum β-lactamase (ESBL) was one of the microorganism that cause nosocomial infection which resistant to beta-lactams antibiotics. Orange Jessamine (Murraya paniculata) was traditional medicine which believed has antibacterial components, such as: fl avonoids, alkaloids, essential oils, coumarins, terpenoids, tannins, and saponins. In the previous studies, there was antibacterial activity in ethanolic extract of Murraya paniculata againsts E.coli, K.pneumoniae, S.typhi, E.faecalis, P.aeruginosa, S.fl exneri, S.aureus, and S.sonneii with concentration 200 mg/ mL. There has not experiment about ethanolic extract of Murraya paniculata against Klebsiella pneumoniae ESBL yet. The aim of this study was to fi nd out the in vitro antibacterial activity of ethanol extracts of Murraya Paniculata against Klebsiella pneumoniae ESBL Broth dilution method with concentration 200 mg/mL, 100 mg/mL, 50 mg/mL, 25 mg/mL, 12,5 mg/mL, 6,25 mg/mL, and 3,125 mg/mL were used for the determination of the Minimal Inhibitory Concentration (MIC). While the Minimal Bacterial Concentration (MBC) was assessed using streaking method in Nutrient Agar Plate. The highest concentration in this study was obtained from 100 g of Murraya paniculata leaves dissolved in 500 mL of 40% ethanol. The study was carried out 4 times replication. At the time of the sterility test extract, germ growth appeared on Nutrient Agar Plate media, so the extract was fi ltered before being used for research. After incubation at 37 °C for 24 hours, growth of bacterial colonies on all agar plates was observed. The concentration of the ethanol extract of Murraya Paniculata (200 mg/mL) did not inhibit the growth of Klebsiella pneumoniae ESBL. The ethanol extracts of Murraya paniculata in concentration 200 mg/mL had no antibacterial activity against Klebsiella pneumoniae ESBL.
Factors that Influence The Onset of Acne Vulgaris :Retrospective Study Asrianti, Nur Ilma; Trisniartami Setyaningrum; Yuani Setiawati; Yuri Widia
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 2 (2024): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.2.2024.98-103

Abstract

Background: Acne vulgaris (AV) is a skin condition that mostly occurs in adolescents, although it can occur at any age. Most occur during adolescence, with a prevalence of around 85%. Acne vulgaris is a multifactorial disease triggered by many factors, namely, genetics, environment, hormonal and emotional stress, food, trauma, cosmetics, and medications. Purpose: This study identifies the precipitating factors of acne vulgaris. Methods: This study was retrospective based on medical record data at the Dermatology and Venereology Outpatient Clinic of Dr. Soetomo General Academic Hospital Surabaya in the period January 2018–December 2019. Results: The number of AV patients within 2 years from January 2018 to December 2019 obtained 517 cases of acne vulgaris patients with complete data. There were female AV patients (80.7%) and male AV patients (19.3%). The most common age of AV patients was 15–24 years old (60.5%), the most common occupation of AV patients was student (59.8%), and patients suffered from AV for >12 months (18.6%). The most precipitating factors for AV are hormonal (69.6%) and cosmetic (50.1%); the most common type of AV is mild AV (64.2%); and the most common AV therapy is the combination of topical tretinoin, benzoyl peroxide (BPO), and topical clindamycin. Conclusion: The results of this study showed that hormonal and cosmetic precipitating factors caused most AV patients in women.
PEMBERDAYAAN KADER KESEHATAN TENTANG TANAMAN OBAT BERKHASIAT ANTI HIPERTENSI PADA MASYARAKAT DI DESA KENTONG KECAMATAN GLAGAH KABUPATEN LAMONGAN: PEMBERDAYAAN KADER KESEHATAN TENTANG TANAMAN OBAT BERKHASIAT ANTI HIPERTENSI PADA MASYARAKAT DI DESA KENTONG KECAMATAN GLAGAH KABUPATEN LAMONGAN Fatimah, Nurmawati; Mustika, Arifa; Setiawati, Yuani; D’Arqom, Annette; Purwaningsih, Sri; Rochmanti, Maftuchah; Nur Indiastuti, Danti; Hasanatuludhhiyah, Nurina; Akbar Kurniawan, Mohammad
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 9 No 2 (2024): Agustus
Publisher : Politeknik Negeri Jember

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Abstract

Pemberdayaan kader kesehatan dalam program GERMAS melalui Posbindu di Desa Kentong, Kecamatan Glagah, Kabupaten Lamongan bertujuan untuk meningkatkan pengetahuan tentang pemanfaatan tanaman obat yang berkhasiat sebagai anti hipertensi. Tingginya prevalensi pasien hipertensi di daerah tersebut, diduga akibat dari kepatuhan berobat yang rendah, pengetahuan perilaku gaya hidup dan diet yang sehat masih belum optimal, serta minimnya informasi dan pengetahuan tentang pemanfaatan tanaman obat pada pasien hipertensi. Solusi yang ditawarkan untuk menyelesaikan permasalahan tersebut adalah memberikan penyuluhan tentang materi pentingnya mengelola hipertensi dengan baik, pengobatan rutin, perilaku gaya hidup serta diet sehat bagi pasien hipertensi,  sosialisasi tanaman obat berkhasiat sebagai antihipertensi dan demonstrasi pelatihan pembuatan sediaan dari tanaman obat. Metode yang digunakan melalui survei, kuesioner dan penyuluhan penyampaian materi, serta demonstrasi langsung di depan peserta. Ditemukan pada kuesioner pretes bahwa kader belum paham tentang ragam tanaman obat dan pengolahan yang tepat, setelah dilakukan penyuluhan dan demonstrasi terjadi peningkatan pengetahuan dengan para kader mampu menjawab pos tes dengan benar, peserta aktif berdiskusi secara oral, hal tersebut sebagai indikator bahwa peserta antusias dan dapat tercipta kader kesehatan yang mandiri.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Basori, Achmad ACHMAD RIFAI Agung Dwi Wahyu Widodo Akbar Kurniawan, Mohammad Anna Surgean Veterini Annete d’Arqom Annette d’Arqom, Annette Arifa Mustika Asrianti, Nur Ilma Baitul Fatimah Benny Iswanto Pantoro Cindy ApriliaEkaPrasanty Citagami, Salsabila Dennia Oktavia Zahidah Hulwah Dennia Oktavia Zahidah Hulwah Dewangga Sakti Satria Kinasih Dewinta Enggar Pramesthi Djoko Marsudi D’Arqom, Annette Eko Budi Koendhori, Eko Budi Fadilah Fadilah Farhadi, Azmi Farhan Nurdiansyah Fatimah, Nurmawati Felicia Jiwantono Feriawan Tan Fiqih Faizara Ustadi Firda Fitra Qolbina Fitriati, Mariza Gatot Soegiarto Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Isyroqiyyah, Nur Moya Izzatul Fithriyah Jihan Bobsaid Jihan Bobsaid Khaerunnisa, Siti Kusuma Eko Purwantari Maftuchah Maftuchah Manaf, Syifa Az Zahrah Maya Hapsari Kusumaningtyas Mhd Zamal Nasution Mia Rahardjo Muflikhah Ramadhani Muflikhah Ramadhani Muhammad Khafidin Al Alim NOOR CHOLIES Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Pepy Dwi Endraswari, Pepy Dwi Purwanta, Marijam Rehatta, Nancy Margarita Rizki Awaluddin Rochmah Kurnijasanti Shazia Hafazhah Aulia Siti Khaerunnisa Siti Khaerunnisa Sri Purwaningsih Sri Purwaningsih Trisniartami Setyaningrum Vivi Permata Sari Wiwin Retnowati Wiyogo, Illona Okvita Yuri Widia, Yuri