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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Nusantara Medical Science Journal Jurnal Keperawatan Padjadjaran Jurnal Kesehatan Prima Oceana Biomedicina Journal Jurnal Ilmu Kefarmasian Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Medical and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal journal of Basic Medical Veterinary Oceana Biomedicina Journal Cerdika: Jurnal Ilmiah Indonesia Jurnal Kedokteran Meditek
Yuani Setiawati
Departemen Farmakologi, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Antibacterial Effect of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 ON Klebsiella pneumoniae Producting Extended-Spectrum β-Lactamase (ESBL) Setiawati, Yuani; Retnowati, Wiwin; Basori, Achmad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1326

Abstract

Klebsiella pneumoniae as an opportunistic pathogen can cause nosocomial infection. The main concern on this bacterium is directed on the extended-spectrum β-Lactamase (ESBL)-producing Klebsiella pneumoniae. The therapy of ESBL-producing Klebsiella pneumoniae infections is very limited because of its multidrug resistance. It had been found new local isolates Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 in mangrove East Coast of Surabaya. These isolates have potential to produce antibiotics (Retnowati, 2008). This study was aimed to prove these isolates may inhibit the growth of ESBL-producing Klebsiella pneumonia. The test of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 using the modification Agar print method against clinical isolates of ESBL-producing Klebsiella pneumoniae. The diameter of inhibition zone (mm) formed shows activity of these isolates. The profiles of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 were different in terms of periode required to reach peak activity, duration of activity and inhibition zone diameter produced during 10 days of observation. Streptomyces sp-MWS3 reached the peak activity most rapidly on day 3 with the largest inhibition zone diameter of 9 mm in ESBL-producing Klebsiella pneumoniae. There were significant differences in inhibition zone diameter between Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 against ESBL-producing Klebsiella pneumoniae.
The Use of Prophylactic Antibiotics on Orthopaedic Procedures in an Academic Hospital in Indonesia Setiawati, Yuani; Farhadi, Azmi
Jurnal Medis Islam Internasional Vol 2 No 2 (2021): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v2i2.2155

Abstract

Background: Surgical site infections (SSIs) are common surgical complications that will increase cost of treatment. The incidence of SSI can be prevented with antibiotic prophylactic. Uncompliance using of prophylactic antibiotics is one of the factors leading to the occurrence a microbes resistance. The data on the using of prophylactic antibiotics in Indonesia is still limited. Objective: This study aims to analyze the using of prophylactic antibiotic guideline on orthopaedic surgery. Methods: The study was conducted retrospectively using data from medical records on patients who had clean and clean-contaminated orthopedic procedures from 2013 to 2016 in the standard operating room of Dr. Soetomo hospital Surabaya. We analyzed the use of prophylactic antibiotics in terms of antibiotic selection, timing of administration, and the compliance to the prophylactic antibiotic local guidelines on orthopaedic surgery. Results: Overall, patient data from 2013 to 2016 was 5246 patients. The compliance rate of prophylactic antibiotics from 2013 to 2016 was 48.3%. This level of compliance uses a selection of antibiotics, dose of administration, delivery mode, delivery time, and route of administration. Conclusion: The results of this study have shown that the prophylactic antibiotic compliance rate on orthophaedic procedures in Soetomo Hospital from 2013 to 2016 was 48,3%. Antibiotic resistance control program quite effective at increasing compliance with the use of the prophylaxis antibiotics.
Effects of Clove Leaf Essential Oil (Syzygium aromaticum) in Inhibiting Biofilm Formation on Candida albicans Isolate Rifai, Achmad; Endraswari, Pepy Dwi; Setiawati, Yuani; Koendhori, Eko Budi
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.70-75

Abstract

Highlights: Candida albicans is capable of forming biofilm, which can lead to resistance to antifungal treatments. Clove leaf essential oil, which can inhibit biofilm formation, making it a potential anti-biofilm agent.   Abstract Introduction: Candida albicans (C. albicans) has a virulence factor, like biofilm formation. Biofilm is a three-dimensional structure that plays a role in antimicrobial resistance, thus requiring antibiofilm agents to address this problem. One of them is Clove leaf (S. aromaticum). S. aromaticum has active phytochemicals (eugenol, β-caryophyllene, and others) that can inhibit biofilm formation in microorganisms, including fungi. This study aimed to prove the effect and to find a concentration of Clove leaf essential oil that affects the biofilm formation of C. albicans isolate. Methods: This study used a microtiter plate with a two-fold dilution technique. The tested concentrations were 6.25%, 3.125%, and 1.5625%. The positive control was 200 µL of C. albicans biofilm suspension, and the negative control was 200 µL of tryptic soy broth media, and all were repeated four times. The biofilm was observed using crystal violet and evaluated using optical density. The data was analyzed statistically using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 26, with a p<0.05 considered statistically significant. Results: The Optical density (O.D.) of the isolate was 2.039, while the negative control was 0.349, indicating that the isolate was a strong biofilm former. The concentrations of 6.25%, 3.125%, and 1.5625% showed inhibition percentages of 8.533%, 17.214%, and 8.484%, respectively. The Optical density was found to be normally distributed but not homogeneous p>0.05, The Kruskal-Wallis’s test was significant, and the Mann-Whitney test was not significant between test groups and positive control. Conclusion: Clove leaf essential oil has inhibitory effects on C. albicans biofilm isolates. However, statistically, there was no significant difference between the test groups and the positive control.
UTILIZATION OF HERBAL POWDER TO INCREASE THE ECONOMY IN NURUL HUDA ISLAMIC BOARDING SCHOOL, SIDOARJO Setiawati, Yuani; kurnijasanti, rochmah; Sudjarwo, Sri Agus; Fitriati, Mariza
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 3 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i3.2024.381-387

Abstract

In the context of global economic contestation, the presence of an independent Islamic boarding school economic community will become social capital and inspiration for the community so that the local community's economy is not defeated and displaced by global players. The Nurul Huda Islamic boarding school is included in the category of Islamic boarding schools that do not yet have a business unit, even though the Nurul Huda Islamic boarding school has vacant land that can be utilized by students by managing herbal plants. Implementation of the community service program is carried out through several activities: 1) Providing material about various kinds of herbs and their benefits 2) Demonstration and practice of formulating and making various kinds of herbal powders 3) Demonstration and practice of formulating and making various kinds of herbal drinks 4) Demonstration and practice of formulation and making herbal granules 5) Demonstration, practice of formulation and making herbal effervescent powder 6) Packing and labelling practices for marketing 7) Making a website for product marketing. This community service produces output in the form of: 1) Publication in the Sinta 4 journal, namely the Abdinus journal / Journal of Indonesian Service 2) Publication on online news media. The results of implementing this activity were able to increase the knowledge and skills of students at Nurul Huda Islamic boarding school.
Stop Bullying Counseling as an Effort to Prevent Bullying Behavior that Occurs in Students at Ketabang Seruni Elementary School Surabaya Fatimah, Nurmawati; Khairul Rizki Purba, Abdul; Fithriyah, Izzatul; Purwaningsih, Sri; Setiawati, Yuani; Khaerunnisa, Siti; Akbar Kurniawan, Mohammad
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 9 No 3 (2024): Desember
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The phenomenon of bullying is a serious problem for child development in Indonesia. Bullying cases in Indonesia are ranked fifth in Indonesia world in bullying incidents (Jayani, 2019). Violence against students at school is a topic of discussion mainstream in the media. The incidence of bullying is 10-60% of children who receive ridicule, ridicule, expulsion, kicking or pushing at least once a week. Cases of bullying in Children can occur anywhere, anytime and by anyone. This makes this case still high incidence rate (Komisi Perlindungan Anak Indonesia, 2020). If this bullying incident continues for a long time, it will have an impact on the victim of bullying, both physically, psychologically and socially. The bullying case at Ketabang Seruni Elementary School Surabaya is of particular concern to the school principal. During break time, students are often heard making fun of each other, and there are friends who are alone because they are ostracized. As a leading public school in the city of Surabaya, hopes that its students can be a good for other schools by implementing free bullying at schools. The solution offered to solve this problem is to provide education to students at Ketabang Seruni Elementary School Surabaya by providing an explanation first about the purpose of the activity, then giving a questionnaire to the students about various things related to the meaning of bullying, types of bullying, causes of bullying, characteristics of perpetrators and victims of bullying, bad impacts of bullying, prevention of bullying, efforts to handle bullying prevention. Education is provided by providing materials using powerpoint media, leaflets and posters which are pasted on the school walls as a means of reminder for the entire community at school, including students, teachers, employees and parents. The result of this activity is that there is an increase in students' understanding of bullying and good practices are obtained by changing the way students socialize to be better and more polite. Keywords — Mental health; Education; Discrimination; Dignity
Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation Isyroqiyyah, Nur Moya; Soegiarto, Gatot; Setiawati, Yuani
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.778 KB) | DOI: 10.20473/fmi.v55i1.24387

Abstract

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient's demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.
Potential of Ethanol Extract of Red Curly Chili (Capsicum annuum L.) as an Antioxidant and Antidiabetic Agent in Mice Citagami, Salsabila; Setiawati, Yuani; Kurnijasanti, Rochmah; Mukono, Indri Safitri
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.71635

Abstract

Medicinal plants containing polyphenols (flavonoid dan tannin),  quercetin and capsaicin have strong antioxidant properties. These compounds can help inhibit oxidative stress that plays a role in various diseases, including diabetes mellitus. Capsicum annuum L is rich in phytochemicals and active compounds such as flavonoids (Quercetin, Luteolin, Kaempferol), tannins, saponins, terpenoids, carotenoids, and vitamin C. This study aimed to evaluate the potential of red curly chili (Capsicum annuum L.) ethanol extract as an antioxidant and antidiabetic agent in mice. The mice will be randomly divided into the following groups (6 mice per group): Diabetic control group (induced diabetes with streptozotocin, no treatment), and Capsicum annuum L group (Diabetic group treated with Capsicum annuum L ethanol extract at dose 100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW for 21 days). On the 21st day, the mice were anesthetized, and blood samples were collected via intracardiac puncture for the analysis of blood glucose and malondialdehyde (MDA) levels. Oral administration of Capsicum annuum L. At 400 mg/kg resulted in a significant reduction in blood glucose and MDA levels (p<0.05) compared to the diabetic group. The results approached those of the normal group, although the difference was not statistically significant. The study confirmed that Capsicum annuum L. extract effectively alleviates oxidative stress associated with type II diabetes in STZ-induced mice, as evidenced by its ability to lower blood glucose levels and reduce MDA levels.
Antibacterial Activity Test of Green Betel Leaf Extract (Piper betle L.) Against Methicillin-Sensitive Staphylococcus aureus Manaf, Syifa Az Zahrah; Wiqoyah, Nurul; Setiawati, Yuani
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 1 (2025): FEBRUARY : Fragmentation In Modern Healthcare Approaches Amid Rising Chronic And
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i1.6521

Abstract

Background: Asia is one of the regions with the highest prevalence rates of Staphylococcus aureus infection. Green betel leaves (Piper betle L.) have been proven to have antibacterial potential with their active compound content, namely essential oils, phenols, chavicol, flavonoids, alkaloids, saponins, tannins, and steroids so it is necessary to investigate whether betel leaf extract has an effect on Methicillin-Sensitive Staphylococcus aureus (MSSA). The aim of this study is to analyze the effect of green betel leaf extract on the growth of MSSA.  Methods: This research is a descriptive experimental study regarding the antibacterial activity test of green betel leaf extract against MSSA. The MSSA bacteria used were bacterial preparations in the Microbiology Laboratory of Faculty of Medicine Airlangga University. Green betel leaf extract was obtained from Batu City in 2023. The antibacterial activity test technique used was the dilution test. Results: In the dilution test, for the growth of MSSA, in tubes with concentrations of 800 mg/mL, 600 mg/mL, 400 mg/mL, 200 mg/mL, and 100 mg/mL appear clear indicates that there is no growth of germs. At a concentration of 50 mg/mL it appears cloudy which indicates the growth of germs. The results obtained for the growth of MSSA on agar plates were at concentrations of 800 mg/mL, 600 mg/mL, 400 mg/mL, and 200 mg/mL, there was no growth of germs. Meanwhile, at concentrations of 100 mg/mL and 50 mg/mL, the growth of MSSA germs was found Conclusions: The conclusion of this research is that the minimum inhibitory concentration (MIC) of green betel leaf extract against MSSA is 100 mg/mL and the minimum bactericidal concentration (MBC) of green betel leaf extract against MSSA is 200 mg/mL. Further research is needed on the antibacterial activity of green betel leaf extract against other bacterial species that are resistant to many drugs.
Antibacterial Activity Test of Green Betel Leaf Extract (Piper betle Linn.) against Methicillin-Sensitive Staphylococcus aureus Manaf, Syifa Az Zahrah; Wiqoyah, Nurul; Setiawati, Yuani
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.131-139

Abstract

Highlights Green betel leaf extract, particularly cultivated in Batu City, can inhibit and kill MSSA. Green betel leaf extract, particularly cultivated in Batu City, can be developed into a new alternative treatment as an effective antibiotic to kill MSSA bacteria.   ABSTRACT Background: Asia is one of the regions with the highest prevalence rates of Staphylococcus aureus (S. aureus) infection. Green betel leaves (Piper betle Linn.) have been shown to possess antibacterial potential due to their active compound content. Objective: To investigate whether betel leaf extract affects methicillin-sensitive Staphylococcus aureus (MSSA). Material and Method: This research was a descriptive experimental study focusing on the antibacterial activity test of green betel leaf extract against MSSA. The MSSA bacteria used were bacterial preparations in the Microbiology Laboratory of the Faculty of Medicine, Universitas Airlangga. The green betel leaf extract was obtained in 2023 in Batu City, East Java, Indonesia. The antibacterial activity test technique used was the dilution test. The tool used in data processing was Microsoft Excel. Results: Germs were found in the dilution test, particularly in tubes with concentrations of 50 mg/mL. The study also highlighted that no growth of germs was found based on the results obtained for the increase of MSSA on agar plates at concentrations of 800 mg/mL, 600 mg/mL, 400 mg/mL, and 200 mg/mL. The study also found that the growth of MSSA germs was at 100 mg/mL and 50 mg/mL. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of green betel leaf extract against MSSA were 100 mg/mL and 200 mg/mL, respectively. Conclusion: The extract of green betel leaves, particularly cultivated in Batu City, East Java, Indonesia has been shown to possess antibacterial activity, which can inhibit and kill MSSA bacteria. Further research is needed on the antibacterial activity of green betel leaf extract against other bacterial species.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Basori, Achmad ACHMAD RIFAI Agung Dwi Wahyu Widodo Akbar Kurniawan, Mohammad Anna Surgean Veterini Annete d’Arqom Annette d’Arqom, Annette Arifa Mustika Asrianti, Nur Ilma Baitul Fatimah Benny Iswanto Pantoro Cindy ApriliaEkaPrasanty Citagami, Salsabila Dennia Oktavia Zahidah Hulwah Dennia Oktavia Zahidah Hulwah Dewangga Sakti Satria Kinasih Dewinta Enggar Pramesthi Djoko Marsudi D’Arqom, Annette Eko Budi Koendhori, Eko Budi Fadilah Fadilah Farhadi, Azmi Farhan Nurdiansyah Fatimah, Nurmawati Felicia Jiwantono Feriawan Tan Fiqih Faizara Ustadi Firda Fitra Qolbina Fitriati, Mariza Gatot Soegiarto Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Isyroqiyyah, Nur Moya Izzatul Fithriyah Jihan Bobsaid Jihan Bobsaid Khaerunnisa, Siti Kusuma Eko Purwantari Maftuchah Maftuchah Manaf, Syifa Az Zahrah Maya Hapsari Kusumaningtyas Mhd Zamal Nasution Mia Rahardjo Muflikhah Ramadhani Muflikhah Ramadhani Muhammad Khafidin Al Alim NOOR CHOLIES Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Pepy Dwi Endraswari, Pepy Dwi Purwanta, Marijam Rehatta, Nancy Margarita Rizki Awaluddin Rochmah Kurnijasanti Shazia Hafazhah Aulia Siti Khaerunnisa Siti Khaerunnisa Sri Purwaningsih Sri Purwaningsih Trisniartami Setyaningrum Vivi Permata Sari Wiwin Retnowati Wiyogo, Illona Okvita Yuri Widia, Yuri