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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi JSFK (Jurnal Sains Farmasi & Klinis) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea JURNAL MEDIA KESEHATAN Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Journal of Health Economic and Policy Research (JHEPR)
Najmiatul Fitria
Departmen Of Pharmacology And Clinical Pharmacy. Faculty Of Pharmacy. Universitas Andalas. Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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EFEKTIVITAS PENGGUNAAN MULTIPLE MICRONUTRIENTS (MMN) TERHADAP JUMLAH PERSALINAN NORMAL DAN SESAR Najmiatul Fitria; Sarah Puti Amalia; Nauratul Ikramah; Hansen Nasif
JURNAL MEDIA KESEHATAN Vol 15 No 2 (2022): Jurnal Media Kesehatan Poltekkes Kemenkes Bengkulu Volume 15 No 2 Desember 2022
Publisher : Politeknik Kesehatan Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jmk.v15i2.856

Abstract

Health problems during pregnancy drop the number of normal deliveries in pregnant women. The World Health Organization recommends pregnant women consume folic acid, iron, and multiple micronutrients. This study aims to determine the effectiveness of using Multiple Micronutrients (MMN) on delivery forms. This research was conducted at Semen Padang Hospital, Padang. This study is a descriptive study with data collection carried out retrospectively. The sample in this study was data from pregnant women who did prenatal care and gave birth at Semen Padang Hospital in January-December 2021. The number of samples in this study was 201 pregnant women, divided into 73 pregnant women with normal deliveries and 128 patients with normal deliveries by cesarean section. In this study, the value of p = 0.767 (p>0.05) with the interpretation of the effectiveness of the use of IFA was not different from the effectiveness of MMN in the number of normal deliveries
UJI EFEK TERATOGEN KAKAO BUBUK PADA FETUS MENCIT PUTIH Almahdy - A; Nurul Afifah Almunawwarah; Najmiatul - Fitria
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 2, No 1 (2013)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.011 KB) | DOI: 10.58327/jstfi.v2i1.22

Abstract

AbstrakTelah dilakukan penelitian mengenai efek teratogen kakao bubuk pada fetus mencit putih. Bubuk kakao diberikan secara oral pada dosis larutan 5,5; 7,0 dan 8,5 g/kg BB pada hari ke-6 hingga hari ke-15 kehamilan. Laparatomi dilakukan pada hari ke-18 kehamilan, kemudian dua pertiga isi perut fetus direndam dalam larutan merah alizarin dan sepertiga bagian lainnya difiksasi hingga mengeras dalam larutan Bouin’s. Hasil pengujian menunjukkan bahwa berat badan tikus dipengaruhi oleh coklat bubuk, tetapi kuantitas dan berat badan fetus tidak terpengaruh oleh variasi dosis. Efek teratogenik diamati secara makroskopik pada fetus dan uterus menunjukkan bahwa kakao bubuk pada dosis 5,5 g/kg BB dapat menyebabkan keterlambatan pertumbuhan, kematian, curling ekor pada janin dan situs resorpsi. Sedangkan pada dosis 7 g/kg BB menyebabkan kelainan tulang, akhir pertumbuhan, kematian, curling ekor pada janin dan situs resorpsi. Bubuk kakao pada dosis 8,5 g/kg BB menyebabkan perdarahan pada tikus, situs resorpsi, kematian dan kelainan tulang pada janin. Kata kunci: Kakao, Teratogenik, Mencit putih AbstractThe teratogenic effect of cocoa powder on white mice has been investigated. Cocoa powder was given orally in solution at doses of 5.5; 7.0 and 8.5 g/kg BW on 6th to 15th day of pregnancy. Laparatomy was performed on 18th day of pregnancy and followed by eviscerating two third of the fetuses with red alizarin and the others were hardened in Bouin’s fixation solution. Body weight of mice are influenced by cocoa powder, but quantity and body weight of fetuses are not influenced at all dosage studied. Teratogenic effect observed macroscopically on fetus, and uterus was displayed that cocoa powder at the dose 5.5 g/kg BW caused late of growth, death, curling tail on fetuses and resorption site. While on the dose of 7 g/kg BW caused skeletal abnormalities, late of growth, death, curling tail on fetuses and resorption site. Cocoa powder at the dose of 8.5 g/kg BW caused bleeding in mice, resorption site, death and skeletal abnormalities on fetuses.  Keywords: Cacao, Teratogenic, White mice
Adherence Assessment on Hypertension Therapy Using The Pill Count Method In Lubuk Kilangan Health Center, Indonesia Najmiatul Fitria; Lailaturrahmi Lailaturrahmi; Yelly Oktavia Sari; Fahira Tri Anata; Khairatul Husnia
Jurnal Sains Farmasi & Klinis Vol 10, No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.28-34.2023

Abstract

Adherence is a major problem in hypertension treatment. Patients' adherence can be evaluated through pill count by counting the remaining amount of the patient's medication at the beginning and the end, using a pillbox as a tool to improve patient medication adherence. The purpose of this study was to describe the differences in adherence between patients who used the pillbox and without the pillbox. The research method used is Pretest-Posttest Control Group Design. The sample of this study is Prolanis (Chronic Disease Management Program) patients in 2021 at the Lubuk Kilangan Health Center in Padang City. They meet the inclusion and exclusion criteria that have been set. Sampling was carried out by total sample and obtained 70 subjects divided into the treatment group and the control group. The research technique used a Home Medication Review (HMR). The results of the study using the Mann-Whitney Test statistical test on adherence (p = 0.007) showed a value (p<0.05). It can be concluded that there are differences in adherence before and after the intervention. This result indicates that adherence is higher in patients who use the pillbox than those without the pillbox.
Pengaruh Penggunaan Kombinasi Metformin-Insulin Glargine dan Metformin-Glimepiride terhadap Kadar Gula Darah Sewaktu dan Total Biaya Medis Langsung pada Pasien DM Tipe 2 di Instalasi Rawat Jalan RSUD Rupit Leliani Fitri Anggraini; Najmiatul Fitria; Yelly Oktavia Sari
Jurnal Farmasi Higea Vol 15, No 1 (2023)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v15i1.517

Abstract

Penelitian ini dilakukan di RSUD Rupit, Kabupaten Musi Rawas Utara pada bulan Desember 2022 sampai Januari 2023 Penelitian ini merupakan penelitian observasional menggunakan studi deskriptif dengan pengumpulan data secara retrospektif terhadap rekam medis pasien BPJS rawat jalan dengan diagnosa DM tipe 2Tujuan penelitian ini untuk mengetahui pengaruh kombinasi metformin-insulin glargine dan metformin-glimepiride terhadap kadar gula darah sewaktu dan total biaya medis langsung.
Analisa Hubungan Biaya Total dan Lama Rawatan Penggunaan Risperidon dan Quetiapin pada Pasien Skizofrenia Paranoid di RS Jiwa Prof HB Saanin Padang Dian Suhery; Yelly Oktavia Sari; Najmiatul Fitria
Jurnal Farmasi Higea Vol 15, No 1 (2023)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v15i1.513

Abstract

Tingginya biaya kesehatan yang dikeluarkan pemerintah dalam hal ini adalah Badan Penyelengara Jaminan Kesehatan (BPJS) di Indonesia dalam menganani suatu penyakit terutama penyakit-penyakit kronis seperti Skizofrenia, yang membutuhkan pengobatan yang cukup lama hingga bertahun-tahun. Untuk kasus penaganan skizofrenia BPJS memiliki pengelompokan Khusus yang disebut Spesial Grup CMG  (Casemix Main Groups) pada tarif INA-CBGs. Penelitian ini ditujukan untuk mengetahui hubungan dari Total biaya langsung dalam paket pada penggunaan Antipsikotik generasi kedua dengan kombinasi risperidon dan quetiapin. Penelitian ini dilakukan di RS Jiwa Prof HB Saanin pada pasien rawat inap dengan diagnosa skozofrenia Paranoid F20.0 menurut ICD.10. Penelitian ini dilakukan secara retrospektif dengan total sampel sebanyak 21 buah, Analisa dilakukan dengan Analisa statistik korelatif Spearman dengan SPSS. Dari analisa statistik deskriptif menunjukkan tidak ada perbedaan yang bermakna antara pendidikan terakhir dan pekerjaan (p-value > 0,05). Sementara itu terdapat hubungan yang bermakna antara perempuan dan laki-laki untuk penggunaan kedua kelompok obat ini. Dari data deskriptif juga didapatkan bahwa pasien yang menggunakan kedua kelompok obat ini masih berada pada rentang usia subur, dengan rerata usia pengguna Risperidon sekitar 37 tahun dan pengguna kombinasi Risperidon dan Quetiapin kurang dari 40 tahun. Dan terdapat hubungan yang bermakna antara total biaya langsung dalam paket pada penggunaan obat kombinasi antipsikotik generasi kedua risperidon dan quetiapin terhadap lama rawat pasien Skizofrenia Paranoid (F20.0) di RS Jiwa Prof HB Saanin Padang.Kata kunci: antipsikotik generasi kedua; risperidon; quetiapine; total biaya langsung
Cost-Effectiveness Analysis of the Combination of Metformin-Insulin Glargine and Metformin-Glimepiride in Type 2 Diabetes Mellitus Patients in Rupit Hospital Najmiatul Fitria; Leliani Fitri Anggraini; Yelly Oktavia Sari
Journal of Health Economic and Policy Research (JHEPR) Vol. 1 No. 1 (2023): Journal of Health Economic and Policy Research
Publisher : Center for Health Economic Studies

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jhepr.v1i1.65

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease requiring lifelong care and much money. A combination of antidiabetic drugs aims to increase effectiveness in lowering blood sugar levels. The combination of two drugs consists of a first-line drug class plus another class of drugs with a different mechanism of action. This study aimed to determine the cost-effectiveness of the combination therapy of metformin-insulin glargine and metformin-glimepiride, expressed by the value of the Cost Effectiveness Incremental Ratio (ICER). Method: This research was a descriptive study, and data collection was carried out retrospectively using patient medical record data. This study used a healthcare provider perspective. Of the 406 population, only 102 samples met the inclusion criteria. Result: Fifty-seven records (55.88%) used the metformin-glimepiride combination, and the other forty-five (44.12%) used metformin-insulin glargine. The ICER value of random blood sugar during (RBG) was IDR 21,748.89 for every 1 mg/dL decrease in RBG. The ICER value of fasting blood sugar (FBG) was IDR 38,824.46 for every 1 mg/dL decrease in FBG. Meanwhile, the ICER of HbA1c value was IDR 43,257.46 for every 1% decrease in HbA1c. Conclusion: The three ICER values were in the northeast quadrant (quadrant I), where the metformin-insulin glargine therapy group had the better blood sugar value. Still, the costs required were also higher than the metformin-glimepiride group.
Edukasi DAGUSIBU (dapatkan, gunakan, simpan, dan buang) Obat untuk Masyarakat Karang Taruna, Jorong Malana Ponco, Tanah Datar Rahmi Yosmar; Dita Permatasari; Najmiatul Fitria
Warta Pengabdian Andalas Vol 30 No 3 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.3.545-553.2023

Abstract

DAGUSIBU stands for get, use, save, and throw away. In this program, people can manage and use drugs properly and correctly. As the frontline in medicine, pharmacists must carry out socialization to create a drug-aware society. The Faculty of Pharmacy Universitas Andalas conducted community service through DAGUSIBU socialization to get an overview of knowledge regarding the management and use of drugs in the Karang Taruna Community in Jorong Malana Ponco, Tanah Datar Regency. Was DAGUSIBU counselling used, followed by filling out the questionnaire about drug use? Of the 34 participants who attended, 16 participants filled out drug use questionnaires. Most participants were women with an age range of 54.81 ± 14.44. From the questionnaire obtained, the initial picture of the Jorong Malano community's knowledge of DAGUSIBU is not very good. Based on these results, it can be concluded that community knowledge about DAGUSIBU can still be increased with continuous socialization and intensive education
Kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi Chytra Bertdiana Ersa; Najmiatul Fitria; Dedy Almasdy
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32264

Abstract

Implementasi terapi Antiretroviral (ARV) dikatakan berhasil apabila kualitas hidup Orang dengan HIV/AIDS (ODHA) menjadi lebih baik (Wu, 2000). Tujuan penelitian ini adalah untuk memberikan gambaran tentang kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi berdasarkan lama penggunaan terapi ARV dan rejimen yang digunakan. Penelitian ini dilakukan secara prospektif mulai Januari hingga April 2023 di klinik VCT RSUD Raden Mattaher Jambi. Kami mengumpulkan data dari pasien klinik VCT RSUD Raden Mattaher Jambi yang memenuhi kriteria inkllusi dan eksklusi sebagai responden. Kuesioner terstruktur, instrument EQ-5D-5L dan EQ-VAS digunakan sebagai instrumen pengumpulan data. Data dianalisis menggunakan Uji Mann Whitney, Kruskall Wallis, Korelasi Spearman. Dari 349 populasi ODHA usia dewasa (≥ 18 tahun) yang terdata di klinik VCT RSUD Raden Mattaher Jambi, 152 (43,55%) diantaranya bersedia menjadi Responden penelitian dan sejumlah 143 (94%) dari total sampel yang dapat dianalisis. Hasil penelitian ini menunjukkan secara sosiodemografi tidak terdapat perbedaan bermakna nilai kualitas hidup pada variabel usia, jenis kelamin, domisili, pekerjaan, pendidikan dan status pernikahan (p<0,05) akan tetapi terdapat perbedaan bermakna nilai kualitas hidup pada faktor resiko penularan dan ada tidaknya penyakit lain (p<0,05). Ditemukan perbedaan bermakna nilai kualitas hidup pada lama penggunaan terapi ARV dimana kelompok responden yang menggunakan terapi ARV ≤ 2 tahun memiliki perbedaan bermakna dibandingkan dengan responden yang telah menggunakan terapi ARV >2 tahun (p<0,05). Tidak terdapat perbedaan bermakna pada kelompok yang menggunakan terapi ARV >2 – 5 tahun,  >5 – 10 tahun maupun > 10 tahun (p>0,05). Tidak ada perbedaan nilai kualitas hidup secara bermakna pada 8 kelompok rejimen terapi ARV (p>0,05). Analisis korelasi menunjukkan terdapat hubungan positif antara nilai UEQ-5D dan UEQ-VAS dengan dengan tingkat cukup (koefisien korelasi 0,348). 
Aspirin-clopidogrel combination therapy for ischemic stroke patients: Clinical efficacy and cost-effectiveness analyses in low-resource setting Fitria, Najmiatul; Febiana, Dian; Akram, Muhammad; Yosmar, Rahmi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.758

Abstract

Understanding the cost-effectiveness of aspirin-clopidogrel combination therapy is crucial in determining its influence on coagulation parameters, specifically prothrombin time (PT) and activated partial thromboplastin time (APTT). The aim of this study was to assess the cost-effectiveness and clinical impact of using the aspirin-clopidogrel combination compared to aspirin alone in managing ischemic stroke. Employing an observational research design, inpatient ischemic stroke cases receiving the aspirin-clopidogrel combination were compared to those treated with aspirin alone. Focusing on the hospital's perspective on costs, the research specifically analyzed medical expenses without discounting costs or effects. The analysis involved comparing the direct medical costs and coagulation parameters between the two treatment groups. Our data revealed that the aspirin-clopidogrel combination demonstrated superior cost-effectiveness over aspirin alone, indicated by the incremental cost-effectiveness ratio (ICER) values for PT (IDR -246,930/second) and APTT (IDR -119,270/second). This indicated that the combination therapy was associated with lower costs while yielding better clinical parameter values. The ICER analysis placed the aspirin-clopidogrel combination in the southeast quadrant, marking its dominance over aspirin monotherapy by demonstrating higher effectiveness at lower costs. These results suggest that combination therapy might be a favorable alternative for managing ischemic stroke, presenting a viable option for consideration in clinical practice. The findings underscore the potential economic and clinical advantages of employing the aspirin-clopidogrel combination in routine stroke management protocols.
Probiotic-rich fermented milk from Lactiplantibacillus plantarum IIA-1A5: Effects on pregnancy health in the animal model Sukma, Ade; Suharto, El LS.; Melia, Sri; Juliyarsi, Indri; Vebriyanti, Ely; Fitria, Najmiatul; Rahmadian, Yudi; Hajrawati, Hajrawati; Arief, Irma I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1052

Abstract

Previous studies of Lactiplantibacillus plantarum IIA-1A5 have shown its potential as a probiotic in modulating gut microbiota and providing health benefits; however, its effects during pregnancy remain underexplored. The aim of this study was to assess the safety of fermented milk enriched with L. plantarum IIA-IA5 in pregnant mice. An experimental study was conducted at Universitas Andalas, Padang, Indonesia. Two groups of pregnant mice (Mus musculus L.) were used, each with six mice. The control group received sterilized milk (10 mL/kg body weight (BW)), while the intervention group was given fermented milk containing L. plantarum IIA-1A5 (107 colony forming unit (CFU)/mL). The evaluated outcomes included maternal weight changes, fetal counts and measurements, and assessments of fetal morphology and skeletal development. Results indicated that the morphology of fetuses showed no significant differences between the control and intervention groups; both groups demonstrated normal development with no detected resorption sites, growth retardation, or hemorrhage. For skeletal development, both groups had the same bone counts, including frontal, parietal, intraparietal, exoccipital, supraoccipital, nasal, pre-maxilla, mandibular, thoracal, lumbar, sternum, and extremities. This study highlights that L. plantarum IIA-1A5-enriched fermented milk was safe, as no significant morphological or bone developmental abnormalities were observed, indicating its potential as a dietary supplement to support pregnancy health. However, further studies involving larger sample sizes may be needed to provide a more comprehensive assessment of its outcomes and safety.
Co-Authors Abdul Muthalib Abdul Muthalib Ade Sukma Ade Sukma Ade Sukma Al Rizka, Nabila Almahdy - A Almahdy A Amni , Hudiyah Anata, Fahira Tri Andela, Mila Arief, Irma I. Asra, Ridho Aulia Zahara Rizki, Nadiatul Chytra Bertdiana Ersa D. Novia Deni Novia Dian Ayu Juwita Dian Suhery Dita Permatasari Dita Permatasari Fahira Tri Anata Febiana, Dian Fitri Handayani Fivi Melva Diana, Fivi Melva Hajrawati, Hajrawati Hansen Nasif Husnia, Khairatul Indri Juliyarsi Khairatul Husnia Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi, Lailaturrahmi Lailiani, Resa Leliani Fitri Anggraini Leliani Fitri Anggraini Machlaurin, Afifah Mardatillah Mardatillah Mariza, Wilnando Melia, Sri Melia, Sri Mila Andela Muhammad Akram Nauratul Ikramah Nguyen, Thang Nur Rahmadani, Intan Nurul Afifah Almunawwarah Rahmadian, Yudi Rahmi Yosmar Rahmi Yosmar Ramadani, Mery Resa Lailiani Rusdi Djamal Sarah Puti Amalia Sari Yulanda Sari, Yelly Oktavia Sri Melia Sri Nani Jelmila Suharto, El LS. Syaputri, Yolanda Zazna Syed Wasif Gillani Tuty Anggraini Vebriyanti, Ely Wilnando Mariza Yelly Oktavia Sari Yolanda Zazna Syaputri Zazna Syaputri, Yolanda