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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi JSFK (Jurnal Sains Farmasi & Klinis) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea JURNAL MEDIA KESEHATAN Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Journal of Health Economic and Policy Research (JHEPR)
Najmiatul Fitria
Departmen Of Pharmacology And Clinical Pharmacy. Faculty Of Pharmacy. Universitas Andalas. Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Comparative Economic and Clinical Utility of Adding Candesartan for Hypertension Management Najmiatul Fitria; Thang Nguyen; Afifah Machlaurin; Nabila Al Rizka; Dian Ayu Juwita
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.111-117.2024

Abstract

Introduction: Antihypertensive drugs require high costs because they are used over a long period. Therefore, consideration is needed in drug selection requirements, effectiveness, and price. This study aimed to see the beneficial results of hypertension therapy and the non-medical costs incurred by patients using cost-utility analysis (CUA). Method: This research was a prospective study. The incremental Cost-Utility Ratio (ICUR) of antihypertensive treatment was calculated using cost-utility data obtained through EQ-5D-5L questionnaires from outpatients at Universitas Andalas Hospital in January- March 2023 who met the inclusion and exclusion criteria. The costs used were from a patient perspective, consisting of direct medical and non-medical costs. This study compared standard treatment (amlodipine) with the addition of candesartan. Results: The number of respondents in this study was 67, consisting of 23 respondents (34.33%) using amlodipine alone and 44 respondents (65.67%) using the amlodipine-candesartan combination. The ICUR value obtained was IDR7,318,674/QALY. The difference in the average utility value of the amlodipine-candesartan combination with amlodipine alone is -0.02, and the difference in cost is -IDR12,224. Based on the cost-utility diagram, the amlodipine-candesartan combination group is included in the southwest quadrant (quadrant III), which illustrates that the cost required for the amlodipine-candesartan combination group is lower than the cost of the amlodipine single treatment group and the outcome is also not better (slightly lower or the same). Conclusion: It was recommended to prioritize using amlodipine alone for hypertension management, as it provides similar outcomes to the amlodipine-candesartan combination while incurring lower costs.
Cost-Effectiveness of ACTH vs. ACT Chemotherapy Regimens at RSUP Dr. M. Djamil Nadiatul Aulia Zahara Rizki; Dita Permatasari; Fitri Handayani; Ridho Asra; Najmiatul Fitria
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.138-144.2025

Abstract

Introduction: Breast cancer is one of the most common cancers and is often diagnosed at a late stage, especially in Indonesia. This highlights the need for cost-effective treatment options. ACT (Adriamycin, Cyclophosphamide, and Taxane) and ACTH (ACT plus Herceptin/Trastuzumab) are used chemotherapy regimens, but studies comparing their cost-effectiveness are still limited. This study aimed to evaluate the cost-effectiveness of ACT versus ACTH for breast cancer treatment using tumor volume reduction. Method: A retrospective cost-effectiveness study was carried out at Dr. M. Djamil Hospital by comparing direct medical costs and tumor volume changes in breast cancer patients treated with ACT or ACTH regimens. Effectiveness was based on the average change in tumor volume, and cost-effectiveness was evaluated using the Incremental Cost-Effectiveness Ratio (ICER). Results: The mean tumor volume reduction in the ACT group was 2820.85 ± 11190.42 cm³, and significantly higher at 9273.50 ± 60101.33 cm³ in ACTH, although the difference was not statistically significant (p = 0.614). The average direct medical cost for ACTH was IDR 67,138,579, compared to IDR 13,005,027 for ACT. The ICER calculation resulted in IDR-838,935 per cm³ of tumor reduction, while the negative ICER might suggest cost savings, it does not imply that ACTH is a dominant strategy indicating that ACTH incurred a higher cost with less effectiveness per unit of tumor reduction than ACT. Conclusion: The high associated cost leads to a negative ICER, suggesting that ACT may be more cost-effective in this setting. These findings are critical for optimizing chemotherapy choices within limited healthcare budgets.
Utilization Of Moringa Leaves As A Nutrient to Prevent Stunting In Children In Gantiang Village, Padang Panjang City Meri Susanti; Annisa Fauzana; Yoneta Srangenge; Nova Syafni; Najmiatul Fitria
Warta Pengabdian Andalas Vol 33 No 2 (2026)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.33.2.166-172.2026

Abstract

Stunting is a critical public health issue in Indonesia. Despite various nutrition programs, the utilization of nutritious local foods, such as Moringa oleifera leaves, has not been maximized due to limited public awareness and inadequate education. This activity aims to increase public knowledge of the nutritional content and benefits of Moringa leaves for preventing stunting, and to provide training in processing Moringa into healthy foods. Methods: The activity was conducted on October 4, 2025, in Gantiang Village, Padang Panjang City. The target group comprised housewives, health care workers, and caregivers of toddlers. Data were collected through pre- and post-tests, as well as surveys of participant satisfaction and interest. Results: Following the educational and processing demonstration, participants' knowledge increased significantly; the program was deemed highly beneficial, and most expressed interest in incorporating Moringa leaf preparations into their family menus. Conclusion: Education and training in Moringa leaf processing have been effective in increasing public knowledge and interest in using Moringa as a nutritious food, thereby potentially supporting efforts to prevent stunting. For sustainability, it is recommended that this program be integrated into integrated health posts (Posyandu) and that further training be conducted to ensure that Moringa leaf consumption becomes a regular part of family eating habits.
Efektivitas Terapi Antikoagulan terhadap Parameter Koagulasi pada Pasien Stroke Iskemik: Studi Retrospektif di RSUP Dr. M. Djamil Padang Suci Wulansari; Dedy Almasdy; Najmiatul Fitria
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1607

Abstract

Introduction: Ischemic stroke is a major cause of global morbidity and mortality, with anticoagulant therapy being the primary choice for secondary prevention in specific cases. However, scientific evidence regarding the effectiveness of anticoagulant therapy in the Indonesian population remains limited. Objective: To evaluate the effectiveness of anticoagulant therapy based on changes in coagulation parameters (PT, APTT, INR) and their association with clinical outcomes in ischemic stroke patients at Dr. M. Djamil General Hospital, Padang. Methods: This retrospective analytical observational study included 68 ischemic stroke patients who received anticoagulant therapy (January–December 2024). Effectiveness was assessed by changes in PT, APTT, and INR before and after treatment using Wilcoxon and Kruskal-Wallis tests. Results: Anticoagulant therapy significantly increased PT, APTT, and INR values in most treatment groups (p<0.05), with no significant differences among anticoagulant types (p>0.05). Patients with mortality outcomes showed higher increases in coagulation parameters, but a significant association was only found for changes in APTT (p=0.033). Conclusion: Anticoagulant therapy effectively affects coagulation parameters in ischemic stroke patients, and increased APTT after therapy is associated with mortality. Further prospective studies are needed to confirm these findings.
Co-Authors Abdul Muthalib Abdul Muthalib Ade Sukma Ade Sukma Ade Sukma Afifah Machlaurin Almahdy - A Almahdy A Amni , Hudiyah Anata, Fahira Tri Andela, Mila Annisa Fauzana Arief, Irma I. Chytra Bertdiana Ersa D. Novia Dedy Almasdy Deni Novia Dian Ayu Juwita Dian Suhery Dita Permatasari Dita Permatasari Fahira Tri Anata Febiana, Dian Fitri Handayani Fitri Handayani Fitri Handayani Fivi Melva Diana, Fivi Melva Hajrawati, Hajrawati Hansen Nasif Husnia, Khairatul Indri Juliyarsi Intan Nur Rahmadani Khairatul Husnia Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi, Lailaturrahmi Lailiani, Resa Leliani Fitri Anggraini Leliani Fitri Anggraini Mardatillah Mardatillah Mariza, Wilnando Melia, Sri Melia, Sri Meri Susanti Mila Andela Muhammad Akram Nabila Al Rizka Nadiatul Aulia Zahara Rizki Nauratul Ikramah Nova Syafni Nur Rahmadani, Intan Nurul Afifah Almunawwarah Rahmadian, Yudi Rahmi Yosmar Rahmi Yosmar Ramadani, Mery Resa Lailiani Ridho Asra Rusdi Djamal Sarah Puti Amalia Sari Yulanda Sari, Yelly Oktavia Sri Melia Sri Nani Jelmila Suci Wulansari Suharto, El LS. Syaputri, Yolanda Zazna Syed Wasif Gillani Thang Nguyen Tuty Anggraini Vebriyanti, Ely Wilnando Mariza Yelly Oktavia Sari Yolanda Zazna Syaputri Yoneta Srangenge Zazna Syaputri, Yolanda