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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi JSFK (Jurnal Sains Farmasi & Klinis) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea JURNAL MEDIA KESEHATAN Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Journal of Health Economic and Policy Research (JHEPR)
Najmiatul Fitria
Departmen Of Pharmacology And Clinical Pharmacy. Faculty Of Pharmacy. Universitas Andalas. Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Adherence Assessment on Hypertension Therapy Using The Pill Count Method In Lubuk Kilangan Health Center, Indonesia Fitria, Najmiatul; Lailaturrahmi, Lailaturrahmi; Sari, Yelly Oktavia; Anata, Fahira Tri; Husnia, Khairatul
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.28-34.2023

Abstract

Adherence is a major problem in hypertension treatment. Patients' adherence can be evaluated through pill count by counting the remaining amount of the patient's medication at the beginning and the end, using a pillbox as a tool to improve patient medication adherence. The purpose of this study was to describe the differences in adherence between patients who used the pillbox and without the pillbox. The research method used is Pretest-Posttest Control Group Design. The sample of this study is Prolanis (Chronic Disease Management Program) patients in 2021 at the Lubuk Kilangan Health Center in Padang City. They meet the inclusion and exclusion criteria that have been set. Sampling was carried out by total sample and obtained 70 subjects divided into the treatment group and the control group. The research technique used a Home Medication Review (HMR). The results of the study using the Mann-Whitney Test statistical test on adherence (p = 0.007) showed a value (p<0.05). It can be concluded that there are differences in adherence before and after the intervention. This result indicates that adherence is higher in patients who use the pillbox than those without the pillbox.
Analisis Efektivitas Biaya Penggunaan Metformin-GlimepirideTerhadap Penurunan Kadar Gula Darah Puasa Pada Pasien Diabetes Mellitus Tipe 2 di RS Universitas Andalas Fitria, Najmiatul; Andela, Mila; Syaputri, Yolanda Zazna; Nasif, Hansen
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.202-207.2022

Abstract

Diabetes melitus (DM) merupakan penyakit metabolik yang bersifat progresif dan ditandai dengan peningkatan kadar glukosa darah akibat disfungsi sel pankreas dan resistensi insulin. Penderita diabetes mellitus menjalani terapi farmakologi seumur hidup, oleh karena itu diperlukan biaya yang besar terkait pengobatan tersebut. Estimasi beban ekonomi diabetes melitus di Indonesia pada tahun 2020 yaitu $1,27 M. Sehingga perlu dilakukan analisis efektivitas biaya untuk membuat keputusan mengenai pemilihan obat dengan -efektifitas yang baikdan biaya yang minimal. Penelitian analisis efektivitas biaya ini bertujuan untuk menentukan nilai Rasio Inkremental Efektivitas Biaya (RIEB) terapi antidiabetes kelompok metformin tunggal dan kombinasi metformin-glimepirid pada pasien DM tipe 2 rawat jalan. Penelitian ini merupakan penelitian deskriptif dan pengambilan data dilakukan secara retrospektif menggunakan data rekam medis pasien. Data yang digunakan berjumlah 114 dari 439 populasi. Dari 114 sampel penelitian, diperoleh sebanyak 23 sampel (20,18%) menerima terapi metformin tunggal dan 91 sampel (79,82%) menerima terapi metformin-glimepirid. Nilai RIEB untuk kadar glukosa darah puasa yaitu Rp 1.284,74 setiap penurunan 1 mg/dl. Penggunaan metformin-glimepirid membutuhkan biaya yang lebih besar dibandingkan pemakaian metformin tunggal namun efek yang dihasilkan juga lebih baik.
Application of Home Medication Review (HMR) on Patient Adherence in Type 2 Diabetes Mellitus (T2DM) Blood Sugar Management Sari, Yelly Oktavia; Permatasari, Dita; Mariza, Wilnando; Fitria, Najmiatul; Lailiani, Resa
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.160-167.2022

Abstract

Non-adherence of type 2 diabetes mellitus (T2DM) patients in treatment will impact expected clinical outcomes, risk of complications, and poor quality of life. Home medication review (HMR) is designed to help achieve optimal treatment, such as patient adherence. This study aimed to determine adherence levels and T2DM blood sugar management. This study with a pretest-posttest control group design was carried out at Andalas Public Health Center, Padang City, West Sumatra-Indonesia with 62 randomly selected respondents and then divided into two groups (pillbox and non-pillbox). The adherence levels were assessed by the pill count method. Changes in blood sugar levels are associated with adherence levels. The results showed an increase in the T2DM adherence level of patients using the pillbox at 7.360% and a decrease in blood sugar levels in those who used the pillbox at 61.161 mg/dL. There was a significant difference in the adherence between patients' levels using the pillbox and non-pillbox with a value of 0.011 (p <0.05). Similarly, the patient's blood sugar levels between the two groups showed a significant difference with a value of 0.007 (p<0.05). The application of HMR to patient adherence is considered to have a role in managing T2DM blood sugar.
Evaluating Economic Outcomes: Single-Use Aspirin vs. Aspirin-Clopidogrel in Ischemic Stroke Patients Based on Barthel Index Scores Yosmar, Rahmi; Febiana, Dian; Fitria, Najmiatul
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.293-299.2023

Abstract

Ischemic stroke is a catastrophic disease that causes large costs in Indonesia. The high prevalence of stroke results in  increased morbidity and mortality rates, which will impact the socioeconomic status of stroke patients. Cost Effectiveness Analysis  (CEA) is a method in pharmaco-economics that aims to make decisions regarding the rational choice of therapy and evaluate  the economic impact on ischemic stroke patients. This study aims to determine the Incremental Cost Effectiveness Ratio (ICER)  value of antiplatelet therapy in the aspirin-clopidogrel combination group and the single aspirin group in ischemic stroke patients  treated at the Regional General Hospital. Dr. M. Djamil Padang. The clinical parameter observed was the Barthel Index (BI) value.  This research is a descriptive study with retrospective data collection using medical record data and the Hospital Management  Information System (SIMRS) at RSUD Dr. M.Djamil Padang. The cost data shows the total direct medical costs incurred in treating  ischemic stroke. Based on the results obtained, the Incremental Cost Effectiveness Ratio (ICER) value is IDR (-) 401,302. 71 per  1% increase. In this study it can be concluded that the aspirin-clopidogrel combination has better cost effectiveness than aspirin  alone.
Comparative Economic and Clinical Utility of Adding Candesartan for Hypertension Management Fitria, Najmiatul; Nguyen, Thang; Machlaurin, Afifah; Al Rizka, Nabila; Ayu Juwita, Dian
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.111-117.2024

Abstract

Introduction: Antihypertensive drugs require high costs because they are used over a long period. Therefore, consideration is needed in drug selection requirements, effectiveness, and price. This study aimed to see the beneficial results of hypertension therapy and the non-medical costs incurred by patients using cost-utility analysis (CUA). Method: This research was a prospective study. The incremental Cost-Utility Ratio (ICUR) of antihypertensive treatment was calculated using cost-utility data obtained through EQ-5D-5L questionnaires from outpatients at Universitas Andalas Hospital in January- March 2023 who met the inclusion and exclusion criteria. The costs used were from a patient perspective, consisting of direct medical and non-medical costs. This study compared standard treatment (amlodipine) with the addition of candesartan. Results: The number of respondents in this study was 67, consisting of 23 respondents (34.33%) using amlodipine alone and 44 respondents (65.67%) using the amlodipine-candesartan combination. The ICUR value obtained was IDR7,318,674/QALY. The difference in the average utility value of the amlodipine-candesartan combination with amlodipine alone is -0.02, and the difference in cost is -IDR12,224. Based on the cost-utility diagram, the amlodipine-candesartan combination group is included in the southwest quadrant (quadrant III), which illustrates that the cost required for the amlodipine-candesartan combination group is lower than the cost of the amlodipine single treatment group and the outcome is also not better (slightly lower or the same). Conclusion: It was recommended to prioritize using amlodipine alone for hypertension management, as it provides similar outcomes to the amlodipine-candesartan combination while incurring lower costs.
Comparative Utility of Doxorubicin, Cyclophosphamide, and Docetaxel in Breast Cancer Treatment in West Sumatera. Fitria, Najmiatul; Nur Rahmadani, Intan; Permatasari, Dita; Handayani, Fitri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.40914

Abstract

The large number of breast cancer cases in Indonesia and the high cost of treatment cause the need for utility analysis. West Sumatra province ranks second with the highest prevalence of breast cancer in Indonesia. This study aimed to determine the quality of life of breast cancer patients at the national referral hospital Dr. M. Djamil, West Sumatra, who underwent chemotherapy. This study used a cross-sectional design from January to April 2024. Data collection was done prospectively by filling out questionnaires at the Chemotherapy Unit. Utility value was obtained from filling out a questionnaire with the EQ-5D-5L instrument. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests. The data obtained was 47 respondents who received Doxorubicin and Cyclophosphamide chemotherapy regimen (24 respondents) and a Docetaxel chemotherapy regimen (23 respondents), all of whom met the inclusion criteria in this study. The average utility value obtained for the doxorubicin and cyclophosphamide regimes is 0.637, and the average utility value for the docetaxel regimen is 0.704. Age did not affect utility (p>0.05), while recent education, occupation, and patient origin affected utility (p<0.05). Both regimens provided similar perceived quality of life and overall health status as measured by utility and VAS scores, suggesting comparable patient-reported quality of life outcomes between these chemotherapy treatments.
SOSIALISASI SANITASI DAN HIGIENIS KERUPUK KULIT PADA IKM RIZKY DI KOTA PADANG Indri Juliyarsi; Sri Melia; Deni Novia; Ade Sukma; Tuty Anggraini; Najmiatul Fitria
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 4 No. 3 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i3.302

Abstract

The skin crackers are well-known and favored as regional superior products which are very potential to be developed. The purpose of this service is to improve sanitation and hygiene aspects, where the layout of production in accordance with SSOP and GMP. Approach methods offered to support knowledge programs using trained and consultation with the methods used are lectures and discussions. The focus of activities is the renovation of layout of production space and sanitation equipment. Based on the service of introducing appropriate technology, Mitra is very enthusiastic about using cleaning tools for wet and clean production spaces with sanitary and hygienic and storage space equipped with container boxes so that it can increase the shelf life of the skin after drying, as well as improve the production space so that the production is running well in accordance with SSOP, GMP in production.
The Effects of Fatty Acid in Population Related to Body Mass Index Fivi Melva Diana; Mery Ramadani Ramadani; Najmiatul Fitria
Jurnal Kesehatan Masyarakat Andalas Vol 16 No 1 (2022): Jurnal Kesehatan Masyarakat Andalas
Publisher : Faculty of Public Health, Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24893/jkma.v16i1.1045

Abstract

Normal body mass index (BMI) is related to a person's health condition. Consumption of fatty acids is used to keep some problems of BMI abnormalities. The study aimed to assess the relationship between fatty acids and changes in BMI. A systematic review to assess articles related to fatty acids and bmi changes. Database searches are conducted through PubMed. Researchers looked for Omega 3, EPA, DHA, Omega 6, AA as fatty acids. Only articles on humans were included in the study. Articles that are not written in English and without full text are not included. Six articles were included in the study. Clinical trials are used in all included studies. Most studies describe the relationship of fatty acids to pregnancy weight gain in pregnant women. Types of fatty acids that play an essential role are Omega 3, EPA, DHA, ALA, omega 6.Not all fatty acids have a positive impact on humans. There are negative symptoms that need to be addressed, especially outside of BMI.
Interaksi Obat Potensial pada Sirosis Hati: Tinjauan Pola dan Faktor Sosiodemografi Amni , Hudiyah; Fitria, Najmiatul; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.910

Abstract

Liver cirrhosis is a chronic condition characterised by the formation of regenerative nodules and fibrotic tissue resulting from prolonged liver damage. This condition is frequently accompanied by comorbidities and complications, often leading to the use of multiple medications (polypharmacy). Polypharmacy increases the risk of potential drug interactions, which may worsen clinical outcomes. This study aimed to describe the patterns of possible drug interactions and the sociodemographic characteristics of hospitalised patients with cirrhosis at Dr M. Djamil Central General Hospital in Padang. A cross-sectional study was conducted using prospectively collected data from patient medical records. A total of 579 medications used by 50 patients were classified into three categories: cirrhosis-specific drugs (48.9%), symptomatic treatments (43.2%), and medications for comorbid conditions (7.95%). Analysis with drugs.com showed potential drug interactions in 96% of patients, most commonly moderate–to–minor combinations (48%), followed by major, moderate, and minor interactions (22%). In comparison, moderate interactions only and major moderate combinations occurred in 18% and 9% of patients, respectively.  In terms of sociodemographic characteristics, most patients were male (58%), under 65 years old (64%), had more than one comorbidity (52%), had a basic education level (32%), were still employed (56%), and did not engage in high-risk social behaviors such as smoking or alcohol consumption (48%).
Amlodipine-Candesartan Combination: A Cost-Effective Strategy for Successful Therapy of Hypertension Fitria, Najmiatul; Zazna Syaputri, Yolanda; Mardatillah, Mardatillah; Akram, Muhammad; Nasif, Hansen
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.32-38.2024

Abstract

Introduction: The combination of amlodipine and candesartan can have a better effect, although the cost-effectiveness analysis was not yet determined. This research aimed to establish the Incremental Cost-Effectiveness Ratio (ICER) value among outpatients with hypertension who used amlodipine-candesartan. Method: This research is a descriptive study that retrospectively gathered data from medical records. It focused on information for hypertensive patients at Universitas Andalas Hospital in 2021. This study compared the standard treatment involving amlodipine-candesartan and sole amlodipine, next to calculate the ICER using cost-effectiveness analysis. Results: Out of the total population of 284, as many as 73 patients were involved in this study. Among these, 21 patients (28.77%) were treated with amlodipine alone, while 52 (71.23%) received an amlodipine-candesartan combination. The Incremental Cost-Effectiveness Ratio (ICER) for reducing systolic blood pressure was IDR 74,738.10 per one mmHg decrease in the northeast quadrant of the cost-effectiveness chart. The ICER for lowering diastolic blood pressure was IDR 205,918.24 per one mmHg decrease in the northeast quadrant on the cost-effectiveness chart. Conclusion: The cost of the amlodipine-candesartan combination yields superior effects; however, warranting a probabilistic sensitivity analysis to determine its ICER robustness is essential for its effective implementation
Co-Authors Abdul Muthalib Abdul Muthalib Ade Sukma Ade Sukma Ade Sukma Al Rizka, Nabila Almahdy - A Almahdy A Amni , Hudiyah Anata, Fahira Tri Andela, Mila Arief, Irma I. Asra, Ridho Aulia Zahara Rizki, Nadiatul Chytra Bertdiana Ersa D. Novia Deni Novia Dian Ayu Juwita Dian Suhery Dita Permatasari Dita Permatasari Fahira Tri Anata Febiana, Dian Fitri Handayani Fivi Melva Diana, Fivi Melva Hajrawati, Hajrawati Hansen Nasif Husnia, Khairatul Indri Juliyarsi Khairatul Husnia Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi, Lailaturrahmi Lailiani, Resa Leliani Fitri Anggraini Leliani Fitri Anggraini Machlaurin, Afifah Mardatillah Mardatillah Mariza, Wilnando Melia, Sri Melia, Sri Mila Andela Muhammad Akram Nauratul Ikramah Nguyen, Thang Nur Rahmadani, Intan Nurul Afifah Almunawwarah Rahmadian, Yudi Rahmi Yosmar Rahmi Yosmar Ramadani, Mery Resa Lailiani Rusdi Djamal Sarah Puti Amalia Sari Yulanda Sari, Yelly Oktavia Sri Melia Sri Nani Jelmila Suharto, El LS. Syaputri, Yolanda Zazna Syed Wasif Gillani Tuty Anggraini Vebriyanti, Ely Wilnando Mariza Yelly Oktavia Sari Yolanda Zazna Syaputri Zazna Syaputri, Yolanda