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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Masyarakat Indonesia (JKMI)
Aswiyanti Asri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Significance of TGF-β Expression in Predicting Lymphovascular Invasion and Lymph Node Metastasis in Colorectal Cancer Aini, Julpa Nurul; Aswiyanti Asri; Noza Hilbertina; Tofrizal; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1182

Abstract

Background: Colorectal cancer (CRC) is a major health burden globally. The prognosis of CRC is strongly influenced by the presence of lymphovascular invasion (LVI) and lymph node (LN) metastasis. Transforming growth factor-beta (TGF-β) is a cytokine with a complex role in CRC progression. This study aimed to evaluate the significance of TGF-β expression in predicting LVI and LN metastasis in CRC. Methods: This cross-sectional study involved 50 patients diagnosed with CRC. The expression of TGF-β was assessed using immunohistochemical staining and the Allred scoring system. The relationship between TGF-β expression and the presence of LVI and LN metastasis was analyzed using the Chi-square test. Results: High TGF-β expression was significantly associated with both LVI (p = 0.011) and LN metastasis (p = 0.012) in CRC. Patients with high TGF-β expression had a higher risk of LVI and LN metastasis compared to those with low TGF-β expression. Conclusion: TGF-β expression is a significant predictor of LVI and LN metastasis in CRC. This finding has potential implications for risk stratification and treatment decisions in CRC patients.
Co-Authors Aini, Julpa Nurul Almurdi Almurdi Avit Suchitra Bobby Indra Utama Dessy Arisanti Dian Pertiwi Dina Arfiani Rusjdi Elmatris Sy Endrinaldi Fachry Abda El Rahman Fitri Nur Handriyani Hafizah Putri Tasyah Hasmiwati Henny Mulyani Hera Novianti Husna Yetti Julizar Nazar Maisyah Nelzima Meta Zulyati Oktora Mohamad Reza Mustika Sari Novita Ariani Noza Hilbertina Pamelia Mayorita Rauza Sukma Rita Rina Gustia Runky Pebranka Syamel Muhammad Tofrizal Wildanur, Sri Yenita Yenita Yessy Setiawati Zelly Dia Rofinda Zulda Musyarifah