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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Chimica et Natura Acta Pharmacology and Clinical Pharmacy Research FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy
Ajeng Diantini, Ajeng
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Aktivitas Antioksidan Daun Iler Plectranthus scutellarioides (L.) R.Br. Moelyono, M W; Rochjana, Anna Uswatun Hasanah; Diantini, Ajeng; Musfiroh, Ida; Sumiwi, Sri Adi; Iskandar, Yoppi; Susilawati, Yasmiwar
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT : Antioxidants are the compounds capable to inhibit free radical reactions in the human body. This research was aimed to identify the antioxidant potency of ethanolic extract of Plectranthus scutellaroides leaves in vitro by using spectrophotometric methods with DPPH (1,1-diphenyl-2-picryl hydrazyl) using vitamin C as reference. Concentrations of samples used were 75, 100, 115, 125 and 135 ppm. The antioxidant activity was measured by visible spectrophotometry at three wavelengths of 498, 518 and 538 nm. The result showed that the n-hexane fraction gave the highest antioxidant activity with IC50 of 52.5 ppm, 15 times lower than that of vitamin C (IC50 of 3.33 ppm). Phytochemical screening of the Plectranthus scutellaroides leaves indicated the presence of flavonoids, polyphenolic, monoterpenoids, sesquiterpenoids, steroids and triterpenoids. Keywords: antioxidant, Plectranthus scutellaroides, leaves, DPPH ABSTRAK Antioksidan merupakan senyawa yang dapat menghambat reaksi radikal bebas dalam tubuh. Penelitian ini bertujuan untuk mengetahui daya antioksidan dari daun Plectranthus scutellarioides (L.) R.Br., secara in vitro dengan metode spektrofotometri menggunakan pereaksi 1,1-difenil 2-pikrilhidrazil (DPPH) dengan vitamin C sebagai pembanding. Daun diekstrak menggunakan etanol lalu difraksinasi dengan n-heksana, etil asetat dan air. Variasi konsentrasi sampel uji yang digunakan pada pengujian ini adalah 75, 100, 115, 125 dan 135 ppm. Aktivitas antioksidan diukur secara spektrofotometri pada tiga panjang gelombang yaitu 498, 518 dan 538 nm. Hasil penelitian menunjukkan bahwa fraksi n-heksana pada konsentrasi tersebut memberikan aktivitas antioksidan paling kuat dengan nilai IC sebesar 52.5 ppm, 15 kali lebih lemah dibandingkan dengan vitamin C (IC50 = 3.33 ppm). Hasil penapisan fitokimia terhadap daun Plectranthus scutellaroides menunjukkan adanya senyawa golongan flavonoid, polifenolat, monoterpenoid, sesquiterpenoid, steroid dan tritertenoid. Kata kunci: antioksidan, Plectranthus scutellaroides, daun, DPPH
Aktivitas Antioksidan Daun Iler Plectranthus scutellarioides (L.) R.Br. Moelyono, M W; Rochjana, Anna Uswatun Hasanah; Diantini, Ajeng; Musfiroh, Ida; Sumiwi, Sri Adi; Iskandar, Yoppi; Susilawati, Yasmiwar
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.122 KB) | DOI: 10.35617/jfi.v8i1.416

Abstract

ABSTRACT : Antioxidants are the compounds capable to inhibit free radical reactions in the human body. This research was aimed to identify the antioxidant potency of ethanolic extract of Plectranthus scutellaroides leaves in vitro by using spectrophotometric methods with DPPH (1,1-diphenyl-2-picryl hydrazyl) using vitamin C as reference. Concentrations of samples used were 75, 100, 115, 125 and 135 ppm. The antioxidant activity was measured by visible spectrophotometry at three wavelengths of 498, 518 and 538 nm. The result showed that the n-hexane fraction gave the highest antioxidant activity with IC50 of 52.5 ppm, 15 times lower than that of vitamin C (IC50 of 3.33 ppm). Phytochemical screening of the Plectranthus scutellaroides leaves indicated the presence of flavonoids, polyphenolic, monoterpenoids, sesquiterpenoids, steroids and triterpenoids. Keywords: antioxidant, Plectranthus scutellaroides, leaves, DPPH ABSTRAK Antioksidan merupakan senyawa yang dapat menghambat reaksi radikal bebas dalam tubuh. Penelitian ini bertujuan untuk mengetahui daya antioksidan dari daun Plectranthus scutellarioides (L.) R.Br., secara in vitro dengan metode spektrofotometri menggunakan pereaksi 1,1-difenil 2-pikrilhidrazil (DPPH) dengan vitamin C sebagai pembanding. Daun diekstrak menggunakan etanol lalu difraksinasi dengan n-heksana, etil asetat dan air. Variasi konsentrasi sampel uji yang digunakan pada pengujian ini adalah 75, 100, 115, 125 dan 135 ppm. Aktivitas antioksidan diukur secara spektrofotometri pada tiga panjang gelombang yaitu 498, 518 dan 538 nm. Hasil penelitian menunjukkan bahwa fraksi n-heksana pada konsentrasi tersebut memberikan aktivitas antioksidan paling kuat dengan nilai IC sebesar 52.5 ppm, 15 kali lebih lemah dibandingkan dengan vitamin C (IC50 = 3.33 ppm). Hasil penapisan fitokimia terhadap daun Plectranthus scutellaroides menunjukkan adanya senyawa golongan flavonoid, polifenolat, monoterpenoid, sesquiterpenoid, steroid dan tritertenoid. Kata kunci: antioksidan, Plectranthus scutellaroides, daun, DPPH
REVIEW ARTIKEL: EFIKASI TERAPI REMDESIVIR PADA PASIEN CORONAVIRUS DISEASES-19 (COVID-19) LISTIANI, NITA; DIANTINI, AJENG
Farmaka Vol 19, No 2 (2021): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v19i2.32322

Abstract

Pada akhir tahun 2019, COVID-19 mulai menyebar ke seluruh belahan dunia, virus ini merupakan tipe baru dari coronavirus (SARS-Cov-2) dan pertama kali ditemukan di Wuhan,China. Hingga saat ini, Covid-19 masih menjadi pandemi yang terus meningkat jumlah kasusnya.  Berbagai penelitian terkait pengobatan penyakit ini banyak dipublikasikan, salahsatunya adalah terapi menggunakan antiviral remdesivir yang telah terbukti secara in vitro berefek pada SARS-Cov-2. Tujuan artikel ini adalah untuk mengetahui efikasi terapi remdesivir pada pasien Covid-19. Metode yang digunakan dalam penyusunan review artikel ini adalah systematic review dengan menggunakan database jurnal PubMed dan NCBI terkait terapi remdesivir melalui uji klinis. Berdasarkan hasil penelusuran, terapi remdesivir pada pasien Covid-19 dengan dosis muatan 200 mg i.v dan dilanjutkan dengan dosis 100 mg i.v rentang terapi 5-10 hari pada beberapa penelitian  memberikan hasil positif yaitu efek waktu pemulihan yang lebih cepat dan menurunnya gejala secara signifikan pada pasien Covid-19. Kata Kunci: Covid-19, Terapi, Remdesivir, Efikasi
Artikel Ulasan: Kajian Aktivitas Anti-hiperlipidemia Beberapa Tanaman yang Digunakan Masyarakat Jawa Barat Berdasarkan Pengetahuan Lokal (Indigenous Knowledge) Rahmayanti, Annisa N.; Febrianti, Raden M.; Diantini, Ajeng
Indonesian Journal of Biological Pharmacy Vol 1, No 1 (2021): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.15 KB) | DOI: 10.24198/ijbp.v1i1.34969

Abstract

Salah satu faktor risiko penyakit jantung koroner yaitu penumpukan kolesterol pada pembuluh darah yang disebabkan oleh kondisi hiperlipidemia. Tingginya angka kejadian penyakit jantung coroner di Indonesia mengharuskan masyarakat Indonesia untuk lebih waspada akan tingginya kadar kolesterol. Masyarakat lokal pada daerah pedalaman cenderung memilih pengobatan tradisional dibandingkan obat kimia karena mereka lebih paham mengenai penggunaan tanaman obat serta bahan-bahannya yang lebih terjangkau dan tidak membutuhkan biaya besar, tidak seperti obat kimia. Artikel ini dibuat untuk sebagai inventarisasi informasi pengetahuan lokal (indigenous knowledge) masyarakat Jawa Barat mengenai tanaman obat yang memiliki aktivitas antihiperlipidemia. Beberapa tanaman tersebut adalah Moringa oleifera, Muntingia calabura, dan Syzygium polyanthum atau Eugenia polyantha. Sebagian besar komponen senyawa bioaktif dengan aktivitas anti-kolesterol yang terkandung dalam tumbuhan tersebut diantaranya adalah flavonoid, saponin, tannin, dan vitamin C serta B3.
A Review of Antidiabetic Potential of Indonesian Medicinal Plants on Streptozotocin (STZ)-Induced Rats Anjabtsawa, Daffa; Febriyanti, Raden Maya; Diantini, Ajeng
Indonesian Journal of Biological Pharmacy Vol 4, No 1 (2024): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i1.54037

Abstract

Diabetes mellitus represents a chronic pathological state affecting a substantial portion of the global population, characterized by elevated levels of blood glucose. The International Diabetes Federation (IDF) documented in 2022 an estimated 537 million individuals aged 20-79 afflicted with this condition. Indonesia is home to various medicinal plants used for centuries to treat various ailments, including diabetes. Some of these plants have been found to have antidiabetic properties and are currently being studied for their potential use in treating diabetes. This review integrates the potential of indigenous Indonesian medicinal plants as antidiabetic agents. Twenty-two herbal species native to Indonesia were examined in diabetic-rat models, revealing promising efficacy as alternatives to conventional antihyperglycemic therapies. These medicinal plants' bioactive constituents, including flavonoids, alkaloids, phenolics, tannins, saponins, steroids, triterpenoids, and glycosides, are hypothesized to modulate glucose metabolism. Data acquisition encompassed scholarly databases such as PubMed, Scopus, Cochrane, Google Scholar, ScienceDirect, and EBSCO, spanning literature published between 2017 and 2023. The investigation underscores the notable reduction in blood glucose levels observed in rats administered doses ranging from 100 to 800 mg/kg body weight (BW). Furthermore, the antihyperglycemic evaluation in rats involved dosing at 40-65 mg/kg BW, eliciting a sustained hyperglycemic state.
A Narrative Review of the Case Reports of Routine Immunization Performance During a Pandemic COVID-19 Rahayuningsih, Nur; Suwantika, Auliya A.; Diantini, Ajeng; Sinuraya, Rano K.
Pharmacology and Clinical Pharmacy Research Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i3.59264

Abstract

Routine immunization is a program that must ensure adequate coverage as one preventive measure against the transmission of vaccine-preventable disease (VPD). Vaccines are the most cost-effective healthcare investment as it has been shown to prevent and reduce the incidence of disease, disability, and death from VPD, which is estimated to kill 2 – 3 million people each year. As of July 11, 2020, the COVID-19 pandemic has been deemed the worst public health emergency in the world, with over 12 million positive cases and 556,342 fatalities documented in 213 nations. The impact of the pandemic on routine immunization has resulted in higher morbidity and mortality from this VPD in countries with low coverage. This review article comprehensively describes routine immunization services and case reports of immunization performance during the COVID-19 pandemic.   
Exploring the Phytochemical Properties and Therapeutic Potential of Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. Anjabtsawa, Daffa; Febriyanti, Raden Maya; Diantini, Ajeng
Indonesian Journal of Biological Pharmacy Vol 4, No 2 (2024): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i2.54035

Abstract

Indonesian people have used medicinal plants for ages to cure various diseases. Traditional medicinal plants offer a variety of health benefits and can be an excellent alternative to prevent various diseases. Herbal tea-based treatment is low-calorie and is good for health with many benefits. Rosella (Hibiscus sabdariffa Linn.) and Stevia (Stevia rebaudiana Bert.) plants are the main composition of herbal tea. They contain various secondary metabolite compounds that play a role in pharmacological activity like alkaloids, flavonoids, phenols, glycosides, steroids, tannins, coumarins, saponins, anthraquinones, and others. This review aims to collect the latest scientific information regarding the possible pharmacological activities of Rosella and Stevia plants. These plants have antioxidative, antibacterial, antidiabetic, antihypertensive, anticancer, antihyperlipidemia, anti-obesity, hepatoprotective, anti-inflammatory, and antiprotozoal potential. PubMed, Scopus, Cochrane, Google Scholar, ScienceDirect, and EBSCO were used to obtain literature published from 2017 to 2023. The study concludes that Rosella (Hibiscus sabdariffa Linn.) and Stevia (Stevia rebaudiana Bert.) plants have potential in the development of traditional medicinal plants with many benefits contained in them.
ERCC2 rs13181 and ERCC1 rs11615 polymorphisms in non-small cell lung cancer patients in West Java: towards personalized medicine approaches Afifah, Nadiya Nurul; Effendi, M. Fariz; Diantini, Ajeng; Barliana, Melisa Intan; Intania, Ruri
Current Research on Biosciences and Biotechnology Vol. 6 No. 2 (2025)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2025.6.2/3DCBQ451

Abstract

Non-Small Cell Lung Cancer (NSCLC) is a disease with a high incidence rate, low survival due to late diagnosis and treatment delays, and varying effectiveness of platinum-based chemotherapy. Individual responses to platinum-based chemotherapy are influenced by genetic polymorphisms in genes affecting pharmacokinetic and pharmacodynamic mechanisms. This study focuses on identifying polymorphisms in the ERCC2 and ERCC1 genes, which play a role in platinum pharmacodynamics, and their effects on chemotherapy response. The study involved 23 NSCLC patients conducted at Dr. H.A. Rotinsulu Lung Hospital in Bandung. Polymorphism data were obtained through genotype analysis using sequencing methods from prospective whole blood samples of patients, while chemotherapy effectiveness was assessed by evaluating chemotherapy response using the RECIST 1.1 method, and radiological response prediction and prognostic factors were determined through CYFRA 21-1 levels. The results showed an OR of 0.964 (95% CI: 0.160 - 5.795) for ERCC2 rs13181 CC + AC vs. AA against chemotherapy response evaluation by RECIST 1.1, and 0.722 (95% CI: 0.062 - 8.464) against CYFRA 21-1 values. Meanwhile, for ERCC1 rs11615, an OR of 0.268 (95% CI: 0.046 - 1.548) CT + TT vs. CC for RECIST 1.1 and 0.3 (95% CI: 0.026 - 3.427) for CYFRA 21-1 values were obtained. In clinical interpretation, it is known that variant alleles at rs13181 and rs11615 have potential for better chemotherapy response although not statistically significant (p>0.05), these results can be considered when assessing patient response to chemotherapy within six cycles. This study provides initial data and forms the basis for future comprehensive cohort observational research.
Hypoglycaemic Properties of The Combination of Roselle Calyx (Hibiscus sabdariffa Linn.) and Stevia Leaves (Stevia rebaudiana B.) in Alloxan-Induced White Rats Febriyanti, Raden Maya; Putri, Refitha Nurul; Diantini, Ajeng; Levita, Jutti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59646

Abstract

Roselle (Hibiscus sabdariffa L.) and stevia (Stevia rebaudiana Bertoni) are known to contain phenolic compounds and flavonoids that act as antioxidants and are beneficial in lowering blood sugar levels. This study aimed to determine the phytochemical content and evaluate the hypoglycemic effects of a combined aqueous extract of H. sabdariffa and S. rebaudiana in a 3:1 ratio on diabetic rats. Aqueous extracts were prepared and analyzed for total phenolic and flavonoid contents using the Folin-Ciocalteu and aluminum chloride methods. Diabetes was induced in male Wistar rats by intraperitoneal injection of alloxan (235 mg/kgBW). Rats in the test groups received 500 or 1000 mg/kgBW of the combination, with blood glucose levels measured on the 0th, 7th, and 14th days post-treatment using a glucometer. H. sabdariffa, S. rebaudiana, and their combination contained total phenolic contents of 102.75, 188.053, and 118.856 mgGAE/g, respectively, and flavonoid contents of 3.099, 6.987, and 4.791 mgQE/g, subsequently. Administration of the combination extract at 1000 mg/kgBW showed the highest hypoglycemic effect, reducing blood glucose levels by 35.98% on the 14th day compared to the negative control (p<0.05). The combination of H. sabdariffa and S. rebaudiana extracts demonstrates significant hypoglycemic activity, attributed to their phenolic and flavonoid content.
Isolat Senyawa dari Spons Laut: Sitotoksisitas terhadap Lini Sel Kanker dan Mekanisme Kematian Sel Amalia, Riezki; Hanifah, Syifa; Hadad, Nur Diana; Sahidin, Idin; Diantini, Ajeng
Indonesian Journal of Clinical Pharmacy Vol 12, No 2 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.2.60970

Abstract

Peningkatan angka kematian akibat kanker menyebabkan berkembangnya penelitian mengenai obat antikanker, terutama penelitian terhadap senyawa penuntun (lead compound) yang diisolasi dari bahan alam. Struktur yang unik disertai dengan kombinasi baru kelompok fungsional dan aktivitas biologis spesifik menyebabkan metabolit yang diisolasi dari spons laut menarik untuk diteliti potensinya sebagai antikanker. Dari berbagai senyawa yang telah diisolasi dari spons laut, diketahui dua diantaranya telah disetujui sebagai obat anti-kanker. Artikel ini membahas keterlibatan berbagai senyawa yang diisolasi dari spons laut terhadap mekanisme kematian sel dan potensinya untuk dikembangkan sebagai antikanker. Sebanyak 14 senyawa, yaitu gukulenin A, aaptamin, halikondramida, skalaradial, kakospongionolida, monanchocidin A, monanchocidin B, monanchoxymycalin C, N6-isopentenyladenosine, (Z)-5-(4-hydroxybenzylidene)-imidazolidine-2,4-dione, stellettin B, sipholenol A, sipholenol L, dan heteronemin, dibahas pada artikel ini serta potensinya sitotoksistasnya terhadap berbagai lini sel kanker dan mekanisme spesifiknya. Pencarian data ilmiah yang digunakan pada artikel review ini dilakukan dengan kata kunci “cancer cell line,” “cytotoxicity,” “marine sponges,” serta “anticancer mechanism,” dan berhasil didapatkan 13 artikel hasil penelusuran secara spesifik menunjukkan potensi sitotoksistas terhadap lini sel kanker senyawa yang diisolasi dari spons laut. Studi in vitro ini menunjukkan bahwa senyawa-senyawa yang dibahas pada review ini memiliki potensi untuk memicu kematian sel melalui berbagai mekanisme, yaitu induksi protein proapoptosis, penghambatan protein antiapoptosis, penghentian siklus sel, inhibisi NF-kB, penekanan metastasis, serta berbagai mekanisme lainnya. Artikel review ini diharapkan dapat menjadi rujukan penelitian lanjutan mengenai potensi sitotoksisitas senyawa yang diisolasi dari spons laut dan pengembangannya sebagai senyawa penuntun antikanker melalui eksplorasi mekanisme spesifik dan modifikasi struktur turunannya.
Co-Authors Amalia, Riezki Anggraeni, Sra R. Anjabtsawa, Daffa Budhi Prihartanto Destiani, Dika P. Effendi, M. Fariz Euis Julaeha Fattah, Miswar Febrianti, Raden M. Febriyanti, Maya Hadad, Nur Diana HANIFAH, SYIFA Ibrahim, Susannia Ida Musfiroh, Ida Intan Barliana, Melisa Intania, Ruri Irma M. Puspitasari, Irma M. Jutti Levita Keri Lestari Listiani, Nita Melisa Intan Barliana, Melisa Intan Mirdayani, Eli Moelyono Moektiwardoyo, Moelyono Moelyono, M W Moelyono, M W Nadiya Nurul Afifah Nur Rahayuningsih, Nur Putri, Norisca A. Putri, Norisca A. Putri, Refitha Nurul Putu Dian, Putu Raden Maya Febriyanti Rahmayanti, Annisa N. Rindarwati, Asti Y. Rizky Abdulah Rochjana, Anna Uswatun Hasanah Rudi Supriyadi Sahidin, Idin Siagian, Bryan J. Sinuraya, Rano K. Sinuraya, Rano K. Sitepu, Rini Daud Sofa D. Alfian, Sofa D. Sri Adi Sumiwi Suwantika, Auliya A. Taofik Rusdiana Tati Herlina Taufik, Adit Tri Mayanti Wibisono, Aditya Seiza Yasmiwar Susilawati Yoppi Iskandar Yulisar, Riza