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All Journal Journal of Agromedicine and Medical Sciences Jurnal Penelitian Sains Jurnal Kesehatan Komunitas Majalah Patologi Indonesia Health and Medical Journal International Islamic Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Cerdika: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas Indonesia Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Noza Hilbertina, Noza
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Liana, Nana; Hilbertina, Noza; Devianti, Loli; Yetti, Husna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP IBU TERKAIT INISIASI MENYUSUI DINI, PEMBERIAN ASI EKSKLUSIF, DAN MAKANAN PENDAMPING ASI DENGAN KEJADIAN STUNTING PADA ANAK DI WILAYAH KERJA PUSKESMAS YANGMEMILIKI ANGKA KEJADIAN STUNTING TERTINGGI DI KOTA PADANG Melayu, Artes Putri; Rachmawati, Nice; Hilbertina, Noza
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 1 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i1.2446

Abstract

Stunting is a condition of malnutrition that persists for a long period of time in children, characterized by the child's height growth not being in accordance with age. The cause of stunting is multifactorial, low nutritional intake is the main cause of stunting. This nutritional intake includes Early Breastfeeding Initiation, exclusive breastfeeding and complementary feeding. Providing nutritional intake to children influenced by the mother's knowledge and attitudes. This study aims to determine the relationship between mothers' knowledge and attitudes regarding early initiation of breastfeeding, exclusive breastfeeding and complementary foods with the incidence of stunting in children. The type of research is analytical observational research with a cross sectional research design with a sample of 67 mothers who had children aged 24-59 months in the work area of the health center which had the highest incidence of stunting in Padang City, namely the Ikur Koto Health Center, Air Children's Health Center and Seberang Padang Health Center . The number of samples was taken based on propotional random sampling technique. This research instrument uses a questionnaire and microtoise. The data analysis using the Chi Square test. The results of the study showed that the frequency of stunting incidents in children aged 24-59 months in the three health center work areas studied was 47,8%. The level of knowledge of respondents was good at 44.8%, and the attitude of respondents was positive at 62.7%. Bivariate analysis obtained a value of p = 0.004 (p value < 0.05) for the relationship between maternal knowledge level and the incidence of stunting and a value of p = 0.005 (p value < 0.05) for the relationship between maternal attitudes and the incidence of stunting. The conclusion of this study is that the level of knowledge and attitudes of mothers regarding IMD, exclusive breastfeeding and MPASI show a statistically significant relationship
CLINICOPATHOLOGICAL CHARACTERISTICS OF PROSTATE CANCER AT THE ANATOMICAL PATHOLOGY LABORATORY OF RSUP DR. M. DJAMIL PADANG 2018–2022 Latifah, Iklil; Yenita, Yenita; Burhan, Ida Rahmah; Hilbertina, Noza; Zulfiqar, Yevri; Lailani, Mutia
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 3 (2026): SINERGI : Jurnal Riset Ilmiah, Maret 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i3.2455

Abstract

Prostate cancer is one of the most common and deadliest cancers among men, both worldwide and in Indonesia. Prostate cancer is a malignant disease characterized by abnormal cellular proliferation within the prostate tissue. Age is the most common risk factor for prostate cancer, with the risk increasing markedly in men aged 50 years and older. The most frequently identified subtype of prostate cancer is adenocarcinoma. This study was a descriptive observational study using medical record data of patients diagnosed with prostate cancer based on histopathological findings at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital, Padang, during the period 2018–2022. Total sampling was employed. The variables analyzed included age, clinical manifestations, prostate-specific antigen (PSA) levels, histopathological cell type, and the degree of cellular differentiation of prostate cancer. The results showed that a total of 41 prostate cancer patients met the inclusion criteria. The most common age group was 55–70 years (63.4%). Local clinical manifestations were observed in 92.7% of patients, serum PSA levels >20 ng/mL in 82.9%, adenocarcinoma as the histopathological type in 100%, and poorly differentiated tumors in 82.9% of cases. The predominant histopathological type of prostate cancer was adenocarcinoma. Most patients were aged 55–70 years, commonly presented with local clinical symptoms, had serum PSA levels >20 ng/mL, and most frequently exhibited a poorly differentiated degree of tumor differentiation.
Clinicopathological Characteristics of Hepatocellular Carcinoma at a Tertiary Hospital: A Retrospective Study Rasfa, Rum Affida; Hilbertina, Noza; Asri, Aswiyanti; -, Yenita; Devianti, Loli
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202637-44

Abstract

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and shows significant regional variations in clinicopathological characteristics. Limited data exist on HCC patterns in Indonesia, particularly in West Sumatra. This study aimed to characterize the clinicopathological features of HCC at Dr. M. Djamil Hospital, Padang, from 2021to2024.Methods: A descriptive retrospective study was conducted using medical records and histopathological re-evaluation of 46 HCC cases. Specimens were examined for demographic data, tumor characteristics, histopathological subtypes according to the WHO 2019 classification, differentiation grade, lymphovascular invasion, and background liver pathology.Results: The median age was 56 years, with male predominance (60.9%). Most specimens were resection specimens (60.9%) with tumor size ≥4 cm in 47.8% of cases and single nodules in 52.1%. Clear cell (39.1%) and macrotrabecular massive (37.0%) were the predominant subtypes, contrasting with global data showing NOS predominance. Most tumors were moderately differentiated (63.0%), with lymphovascular invasion present in 65.2% and cirrhotic background in 58.7% of casesConclusion: HCC in West Sumatra demonstrates distinct histopathological patterns, with a predominance of clear cell and macrotrabecular massive subtypes and high rates of lymphovascular invasion. These finding suggest histopathological features associated with aggressive tumor behavior (particularly macrotrabecular massive subtype and lymphovascular invasion), although no clinical outcome or survival analysis was performed.
Epidermal Growth Factor Receptor Expression and Mutations as Diagnostic and Predictive Biomarkers in Lung Cancer: A Literature Review Munir, Sri Melati; Harahap, Wirsma Arief; Basyar, Masrul; Hilbertina, Noza
Jurnal Kesehatan Komunitas Indonesia Vol 6 No 1: April 2026
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jkki.v6i1.712

Abstract

Lung cancer remains a leading cause of cancer-related mortality worldwide, with diagnostic challenges due to nonspecific symptoms and limitations in tissue sampling. Molecular biomarkers, particularly Epidermal Growth Factor Receptor (EGFR), have gained attention for improving diagnostic accuracy and understanding tumor biology. EGFR plays a critical role in regulating cell proliferation, differentiation, and survival through multiple signaling pathways. This study aims to analyze the role of EGFR expression as a diagnostic biomarker in lung cancer by reviewing its biological function, molecular mechanisms, and clinical relevance. This study used a literature review approach by collecting relevant articles from databases such as PubMed, Scopus, and Google Scholar. Keywords including “EGFR,” “lung cancer,” and “biomarker” were used to identify studies discussing EGFR expression and its diagnostic value. EGFR overexpression and mutations are frequently found in lung cancer, especially non-small cell lung cancer. Activation of EGFR triggers signaling pathways such as MAPK, PI3K, and STAT, promoting tumor proliferation and survival. Detection methods, including immunohistochemistry, PCR, and FISH, are widely used. EGFR expression has shown potential as a diagnostic biomarker and provides important information for targeted therapy. EGFR expression plays a significant role in lung cancer diagnosis and offers potential as a diagnostic biomarker. However, variations across populations and tumor subtypes require careful interpretation in clinical applications.
Co-Authors -, Yenita Addina, Rina Adelia Rachmita, Prima Aden, Kuntum Annisa Tiara Aisyah Elliyanti Arnofyan, Budi Pratama Aswiyanti Asri Daan Khambri Devianti, Loli Fasril , Thira Fereshti Lailani Ginting, Desi Scorpinasari Hafni Bachtiar Harahap, Wirsma Arief Hasmiwati henny Mulyani Husna Yetti Ida Rahmah Burhan Jeanne Adiwinata Pawitan Karmia, Hudila Rifa Kusumardani, Dini Latifah, Iklil liana, nana Malinda Meinapuri Masrul Basyar Melayu, Artes Putri Nurhayati Nurhayati Nuzulia Irawati Rachmawati, Nice Rum Affida Rasfa Safnita, Dewi Salmiah Agus Selfi Renita Rusjdi Setiawati, Yessy Sri Melati Munir Suchitra, Avit Tofrizal Wildanur, Sri Wildanur Yanwirasti Yanwirasti Yenita . Yona, Fajriza Zulfiqar, Yevri