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All Journal Journal of Agromedicine and Medical Sciences Jurnal Penelitian Sains Jurnal Kesehatan Komunitas Majalah Patologi Indonesia Health and Medical Journal International Islamic Medical Journal Cerdika: Jurnal Ilmiah Indonesia Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Noza Hilbertina, Noza
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Liana, Nana; Hilbertina, Noza; Devianti, Loli; Yetti, Husna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP IBU TERKAIT INISIASI MENYUSUI DINI, PEMBERIAN ASI EKSKLUSIF, DAN MAKANAN PENDAMPING ASI DENGAN KEJADIAN STUNTING PADA ANAK DI WILAYAH KERJA PUSKESMAS YANGMEMILIKI ANGKA KEJADIAN STUNTING TERTINGGI DI KOTA PADANG Melayu, Artes Putri; Rachmawati, Nice; Hilbertina, Noza
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 1 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i1.2446

Abstract

Stunting is a condition of malnutrition that persists for a long period of time in children, characterized by the child's height growth not being in accordance with age. The cause of stunting is multifactorial, low nutritional intake is the main cause of stunting. This nutritional intake includes Early Breastfeeding Initiation, exclusive breastfeeding and complementary feeding. Providing nutritional intake to children influenced by the mother's knowledge and attitudes. This study aims to determine the relationship between mothers' knowledge and attitudes regarding early initiation of breastfeeding, exclusive breastfeeding and complementary foods with the incidence of stunting in children. The type of research is analytical observational research with a cross sectional research design with a sample of 67 mothers who had children aged 24-59 months in the work area of the health center which had the highest incidence of stunting in Padang City, namely the Ikur Koto Health Center, Air Children's Health Center and Seberang Padang Health Center . The number of samples was taken based on propotional random sampling technique. This research instrument uses a questionnaire and microtoise. The data analysis using the Chi Square test. The results of the study showed that the frequency of stunting incidents in children aged 24-59 months in the three health center work areas studied was 47,8%. The level of knowledge of respondents was good at 44.8%, and the attitude of respondents was positive at 62.7%. Bivariate analysis obtained a value of p = 0.004 (p value < 0.05) for the relationship between maternal knowledge level and the incidence of stunting and a value of p = 0.005 (p value < 0.05) for the relationship between maternal attitudes and the incidence of stunting. The conclusion of this study is that the level of knowledge and attitudes of mothers regarding IMD, exclusive breastfeeding and MPASI show a statistically significant relationship
CLINICOPATHOLOGICAL CHARACTERISTICS OF PROSTATE CANCER AT THE ANATOMICAL PATHOLOGY LABORATORY OF RSUP DR. M. DJAMIL PADANG 2018–2022 Latifah, Iklil; Yenita, Yenita; Burhan, Ida Rahmah; Hilbertina, Noza; Zulfiqar, Yevri; Lailani, Mutia
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 3 (2026): SINERGI : Jurnal Riset Ilmiah, Maret 2026( In Press)
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i3.2455

Abstract

Prostate cancer is one of the most common and deadliest cancers among men, both worldwide and in Indonesia. Prostate cancer is a malignant disease characterized by abnormal cellular proliferation within the prostate tissue. Age is the most common risk factor for prostate cancer, with the risk increasing markedly in men aged 50 years and older. The most frequently identified subtype of prostate cancer is adenocarcinoma. This study was a descriptive observational study using medical record data of patients diagnosed with prostate cancer based on histopathological findings at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital, Padang, during the period 2018–2022. Total sampling was employed. The variables analyzed included age, clinical manifestations, prostate-specific antigen (PSA) levels, histopathological cell type, and the degree of cellular differentiation of prostate cancer. The results showed that a total of 41 prostate cancer patients met the inclusion criteria. The most common age group was 55–70 years (63.4%). Local clinical manifestations were observed in 92.7% of patients, serum PSA levels >20 ng/mL in 82.9%, adenocarcinoma as the histopathological type in 100%, and poorly differentiated tumors in 82.9% of cases. The predominant histopathological type of prostate cancer was adenocarcinoma. Most patients were aged 55–70 years, commonly presented with local clinical symptoms, had serum PSA levels >20 ng/mL, and most frequently exhibited a poorly differentiated degree of tumor differentiation.
Co-Authors Addina, Rina Adelia Rachmita, Prima Aden, Kuntum Annisa Tiara Aisyah Elliyanti Arnofyan, Budi Pratama Aswiyanti Asri Daan Khambri Devianti, Loli Fasril , Thira Fereshti Lailani Ginting, Desi Scorpinasari Hafni Bachtiar Hasmiwati henny Mulyani Husna Yetti Ida Rahmah Burhan Jeanne Adiwinata Pawitan Karmia, Hudila Rifa Kusumardani, Dini Latifah, Iklil liana, nana Malinda Meinapuri Melayu, Artes Putri Nurhayati Nurhayati Nuzulia Irawati Rachmawati, Nice Safnita, Dewi Salmiah Agus Selfi Renita Rusjdi Setiawati, Yessy Suchitra, Avit Tofrizal Wildanur, Sri Wildanur Yanwirasti Yanwirasti Yenita . Yona, Fajriza Zulfiqar, Yevri