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All Journal Jurnal Kimia (Journal of Chemistry) The Journal of Pure and Applied Chemistry Research Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan GERVASI: Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Al-Ikhlas Berkala Ilmiah Mahasiswa Farmasi Sainsbertek Jurnal Ilmiah Sains & Teknologi Prosiding Seminar Nasional Universitas Ma Chung Jurnal Pengabdian Masyarakat Charitas Rafflesia Journal of Natural and Applied Sciences (RJNAS) Journal of Public Health Indonesian NAWASENA: Journal of Community Service
Muhammad Hilmi Afthoni
Program Studi Farmasi, Fakultas Farmasi, Universitas Jember
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Potential Cytotoxic Activity of Methanol Extract, Ethyl Acetate, and n-Hexane Fraction from Clitoria ternatea L. on MCF-7 Breast Cancer Cell Line and Molecular Docking Study to P53 Rollando Rollando; Marsha Anggita Amelia; Muhammad Hilmi Afthoni; Kestrilia Rega Prilianti
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.705

Abstract

Breast cancer is a condition where the cells in breast tissue lose control and multiply uncontrollably. In this study, MCF-7 breast cancer cells were tested for cytotoxic activity using the MTT assay and the active compound's interaction with the p53 protein was tested in silico. The most active fraction was found to be the ethyl acetate fraction, with an IC50 value of 1.730 μg/mL and a selectivity index of 2.485. However, the selectivity index was less than 3, and Vero cells showed changes in morphology with the addition of the ethyl acetate fraction. GC-MS was used to identify 19 compounds in the ethyl acetate fraction, and in-silico tests were performed on 5 potential anticancer compounds. Lipinski's Rule of Five test showed that only 3 of these compounds could undergo molecular docking. The results indicated that Anethole compound can interact with p53 protein, while Cinnamaldehyde, (E)- can interact with p21 protein.
Reduksi Katalitik 4-Nitrofenol dengan Katalis Nanopartikel Perak Terkonjugasi L-Lisine Rokiy Alfanaar; Muhammad Hilmi Afthoni
RAFFLESIA JOURNAL OF NATURAL AND APPLIED SCIENCES Vol. 1 No. 2 (2021): Oktober
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/rjna.v1i2.18572

Abstract

Nanopartikel perak berpotensi menjadi katalis homogen dalam reduksi 4-nitrofenol menjadi 4-aminofenol. Berbagai penelitian menunjukan L-lisine berpotensi bertindak sebagai agen penstabil nanopartikel perak sehingga mempengaruhi sifat katalitik nanopartikel perak. Pada penelitian ini dilakukan reduksi 4-nitrofenol menggunakan katalis nanopartikel perak yang terkonjugasi dengan L-lisini dengan reduktor NaBH4.  Dari hasil reduksi didapatkan nanopartikel perak dengan dosis 50 ?L mampu mengubah 99,99% 4-nitrofenol menjadi 4-aminofenol dengan tetapan laju reaksi 0,1130 menit-1.
Penentuan masa kadaluarsa sebagai upaya kontrol kualitas sambal di usaha mikro kecil menengah (UMKM) Alfanaar, Rokiy; Yoedistira, Chresiani; afthoni, muhammad
Jurnal Pengabdian Masyarakat Charitas Vol. 3 No. 01 (2023): Jurnal Pengabdian Masyarakat Charitas Juni 2023
Publisher : Program Studi Teknik Industri, Fakultas Teknik, Universitas Katolik Indonesia Atma Jaya Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/charitas.v3i01.4364

Abstract

Sambal holds a significant place in Indonesian culinary heritage, reflecting the traditions of past generations. To address the issue of improper sambal storage leading to a shorter shelf life, a new approach in packaging has been introduced. The objective of this community service project is to establish the appropriate shelf life for sambal and provide storage recommendations. Through testing under different conditions, it was found that sambal can last for 4 days at room temperature, while the recommended storage temperature is between 2 and 8 degrees Celsius for a duration of 2 weeks.
PENINGKATAN KONTROL KUALITAS PADA KOPI ARABIKA Coffea arabica FERMENTASI DESA KUCUR DENGAN OPTIMASI SUHU PENGERINGAN Lutfi, Moh; llando, Ro; Aftoni, Muhammad Hilmi Aftoni
Sainsbertek Jurnal Ilmiah Sains & Teknologi Vol. 4 No. 1 (2023): September - Sainsbertek Jurnal Ilmiah Sains & Teknologi
Publisher : Ma Chung Press, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/sb.v4i1.259

Abstract

Kopi ialah sebuah minuman dimana merupakan salah satu minuman yang disukai di Indonesia yaitu orang tua bahkan anak muda yang banyak mengandung kafein. Di Indonesia ragam kopi dimana banyak didayagunakan adalah kopi dengan ragam arabika, pada perkebunan rakyat dominan dimainkan kopi dengan ragam arabika sebab dianggap mempunyai kecenderungan rasa yang tinggi. Riset ini mempunyai tujuan guna mencari tau suhu maksimal untuk mengeringkan kopi arabika sehingga menghasilkan kualitas kopi yang baik dan pula mengetahui kadar kafein pada berbagai perlakuan suhu 45oC, 50oC, serta 55oC yangmana yang akan diukur menggunakan alat spektrofotometer Uv-Vis. Jenis riset ini yaitu riset percobaan laboratorium guna melakukan pengujian serta menghitung jumlah kafein yang ada di kopi arabika menggunakan tiga suhu pengeringan yaitu suhu 45oC, 50oC, dan 55oC yangmana di ambil dari Desa Kucur. Variabel terikat penelitian ini adalah optimasi suhu pengeringan kopi arabika fermentasi dan variabel bebas dalam riset ini yaitu suhu pengeringan kopi arabika yangmana dipakai di riset ini yaitu pada suhu 45oC, 50oC, dan 55oC. Analisis data riset memakai metode ANOVA one way dimana mempunyai tujuan yaitu guna mengetahui apakah ada perbedaan yang disignifikan atau tidak pada kadar kafein dalam kopi arabika dengan tiga suhu pengeringan yang berbeda. Menurut riset yangmana sudah dilaksanakan, bisa ditarik konklusi yaitu suhu pengeringan serta lamanya fermentasi bisa memberikan pengaruh jumlah kafein pada kopi arabika yangmana diketahui dari analisis ANOVA one way dimana P-value yaitu 8,67x10-9 < a yaitu 0,05. Pada suhu 45oC didapatkan hasil kadar kafein 4,03ppm, suhu 50oC 1,239ppm, dan suhu 55oC 1,053ppm.
Molecular Docking and Molecular Dynamic Studies of Secondary Metabolites from Momordica Charantia as Natural Antidiabetic: Studi Penambatan dan Dinamika Molekuler Senyawa Metabolit Sekunder Momordica Charantia sebagai Antidiabetes Alami Rollando, Rollando; Chandra, Melisa Dwi; Aftoni, Muhammad Hilmi; Swastika, Windra
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.15976

Abstract

Background: Diabetes Mellitus is a non-contagious disease characterized by hyperglycemia. Diabetes mellitus occurs when the body cannot receive or use insulin properly. If you already have diabetes, then the patient must take medication continuously because diabetes mellitus is a lifelong disease. Because medicines are quite expensive, alternative ways to cure the disease are needed by consuming traditional medicines, one of which is bitter melon (Momordica charantia). Objectives: This research aims to predict the secondary metabolite compounds in the bitter melon plant, analyze molecular interactions, and identify compounds that can lower blood sugar levels. Material and Methods: 12 compounds from the Momordica charantia plant and six proteins (1IR3, 1RHF, 1XU7, 4PNZ, 4YVP, 2NT7) that will be docked using Pyrx and Yasara Dynamics applications. Results: From the molecular docking results, three compounds with the highest binding affinity were found in Momordica charantia: momordenol, oleanolic acid, and momordicin. Based on molecular dynamics simulations, these three compounds were stable in their interactions with the six proteins tested, namely 1IR3, 1RHF, 4PNZ, 4YVP, 1XU7, and 2NT7. Momordenol and momordicin showed the most stable interaction profiles. Furthermore, ADMET tests showed that momordenol, oleanolic acid, and momordisin have drug-like characteristics. Conclusions: The Momordica charantia plant has the potential to act as an antidiabetic agent.
PENINGKATAN PEMAHAMAN MASYARAKAT TERHADAP PENYAKIT ASAM URAT DI APOTEK MALANG RAYA MELALUI MEDIA ONLINE FX Haryanto Susanto; Chresiani Destiana Yoedistira; Sultan Arif Rahmadianto; Rokiy Alfanaar; Muhammad Hilmi Afthoni
JURNAL PENGABDIAN AL-IKHLAS UNIVERSITAS ISLAM KALIMANTAN MUHAMMAD ARSYAD AL BANJARY Vol 9, No 1 (2023): AL-IKHLAS JURNAL PENGABDIAN
Publisher : Universitas Islam kalimantan MAB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jpaiuniska.v9i1.11131

Abstract

Asam urat adalah jenis penyakit yang disebabkan oleh diet dan konsumsi makanan yang tinggi di purin konten yang mengakibatkan adanya ketidakseimbangan antara masuknya purin dan kemampuan tubuh untuk metabolisme mereka, penumpukan asam urat menyebabkan sebuah kristal di sendi. Pandemik yang telah berakibat pada pembatasan covid-19 tentang penyelenggaraan penyuluhan membuat keberadaan media online dapat digunakan sebagai metode alternatif untuk penyuluhan. Metode pelaksanaan padapengabdian ini adalah dengan metode pengambilan survei dari partisipan komunitas kesehatan pada apotek patimura, Apotek Madyopuro, dan Apotek sehat di Malang. Peningkatan pengetahuan asam urat dengan media video berhasil dan dapat memberikan hasil baik, dibuktikan dengan peningkatan hasil pengetahuan yang berbeda signifikan secara statistik. Untuk pengembangan pengabdian masyarakat dapat dilakukan pada area yang lebih luas dan variasi materi yang berbeda.
Community-Based Efforts to Control Infectious Diseases Mustar, Mustar; Yamtana, Yamtana; Hasnidar, Hasnidar; afthoni , Muhammad Hilmi
Journal of Public Health Indonesian Vol. 2 No. 1 (2025): MAY-JHH
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/6y5fqv92

Abstract

This study aims to analyze the effectiveness of community-based approaches in addressing infectious diseases at the local level, particularly in the city of Surakarta. This approach involves community empowerment through the engagement of local health cadres and the formation of environmental awareness groups that actively carry out disease prevention activities. The method used is a case study with data collected through interviews, observations, and documentation. The results of the study indicate that the community-based approach has successfully increased awareness and behavioral changes among the public in adopting healthy lifestyles, such as maintaining environmental cleanliness and independently conducting case tracking. Moreover, the strengthening of social capital and local leadership has proven to be crucial factors in the success of the program. Challenges encountered include low digital literacy among cadres and the general community, limiting the use of information technology. In conclusion, the community-based approach is an effective strategy to complement formal healthcare services in controlling infectious diseases. This model is recommended for replication with adjustments tailored to local socio-cultural characteristics.
Peningkatan Kesadaran Generasi Muda tentang Pentingnya Kendaraan Listrik Melalui Kampanye Media Sosial Sugiani, Tina; Nababan, Jessicca; Yuneta; Alfanaar, Rokiy; Ariefin, Mokhamat; Wahyuningsih Manurung, Tety; Yuniarti, Yuyun; Hilmi Afthoni, Muhammad; Horale Pasaribu, Marvin
NAWASENA : JOURNAL OF COMMUNITY SERVICE Vol. 2 No. 01 (2024): Vol 02 No 1 2024
Publisher : NAWASENA : JOURNAL OF COMMUNITY SERVICE

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kampanye media sosial telah dilakukan untuk meningkatkan kesadaran generasi muda tentang pentingnya kendaraan listrik, sebuah solusi mobilitas berkelanjutan yang semakin relevan dalam upaya mengatasi polusi udara dan perubahan iklim. Kampanye ini melibatkan produksi dan distribusi video informatif melalui Instagram, yang mencakup lima poin utama: polusi udara, dampak kendaraan konvensional, konversi kendaraan BBM ke listrik, kelebihan kendaraan listrik terhadap lingkungan, dan perkembangan teknologi kendaraan listrik. Hasil kampanye menunjukkan video ditonton sebanyak 39.100 kali, memperoleh 440 likes, dan 52 komentar, dengan lebih dari 90% komentar berasal dari generasi muda. Respons positif ini menegaskan bahwa kampanye berhasil mencapai dan melibatkan audiens yang ditargetkan. Keberhasilan ini menunjukkan bahwa media sosial adalah alat yang efektif untuk edukasi dan promosi perubahan positif di kalangan generasi muda, mendukung adopsi kendaraan listrik dan transisi menuju mobilitas berkelanjutan.
Co-Authors Alfanaar, Rokiy Ayu Merli Wahyuni Chandra, Melisa Dwi Chresiani Destiana Yoedistira Dzurriatul Maghfiroh E. Monica Ega Malia Jiska Eka Anggie Amalia Eka Anggie Amalia Erlinawati Santoso Erlinawati Santoso Eva Monica Eva Monica Eva Monica Feliadewi Ruth Fibe Yulinda Cesa FX Haryanto Susanto Hasnidar Horale Pasaribu, Marvin Kestrilia Rega Prilianti llando, Ro Maria Sindy Marsha Anggita Amelia Martanty Aditya, Martanty moh lutfi, moh Mokhamat Ariefin Mustar Nababan, Jessicca Nurul Azmi Wibawanty P. N. Alfiyandri Rollando, Rollando Sugiani, Tina Sultan Arif Rahmadianto Trianom Suryandharu W. Swastika Wahyuningsih Manurung, Tety Windra Swastika Yamtana Yamtana, Yamtana Yoedistira, Chresiani Yuneta Yurida Ekawati Yurida Ekawati Yuyun Yuniarti, Yuyun