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Syahbudin Hasibuan, Syahbudin
Program Studi Agroteknologi Fakultas Pertanian Universitas Medan Area Jl. Kolam No. 1 Medan Estate Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Social Sciences

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Journal : Journal of Applied Agricultural Science and Technology

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Phytochemical Screening of Mahogany (Swietenia mahogany) Secondary Extract Potential as COVID-19 Medication Candra, Ifan Aulia; Hasibuan, Syahbudin; Khoir, Fastabiqul
Journal of Applied Agricultural Science and Technology Vol. 8 No. 3 (2024): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55043/jaast.v8i3.247

Abstract

Mahogany secondary metabolite is proven effective as lung disease medication, including COVID-19 through docking analysis. Therefore, this study aimed to identify total secondary metabolite from leaves, stem barks, and seeds of mahogany (Swietenia mahogany). The study was carried out using an experimental and descriptive method by observing the visual changes in the sample including color and foam formation, total levels of flavonoids, alkaloids, and saponins using Gas Chromatography and Mass Spectroscopy (GC-MS). Phytochemical analysis was analyzed to identify secondary metabolites namely flavonoids, alkaloids, tannins, triterpenoid saponins, and steroids. The results of the GC-MS analysis showed that mahogany seeds extract had the highest retention time, with a total of 46,484, containing alpha -D Glucopyranoside, 3-Penten-2-one, and gamma-Tocopherol. These compounds belonged to derivatives of flavonoids and saponins, serving as potential COVID-19 medication. The other were terpenoid, steroid, and fatty acid group compounds (alpha humulene, neophyte diene, n-hexadecanoic acid, 9- Octadecenoic acid, Octadecanoic acid, Squalene, and Stigmasterol). In conclusion, these identified compounds have the potential for COVID-19 medication due to their anti-inflammatory, antiviral, antimicrobial immunosuppressant, anticancer, and anti-asthma properties.
Co-Authors AHMAD RAFIQI TANTAWI Astuti Kuswardani, Retno Budi Sakti, Anto Dohar Candra, Ifan Aulia Damanik, Kevin Aditya E. Harso Kardhinata Ebsan Marihot Sianipar Efendi, Ihsan Erwin Nyak Akoeb, Erwin Nyak Hadi Reka Utama, Muhamad Hamdani Hamdani Hasan, Uswatul Hasnudi, Hasnudi Ifan, Ifan Aulia Candra Iif Rahmat Fauzi, Iif Rahmat Ilvira, Rika Fitri Khoir, Fastabiqul Litna Nurjannah Ginting Maimunah Maimunah Marleni Marleni Nasution, May Sarah Pakpahan, Plawer Arimbi pane, dona syahraina Prizoise Nababan, Christolo Retna Astuti Kuswardani Salqura, Siti Saragih, Bahdan Siagian, Hotma Simatupang, Bernat Siregar, Tumpal H.S. Siregat, Akbar Siti Mardiana SP, Rizky Hafrizany suswati suswati Tarigan, Eva Elfriani Tri Martial Yusniar Lubis Zulkarnain Lubis