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Viski Fitri Hendrawan
Faculty Of Veterinary Medicine, Universitas Brawijaya
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Journal : Veterinary Biomedical and Clinical Journal

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Solasodine and Gosipol Effectivity as a Male Contraception Inhibit LH Expression and Spermatogenesis in Rat Wulansari, Desi; Oktanella, Yudit; Hendrawan, Viski Fitri; Agustina, Galuh Chandra
Veterinary Biomedical and Clinical Journal Vol. 1 No. 2 (2019)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.671 KB) | DOI: 10.21776/ub.VetBioClinJ.2019.001.02.7

Abstract

Rabies related to increasing canine population in Bali. Uncontrolled wild animal populations caused disease transmission from animal to human. Various attempt at population control are carried out such as the use of natural contraception. Some compounds are known to have potential as antifertility are solasodine and gosipol. Solasodine is known have an antifertility affect. Gosipol, fenolic compound in Ceiba pentandra, inhibits spermatogenesis, reduce sperm concentration, motility and viability. This research aims to compare effectiveness of terong cepoka and Ceiba pentandra as antifertility. This research was conducted at Mei-November 2018. Eight-teen rats were used in this study and divided into three groups: control, P1 extract Solanum torvum 1g/kg BW and P2 extract Ceiba pentandra 0,1g/kg BW PO. Rats were treated with extract for 10 days and euthanazed at day 11. Testis were collected for histopathology using HE staining to observe spermatogenesis and using immunohistochemistry to observe LH expression. The result are analyzed using one way ANOVA P<0.05. the result show that extract solanum torvum 1g/kg BW and ceiba pentandra 0,1g/kgBW cannot reduce spermatogenesis and LH expression. This study used crude extract which still consist any other compound like antioxidant. Future study we need use isolated and pure solasodine and gosipol.
Co-Authors Aditya, Siska Agustina, Galuh Chandra Andre Giovanni Aprilia, Rizka Muizzu Asri Nurul Huda Aulia Firmawati Cahyani, Ayunda Ageng Chanif Mahdi Chanif Mahdi Dameanti, Fidi Nur Aini Eka Puji Desi Wulansari Desi Wulansari Dewi Mariyam Dhea Salsabila Erma Safitri Firmawati, Aulia Galuh Candra Agustina Galuh Chandra Agustina Hendrawan Soetanto Intan Firdha Olien N. A. I. Khoirus Viestaria Mafruchati, Maslichah Mariyam, Dewi Nurul Luthfiana Pudji Srianto Rimayanti Rimayanti Ritonga, Azra Salsabila Shabira, Zahra Siska Aditya Sruti Listra Adrenalin Suherni Susilowati Tita Damayanti Lestari Ujiati Kamulyan Widi Nugroho Widjiati Widjiati Widjiati Widjiati, Widjiati Yudit Oktanela Yudit Oktanella, Yudit