According to PISA data, the level of scientific literacy in Indonesia is relatively low, highlighting the need for innovative learning media tailored to the needs of Generation Z students. This study aims to develop an e-module based on socio-scientific issues using the Liveworksheets platform to enhance students' scientific literacy on acid-base topics. The research employed a Research and Development (RD) method with the ADDIE model, encompassing analysis, design, and development phases. Product validation was conducted by material experts, media experts, and reviewers, while a limited trial was carried out with students. Validation results revealed that the e-module achieved an excellent category from material experts, media experts, and reviewers, with an average ideality percentage of 95%. Student trials also yielded positive responses with excellent content, language, and user-friendliness ratings. The developed e-module incorporates relevant socio-scientific issues, supports technology-based learning, and is designed to accommodate visual, auditory, and kinesthetic learning styles. Therefore, this e-module is an innovative and effective alternative learning medium to improve students' scientific literacy on acid-base topics. In addition, this e-module has the potential to nurture scientifically literate citizens who can contribute to solving socio-scientific issues in society.