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All Journal Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Berkala Kedokteran JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Journal of Kidney and Hypertension CRJIM (Clinical and Research Journal in Internal Medicine) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Mohammad Rudiansyah
Divisi Ginjal Dan Hipertensi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Lambung Mangkurat / RSUD Ulin Banjarmasin, Indonesia.
Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Prognostic Nutritional Index (PNI) at Admission Predicts In-Hospital Mortality of COVID-19-Infected Patients Haryati, Haryati; Isa, Mohamad; Rudiansyah, Mohammad; Juhairina, Juhairina; Nor, Muhamad; Arganita, Fidya Rahmadhany
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3930

Abstract

Corona Virus Disease-2019 (COVID-19) was declared a pandemic in March 2020 and caused considerable deaths in all parts of the world. Mortality is influenced by the immune system status and increased vulnerability to infection, both related to nutritional status. The Prognostic Nutritional Index (PNI), calculated using lymphocyte count and albumin levels, may have the ability to more accurately characterize the nutritional and inflammatory conditions of COVID-19 patients. This retrospective study analyzed 967 COVID-19 patients at Ulin Hospital Banjarmasin, Indonesia, by examining demographic data, laboratory results, and PNI in relation to survival outcomes. The study revealed that factors such as age, sex, comorbidities (including hypertension, diabetes mellitus/DM, obesity, etc.), number of comorbidities, and disease severity correlated with mortality. Leucocyte count, lymphocyte count, albumin levels, and PNI all showed significant correlations with survival (p<0.001), suggesting that these factors may serve as useful prognostic indicators for COVID-19 patient’s survival. The PNI was associated with an increased risk of mortality, with a univariate odds ratio (OR) of 0.923. Receiver operating characteristic (ROC) analysis demonstrated that a PNI cut-off value of p<41.9 had a sensitivity of 44.9% and a specificity of 82.4%, with an area under the curve (AUC) of 0.666 (p<0.001). Hence, PNI at admission, which reflects patients' immune system and nutritional status upon hospital admission, can be used as a simple, cost-effective, and reliable predictor of mortality in COVID-19 patients.
Comparison of stingless bee honey and silver sulfadiazine on diabetic wound healing in rat models Fajari, Nanang Miftah; Pranoto, Agung; Perdanakusuma, David Sontani; Prenggono, Muhammad Darwin; Rudiansyah, Mohammad; Nur'amin, Hendra Wana; Syarifa, Yulia; Hasrianti, Nuvita; Saputri, Imelda Nita; Afrianto, Muhammad Irawan; Husna, Annisa Halida
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257974

Abstract

BACKGROUND Diabetic foot ulcers (DFUs) are a major health concern in Indonesia. Adjuvant therapies may improve healing by avoiding secondary infections, promoting angiogenesis, and supporting oxygen circulation. This aimed to evaluate the effect of stingless bee honey (SBH) from Heterotrigona itama on diabetic wound size in rats (Rattus norvegicus), compared to silver sulfadiazine (SSD). METHODS An experimental study was conducted on 13 diabetic wounds in streptozotocin-induced diabetic rats treated with three types of therapies: SSD (n = 5), pure SBH (n = 5), and SBH with 20% water content (n = 3). The study initially involved 21 rats, but eight died during the diabetes modeling and wound observation phases, presumably due to hyperglycemia. Baseline characteristics did not differ significantly across the groups. RESULTS SBH with 20% water content and pure SBH reduced wound size by 95.1% and 92.1%, outperforming SSD (77.4%), with all therapies showing statistically significant improvement (p<0.05). However, the differences between groups were not statistically significant (p = 0.162). CONCLUSIONS Topically applied SBH is a potential natural therapeutic agent for diabetic wounds, in addition to standard treatment such as SSD.
Efek Toksik Pemberian Ekstrak Daun Mundar (Garcinia forbesii King) Pada Ginjal Rattus norvegicus Jantan Galur Wistar Rosida, Azma; Reyhana, Adinda Salma; Wydiamala, Erida; Joharman, Joharman; Rudiansyah, Mohammad; Fujiati, Fujiati
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.97631

Abstract

Tumbuhan mundar (Garcinia forbesii King) merupakan tanaman khas yang tumbuh di Indonesia dan Malaysia telah dimanfaatkan masyarakat secara empiris sebagai obat penyakit kulit, malaria, dan diabetes. Tujuan penelitian untuk mengetahui efek toksik pemberian ekstrak daun Mundar terhadap ginjal. Metode penelitian menggunakan uji toksisitas akut berdasarkan pedoman BPOM (Badan Pengawas Obat dan Makanan) nomor 10 tahun 2022. Hewan uji terdiri dari 25 Rattus norvegicus (tikus putih) jantan galur Wistar terbagi 4 kelompok perlakuan dosis 5, 50, 300, 2000 mg/KgBB dan 1 kelompok kontrol (akuades). Pengamatan dilakukan selama 14 hari. Hasil uji One-Way ANOVA menunjukkan perbedaan signifikan kadar ureum (p=0,003) dan kreatinin (p= 0,006), sedangkan indeks ginjal (p=0,60) tidak terdapat perbedaan bermakna antar kelompok. Ekstrak daun Mundar dosis 300 dan 2000 mg/KgBB meningkatkan rerata kadar ureum di atas normal, sedangkan rerata kadar kreatinin masih dalam rentang normal. Pemeriksaan histopatologi ginjal menunjukkan nekrosis tubulus proksimal dan atrofi glomerulus ginjal pada dosis 300 dan 2000 mg/KgBB. Kesimpulan ekstrak daun Mundar dosis 300 dan 2000 mg/KgBB meningkatkan kadar ureum, menyebabkan kerusakan tubulus dan glomerulus ginjal tikus putih (Rattus norvegicus) jantan galur Wistar. 
Co-Authors Abimanyu Abimanyu Afrianto, Muhammad Irawan Agung Biworo Agung Biworo Agung Pranoto Alfi Yasmina Annisa Halida Husna, Annisa Halida Arganita, Fidya Rahmadhany Ariewardana, Angger Azma Rosida Azma Rosida, Azma Devi, Wivina Riza Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dhia Rona Nabilah Djallalluddin Djallalluddin Djallalludin, Djallalludin Dona Marisa, Dona Dwi Laksono Adiputro Dwi Laksono Adiputro Fariz, Adlan Farsya, Aqila Layyina Fauzan Muttaqien Fauzia Noor Liani Franciscus Xaverius Hendriyono Fransiscus Xaverius Hendriyono Fujiati ., Fujiati FX Hendriyono FX. Hendriyono Hafizhah Dzikra Radhiyyah Hartono, Ivan Haryati Haryati Hasrianti, Nuvita Hendra Wana Nur&#039;amin I Nyoman Suarjana Isa, Mohamad Joharman Joharman Juhairina, Juhairina Kurniaatmaja, Enita Rakhmawati Marcella Pavita Meyta Saskia Regita Putri Mohammad Bakhriansyah Mutaqqien, Fauzan Nanang Miftah Fajari Nani Zaitun Nia Kania Nila Nirmalasari, Nila Nor, Muhamad Nur M Faisal Ghani Nur'amin, Hendra Wana Nurazizah Yunus Nurhayati Nurhayati Nurulhuda Suwandari Ningrum Oski Illiandri Oski Illiandri Perdanakusuma, David Sontani Prenggono, Muhamad Darwin Reka Amelia Reyhana, Adinda Salma Ridha Paramadina Aizhar Saputri, Imelda Nita Syahputra, Harry Andhika Syarifa, Yulia Syifa Khairani Triska Dianti Wahyuningrum Wiwit Agung Sri Nur Cahyawati Wulandari, Nanik Tri Wydiamala, Erida Zulfikar, Muhammad Rakha