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All Journal BALI MEDICAL JOURNAL (BMJ) journal of internal medicine E-Jurnal Medika Udayana Media Kesehatan Masyarakat Indonesia Indonesian Journal of Tropical and Infectious Disease Universa Medicina ISM (Intisari Sains Medis) : Jurnal Kedokteran CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Journal of Global Pharma Technology Jurnal Penyakit Dalam Indonesia
I Ketut Agus Somia
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universtas Udayana-RSUP Sanglah Denpasar, Bali-Indonesia
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Inverse Correlation between Combination of Antiretroviral Therapy with the level of Serum Interleukin-6, Ferritin, and Hepcidin in HIV Patients with Anemia Chronic Disease I Ketut Agus Somia; Ketut Tuti Parwati Merati; I Made Bakta; Ida Bagus Putra Manuaba; Wayan Putu Sutirta Yasa; I Dewa Made Sukrama; Ketut Suryana; Rudi Wisaksana
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The purpose of this study was to determine whether the cARV therapy correlates with the serum level of IL-6, ferritin, and hepcidin in HIV infected patients with ACD.Methods: A cross-sectional study conducted in HIV patients with ACD, aged 15-65 years with exclusion criteria such as chronic renal disease, chronic liver disease, treated for anemia in the last 3 months, taking iron supplements in the last 3 months, history of blood transfusion in the last 1 year, suffering from acute infection, tuberculosis infection, malignancy, hepatitis C virus infection, acute hypersensitivity reaction and pregnancy. Blood specimen examined by high sensitivity human IL-6 In vitro ELISA, DRG Hepcidin- 25 ELISA, serum ferritin by agglutination method and CD4 cell count by flow cytometry. Results: A total of 86 HIV patients with ACD consist of 42 subjects with experienced cARV and 44 subjects with naive cARV. There are several differences between cARV naïve and experienced cARV including: Hb (g/dl) [ 10.8 ( 9.88 – 11.75) Vs. 11.60 (11.00 – 12.34) p: 0.058 ], serum iron (mg/dl) [ 50.00 (31 – 66.8) Vs. 71.40 (56.00 – 108.00) p: 0.121 ), serum ferritin (ug/dl) [ 630 ( 194 – 1101) Vs. 195.40 (128.25 – 589.47) p: 0.008 ], IL-6 (pg/mL) [7.20 (3.88 – 10.76) Vs. 4.03 (1.69 – 8.49) p: 0.009), serum hepcidin (ng/mL) [45.54 (16.74 – 95.31) Vs. 23.35 (6.58 – 49.99) p: 0.007] , CD4 cell count (cell/uL) [31.5 (14.25 – 90.75) Vs. 307 (168.5 – 458.75) p : < 0.001)] There is a significant inverse correlation between the cARV therapy with level of serum IL-6 ( r: - 0. 285, p: 0.008), ferritin (r: - 0.321, p: 0.007) and hepcidin (r: - 0.293, p: 0.006). While there was a significant positive correlation between the cARV therapy with CD4 cell count (r: 0.676, p: 0.001). There was no correlation between the cARV therapy with serum iron levels ( r: 0.176, p: 0.121).Conclusion: There is an inverse correlation between the cARV therapy with serum level of IL-6, ferritin, and hepcidin in HIV patients with ACD.  Keywords: cARV, ACD, IL-6, Ferritin, Hepcidin.
Kidney Disease and Its Impact on COVID-19 Patients at Sanglah Hospital Denpasar, Bali, Indonesia in 2021 Upadhana, Putu Satyakumara; Sastrawan, I Gede Gita Sastrawan; Chintya Cahyarini, I Gusti Agung Ayu; Umam, Anbiya Khairul; Putri, Amanda Trisliana Dwi; Adhyatma, I Gede Raka; Somia, I Ketut Agus
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Introduction. Besides having an impact on the respiratory system, COVID-19 also has an impact on other organ such as the kidneys. The systemic inflammatory response thought to be associated with bad prognosis of COVID-19 patients with kidney disease. This study aimed to determine the impact of kidney disease on COVID-19 patients. Methods. This study is an observational analytic study with a cross-sectional approach. The data used is secondary data from the records of confirmed COVID-19 patients who were treated at Sanglah Hospital from 1 May 2021 to 31 August 2021 using total sampling technique.Results. There were 248 patients included in this study. The majority of patients were male (52.4%) with the median overall age of the patients was 59 (range 20–92) years. Most of the patients were severe COVID-19 (65.3%). A total of 77 patients had kidney disease (31.0%) which the most common kidney disease found in patients was acute on chronic kidney disease (n=33; 42.8%). There were significant differences in hemoglobin (p<0.001), blood urea nitrogen (BUN) (p<0,001), serum creatinine (p<0.001), and procalcitonin (p<0.001) in patients classified based on kidney disease. Chi-square analysis showed that COVID-19 patients with kidney disease was correlated with sepsis [PR=2.587 (95%CI 1.750-3.824); p<0.001)], mortality [PR=1.696 (95%CI 1.114-2.583); p=0.018)], and severe COVID-19 [PR=1.513 (95%CI 1.077-2.342); p=0.040)]. Logistic regression analysis showed that COVID-19 patients with kidney disease was correlated with sepsis [PR=4.318 (95%CI 1.767-10.553); p<0,001] and mortality [PR=1.413 (95%CI 1.664-3.005); p=0.045)].Conclusion. Kidney disease increases the risk for sepsis and mortality in COVID-19 patients.
Epidemiological and Clinical Features of Critical and Non-Critical Elderly COVID-19 Patients in Udayana University Academic Hospital: A Retrospective Study Purnamasidhi, Cokorda Agung Wahyu; Somia, I Ketut Agus; Junior, Darren; Suteja, Richard Christian; Adiputra, I Komang Hotra; Purnama, Giovanca Verentzia; Weisnawa, I Gede Purna; Jerry; Wulandari, Putu Kintan; Shanti, Dewa Ayu Fony Prema; Diksha, I Gusti Ngurah Ariestha Satya
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.43097

Abstract

Elderly COVID-19 patients have been associated with worse outcomes and have been presented with the highest mortality rate. However, studies on the clinical features and the differences between critical and non-critical elderly COVID-19 patients in Indonesia and even other countries are still lacking and rare. In this retrospective study, the epidemiological and clinical features of critical and non-critical elderly COVID-19 patients admitted to Udayana University Academic Hospital between April 2020 and March 2021 were analyzed and then compared. Of the 280 medical records analyzed, 60.7% were male and the median age was 65.0 years old. Based on the medical records, 18.2% of elderly patients met our criteria of critical patients. The most common symptoms presented in both category upon admission included fever and coughing. The most common comorbidity found in critical patients was heart disease and hypertension in non-critical patients. Laboratory results differences included leukocytes, neutrophils, lymphocytes, Neutrophil-to-Lymphocyte Ratio, platelets, SGOT, SGPT, and urea. Only 9.9% of critical patients and 6.1% of non-critical patients were given antiviral therapy. In contrast, 68.6% of critical patients and 76% of non-critical patients were given antibiotics. The mortality rate in critical patients was 70.6% and 0.4% in non-critical patients. Based on the results, a multimodal approach in the treatment of elderly COVID-19 patients is very essential. The higher mortality rate in elderly patients should be able to be reduced by giving early and timely antiviral therapy with the addition of effective choice of drugs.
Comorbid Diseases and Outcomes of Critically Ill COVID-19 Patients Admitted to an Indonesian Intensive Care Unit from May to October 2021 Siahaan, Katrin Wilentina; Somia, I Ketut Agus; Utama, I Made Susila; Dian, Ni Made Dewi; Gayatri, Anak Agung Ayu Yuli; Purnamasidhi, Cokorda Agung Wahyu; Merati, Ketut Tuti Parwati
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.54859

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The spread of COVID-19 has become a worldwide health threat, with 583,038,110 cases and a death toll of 6,416,023. This study attempted to determine the relationship of age, sex, and comorbid diseases with the outcomes of critically ill COVID-19 patients at Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, Indonesia. Methods: This analytic study employed a retrospective approach, analyzing secondary data from medical records using a purposive sampling method. The research included univariate analysis, bivariate analysis using the chi-square test, and multivariate analysis using a general linear model performed with the assistance of IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA). A statistical analysis result with a p-value of less than 0.05 was deemed significant. Results: A total of 264 critically ill COVID-19 patients were hospitalized in the Intensive Care Unit of Prof. Dr. IGNG Ngoerah Central General Hospital from May to October 2021. Comorbid diseases were present in 215 patients. The comorbid diseases that had the greatest impact on increasing mortality were diabetes mellitus, hypertension, kidney disease, and cardiovascular disease (p=0.000–0.006, 95% CI). Conclusion: Age and sex do not have any significant relationship with the outcomes of critically ill COVID-19 patients. Meanwhile, comorbid diseases, such as diabetes mellitus, hypertension, and renal and cardiovascular diseases, pose a significant impact on the mortality rate of critically ill COVID-19 patients.   Highlights: 1. This study investigated patients who were critically ill with COVID-19 to determine the relationship between age, sex, comorbidities, and patient outcomes. 2. The findings of this study may provide additional data on the impact of comorbidities on the severity of COVID-19, which can be valuable to prevent mortality due to the infection.
Co-Authors Adhyatma, I Gede Raka Adiputra, I Komang Hotra Aditya Darmika Amanda Trisliana Dwi Putri Anak Agung Ayu Yuli Gayatri Anak Agung Gde Putra Wiraguna Anbiya Umam Anthony Widyanata Lebuan Chintya Cahyarini, I Gusti Agung Ayu Cindy Gracia Trisina Cokorda Agung Wahyu Purnamasidhi Derian Adiguna Sutanto Desak Made Wihandani Dian, Ni Made Dewi Diksha, I Gusti Ngurah Ariestha Satya Gayatri, Anak Agung Ayu Yuli Gede Wira Mahadita Haruko Akatsu I Dewa Made Sukrama I Dewa Nyoman Wibawa I G A Gita Dewi Rahmautami I Gede Gita Sastrawan I Gede Gita Sastrawan I Gede Gita Sastrawan Sastrawan I Gede Raka Adhyatma I Gusti Agung Ayu Chintya Cahyarini I Gusti Agung Bagus Arya Wiradarma I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ngurah Bagus Jayanta Ananda I Komang Gede Triana Adiputra I Made Bakta I Made Siswadi Semadi I Made Susila Utama I Nyoman Bayu Andika Wiguna I Putu Pande Agus Asmara Widhiana Saputra I Wayan Putu Sutirta Yasa Ida Ayu Santhi Pertiwi Manuaba Ida Bagus Nyoman Putra Dwija Ida Bagus Putra Manuaba IGA Putri Purwanthi Jerry Junior, Darren Kadek Aprilia Sukma Dewi Ketut Ridana Wibawa Ketut Suryana Ketut Tuti Parwati Merati Komang Adya Data Agrasidi Komang Agus Trisna Amijaya, Komang Agus Trisna Komang Andjani Putri Komang Vika Nariswari Ratna Kinasih Made Yogi Oktavian Prasetia Made Yogi Oktavian Prasetia, Made Yogi Oktavian Merry Merry Merry Ni Made Dewi Dian Sukmawati Ni Made Dwi Puspawati Ni Putu Kostarika Melia Daradila Ni Wayan Winarti Nittaya Phanuphak, Nittaya NN Ayu Dewi Purnama, Giovanca Verentzia Putri, Amanda Trisliana Dwi Putu Ardy Hartadi Putu Herdita Sudiantara Putu Novi Handayani Putu SAtherogenic Index Of Plasma iatyakumara Upadhana Putu Satyakumara Upadhana Putu Sudarmika Robertus Brian Junarli Rudi Wisaksana Sastrawan, I Gede Gita Sastrawan Sawitri, Anak Agung Sagung Shanti, Dewa Ayu Fony Prema Siahaan, Katrin Wilentina Suteja, Richard Christian Tika Rizki Nur Laela Tuti Parwati Umam, Anbiya Khairul Upadhana, Putu Satyakumara Utama, I Made Susila Weisnawa, I Gede Purna Wulandari, Putu Kintan Yundari, Yundari