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All Journal Setrum : Sistem Kendali-Tenaga-elektronika-telekomunikasi-komputer Biology, Medicine, & Natural Product Chemistry IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Bakti Masyarakat Indonesia Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Jurnal Abdimas Kesehatan Terpadu AMMA : Jurnal Pengabdian Masyarakat Jurnal RAP (Riset Aktual Psikologi Universitas Negeri Padang)
Alfred Pakpahan
Faculty Of Dentistry, Universitas Trisakti, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Inositol Hexakisphosphate (InsP₆) Induces Apoptosis via Caspase-Dependent Pathways: Molecular Docking Insights Ferry Sandra; Dewi Ranggaini; Johni Halim; Alfred Pakpahan; Visi Endah Pratitis; Kyung Hoon Lee
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3810

Abstract

BACKGROUND: Inositol hexakisphosphate (InsP₆) exhibits anticancer activity, especially by inducing intrinsic and extrinsic apoptotic pathways. However, there is still no molecular docking evidence that directly examines InsP₆ interactions with either upstream or downstream apoptotic regulators. Therefore, the current study was conducted to investigate the molecular docking of InsP₆ to caspases as upstream/downstream apoptotic regulators.METHODS: Ligands including InsP₆, InsP₅, InsP₄, histone deacetylase inhibitor, and caspase inhibitors were retrieved from PubChem, while target proteins (histone, caspase-8, caspase-2, and caspase-3) were obtained from the Protein Data Bank. Ligand toxicity was predicted using ProTox-3.0, and physicochemical properties were analyzed with SwissADME. Ligand structures were energy-minimized using PyRx with the Universal Force Field, while proteins were prepared by removing water molecules and non-essential heteroatoms in BIOVIA Discovery Studio. Molecular docking was conducted using CB-Dock 2.0, with binding poses selected based on the lowest Vina score, and ligand–protein interactions were visualized in Discovery Studio.RESULTS: Molecular docking results showed that InsP₆ bound strongly to histone, caspase-8, caspase-2, and caspase-3 with affinities comparable to reference inhibitors, forming multiple hydrogen bonds with key active-site residues. InsP₆, InsP₅, and InsP₄ exhibited several similar binding sites to caspase-3, with only minor differences in binding affinity.CONCLUSION: InsP₆ shows strong binding to histone, caspase-8, caspase-2, and caspase-3 based on in silico results, supporting its role in inducing both extrinsic and intrinsic apoptotic pathways. Taken together, InsP₆ could be a potential inducer of apoptosis in cancer cells.KEYWORDS: cancer, apoptosis, InsP₆, InsP₅, InsP₄, caspase, in silico, molecular docking
The Potency of Kuldon® Solution in The Healing Process of Aphthous Stomatitis Dewi Priandini; Alfred Pakpahan; Rahmi Amtha; Aprilia Puspita Sulistia; Abrijanto Abrijanto
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1241-1245

Abstract

Objectives: This study aimed to assess the efficacy of Kuldon® solution in the healing process of aphthous stomatitis.  Methods: A double-blind randomized controlled trial was conducted involving 60 subjects (27 males, 33 females), randomly assigned to receive either Kuldon® solution (Drug A) or hyaluronic acid rinse (Drug B). Pain was evaluated using the Visual Analogue Scale (VAS), and lesion diameter was measured on days 2, 5, and 7. Data were analyzed using the Mann-Whitney test (p < 0.05). Results: Drug A showed a greater reduction in pain and lesion size compared to Drug B. By day 5, 100% of Drug A users reported no pain, with 90% showing lesion reduction.Conclusion: Kuldon® solution demonstrates significant therapeutic potential in managing aphthous stomatitis.
IMPLEMENTATION OF THE SMART ABA METHOD ON TOILET TRAINING SKILLS IN CHILDREN WITH AUTISM SPECTRUM DISORDER Rudy Sutadi; Agita Tunjungsari; Alfred Pakpahan; Arneliza Arneliza; Kuncono Teguh Yunanto
Jurnal RAP (Riset Aktual Psikologi Universitas Negeri Padang) Vol. 15 No. 2 (2024)
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/rap.v15.i2.75

Abstract

Independent toilet skills are basic skills that must be mastered by every child, including children with autism spectrum (ASD). This skill begins with toilet training. However, toilet training for ASD children is a challenge in itself. Children with ASD have developmental disorders that impact many aspects of their lives, including toilet training skills. This study aims to determine the effectiveness of the Smart ABA (Smart Applied Behavior Analysis) Method on the toilet training ability of ASD children. Smart ABA is a development of Applied Behavior Analysis (ABA). This study uses an experimental method with a single research subject design and data analysis using visual graphs. The subjects of this study are two children with ASD, a boy aged 5 years and 7 years. The parents of the subjects were included in this study. The Smart ABA therapists who trained the subjects in this study have fulfilled their competencies as Smart ABA therapists. The most important finding of this study was the success of both subjects in daytime toilet training within 43 to 67 days.  These findings show the effectiveness of the Smart ABA method in achieving independence in toilet skills for ASD children. The results of this study will provide an in-depth understanding for parents of children with ASD, therapists, professionals, and doctors in the management of toilet training. The results of this study make an important scientific contribution to independent toilet skills in children with ASD. The stages of self-toilet skills using Smart ABA are discussed.
Tingkat Pengetahuan Kecacingan Di Desa Sukasari Pandeglang David Tjahyadi; Edy Parwanto; Haryo Ganeca Widyatama; Sisca Sisca; Reza Aditya Digambiro; Alfred Pakpahan
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 6 : Juli (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Worm disease still a serious problem and is second health problem in Indonesia come after malnutrition. Cumulative worms in human body can cause loss of substances that are useful for growth. The Filariasis and Worm Worms Sub-Directorate of P2PL stated that the prevalence of worm diseases in Pandeglang Regency was 58.3%. Various worm larvae were found when examining soil samples taken at the homes of residents of Sukasari, Pulosari, Pandeglang villages. The aim of this community service (PKM) is to increase knowledge about worm diseases. This Community Service Method (PKM) uses the counseling or lecture method by the presenter. Before and after counseling, residents were given a questionnaire to measure their level of knowledge about worm diseases. Residents' knowledge increased after being given counseling and it is hoped that this can help the community to prevent the emergence of worm diseases in the future.
Co-Authors Abrijanto Abrijanto Agita Tunjungsari Anggraeni, Rezky Aprilia Puspita Sulistia Areta Vania Bhanuwati Ariffandi, Bagas Ariyani, Annisaa Putri Arneliza Arneliza Binti Solihah David Tjahyadi Dewi Priandini Dewi Ranggaini Dipankara, Jackson Edy Parwanto Ferry Sandra Hadrian, Gary Halim, Johni Haryo Ganeca Widyatama Henry Candra Iqbal Zein Assyidiqie Johan Arief Budiman Johni Halim Komariah Komariah Kuncono Teguh Yunanto Kurnia Ningsih, Yuli Kurniawan, Vanesha Jane Kurniawati, Nazmia Kusmardi Kusmardi Kyung Hoon Lee Lestari, Tri Wahyuni Lidwina, Naomi Lies Zubardiah Lubis, Nadar Sukri Melyda, Ananda Shelly Nursolihati, Vidya Putri Reno Intan R. Deiny Mardian Rahmi Amtha Ranggaini, Dewi Reza Aditya Digambiro Riad, Anastasya Muna Ricky Anggara Putranto Rudy Sutadi Sisca Sisca Sri Ratna Laksmiastuti Suhartati Agoes Suhartati Agoes Susanto, Shannon Winnie Suwartini, Tien Tiarma Talenta Theresia Tri swasono adi Visi Endah Pratitis Wiwiek Poedjiastoeti, Wiwiek Yuniar Zen